Abstract:
:The effects of intravenous doses (200 mug) of LSD on the activity of single neurones in the primary visual cortex have been studied in cats anaesthetized with urethane. Cells were stimulated with a bright bar of light moved over the receptive field, and orientation tuning was assessed quantitatively before and after administration of the drug. Changes in neuronal activity were compared with those observed in a control sample of cells recorded when the cats were given no drug. LSD increased the responsiveness of some cells to visual stimuli and decreased that of others, but some cells were not affected. The changes in responsiveness were dose dependent; the larger doses of the drug (expressed in mug/kg body weight) tended to depress the responses and the smaller doses to enhance them. The effects appeared earlier in complex cells than in simple cells. Changes in spontaneous activity, direction selectivity and orientational properties were found in some cells.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Rose D,Horn Gdoi
10.1007/BF00234826subject
Has Abstractpub_date
1977-01-18 00:00:00pages
71-80issue
1eissn
0014-4819issn
1432-1106journal_volume
27pub_type
杂志文章abstract::Electrical stimulation over the cerebellum is known to transiently suppress the contralateral motor cortex in humans. However, projections from the cerebellar nuclei to the primary motor cortex are disynaptic excitatory pathways through the ventral thalamus. In the present investigation we studied facilitatory effects...
journal_title:Experimental brain research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00221-004-1979-x
更新日期:2004-12-01 00:00:00
abstract::It is well known that visual expectation and attention modulate object perception. Yet, the mechanisms underlying these top-down influences are not completely understood. Event-related potentials (ERPs) indicate late contributions of expectations to object processing around the P2 or N2. This is true independent of wh...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-015-4362-1
更新日期:2015-10-01 00:00:00
abstract::We have studied the dynamics of human saccades along various cardinal (horizontal and vertical) and oblique directions in two different experimental paradigms yielding fast and slow saccades, respectively. We found that the saturation of vectorial peak velocity with amplitude, which is already well known from earlier ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00228123
更新日期:1990-01-01 00:00:00
abstract::Vigilance is the ability to sustain attention to information for prolonged periods of time, particularly in environments where critical signals may be rare. Recent research in the domain of mind-wandering has suggested that processes associated with mind-wandering may underpin the typical decline in vigilance task per...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-018-5438-5
更新日期:2019-02-01 00:00:00
abstract::Geniculate cell responses to moving bars and moving texture were compared in normal cats and in cats in which the corticofugal feedback was removed by cortical ablation. In experimental animals the response strength and the velocity upper cutoff assessed with a moving bar was reduced compared to control animals. The s...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00608257
更新日期:1990-01-01 00:00:00
abstract::Inter-limb learning transfer (ILT) between the upper-limbs has been well documented, but no corresponding study of the lower limbs has been done. We investigated ILT in the lower limbs of subjects who learned to move a cursor toward targets within 800 ms using ankle movements: plantar/dorsi-flexion and inversion/evers...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-008-1547-x
更新日期:2009-01-01 00:00:00
abstract::Dorsal horn neurons that express the neurokinin 1 receptor (NK-1R) play an important role in nociceptive processing. The targetting of NK-1R neurons by serotoninergic (5-hydroxytryptamine, 5-HT) axons would provide a straightforward means to exert an inhibitory analgesic effect at spinal level. This study used single ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-004-2018-7
更新日期:2005-01-01 00:00:00
abstract::The phenotypic effect of the weaver mutation in the ventral midbrain of homozygous mutants is associated with the progressive loss of dopaminergic neurons. To discover whether the number of mesencephalic dopaminergic cells is altered in weaver heterozygotes (wv/+), we studied mice between 20 and 365 days of age. We co...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF02454137
更新日期:1997-01-01 00:00:00
abstract::Extracellularly recorded action potentials from 49 Bötzinger-complex, bulbospinal expiratory neurones were used as triggers to compute 162 spike-triggered averages (STAs) of intracellular potentials recorded from 167 respiratory neurones in the ventral respiratory group (VRG) near the obex in 15 vagotomized, paralysed...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210050612
更新日期:1999-01-01 00:00:00
abstract::The interaction between pain and the motor system is well-known, with past studies showing that pain can alter corticomotor excitability and have deleterious effects on motor learning. The aim of this study was to better understand the cortical mechanisms underlying the interaction between pain and the motor system. E...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-017-4880-0
更新日期:2017-04-01 00:00:00
abstract::Absolute refractory periods of a subpopulation of corticomedial amygdala (CMA) neurones which project to the medial preoptic/anterior hypothalamic junction (MPH) via the stria terminalis were recorded in the female rat. Previous experiments have shown that this sub-population of CMA neurones is testosterone-sensitive ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00236571
更新日期:1981-01-01 00:00:00
abstract::Several recent studies indicate that saccades elicited in the absence of a visual target are slower than visually-guided movements of the same size. In addition, we have shown earlier that the slower saccades observed in two different paradigms had more asymmetrical (skewed) velocity profiles. Recently, it has been re...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00253624
更新日期:1989-01-01 00:00:00
abstract::The results of this study show that the different receptive fields of multisensory neurons in the cortex of the cat anterior ectosylvian sulcus (AES) were in spatial register, and it is this register that determined the manner in which these neurons integrated multiple sensory stimuli. The functional properties of mul...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00227844
更新日期:1992-01-01 00:00:00
abstract::Extracellular recordings were obtained from inferior olivary neurones of the rat. The responses of fifty neurones evoked by electrical stimulation of a branch of the trigeminal nerve were recorded. Maxillary nerve stimulation was most effective. The response was characterized by an early discharge (single spike and wa...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00238283
更新日期:1976-09-24 00:00:00
abstract::Visual information regarding limb location can override proprioceptive information when there is conflict between the two-a phenomenon referred to as visual capture. In three experiments, we employed the "mirror illusion," in which the perceived location of one's hand is influenced by the visual information specified ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-010-2445-6
更新日期:2010-12-01 00:00:00
abstract::Saccular and utricular organs are essential for postural stability and gaze control. Although saccular and utricular inputs are known to terminate on vestibular neurons, few previous studies have precisely elucidated the origin of these inputs. We investigated the saccular and utricular inputs to single vestibular neu...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002219900312
更新日期:2000-04-01 00:00:00
abstract::Many studies have reported that blind people compensate for their visual deficit by sharpening auditory processes. Here we compare the sensitivity to echo cues between blind and sighted subjects. In the first experiment, the blind subjects were more accurate than the sighted subjects in localizing an object on the bas...
journal_title:Experimental brain research
pub_type: 临床试验,杂志文章
doi:10.1007/s00221-005-2329-3
更新日期:2005-09-01 00:00:00
abstract::Earlier studies have reported temporal rotation of Listing's plane with convergence of the eyes causing torsion, which is dependent on eye elevation. The amount by which the planes rotate differs from study to study. To gain insight into the functional significance of the temporal tilt of Listing's plane for vision, w...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210050727
更新日期:1999-05-01 00:00:00
abstract::Saccadic adaptation maintains saccade accuracy and has been studied with the intrasaccadic target displacement procedure: displacing a target backwards (or forwards) during saccade execution gradually decreases (or increases) subsequent saccade amplitude. Adaptation has traditionally been studied with targeting saccad...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-010-2282-7
更新日期:2010-06-01 00:00:00
abstract::Caloric vestibular stimulation (CVS) is a physiological technique demonstrated to transiently improve hemianaesthesia in right brain-damaged patients (Bottini et al. in Exp Brain Res 99(1):164-169, 1994, Nature 376:778-781, 1995, Neurology 65(8):1278-1283, 2005). Recent studies suggest that these effects are based on ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-010-2450-9
更新日期:2011-01-01 00:00:00
abstract::Even the simplest volitional movements must be precisely coordinated with anticipatory postural adjustments. Little is currently known about the neural networks that coordinate these adjustments in healthy adults. We measured brain activity prior to movement during a bimanual load-lifting task, designed to elicit anti...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-010-2470-5
更新日期:2011-01-01 00:00:00
abstract::During goal-directed arm movements, the eyes, head, and arm are coordinated to look at and reach the target. We examined whether the expectancy of visual information about the target modifies Anticipatory Postural Adjustments (APAs). Ten standing subjects had to (1) move the eyes, head and arm, so as to reach, with bo...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-017-4898-3
更新日期:2017-05-01 00:00:00
abstract::Extracellular focal synaptic potentials (FSPs) were recorded in forelimb segments of cats in the region where corticospinal volleys (pyramidal stimulation) gave a maximal FSP. No FSP was recorded in this region on stimulation of the medial part of the lateral reticular nucleus (LRN), provided that ventral spinal pathw...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00235897
更新日期:1982-01-01 00:00:00
abstract::In the context of an analysis concerning factors of importance for the relative contributions of recruitment and rate gradation of muscle force, the distribution of electrical excitability was analyzed for medial gastrocnemius (MG) motoneurones of rat and cat. The experimental data came from previously collected intra...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00232439
更新日期:1994-01-01 00:00:00
abstract::Human sensorimotor synchronization is flexible but subject to temporal constraints. Previous research has shown that musicians tend to lose synchrony with target tones in an isochronous sequence when the sequence rate exceeds 8-10 Hz, presumably because phase correction ceases to function. The present study investigat...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-010-2462-5
更新日期:2011-01-01 00:00:00
abstract::In the present work, we characterize electrophysiologically a commissural subcortical pathway which is related to binocular interactions in the nucleus of the optic tract (NOT) of the opossum. The main role played by the circuit comprising this pathway seems to be in relaying information coming from the ipsilateral ey...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00227519
更新日期:1994-01-01 00:00:00
abstract::The vestibulo-ocular reflex (VOR) was intermittently suppressed by fixating a head-fixed target (light on: 9 s; darkness: 2 s) during whole-body (60-100 deg/s peak; 0.01-0.17 Hz) sinusoidal and triangular oscillation about the vertical axis for about 2 min. Eye movements associated with intervals of darkness at differ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00261343
更新日期:1985-01-01 00:00:00
abstract::We studied intermanual motor transfer for right-to-left or left-to-right direction of transfer between either proximal or distal upper extremity muscle groups. The influence of previously acquired motor engrams (original learning, OL) on learning efficiency of the contralateral side (transfer learning, TL) was examine...
journal_title:Experimental brain research
pub_type: 临床试验,杂志文章
doi:10.1007/BF00228105
更新日期:1996-03-01 00:00:00
abstract::In a recent study (Whitwell et al. in Exp Brain Res 185:111-119, 2008), we showed that the visuomotor system is "cognitively impenetrable" to the extent that explicit predictive knowledge of the availability of visual feedback on an upcoming trial fails to optimize grasping. The results suggested that the effects of t...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-009-1737-1
更新日期:2009-04-01 00:00:00
abstract::We examined the effect of the smoothness of motion on vection strength. The smoothness of stimulus motion was modulated by varying the number of frames comprising the movement. In this study, a horizontal grating translated through 360° of phase in 1 s divided into steps of 3, 4, 6, 12, 20, 30, or 60 frames. We hypoth...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-017-5122-1
更新日期:2018-01-01 00:00:00