The mouse and human homologs of DMC1, the yeast meiosis-specific homologous recombination gene, have a common unique form of exon-skipped transcript in meiosis.


:Genetic recombination in meiosis plays an important role in generating diversity of genetic information. In yeast an Escherichia coli RecA-like gene, DMC1, is expressed in meiotic prophase and its product co-localizes with Rad51 protein on zygotene chromosomes. We have cloned the mouse and human homologs of the yeast DMC1 gene. The predicted human and mouse DMC1 proteins showed 54.1% sequence identity with yeast Dmc1 protein. The domain II region, highly conserved in the E.coli RecA-like protein family, was also found in the mammalian DMC1 proteins, including the two ATP binding motifs and DNA binding sites with the region. In situ hybridization analysis revealed expression of the mouse Dmc1 gene in testicular germ cells in meiosis; RT-PCR showed expression in embryonal ovaries. These findings suggest that DMC1 plays an important role in meiotic homologous recombination. From both the man and mouse we have isolated an alternative spliced form of Dmc1 cDNA (Dmc1-d), which is deleted for a region between the two motifs involved in nucleotide binding. Since the alternatively spliced Dmc1-d transcript was detected in both male and female germ cells, the encoded protein DMC1-D may have a novel role in mammalian genetic recombination in meiosis.


Nucleic Acids Res


Nucleic acids research


Habu T,Taki T,West A,Nishimune Y,Morita T




Has Abstract


1996-02-01 00:00:00














  • Antisense-induced ribosomal frameshifting.

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    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Henderson CM,Anderson CB,Howard MT

    更新日期:2006-01-01 00:00:00

  • Molecular characterization of a gene encoding a photolyase from Streptomyces griseus.

    abstract::By using a synthetic DNA probe derived from an amino acid sequence in the most conserved region of three known photolyases (Escherichia coli, Anacystis nidulans and Saccharomyces cerevisiae), we isolated a DNA fragment containing two long open reading frames (ORFs) from a genomic DNA library of Streptomyces griseus. O...

    journal_title:Nucleic acids research

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    authors: Kobayashi T,Takao M,Oikawa A,Yasui A

    更新日期:1989-06-26 00:00:00

  • Structure of the 70S ribosome from human pathogen Staphylococcus aureus.

    abstract::Comparative structural studies of ribosomes from various organisms keep offering exciting insights on how species-specific or environment-related structural features of ribosomes may impact translation specificity and its regulation. Although the importance of such features may be less obvious within more closely rela...

    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Khusainov I,Vicens Q,Bochler A,Grosse F,Myasnikov A,Ménétret JF,Chicher J,Marzi S,Romby P,Yusupova G,Yusupov M,Hashem Y

    更新日期:2016-12-01 00:00:00

  • RB signaling prevents replication-dependent DNA double-strand breaks following genotoxic insult.

    abstract::Cell cycle checkpoints induced by DNA damage play an integral role in preservation of genomic stability by allowing cells to limit the propagation of deleterious mutations. The retinoblastoma tumor suppressor (RB) is crucial for the maintenance of the DNA damage checkpoint function because it elicits cell cycle arrest...

    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Bosco EE,Mayhew CN,Hennigan RF,Sage J,Jacks T,Knudsen ES

    更新日期:2004-01-02 00:00:00

  • Nascent RNA sequencing reveals mechanisms of gene regulation in the human malaria parasite Plasmodium falciparum.

    abstract::Gene expression in Plasmodium falciparum is tightly regulated to ensure successful propagation of the parasite throughout its complex life cycle. The earliest transcriptomics studies in P. falciparum suggested a cascade of transcriptional activity over the course of the 48-hour intraerythrocytic developmental cycle (I...

    journal_title:Nucleic acids research

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    authors: Lu XM,Batugedara G,Lee M,Prudhomme J,Bunnik EM,Le Roch KG

    更新日期:2017-07-27 00:00:00

  • Role of the RAD51-SWI5-SFR1 Ensemble in homologous recombination.

    abstract::During DNA double-strand break and replication fork repair by homologous recombination, the RAD51 recombinase catalyzes the DNA strand exchange reaction via a helical polymer assembled on single-stranded DNA, termed the presynaptic filament. Our published work has demonstrated a dual function of the SWI5-SFR1 complex ...

    journal_title:Nucleic acids research

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    authors: Su GC,Yeh HY,Lin SW,Chung CI,Huang YS,Liu YC,Lyu PC,Chi P

    更新日期:2016-07-27 00:00:00

  • An hnRNP-like RNA-binding protein affects alternative splicing by in vivo interaction with transcripts in Arabidopsis thaliana.

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    journal_title:Nucleic acids research

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    authors: Streitner C,Köster T,Simpson CG,Shaw P,Danisman S,Brown JW,Staiger D

    更新日期:2012-12-01 00:00:00

  • The histone 3'-terminal stem-loop is necessary for translation in Chinese hamster ovary cells.

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    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Gallie DR,Lewis NJ,Marzluff WF

    更新日期:1996-05-15 00:00:00

  • An obligate intermediate along the slow folding pathway of a group II intron ribozyme.

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    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Su LJ,Waldsich C,Pyle AM

    更新日期:2005-11-27 00:00:00

  • Assembly and structural analysis of a covalently closed nano-scale DNA cage.

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    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Andersen FF,Knudsen B,Oliveira CL,Frøhlich RF,Krüger D,Bungert J,Agbandje-McKenna M,McKenna R,Juul S,Veigaard C,Koch J,Rubinstein JL,Guldbrandtsen B,Hede MS,Karlsson G,Andersen AH,Pedersen JS,Knudsen BR

    更新日期:2008-03-01 00:00:00

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    journal_title:Nucleic acids research

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    authors: Gaulton A,Attwood TK

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    authors: Changchien LM,Craven GR

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  • Bacillus cereus DNA topoisomerase I and IIIalpha: purification, characterization and complementation of Escherichia coli TopoIII activity.

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    journal_title:Nucleic acids research

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    authors: Li Z,Hiasa H,DiGate R

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    authors: Balakin AG,Skripkin EA,Shatsky IN,Bogdanov AA

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    authors: Horstick EJ,Jordan DC,Bergeron SA,Tabor KM,Serpe M,Feldman B,Burgess HA

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    authors: Smeenk L,van Heeringen SJ,Koeppel M,van Driel MA,Bartels SJ,Akkers RC,Denissov S,Stunnenberg HG,Lohrum M

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    journal_title:Nucleic acids research

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    authors: Waltz SE,Trivedi AA,Leffak M

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    journal_title:Nucleic acids research

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    authors: Kiyama R,Oishi M

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    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Jacobsen N,Nielsen PS,Jeffares DC,Eriksen J,Ohlsson H,Arctander P,Kauppinen S

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    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: De Rijk P,Caers A,Van de Peer Y,De Wachter R

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  • Recognition of distinct HLA-DQA1 promoter elements by a single nuclear factor containing Jun and Fos or antigenically related proteins.

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    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Neve Ombra M,Autiero M,DeLerma Barbaro A,Barretta R,Del Pozzo G,Guardiola J

    更新日期:1993-04-25 00:00:00

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    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Kelly L,Huang KH,Ding H,Chisholm SW

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    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Olorunniji FJ,Lawson-Williams M,McPherson AL,Paget JE,Stark WM,Rosser SJ

    更新日期:2019-12-02 00:00:00

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    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Kozlowski P,Krzyzosiak WJ

    更新日期:2001-07-15 00:00:00

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    abstract::Comparisons of proteins show that they evolve through the movement of domains. However, in many cases, the underlying mechanisms remain unclear. Here, we observed the movements of DNA recognition domains between non-orthologous proteins within a prokaryote genome. Restriction-modification (RM) systems, consisting of a...

    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Furuta Y,Kobayashi I

    更新日期:2012-10-01 00:00:00

  • Crystallographic characterization of CCG repeats.

    abstract::CCG repeats are highly over-represented in exons of the human genome. Usually they are located in the 5' UTR but are also abundant in translated sequences. The CCG repeats are associated with three tri-nucleotide repeat disorders: Huntington's disease, myotonic dystrophy type 1 and chromosome X-linked mental retardati...

    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Kiliszek A,Kierzek R,Krzyzosiak WJ,Rypniewski W

    更新日期:2012-09-01 00:00:00

  • DNA replication in Physarum polycephalum: characterization of DNA replication products made in vivo in the presence of cycloheximide in strains sensitive and resistant to cycloheximide.

    abstract::Synchronous plasmodia of cycloheximide-sensitive and cycloheximide-resistant strains of Physarum polycephalum were labelled with 3[H]-deoxyadenosine in pulse and pulse-chase experiments in presence and absence of cycloheximide. The replication products were studied with alkaline sucrose gradient sedimentation analysis...

    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Funderud S,Haugli F

    更新日期:1977-02-01 00:00:00