Abstract:
:Antigen receptor-stimulated cell death of developing, immature T cells plays an important role in shaping the repertoire of antigens to which mature T cells will respond, but a role for receptor-stimulated death in controlling responses of mature T cells is controversial. Mutant lpr/lpr mice exhibit an autoimmune syndrome similar to systemic lupus erythematosus. Here we demonstrate that these mice have a defect in antigen-stimulated suicide of activated T cells in mature CD4+ and CD8+ T cell compartments. The defective suicide pathway is evident when the T cells are stimulated with antigen on antigen-presenting cells or with immobilized anti-CD3 in the absence of antigen-presenting cells. These studies, in concert with the work of others, suggest that antigen-stimulated death of mature cells may be important both in establishing peripheral tolerance and in limiting inflammation during normal immune responses.
journal_name
Proc Natl Acad Sci U S Aauthors
Russell JH,Rush B,Weaver C,Wang Rdoi
10.1073/pnas.90.10.4409subject
Has Abstractpub_date
1993-05-15 00:00:00pages
4409-13issue
10eissn
0027-8424issn
1091-6490journal_volume
90pub_type
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