Intracranial bleeding during therapy with L-asparaginase in childhood acute lymphocytic leukemia.

Abstract:

:Two patients developed clinical features of intracranial bleeding--which were confirmed by computerized axial tomograms--during their induction therapy for acute lymphocytic leukemia. Coagulation studies showed clotting abnormalities including severe hypofibrinogenemia. These findings most probably were related to the effect of L-asparaginase which was part of the treatment protocol. Central nervous system leukemia, intrathecal chemotherapy, cranial irradiation, extreme leukocytosis, or thrombopenia at the time of diagnosis or day of stroke did not appear to be predisposing factors in these cases.

journal_name

Eur J Pediatr

authors

Urban C,Sager WD

doi

10.1007/BF00443266

subject

Has Abstract

pub_date

1981-11-01 00:00:00

pages

323-7

issue

3

eissn

0340-6199

issn

1432-1076

journal_volume

137

pub_type

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