Abstract：
:Two regimens of steroid treatment for the initial attack of idiopathic nephrotic syndrome (NS) in children were compared in a controlled prospective multi-centre study. Long prednisone therapy consisted of 60 mg/m2 per 24 h for 6 weeks, followed by alternate day 40 mg/m2 per 48 h for 6 weeks. The standard prednisone therapy was 60 mg/m2 per 24 h for 4 weeks, followed by 40 mg/m2 per 48 h for 4 weeks. A total of 71 children with an initial attack of idiopathic NS were allocated at random to the two groups. The cumulative rate of patients with sustained remissions after 2 years was significantly higher after the long course than after the standard treatment (49% vs 19%, P = 0.0079). The mean relapse rate per patient at intervals of 3, 6 and 12 months was lower in the long-course prednisone group than in the standard prednisone group, and the proportion of children with frequent relapses during any subsequent 6 months period was lower in the long-course group than in the standard group (29% vs 57%, P = 0.03). Mild side-effects of corticosteroid therapy were observed more frequently after long-course prednisone treatment. It is concluded that long-course prednisone therapy of the initial attack of steroid responsive NS is preferable to the standard regimen because it reduces the rate of subsequent relapses without increasing the risk for severe steroidal side-effects.
journal_name
Eur J Pediatrjournal_title
European journal of pediatricsauthors
Ehrich JH,Brodehl Jdoi
10.1007/BF01956754subject
Has Abstractpub_date
1993-04-01 00:00:00pages
357-61issue
4eissn
0340-6199issn
1432-1076journal_volume
152pub_type
临床试验,杂志文章,多中心研究,随机对照试验abstract：:Using a randomized double blind study design, the bronchodilating effect of 200 micrograms inhaled oxitropium bromide (OB) was compared with 200 micrograms inhaled fenoterol (F) after an interval of 20 min, in 20 asthmatic children aged 12.7 years (range: 4.9-15.1 years), suffering from mild bronchoconstriction (mean ...
journal_title：European journal of pediatrics
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF02190670
更新日期：1994-08-01 00:00:00
abstract：:The factors influencing the final height of central precocious puberty patients treated with gonadotrophin releasing hormone (GnRH) analogues remain a critical issue. This study compares the predicted final height before and after GnRH analogue therapy to identify predictive factors for final height. Fourteen girls wi...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF01959077
更新日期：1992-10-01 00:00:00
abstract：:In the serum of two infant sisters with a congenital renal salt-losing syndrome, Na was rather low and K considerably increased. Even with Na levels of 126 mval/1, sodium was excreted in the urine. Creatinine and hippurate clearances were normal. Primary disturbances of the steroid metabolism were not detectable; plas...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00443063
更新日期：1976-01-02 00:00:00
abstract：UNLABELLED:Patients with glycogen storage disease type 1b (GSD1b) not only show hepatomegaly, hypoglycaemia and lactic acidosis, but also neutropenia and neutrophil dysfunction. Here, we report improvement of neutropenia and neutrophil function in a 22-year-old male GSD1b patient who had undergone living-related partia...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-004-1405-1
更新日期：2004-04-01 00:00:00
abstract：:Recent studies revealed that fluid overload is associated with higher mortality in critically ill children and adults. This study aimed to evaluate the association between fluid overload in the first 3 days of life and mortality in extremely low birth weight infants. This single-center retrospective cohort study inclu...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-020-03654-z
更新日期：2020-11-01 00:00:00
abstract：:Inappropriate use of antibiotics in human and animal is one of the causes of antimicrobial resistance. This study evaluates the prevalence and predictors of antibiotic use among pediatric patients visiting the Emergency Department (ED) in Malaysia. A retrospective cross-sectional study was conducted in the ED of a ter...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-019-03560-z
更新日期：2020-05-01 00:00:00
abstract：:A 10-year-old boy presented with priapism of 10 h duration which after unsuccessful conservative measures, was relieved by a saphenocorporeal shunt. A 4-year history of intermittent vague aching of fingers and toes accompanied by low-grade fever was reported. Fabry disease was confirmed by the lack alpha-galactosidase...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF01959404
更新日期：1990-04-01 00:00:00
abstract：:The traditional recommendation that Swiss children receive vitamin D during the first year of life was recently extended to the second and third year of life and during winter for older children. The aim of the study was to identify how Swiss pediatricians prescribe vitamin D. Between December 2016 and March 2017, 795...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-019-03400-0
更新日期：2019-07-01 00:00:00
abstract：:A 17-year-old patient suffering from Crohn disease (CD) and liver cirrhosis is presented. At an advanced stage of the disease, he died of a concomitant urosepsis. Autopsy showed that the liver cirrhosis was caused by sclerosing cholangitis. This very rare complication of CD in adolescence is discussed. ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02072206
更新日期：1991-06-01 00:00:00
abstract：:Exchange transfusion using a peripheral artery and vein was carried out 18 times in 17 newborn infants. The arteries use to withdraw blood were the radial [13], the ulnar [3] an the posterior tibial [2]. Infusion of blood was carried out simultaneously through a peripheral vein. There was no mortality or morbidity dir...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00443258
更新日期：1981-11-01 00:00:00
abstract：:Lower respiratory tract infections (LRTI) caused by adenovirus can be severe with resultant chronic pulmonary sequelae. More than 50 serotypes have been recognized; however, the exact association of serotype with clinical phenotype is still unclear. There have been no reports on the adenovirus serotype pattern in Hong...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-013-2127-z
更新日期：2014-03-01 00:00:00
abstract：:A 4-year-old boy is described with abdominal pain, emesis, weight loss, hypoproteinemia and edema. The diagnosis of Menetrier disease was made based on radiographic studies, gastroscopy and gastric biopsy. There was little response to medical treatment and enteral feedings were poorly tolerated for many weeks. Althoug...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00441749
更新日期：1986-02-01 00:00:00
abstract：:Two patients developed clinical features of intracranial bleeding--which were confirmed by computerized axial tomograms--during their induction therapy for acute lymphocytic leukemia. Coagulation studies showed clotting abnormalities including severe hypofibrinogenemia. These findings most probably were related to the...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00443266
更新日期：1981-11-01 00:00:00
abstract：UNLABELLED:We describe the case of a 6-year-old girl brought to the emergency department for the sudden onset of anticholinergic syndrome after the ingestion of a few home-made partially debittered lupine beans. She complained of blurry vision, headache, photophobia and nausea. No specific treatment was needed, and the...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-013-2088-2
更新日期：2014-12-01 00:00:00
abstract：:The Rubinstein-Taybi syndrome is a condition characterized by mental retardation, typical facial changes and broad thumbs and big toes. The cause is unknown; almost all cases are sporadic. We describe a mother and son with Rubinstein-Taybi syndrome. Literature search documented at least 413 cases with 558 sibs. An aff...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00595907
更新日期：1989-02-01 00:00:00
abstract：UNLABELLED:The aim of this study was to provide growth and sexual maturation reference data for Turkish children living in The Netherlands. We also compared these references with the reference data of children of Dutch origin and with Turkish reference data collected in Turkey and elsewhere in Europe. Cross-sectional g...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-003-1292-x
更新日期：2003-11-01 00:00:00
abstract：:We report the 9-year follow-up of a patient suffering from N-acetylglutamate synthetase deficiency, an urea cycle disorder leading to severe neonatal hyperammonaemia. Hitherto two patients from two families with this inborn error of metabolism had been observed. Our management consisted mainly of a protein-restricted ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF01955939
更新日期：1991-03-01 00:00:00
abstract：:A case of lithium intoxication in the newborn is presented. Besides displaying extreme hypotonia and a goitre, the infant developed symptoms of congenital heart disease immediately after birth. Cardiac catheterization and angiocardiography revealed an elevated pulmonary vascular resistance and indicated that the cardi...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00442508
更新日期：1982-07-01 00:00:00
abstract：:An adolescent girl with severe thrombotic thrombocytopenic purpura (TTP) remained in a critical condition after 3 weeks of combined treatment with antiplatelet drugs, plasma infusions and plasma exchange. The introduction of vincristine resulted in gradual improvement and eventual complete remission which lasted for 2...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF01957008
更新日期：1994-07-01 00:00:00
abstract：:Despite advancement in medical care, Rh alloimmunisation remains a major cause of neonatal hyperbilirubinaemia, neuro-morbidity, and late-onset anaemia. Delayed cord clamping (DCC), a standard care now-a-days, is yet not performed in Rh-alloimmunised infants due to paucity of evidence. Hence, we randomised these infan...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-020-03578-8
更新日期：2020-06-01 00:00:00
abstract：:The name of the co-author Wendy J. Ungar was inadvertently omitted on the original published article. Her name and affiliation have now been added to the author list. ...
journal_title：European journal of pediatrics
pub_type： 已发布勘误
doi：10.1007/s00431-019-03526-1
更新日期：2020-02-01 00:00:00
abstract：:The effect of intranasal LH-RH on cryptorchidism was investigated in 45 prepubertal boys with 68 undescended testes. A daily dose of 1.2 mg LH-RH was given for 4 weeks. A total of 16 testes (24%) descended. Follow-up examination 5 years later showed that relapse had occurred in two cases. Fifty-two testes did not desc...
journal_title：European journal of pediatrics
pub_type： 临床试验,杂志文章
doi：10.1007/BF00452869
更新日期：1987-01-01 00:00:00
abstract：:Clinical, morphological, ultrastructural and immunological studies were performed in a case of congenital self-healing non-Langerhans cell histiocytosis. The patient showed several aspects that have not been published before: a large nodule in the vulvar region, vesiculobullous elements and pneumonia (asymptomatic). T...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00441808
更新日期：1988-10-01 00:00:00
abstract：:Cardiac function is impaired in adults or children with hypothyroidism and it can be reversed by levothyroxine (L-T(4)) substitution therapy. However, only a few studies are available on left and right ventricular function in neonates with congenital hypothyroidism (CH), most of which were performed with standard echo...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-007-0417-z
更新日期：2007-12-01 00:00:00
abstract：:Hypoglycaemia in children can be a life-threatening situation that needs to be assessed rigorously in order to treat efficiently and avoid relapse that can be responsible for cerebral damage. The diagnosis of impairment in glucose homeostasis requires the knowledge of the mechanisms regulating blood glucose concentrat...
journal_title：European journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s00431-007-0600-2
更新日期：2008-03-01 00:00:00
abstract：:Vascularization of the arms has been studied by impedance plethysmography (rheography) in eight children with Poland syndrome, a common malformation characterized by unilateral hand anomaly and ipsilateral aplasia of the inferior head of the pectoralis major muscle. A marked decrease of the velocity of the systolic in...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00496922
更新日期：1978-05-22 00:00:00
abstract：UNLABELLED:The pathogenesis of sporadic hemiplegic migraine remains unclear, and perfusion-weighted magnetic resonance imaging (PWI) has been used for characterization of hemodynamic changes in migraine aura. We report a case of sporadic hemiplegic migraine in which magnetic resonance perfusion imaging showed left cere...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-015-2609-2
更新日期：2016-02-01 00:00:00
abstract：:Polyarteritis nodosa (PAN) is a non-frequent vasculitis of small- and medium-sized vessels. Psoriatic arthritis (PA) is described as a "unique inflammatory arthritis associated with psoriasis" with an inexact prevalence rate due to the lack of widely accepted classification criteria. We describe the case of an 11-year...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-011-1459-9
更新日期：2011-09-01 00:00:00
abstract：:Inflammatory bowel disease (IBD) is a cause of chronic intestinal inflammation in children. In a subset of patients affected by IBD, arthropathy may be the leading presenting sign. In the past years, remarkable advances in gastrointestinal endoscopy techniques have been achieved; recently, the development of capsule e...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-011-1505-7
更新日期：2011-10-01 00:00:00
abstract：UNLABELLED:Tracheal bronchus (TB) associated with VACTERL has not been reported previously. A 5-month-old girl with VACTERL association was ventilator-dependent following surgical closure of a patent ductus arteriosus (PDA). Chest radiographs showed persistent hyperinflation of the right upper lobe. Bronchoscopy showed...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-002-1109-3
更新日期：2003-03-01 00:00:00
