Abstract:
:Different doses dexamethasone (0.25, 0.5, and 1 mg) or cortisol (30, 60, and 120 mg) were administered PO at 2230h to 39 depressed patients and 20 healthy subjects on nonsuccessive days. The inhibiting capacity of the two steroids on hypothalamo-pituitary axis (HPA) function was evaluated by measuring the plasma levels of cortisol, ACTH, and beta-endorphin at 0900h and 1530h each day following treatment. Baseline levels of the hormones were measured before starting treatment. A dose-dependent suppressive effect of both steroids on the plasma levels of cortisol, ACTH, and beta-endorphin was found both in patients and controls, except for the 0900h levels of cortisol after cortisol treatment. The effects were most profound in the morning. Differences between patients and controls were observed after cortisol treatment, but not dexamethasone, with respect to cortisol, ACTH, and beta-endorphin plasma levels in the morning. Cortisol treatment discriminated dexamethasone nonsuppressors from suppressors (patients and controls) and patients categorized as dexamethasone suppressors from controls in a way that dexamethasone treatment could not. The data favour the idea of impaired corticosteroid feedback beyond the pituitary level as part of HPA dysfunction.
journal_name
Psychoneuroendocrinologyjournal_title
Psychoneuroendocrinologyauthors
Gispen-de Wied CC,D'Haenen H,Verhoeven WM,Wynne HJ,Westenberg HG,Thijssen JH,Van Ree JMdoi
10.1016/0306-4530(93)90004-5subject
Has Abstractpub_date
1993-01-01 00:00:00pages
191-204issue
3eissn
0306-4530issn
1873-3360pii
0306-4530(93)90004-5journal_volume
18pub_type
杂志文章abstract::Autoimmune thyroid disease (ATD) (Graves' disease and Hashimoto's thyroiditis) has been one of a number of autoimmune diseases possibly associated with left-handedness, mixed dominance, and learning disability. In the present study, 74 men with ATD were compared to 24 control men with non-ATD. An increased frequency o...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
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journal_title:Psychoneuroendocrinology
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更新日期:2019-10-01 00:00:00
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journal_title:Psychoneuroendocrinology
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journal_title:Psychoneuroendocrinology
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pub_type: 杂志文章
doi:10.1016/j.psyneuen.2007.03.012
更新日期:2007-06-01 00:00:00
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journal_title:Psychoneuroendocrinology
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doi:10.1016/0306-4530(90)90033-6
更新日期:1990-01-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2016.12.015
更新日期:2017-03-01 00:00:00
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更新日期:2002-01-01 00:00:00
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更新日期:2012-08-01 00:00:00
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更新日期:2019-05-01 00:00:00
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更新日期:2003-01-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/0306-4530(90)90060-m
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更新日期:2017-03-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
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更新日期:1996-08-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2016.01.012
更新日期:2016-04-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 临床试验,杂志文章
doi:10.1016/s0306-4530(01)00021-x
更新日期:2001-10-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2015.06.017
更新日期:2015-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.psyneuen.2018.02.017
更新日期:2018-05-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.psyneuen.2014.01.008
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND:Subtle and inconsistent differences in hypothalamic-pituitary-adrenal (HPA) axis activity have been reported for patients with panic disorder. While these patients show little or no alterations in basal ACTH and cortisol levels, it has been hypothesized that HPA hyperresponsivity was a trait in panic patient...
journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2009.08.003
更新日期:2010-04-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2017.11.010
更新日期:2018-02-01 00:00:00