Heritable, population-wide damage to cells as the driving force of neoplastic transformation.

abstract：:The hereditary hearing-vision loss disease Usher syndrome (USH) is caused by defects in several proteins, most of which form an integrated protein network called Usher interactome. Harmonin/Ush1C is a master scaffold in the assembly of the Usher protein complexes, because harmonin is known to bind to every protein in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pan L,Yan J,Wu L,Zhang M

更新日期：2009-04-07 00:00:00

abstract：:Tau is a highly soluble protein, yet it aggregates abnormally in Alzheimer's disease. Here, we address the question of proteolytic processing of tau and the nucleation of aggregates by tau fragments. We show in neuronal cell models that fragments of the repeat domain of tau containing mutations of FTDP17 (frontotempor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang YP,Biernat J,Pickhardt M,Mandelkow E,Mandelkow EM

更新日期：2007-06-12 00:00:00

abstract：:Seed germination is a complex trait of key ecological and agronomic significance. Few genetic factors regulating germination have been identified, and the means by which their concerted action controls this developmental process remains largely unknown. Using publicly available gene expression data from Arabidopsis th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bassel GW,Lan H,Glaab E,Gibbs DJ,Gerjets T,Krasnogor N,Bonner AJ,Holdsworth MJ,Provart NJ

更新日期：2011-06-07 00:00:00

abstract：:Cell-to-cell communication is essential for the development and patterning of multicellular organisms. In plants, plasmodesmata (PD) provide direct routes for intercellular signaling. However, the role that PD-mediated signaling plays in plant development has not been fully investigated. To gain a comprehensive view o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu S,O'Lexy R,Xu M,Sang Y,Chen X,Yu Q,Gallagher KL

更新日期：2016-10-11 00:00:00

abstract：:We describe a method that combines two- and three-color single-molecule FRET spectroscopy with 2D FRET efficiency-lifetime analysis to probe the oligomerization process of intrinsically disordered proteins. This method is applied to the oligomerization of the tetramerization domain (TD) of the tumor suppressor protein...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chung HS,Meng F,Kim JY,McHale K,Gopich IV,Louis JM

更新日期：2017-08-15 00:00:00

abstract：:Antigen receptor-stimulated cell death of developing, immature T cells plays an important role in shaping the repertoire of antigens to which mature T cells will respond, but a role for receptor-stimulated death in controlling responses of mature T cells is controversial. Mutant lpr/lpr mice exhibit an autoimmune synd...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Russell JH,Rush B,Weaver C,Wang R

更新日期：1993-05-15 00:00:00

abstract：:Autopsy studies suggest that most aging men will develop lesions that, if detected clinically, would be diagnosed as prostate cancer (PCa). Most of these cancers are indolent and remain localized; however, a subset of PCa is aggressive and accounts for more than 27,000 deaths in the United States annually. Identificat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu J,Zheng SL,Isaacs SD,Wiley KE,Wiklund F,Sun J,Kader AK,Li G,Purcell LD,Kim ST,Hsu FC,Stattin P,Hugosson J,Adolfsson J,Walsh PC,Trent JM,Duggan D,Carpten J,Grönberg H,Isaacs WB

更新日期：2010-02-02 00:00:00

abstract：:30S ribosomal proteins from Bacillus stearothermophilus (B. proteins) have been fractionated and characterized with respect to their ability to replace various E. coli 30S proteins (E. proteins) in the E. coli 30S ribosome reconstitution system. The functional counterparts of all the E. proteins, except S1, S6, S9, an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Higo K,Held W,Kahan L,Nomura M

更新日期：1973-03-01 00:00:00

abstract：:The regulation of initiation of DNA replication is crucial to ensure that the genome is replicated only once per cell cycle. In the Gram-positive bacterium Bacillus subtilis, the function of the YabA protein in initiation control was assigned based on its interaction with the DnaA initiator and the DnaN sliding clamp ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Noirot-Gros MF,Velten M,Yoshimura M,McGovern S,Morimoto T,Ehrlich SD,Ogasawara N,Polard P,Noirot P

更新日期：2006-02-14 00:00:00

abstract：:A major challenge of the 21st century is to produce more food for a growing population without increasing humanity's agricultural footprint. Urban food production may help to solve this challenge; however, little research has examined the productivity of urban farming systems. We investigated inputs and produce yields...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McDougall R,Kristiansen P,Rader R

更新日期：2019-01-02 00:00:00

abstract：:Successful adaptation to changes in an animal's emotional and motivational environment depends on behavioral flexibility accompanied by changes in bodily responses, e.g., autonomic and endocrine, which support the change in behavior. Here, we identify the orbitofrontal cortex (OFC) as pivotal in the flexible regulatio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reekie YL,Braesicke K,Man MS,Roberts AC

更新日期：2008-07-15 00:00:00

abstract：:Cell-cell interactions organize lens fiber cells into highly ordered structures to maintain transparency. However, signals regulating such interactions have not been well characterized. We report here that ephrin-A5, a ligand of the Eph receptor tyrosine kinases, plays a key role in lens fiber cell shape and cell-cell...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cooper MA,Son AI,Komlos D,Sun Y,Kleiman NJ,Zhou R

更新日期：2008-10-28 00:00:00

abstract：:Ghrelin is a newly discovered peptide and an endogenous ligand for growth hormone (GH) secretagogue (GHS) receptor. It has been shown to possess various central and peripheral effects, including GH secretion, food intake, and gastric and cardiac effects. Ghrelin and the GHS receptor are expressed also in pancreatic is...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Doi A,Shono T,Nishi M,Furuta H,Sasaki H,Nanjo K

更新日期：2006-01-24 00:00:00

abstract：:Phylogenies describe the origins and history of species. However, they can also help to predict species' fates and so can be useful tools for managing the future of biodiversity. This article starts by sketching how phylogenetic, geographic, and trait information can be combined to elucidate present mammalian diversit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Davies TJ,Fritz SA,Grenyer R,Orme CD,Bielby J,Bininda-Emonds OR,Cardillo M,Jones KE,Gittleman JL,Mace GM,Purvis A

更新日期：2008-08-12 00:00:00

abstract：:Aquaporin (AQP) 4 is the predominant water channel in the mammalian brain, abundantly expressed in the blood-brain and brain-cerebrospinal fluid interfaces of glial cells. Its function in cerebral water balance has implications in neuropathological disorders, including brain edema, stroke, and head injuries. The 1.8-A...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ho JD,Yeh R,Sandstrom A,Chorny I,Harries WE,Robbins RA,Miercke LJ,Stroud RM

更新日期：2009-05-05 00:00:00

abstract：:We study a simple antiplane fault of finite length embedded in a homogeneous isotropic elastic solid to understand the origin of seismic source heterogeneity in the presence of nonlinear rate- and state-dependent friction. All the mechanical properties of the medium and friction are assumed homogeneous. Friction inclu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Madariaga R,Cochard A

更新日期：1996-04-30 00:00:00

abstract：:Two precursors to Chinook salmon (Oncorhynchus tshawytscha) melanin-concentrating hormone, an important factor in teleosts involved in the control of skin pigmentation and stress responsiveness, have been identified from DNA sequence analysis. Both precursors encode proteins of 132 amino acids and they share 107/132 a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Minth CD,Qiu H,Akil H,Watson SJ,Dixon JE

更新日期：1989-06-01 00:00:00

abstract：:The peripheral axonal branch of primary sensory neurons readily regenerates after peripheral nerve injury, but the central branch, which courses in the dorsal columns of the spinal cord, does not. However, if a peripheral nerve is transected before a spinal cord injury, sensory neurons that course in the dorsal column...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Neumann S,Skinner K,Basbaum AI

更新日期：2005-11-15 00:00:00

abstract：:The brain contains an astonishing diversity of neurons, each expressing only one set of ion channels out of the billions of potential channel combinations. Simple organizing principles are required for us to make sense of this abundance of possibilities and wealth of related data. We suggest that energy minimization s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hasenstaub A,Otte S,Callaway E,Sejnowski TJ

更新日期：2010-07-06 00:00:00

abstract：:Although infection by primary HIV type 1 (HIV-1) isolates normally requires the functional interaction of the viral envelope protein with both CD4 and the CCR-5 coreceptor, a subset of such isolates also are able to use the distinct CCR-3 receptor. By analyzing the ability of a series of wild-type and chimeric HIV-1 e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ross TM,Cullen BR

更新日期：1998-06-23 00:00:00

abstract：:To permit rapid optical control of brain activity, we have engineered multiple lines of transgenic mice that express the light-activated cation channel Channelrhodopsin-2 (ChR2) in subsets of neurons. Illumination of ChR2-positive neurons in brain slices produced photocurrents that generated action potentials within m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang H,Peca J,Matsuzaki M,Matsuzaki K,Noguchi J,Qiu L,Wang D,Zhang F,Boyden E,Deisseroth K,Kasai H,Hall WC,Feng G,Augustine GJ

更新日期：2007-05-08 00:00:00

abstract：:The clinical severity of the neurodegenerative disorder spinal muscular atrophy (SMA) is dependent on the levels of functional Survival Motor Neuron (SMN) protein. Consequently, current strategies for developing treatments for SMA generally focus on augmenting SMN levels. To identify additional potential therapeutic a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sen A,Dimlich DN,Guruharsha KG,Kankel MW,Hori K,Yokokura T,Brachat S,Richardson D,Loureiro J,Sivasankaran R,Curtis D,Davidow LS,Rubin LL,Hart AC,Van Vactor D,Artavanis-Tsakonas S

更新日期：2013-06-25 00:00:00

abstract：:Escherichia coli cells lacking the histone-like protein HU form filaments and have an abnormal number of anucleate cells. Furthermore, their phenotype resembles that of rfa mutants, the well-characterized deep-rough phenotype, as they show an enhanced permeability that renders them hypersensitive to chloramphenicol, n...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Painbeni E,Caroff M,Rouviere-Yaniv J

更新日期：1997-06-24 00:00:00

abstract：:We have measured the opioid receptor reserve in the guinea pig ileum myenteric plexus by means of the site-directed alkylating agent, beta-chlornaltrexamine. Treatment of the tissue with low (less than 10 nM) concentrations of beta-chlornaltrexamine caused a parallel shift of the log concentration-response curves for ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chavkin C,Goldstein A

更新日期：1984-11-01 00:00:00

abstract：:The lymphocyte differentiation (Ly) antigen phenotype of cytotoxic effector T cells specific for H-2 mutant alloantigens was determined. Cytotoxic effectors generated in primary mixed lymphocyte culture and specific for H-2Kba and H-2Dda alloantigens are sensitive to both anti-Ly-1 and anti-Ly-2 serum plus complement....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wettstein PJ,Bailey DW,Mobraaten LE,Klein J,Frelinger JA

更新日期：1979-07-01 00:00:00

abstract：:Disordered systems like liquids, gels, glasses, or granular materials are not only ubiquitous in daily life and in industrial applications, but they are also crucial for the mechanical stability of cells or the transport of chemical and biological agents in living organisms. Despite the importance of these systems, th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang Z,Kob W

更新日期：2020-06-23 00:00:00

abstract：:In colloidal systems, the interplay between the short range attraction and long-range repulsion can lead to a low density associated state consisting of clusters of individual particles. Recently, such an equilibrium cluster phase was also reported for concentrated solutions of lysozyme at low ionic strength and close...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shukla A,Mylonas E,Di Cola E,Finet S,Timmins P,Narayanan T,Svergun DI

更新日期：2008-04-01 00:00:00

abstract：:Amphiregulin (AR) and cripto are proteins that are structurally related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). AR is also functionally related to this family of growth regulatory molecules and is able to bind and activate the 170-kDa EGF receptor (EGFR). Human EGFR-3 (HER3)/...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ciardiello F,Kim N,Saeki T,Dono R,Persico MG,Plowman GD,Garrigues J,Radke S,Todaro GJ,Salomon DS

更新日期：1991-09-01 00:00:00

abstract：:Thymidine dinucleotide (pTpT) stimulates melanogenesis in mammalian pigment cells and intact skin, mimicking the effects of UV irradiation and UV-mimetic DNA damage. Here it is shown that, in addition to tanning, pTpT induces a second photoprotective response, enhanced repair of UV-induced DNA damage. This enhanced re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eller MS,Maeda T,Magnoni C,Atwal D,Gilchrest BA

更新日期：1997-11-11 00:00:00

abstract：:When an unusually high frequency of an allele is encountered in a population, "founder effect" is often invoked as an explanation. As usually used, the term implies the disproportionate increase through chance (rather than selection) of an allele contributed to the population by a particular ancestor. While genetic th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thompson EA,Neel JV

更新日期：1978-03-01 00:00:00