Abstract:
:The variation of the proton chemical shifts due to the formation intermolecular hydrogen bonds is computed for a number of complexes which can be formed between the bases of the nucleic acids. The shifts expected for the isolated base pairs, in particular for the G-N1 H, T(or U)-N3H protons and the protons of the amino groups of A, G c, when combined with previous computations on the shifts to be expected upon base stacking, may enable a refined analysis of the high resolution NMR spectra of self complementary polynucleotides or tRNAs. Two examples are presented of a direct computation of proton shits associated with helix-coil transitions, helpful for deducing the helical structure in solution.
journal_name
Nucleic Acids Resjournal_title
Nucleic acids researchauthors
Giessner-Prettre C,Pullman B,Caillet Jdoi
10.1093/nar/4.1.99subject
Has Abstractpub_date
1977-01-01 00:00:00pages
99-116issue
1eissn
0305-1048issn
1362-4962journal_volume
4pub_type
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