Structure-function interrelation and clinical effect of atrial natriuretic peptide (ANP).

Abstract:

:Atriopeptin III (AP III) and its six analogues were synthesized by solid phase method and their diuretic and hypotensive activities were determined. Among these analogues, analogue [D-Ala-5, D-Arg-23] AP III was nearly 10 times as potent as AP III in diuretic activity while its hypotensive activity increased only 50% of that of AP III. Analogue des [Ser-15Gly-16Leu-17Gly-18Asn-20Ser-21] AP III was 15% as potent as AP III in diuretic activity, but it still maintained about 60% of the hypotensive activity of AP III. Meanwhile, we tried analogue [D-Ala-5, D-Agr-23] AP III for the treatment of hypertensive syndrome in pregnancy and obtained some good results.

journal_name

Chin Med J (Engl)

journal_title

Chinese medical journal

authors

Wang J,Shi P

subject

Has Abstract

pub_date

1995-04-01 00:00:00

pages

255-8

issue

4

eissn

0366-6999

issn

2542-5641

journal_volume

108

pub_type

杂志文章
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  • Relationship Between Serum Zinc Level and Microvascular Complications in Patients with Type 2 Diabetes.

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    pub_type: 临床试验,杂志文章,随机对照试验

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    journal_title:Chinese medical journal

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    authors: Niu HX,Hua W,Zhang S,Sun X,Wang FZ,Chen KP,Wang H,Chen X

    更新日期:2006-05-20 00:00:00

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  • HIV-1B gp120 genes from one patient with AIDS dementia complex can affect the secretion of tumor necrosis factor and interleukin 1β in glial cells.

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    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Yan YF,Wang ZY,Pu SS,Wen HL,Huang T,Song YY,Xu HZ,Zhao L

    更新日期:2011-12-01 00:00:00

  • Increased RhoGDI2 and peroxiredoxin 5 levels in asthmatic murine model of beta2-adrenoceptor desensitization: a proteomics approach.

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    journal_title:Chinese medical journal

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    authors: Liu H,Zhou LF,Zhang Q,Qian FH,Yin KS,Huang M,Zhang XL

    更新日期:2008-02-20 00:00:00

  • Neuroprotective effect of exogenous vascular endothelial growth factor on rat spinal cord neurons in vitro hypoxia.

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    journal_title:Chinese medical journal

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    更新日期:2005-10-05 00:00:00

  • Biomechanical properties of peripheral nerve after acellular treatment.

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  • Chronic obstructive pulmonary disease assessment test score correlated with dyspnea score in a large sample of Chinese patients.

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    pub_type: 杂志文章,多中心研究

    doi:

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  • Effect of fixing distal radius fracture with volar locking palmar plates while preserving pronator quadratus.

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  • Diagnosis and treatment of solid brainstem tumors in adults.

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  • Big Data Research in Chronic Kidney Disease.

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    doi:10.4103/0366-6999.245275

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  • Effects of diabetes mellitus on prognosis of the patients with colorectal cancer undergoing resection: a cohort study with 945 patients.

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  • Clinicopathological characteristics and prognostic factors of intrahepatic biliary cystadenocarcinoma.

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    doi:10.4103/0366-6999.156108

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  • Association of genetic variations of the prostasin gene with essential hypertension in the Xinjiang Kazakh population.

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  • Pathologic analysis of preterm delivery placentas.

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    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

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    更新日期:1990-10-01 00:00:00

  • Pathological demography of native patients in a nephrology center in China.

    abstract:OBJECTIVE:To analysis the pathological demography in Chinese patients undergoing renal biopsy from our nephrology center. METHODS:Between January 1979 and October 2000 in Jinling Hospital, Nanjing, China, 10,002 attempts of percutaneous renal were performed in patients with renal disease from 33 provinces of China. Th...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

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    authors: Chen H,Tang Z,Zeng C,Hu W,Wang Q,Yu Y,Yao X,Wang J,Zhu M,Zhou H,Liu H,Liu Z,Li L

    更新日期:2003-09-01 00:00:00

  • Management of cerebral ischemia due to Takayasu's arteritis.

    abstract:OBJECTIVE:To explore the management of cerebral ischemia caused by Takayasu's arteritis. METHODS:Ninety-three cases treated from June 1984 to September 1999 at the General Post & Telecom Hospital, the Sir Run Run Shaw Hospital, the First Affiliated Hospital of Zhejiang University, the Second Medical College of Beijing...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Wang Z,Shen L,Yu J,Gu Y,Wang S,Guan H,Wu Q,Zhang X,Li M,Wu J,Li G,Pan S,Zhang H,Jin W

    更新日期:2002-03-01 00:00:00

  • Altered regional homogeneity in spontaneous cluster headache attacks: a resting-state functional magnetic resonance imaging study.

    abstract:BACKGROUND:Functional neuroimaging study has opened an avenue for exploring the pathophysiology of cluster headache (CH). The aim of our study was to assess the changes in brain activity in CH patients by the regional homogeneity method using resting-state functional magnetic resonance imaging technique. METHODS:The f...

    journal_title:Chinese medical journal

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    更新日期:2012-02-01 00:00:00

  • Preliminary observation on human saliva alpha-fetoprotein in patients with hepatocellular carcinoma.

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    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: You XY,Jiang J,Yin FZ

    更新日期:1993-03-01 00:00:00

  • Effect of lumbar angular motion on central canal diameter: positional MRI study in 491 cases.

    abstract:BACKGROUND:Lumbar spinal stenosis is a common problem that is receiving attention with the advent of novel treatment procedures. Prior positional MRI studies demonstrated lumbar canal diameter changes with flexion and extension. There have not been any studies to examine the amount of spinal canal diameter change relat...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Wei F,Wang J,Zou J,Hong SW,Zhang H,He W,Miyazaki M,Lee SH,Alanay A

    更新日期:2010-06-01 00:00:00

  • Enhancing DNA vaccine potency against hantavirus by co-administration of interleukin-12 expression vector as a genetic adjuvant.

    abstract:BACKGROUND:The heavy incidence and mortality of hemorrhagic fever with renal syndrome, as well as no specific drugs in curing the disease, clearly indicate the need for development of the more effective hantavirus vaccine. Refining the DNA vaccination strategy to elicit more clinically efficacious immune responses is n...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Zheng LY,Mou L,Lin S,Lu RM,Luo EJ

    更新日期:2005-02-20 00:00:00

  • Single nucleotide polymorphisms in the D-loop region of mitochondrial DNA and age-at-onset of patients with chronic kidney disease.

    abstract:BACKGROUND:The mitochondrial displacement loop (D-loop) accumulates mutations and single nucleotide polymorphisms (SNPs) at a higher frequency than other regions of mitochondrial DNA (mtDNA). We previously identified disease risk-associated SNPs in the D-loop of chronic kidney disease (CKD) patients; in this study, we ...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Bai Y,Guo Z,Xu J,Zhang J,Cui L,Zhang H,Zhang S,Ai X

    更新日期:2014-01-01 00:00:00

  • Phosphoproteomics Analysis of Endometrium in Women with or without Endometriosis.

    abstract:BACKGROUND:The molecular mechanisms underlying the endometriosis are still not completely understood. In order to test the hypothesis that the approaches in phosphoproteomics might contribute to the identification of key biomarkers to assess disease pathogenesis and drug targets, we carried out a phosphoproteomics anal...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:10.4103/0366-6999.166022

    authors: Xu HM,Deng HT,Liu CD,Chen YL,Zhang ZY

    更新日期:2015-10-05 00:00:00

  • Circular RNAs: from biogenesis and function to diseases.

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    journal_title:Chinese medical journal

    pub_type: 杂志文章,评审

    doi:10.1097/CM9.0000000000000465

    authors: Li D,Yang Y,Li ZQ,Li LC,Zhu XH

    更新日期:2019-10-20 00:00:00

  • Serological survey of nasopharyngeal carcinoma in 21 cities of south China.

    abstract::This paper reports the results of serological survey of 318,912 persons for nasopharyngeal carcinoma (NPC) in 21 cities and counties of south China. There were 8,441 persons with positive VCA-IgA antibody (single item positive) of EB virus (EBV), with a rate of 2.65%. In these VCA-IgA positive persons, 287 persons als...

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    pub_type: 杂志文章,多中心研究

    doi:

    authors: Deng H,Zeng Y,Lei Y,Zhao Z,Wang P,Li B,Pi Z,Tan B,Zheng Y,Pan W

    更新日期:1995-04-01 00:00:00

  • CT features of colloid carcinomas of the pancreas.

    abstract:BACKGROUND:Colloid carcinomas of the pancreas have better prognosis than ordinary ductal adenocarcinoma, and preoperative distinction of colloid carcinoma from other pancreatic tumors is valuable for patient therapeutic planning and prognosis assessment. However, data about CT features of colloid carcinoma are very lim...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

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    authors: Ren FY,Shao CW,Zuo CJ,Lu JP

    更新日期:2010-05-20 00:00:00

  • Magnetic suspension hip joint: an ideal design of an artificial joint.

    abstract:BACKGROUND:Artificial joints present certain problems such as osteal absorption and lysis induced by wear debris which leads to loosening of the prosthesis over a period of time. Here we propose a design of an artificial magnetic suspension joint that was prepared by integrating the medical theories of modern material ...

    journal_title:Chinese medical journal

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  • A randomized control trial on interruption of HBV transmission in uterus.

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