Abstract:
:A prospective longitudinal study was conducted to determine whether single-donor fresh frozen plasma (FFP) substitution was able to influence L-asparaginase-associated hypoproteinemia. Within a 36-month period, 20 of 42 children with ALL received a total of 42 prophylactic FFP doses at a median of 10 (5-20) mliter/kg when fibrinogen levels decreased to < 60 mg/dL and thrombin time was lengthened. Laboratory monitoring before, during and after FFP substitution showed no short-term improvements and demonstrated only a minimal increase in fibrinogen and alpha 2-antiplasmin. Plasma levels of antithrombin and plasminogen remained unchanged. Furthermore, administration of FFP had no influence on thrombin generation, the plasmin/alpha 2-antiplasmin complex or enhanced D-dimer formation.
journal_name
Haematologicajournal_title
Haematologicaauthors
Nowak-Göttl U,Rath B,Binder M,Hassel JU,Wolff J,Husemann S,Ritter Jsubject
Has Abstractpub_date
1995-09-01 00:00:00pages
451-3issue
5eissn
0390-6078issn
1592-8721journal_volume
80pub_type
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