Plasma thrombomodulin concentrations in infants and children undergoing cardiac catheterization.

abstract：BACKGROUND AND OBJECTIVES:Whether degree of iron stores influences progression of human immunodeficiency virus (HIV) disease is controversial. We studied the relationship of indirect measures of iron stores with mortality in highly active antiretroviral therapy (HAART)-naive participants from the Women's Interagency HI...

journal_title：Haematologica

authors： Gordeuk VR,Onojobi G,Schneider MF,Dawkins FW,Delapenha R,Voloshin Y,von Wyl V,Bacon M,Minkoff H,Levine A,Cohen M,Greenblatt RM

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Myelodysplastic syndromes (MDS) comprise a group of heterogeneous hematologic disorders with risk of leukemic evolution (LE). The French-American-British (FAB) co-operative group classifies them into five morphologic entities and the International Prognostic Scoring System (IPSS) proposes four...

journal_title：Haematologica

authors： Belli C,Acevedo S,Bengio R,Arrossagaray G,Watman N,Rossi N,García J,Flores G,Goldztein S,Larripa I

更新日期：2002-01-01 00:00:00

abstract：:Adoptive transfer of ex vivo expanded CD4(+)CD25(+)FOXP3(+) regulatory T cells is a successful therapy for autoimmune diseases and transplant rejection in experimental models. In man, equivalent manipulations in bone marrow transplant recipients appear safe, but questions regarding the stability of the transferred reg...

journal_title：Haematologica

authors： Scottà C,Esposito M,Fazekasova H,Fanelli G,Edozie FC,Ali N,Xiao F,Peakman M,Afzali B,Sagoo P,Lechler RI,Lombardi G

更新日期：2013-08-01 00:00:00

abstract：:Home care (HC) has an increasingly expanding role in the global management of patients affected by hematologic malignancies. Integrated strategies, including causal-targeted and supportive treatments according to hematologic expertise and a holistic approach inspired by the philosophy and practice of palliative medici...

journal_title：Haematologica

authors： Niscola P,de Fabritiis P,Cartoni C,Romani C,Sorrentino F,Dentamaro T,Piccioni D,Scaramucci L,Giovannini M,Amadori S,Mandelli F

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:We previously found a high-level amplification in chromosomal region 21q22 in two children with acute lymphoblastic leukemia (ALL) using comparative genomic hybridization. The same region harbors the AML1 gene. The aim of the present study was to investigate whether AML1 is a target gene in the...

journal_title：Haematologica

authors： Niini T,Kanerva J,Vettenranta K,Saarinen-Pihkala UM,Knuutila S

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common human metabolic disorder in southern China. We investigated the incidence and distribution of mutations, the molecular pathology of affected females and the haplotype association with G6PD deficiency in patients from the Gu...

journal_title：Haematologica

authors： Yan T,Cai R,Mo O,Zhu D,Ouyang H,Huang L,Zhao M,Huang F,Li L,Liang X,Xu X

更新日期：2006-10-01 00:00:00

abstract：:About 25-30% of patients with immune thrombocytopenic purpura (ITP) are refractory to corticosteroids, splenectomy and other treatments. It has been suggested that interferon-alpha 2b (IFN-alpha 2b) may be useful in the treatment of chronic refractory ITP patients. We treated 9 chronic refractory ITP patients with IFN...

journal_title：Haematologica

authors： Vianelli N,Tazzari PL,Baravelli S,Ricci F,Valdrè L,Tura S

更新日期：1998-08-01 00:00:00

abstract：:We previously reported initial results in 102 multiple myeloma (MM) patients treated with sequential high-dose melphalan and autologous hematopoietic cell transplantation followed by 200 cGy total body irradiation with or without fludarabine 90 mg/m2 and allogeneic hematopoietic cell transplantation. Here we present l...

journal_title：Haematologica

authors： Maffini E,Storer BE,Sandmaier BM,Bruno B,Sahebi F,Shizuru JA,Chauncey TR,Hari P,Lange T,Pulsipher MA,McSweeney PA,Holmberg L,Becker PS,Green DJ,Mielcarek M,Maloney DG,Storb R

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:The nucleoside analogue fludarabine is used in the treatment of chronic lymphocytic leukemia. It triggers p53-mediated apoptosis, although the mutational status of p53 does not fully account for heterogeneity in responsiveness to treatment. The aim of this study was to identify new genes implicated in fludar...

journal_title：Haematologica

authors： López-Guerra M,Trigueros-Motos L,Molina-Arcas M,Villamor N,Casado FJ,Montserrat E,Campo E,Colomer D,Pastor-Anglada M

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Patients with beta-thalassemia, like those with genetic hemochromatosis, develop iron overload due to increased iron absorption, and their iron burden is further exacerbated by transfusion therapy. Hepcidin, a hepatic hormone, regulates systemic iron homeostasis by inhibiting the absorption of...

journal_title：Haematologica

authors： Origa R,Galanello R,Ganz T,Giagu N,Maccioni L,Faa G,Nemeth E

更新日期：2007-05-01 00:00:00

abstract：:Blastic plasmacytoid dendritic cell neoplasm is an aggressive malignancy derived from plasmacytoid dendritic cells. There is currently no accepted standard of care for treating this neoplasm, and therapeutic strategies have never been prospectively evaluated. Since blastic plasmacytoid dendritic cell neoplasm cells ex...

journal_title：Haematologica

authors： Angelot-Delettre F,Roggy A,Frankel AE,Lamarthee B,Seilles E,Biichle S,Royer B,Deconinck E,Rowinsky EK,Brooks C,Bardet V,Benet B,Bennani H,Benseddik Z,Debliquis A,Lusina D,Roussel M,Solly F,Ticchioni M,Saas P,Garna

更新日期：2015-02-01 00:00:00

abstract：:Homeobox containing transcription factors are frequently deregulated in human hematologic malignant diseases either indirectly through an abnormality of an upstream factor, or directly through rearrangement of the gene itself. Study of T-cell acute lymphoblastic leukemia identified the related non-clustered homeobox t...

journal_title：Haematologica

authors： Su X,Della-Valle V,Delabesse E,Azgui Z,Berger R,Merle-Béral H,Bernard OA,Nguyen-Khac F

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND:Persistent mixed chimerism represents a state in which recipient and donor cells stably co-exist after hematopoietic stem cell transplantation. However, since in most of the studies reported in literature the engraftment state was observed in the nucleated cells, in this study we determined the donor origin ...

journal_title：Haematologica

authors： Andreani M,Testi M,Gaziev J,Condello R,Bontadini A,Tazzari PL,Ricci F,De Felice L,Agostini F,Fraboni D,Ferrari G,Battarra M,Troiano M,Sodani P,Lucarelli G

更新日期：2011-01-01 00:00:00

abstract：:Chronic lymphocytic leukemia is a disease with up-regulated expression of the transmembrane tyrosine-protein kinase ROR1, a member of the Wnt/planar cell polarity pathway. In this study, we identified COBLL1 as a novel interaction partner of ROR1. COBLL1 shows clear bimodal expression with high levels in chronic lymph...

journal_title：Haematologica

authors： Plešingerová H,Janovská P,Mishra A,Smyčková L,Poppová L,Libra A,Plevová K,Ovesná P,Radová L,Doubek M,Pavlová Š,Pospíšilová Š,Bryja V

更新日期：2018-02-01 00:00:00

abstract：:Hemophagocytic lymphohistiocytosis is a life-threatening systemic hyperinflammatory disorder with primary and secondary forms. Primary hemophagocytic lymphohistiocytosis is associated with inherited defects in various genes that affect the immunological cytolytic pathway. Secondary hemophagocytic lymphohistiocytosis i...

journal_title：Haematologica

authors： Tsuboi I,Harada T,Hirabayashi Y,Aizawa S

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:Chronic lymphocytic leukemia is a neoplastic disorder that arises largely as a result of defective apoptosis leading to chemoresistance. Stromal cell-derived factor-1 and its receptor, CXCR4, have been shown to play an important role in chronic lymphocytic leukemia cell trafficking and survival. DESIGN AND ...

journal_title：Haematologica

authors： Stamatopoulos B,Meuleman N,De Bruyn C,Delforge A,Bron D,Lagneaux L

更新日期：2010-07-01 00:00:00

abstract：:Rituximab use in severe auto-immune diseases has recently increased. Scattered reports of opportunistic infections were the only reported serious side effects related to rituximab in pediatric patients .Here, we report transient severe acute thrombocytopenia and neutropenia respectively a few days after rituximab infu...

journal_title：Haematologica

authors： Larrar S,Guitton C,Willems M,Bader-Meunier B

更新日期：2006-08-01 00:00:00

abstract：:The FMS-like tyrosine kinase 3 (FLT3) gene is mutated in 25-30% of patients with acute myeloid leukemia (AML). Because of the poor prognosis associated with FLT3-internal tandem duplication mutated AML, allogeneic hematopoietic stem-cell transplantation (SCT) was commonly performed in first complete remission. Remarka...

journal_title：Haematologica

authors： Bazarbachi A,Bug G,Baron F,Brissot E,Ciceri F,Dalle IA,Döhner H,Esteve J,Floisand Y,Giebel S,Gilleece M,Gorin NC,Jabbour E,Aljurf M,Kantarjian H,Kharfan-Dabaja M,Labopin M,Lanza F,Malard F,Peric Z,Prebet T,Ravan

更新日期：2020-06-01 00:00:00

abstract：:Five patients with lymphoid blastic transformation of chronic myeloid leukemia have been treated with IL2 associated with Vincristine (VCR) plus Prednisone (PDN). Our study indicates that IL2 may be employed in the management of this disease without excessive toxicity at the higher doses in hospitalized patients and a...

journal_title：Haematologica

authors： Meloni G,Foà R,Tosti S,Vignetti M,Gavosto F,Mandelli F

更新日期：1990-11-01 00:00:00

abstract：:Rituximab has improved response rates and overall survival in B-cell lymphoma (DLBCL). Radiotherapy is an effective treatment modality for lymphomas, but there is uncertainty on its use as consolidation after chemo-immunotherapy mainly in advanced stages. We evaluated its efficacy with a comprehensive meta-analysis an...

journal_title：Haematologica

authors： Berger MD,Trelle S,Büchi AE,Jegerlehner S,Ionescu C,Lamy de la Chapelle T,Novak U

更新日期：2020-06-18 00:00:00

abstract：BACKGROUND:Phosphatidylserine exposure by red blood cells is acknowledged as a signal that initiates phagocytic removal of the cells from the circulation. Several disorders and conditions are known to induce phosphatidylserine exposure. Removal of phosphatidylserine-exposing red blood cells generally occurs by macropha...

journal_title：Haematologica

authors： Fens MH,van Wijk R,Andringa G,van Rooijen KL,Dijstelbloem HM,Rasmussen JT,de Vooght KM,Schiffelers RM,Gaillard CA,van Solinge WW

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The outcome of patients with severe aplastic anemia (SAA) has improved considerably over the last decades. Bone marrow transplantation (BMT) is the treatment of choice in young patients who have an HLA-identical sibling donor. This study analyzes the outcome and factors related to survival in p...

journal_title：Haematologica

authors： Hernández-Boluda JC,Marín P,Carreras E,Aguilar JL,Grañena A,Rozman C,Montserrat E

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Identification of chromosomal rearrangements is important for a precise risk-stratified diagnosis of hematologic malignancies. As the number of known translocations, specific for different types of leukemia increases, it takes ever more time and increasing amounts of patient's material to scre...

journal_title：Haematologica

authors： Nasedkina T,Domer P,Zharinov V,Hoberg J,Lysov Y,Mirzabekov A

更新日期：2002-04-01 00:00:00

abstract：:We evaluate the long-term results of a prospective clinical study enrolling more than 100 adult patients with Burkitt lymphoma/leukemia. Depending on extent of disease, treatment consisted of six to eight rituximab infusions and four to six courses of intensive chemotherapy (attenuated in patients aged >55 years) with...

journal_title：Haematologica

authors： Intermesoli T,Rambaldi A,Rossi G,Delaini F,Romani C,Pogliani EM,Pagani C,Angelucci E,Terruzzi E,Levis A,Cassibba V,Mattei D,Gianfaldoni G,Scattolin AM,Di Bona E,Oldani E,Parolini M,Gökbuget N,Bassan R

更新日期：2013-11-01 00:00:00

abstract：:Rituximab plus CHOP (R-CHOP) has been proven to increase overall survival in aggressive bcl-2-positive lymphoma patients. Using competing risk analysis, we studied the long-term impact of this treatment in patients from a GELA trial: R-CHOP prevented from progression or relapse in both bcl-2-positive and bcl-2-negativ...

journal_title：Haematologica

authors： Mounier N,Briere J,Gisselbrecht C,Reyes F,Gaulard P,Coiffier B,Groupe d'Etude des Lymphomes de l'Adulte.

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND:Chronic lymphocytic leukemia has a variable clinical course. Genomic aberrations identify prognostic subgroups, pointing towards distinct underlying biological mechanisms that are poorly understood. In particular it remains unclear whether the prognostic subgroups of chronic lymphocytic leukemia are characte...

journal_title：Haematologica

authors： Winkler D,Schneider C,Zucknick M,Bögelein D,Schulze K,Zenz T,Mohr J,Philippen A,Huber H,Bühler A,Habermann A,Benner A,Döhner H,Stilgenbauer S,Mertens D

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND:Oral deferiprone was suggested to be more effective than subcutaneous desferrioxamine for removing heart iron. Oral once-daily chelator deferasirox has recently been made commercially available but its long-term efficacy on cardiac iron and function has not yet been established. Our study aimed to compare th...

journal_title：Haematologica

authors： Pepe A,Meloni A,Capra M,Cianciulli P,Prossomariti L,Malaventura C,Putti MC,Lippi A,Romeo MA,Bisconte MG,Filosa A,Caruso V,Quarta A,Pitrolo L,Missere M,Midiri M,Rossi G,Positano V,Lombardi M,Maggio A

更新日期：2011-01-01 00:00:00

abstract：:Tissue Factor is a cell-surface glycoprotein expressed in various cells of the vasculature and is the principal regulator of the blood coagulation cascade and hemostasis. Notably, aberrant expression of Tissue Factor is associated with cardiovascular pathologies such as atherosclerosis and thrombosis. Here, we sought ...

journal_title：Haematologica

authors： Kurakula K,Koenis DS,Herzik MA Jr,Liu Y,Craft JW Jr,van Loenen PB,Vos M,Tran MK,Versteeg HH,Goumans MTH,Ruf W,de Vries CJM,Şen M

更新日期：2018-06-01 00:00:00

abstract：:We reviewed cardiac T2* assessments from 77 thalassemia major patients between the ages of 2.5 and 18 years to study optimal timing of cardiac iron screening by magnetic resonance imaging. No patient under 9.5 years of age showed detectable cardiac iron in contrast to 36% of patients between the ages of 15-18 years ol...

journal_title：Haematologica

authors： Wood JC,Origa R,Agus A,Matta G,Coates TD,Galanello R

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Peripheral blood stem cells (PBSC) following reduced intensity conditioning (RIC) are being increasingly used for allogeneic transplantation in multiple myeloma. The purpose of this study was to compare outcome of patients transplanted with either PBSC or bone marrow (BM) following RIC or myel...

journal_title：Haematologica

authors： Gahrton G,Iacobelli S,Bandini G,Björkstrand B,Corradini P,Crawley C,Hegenbart U,Morgan G,Kröger N,Schattenberg A,Schönland SO,Verdonck LF,Volin L,de Witte T,Niederwieser D,Myeloma Subcommittee of the EBMT.

更新日期：2007-11-01 00:00:00