Biotransformation of acetone to isopropanol observed in a motorist involved in a sobriety check.

Abstract:

:We report the identification of acetone (0.45 mg/mL) and isopropanol (0.17 mg/mL) but without the presence of ethanol in a blood sample from a man suspected of driving under the influence of alcohol. A preliminary breath screening test with an electrochemical instrument (Alcolmeter S-L2) was positive and an evidential breath-test with a dual wavelength infrared analyzer (Intoxilyzer 5000), recognized the presence of an interferant in the subject's breath. The man admitted drinking moderate amounts of alcohol (vodka) the previous evening and was being treated by his doctor for hyperglycemia by special dietary control. This case scenario provides a good example of severe metabolic ketoacidosis in an ostensibly healthy man driving on the highway. Biotransformation of the abnormally high concentration of blood-acetone to isopropanol occurs through the alcohol dehydrogenase pathway.

journal_name

J Forensic Sci

authors

Jones AW,Andersson L

subject

Has Abstract

pub_date

1995-07-01 00:00:00

pages

686-7

issue

4

eissn

0022-1198

issn

1556-4029

journal_volume

40

pub_type

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