Abstract：
:Using the constant infusion technique we have measured the metabolic clearance rates (MCR) for delta 4-androstenedione (A), testosterone (T), oestrone (E1) and oestradiol (E2) in a large group of post-menopausal women. Their mean +/- SE age was 64.5 +/- 1.6 yr, their ages ranged from 46-90 yr. When the MCRs for each steroid were related to age by linear regression analysis no significant correlation was found for any of the steroids. Similarly, when the women were grouped according to their age by decade, the mean MCR for each steroid showed no trend with increasing age. There was no difference in the MCRs for A, T and E1 of the post-menopausal women and a large group of pre-menopausal women. However, there was a significant decrease in the mean MCR for E2 between the two groups which is probably related to the marked decrease in circulating E2 in post-menopausal women. We conclude that for these steroids age, per se, does not appear to be a major determinant of the MCR.
journal_name
Maturitasjournal_title
Maturitasauthors
Longcope C,Jaffee W,Griffing Gdoi
10.1016/0378-5122(80)90030-4subject
Has Abstractpub_date
1980-12-01 00:00:00pages
283-90issue
4eissn
0378-5122issn
1873-4111pii
0378-5122(80)90030-4journal_volume
2pub_type
杂志文章相关文献
MATURITAS文献大全abstract：:Older people with chronic disease have great potential to benefit from their medications but are also at high risk of harm from their medications. The use of medications is particularly important for symptom control and disease progression in older people. Under-treatment means older people can miss out on the potenti...
journal_title：Maturitas
pub_type： 杂志文章,评审
doi：10.1016/j.maturitas.2016.06.006
更新日期：2016-09-01 00:00:00
abstract：BACKGROUND:Depression is related to increased morbidity and mortality in the general population and among patients with coronary artery disease (CAD). The prevalence of major depression is two-times higher in women than men in the general population, but whether this pattern holds true in the CAD population has not bee...
journal_title：Maturitas
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.maturitas.2012.09.005
更新日期：2012-12-01 00:00:00
abstract：OBJECTIVE:Estrogen replacement therapy (ERT) has been reported to affect blood pressure. Since natriuretic peptides have natriuretic and vasodilatory activity and also inhibit the renin-angiotensin-aldosterone system and lower blood pressure, it was hypothesized that the changes in blood pressure effected by ERT might ...
journal_title：Maturitas
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/S0378-5122(03)00279-2
更新日期：2004-03-15 00:00:00
abstract：INTRODUCTION:The complexity of care required by many older people living in long-term care (LTC) facilities poses challenges that can lead to potentially avoidable referrals to a hospital emergency department (ED). The Aged Residential Care Intervention Project (ARCHIP) ran an implementation study to evaluate a multidi...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2018.08.014
更新日期：2018-11-01 00:00:00
abstract：:An open prospective multicentric trial has been conducted over 6 months in 241 postmenopausal volunteers. One-hundred forty-one women had an intact uterus. All patients received a fixed peroral combination of conjugated estrogens CE (1.25 mg per day from day 1 to day 21) and medrogestone (5 mg per day from day 12 to d...
journal_title：Maturitas
pub_type： 杂志文章,多中心研究
doi：10.1016/0378-5122(93)90055-m
更新日期：1993-03-01 00:00:00
abstract：:Serum and urine electrolytes, and biochemical indices of bone metabolism and liver function were measured in 51 post-menopausal women treated with two hormone replacement therapy regimens for 24 wk. Twenty-six of the women were treated continuously with conjugated equine oestrogens (0.625 mg/day) and the remainder wer...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/0378-5122(88)90100-4
更新日期：1988-03-01 00:00:00
abstract：OBJECTIVES:Assessing the combined impact of mutation position, regarding the ovarian cancer cluster region (OCCR), and type of cancer family history (FH) on age-related penetrance of ovarian cancer (OC) in women from BRCA1/2 families from the northern Netherlands. STUDY DESIGN:A consecutive series of 1763 mutation car...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2015.07.001
更新日期：2015-10-01 00:00:00
abstract：OBJECTIVE:The objective of this study was to evaluate gynecologists' knowledge of the WHI study, and its repercussions on their attitudes and practice 3 years after publication. DESIGN:A self-administered, anonymous questionnaire containing 19 questions was sent to 6000 gynecologists, members of the São Paulo Society ...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2006.06.022
更新日期：2007-02-20 00:00:00
abstract：:Hot flashes are a common complaint among women as they transition through menopause. This article reviews the evidence of lifestyle alterations for the amelioration of hot flashes including obesity, exercise, smoking, relaxation techniques, and acupuncture. Further randomized controlled trials regarding these lifestyl...
journal_title：Maturitas
pub_type： 杂志文章,评审
doi：10.1016/j.maturitas.2011.12.006
更新日期：2012-03-01 00:00:00
abstract：INTRODUCTION:Epilepsy is a major public health problem worldwide which is clinically characterized by recurrent seizures. AIM:The aim of this position statement is to provide evidence-based advice on management of the menopause in postmenopausal women derived from the limited data available. MATERIALS AND METHODS:Lit...
journal_title：Maturitas
pub_type： 共识发展会议,杂志文章,评审
doi：10.1016/j.maturitas.2010.03.026
更新日期：2010-07-01 00:00:00
abstract：:Bone and muscle are required for mobility but they also have endocrine and metabolic functions. In ageing as well as in many chronic diseases, bone loss and muscle atrophy occur simultaneously, leading to concomitant osteoporosis and sarcopenia. This occurs in both genders but compared with postmenopausal women, men a...
journal_title：Maturitas
pub_type： 杂志文章,评审
doi：10.1016/j.maturitas.2019.01.006
更新日期：2019-04-01 00:00:00
abstract：BACKGROUND:Studies assessing physical functionality with questions on ability to perform activities of daily living (ADLs) commonly make use of self- and informant-report measures. OBJECTIVES:Delineate the scenarios from which disagreement can arise and show evidence for the presence of disagreements when reporting on...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2012.06.012
更新日期：2012-10-01 00:00:00
abstract：OBJECTIVE:To investigate the relationship between hormone replacement therapy (HRT) and level of cognitive performance intra-individual variability, and interactions with statin use, progesterone therapy and type of menopause. METHODS:A representative sample of 60-64 year olds was recruited from the Canberra and Quean...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2005.09.001
更新日期：2006-04-20 00:00:00
abstract：OBJECTIVES:There is evidence that menopausal symptoms manifested at peri-menopause occur less frequently when compared to the symptoms experienced at post-menopause. The aim of this study was to investigate this and to test the hypothesis that depressive symptomatology mediates the relationship between menopausal stage...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2015.03.007
更新日期：2015-06-01 00:00:00
abstract：:The Women's Health in the Lund Area (WHILA) project (n=6917) is a cohort study that started in 1995 and includes a postal questionnaire, physical examination, bone density measurement and blood laboratory analyses. Fracture data have been added, and in this report fracture risk and its association with sex hormones wa...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2013.04.010
更新日期：2013-07-01 00:00:00
abstract：OBJECTIVE:To assess beneficial effects of a soy rich diet on the main biomarkers of cardiovascular health in menopause, compared with the effects of the hormone replacement therapy (HRT). METHODS:187 healthy asymptomatic postmenopausal women, aged 39-60, were recruited and randomized into three groups: a soy rich diet...
journal_title：Maturitas
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0378-5122(01)00259-6
更新日期：2002-02-26 00:00:00
abstract：BACKGROUND:Several studies drawn from the Ecuadorian population have previously reported that more than half of mid-aged women present hot flushes, which can impair their quality of life. However up-to-date risk factors for their presence and severity have not been assessed. OBJECTIVE:To assess hot flush frequency and...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2009.11.024
更新日期：2010-04-01 00:00:00
abstract：OBJECTIVE:The activated vitamin D receptor (VDR) may have an important role in vascular health. The objective of this study was to determine whether there is an association between the expression of VDRs in coronary arteries and the extent of diet-induced atherosclerosis. METHODS:Utilizing a cohort of 39 postmenopausa...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2012.03.014
更新日期：2012-10-01 00:00:00
abstract：UNLABELLED:Social engagement provides dynamic stimulation for older individuals that influences cognition. Grandparenting is an increasingly popular form of childcare that provides social activity for older adults. OBJECTIVE:To investigate the relationship between grandparenting, as a form of social engagement, and co...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2015.03.013
更新日期：2015-06-01 00:00:00
abstract：OBJECTIVES:To describe the characteristics, metabolic control and health-related quality of life (HRQL) of type 2 diabetes mellitus (T2DM) geriatric patients. STUDY DESIGN:Cross-sectional descriptive study of consecutive patients attended at a geriatric outpatient clinic in a tertiary hospital over three months. Socio...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2011.05.001
更新日期：2011-08-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Cutaneous intrinsic ageing has been shown to be improved by hormone replacement therapy (HRT). Photoageing is, however, unresponsive to such treatment. The present double-blind study was undertaken to compare the beneficial effect of a 1-month topical treatment with 0.05% all-trans-retinoic ac...
journal_title：Maturitas
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0378-5122(95)00983-3
更新日期：1996-04-01 00:00:00
abstract：OBJECTIVES:To study the fracture reducing potential of hormonal replacement therapy (HRT) in recent postmenopausal women in a primary preventive scenario. METHODS:Prospective controlled comprehensive cohort trial: 2016 healthy women aged 45-58 years, from three to 24 months past last menstrual bleeding were recruited ...
journal_title：Maturitas
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0378-5122(00)00158-4
更新日期：2000-10-31 00:00:00
abstract：OBJECTIVE:To investigate the effects of hormone therapy (HT) administered to postmenopausal women on pulmonary function tests (PFT). METHODS:Eighty-two postmenopausal women who were having natural or surgically initiated menopause and had no risk factor that could affect the respiratory system were included into this ...
journal_title：Maturitas
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.maturitas.2004.01.009
更新日期：2004-11-15 00:00:00
abstract：:Serum oestrone, oestradiol and oestriol concentrations were investigated during oral treatment with oestradiol valerate and oestriol succinate in ovariectomized women. The dosages used were 1 mg oestradiol valerate in the morning and 2 mg oestriol succinate in the evening of the first day and 2 mg oestradiol valerate ...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/0378-5122(78)90014-2
更新日期：1978-09-01 00:00:00
abstract：:Ageing of human skin may result from both the passage of time (intrinsic ageing) and from cumulative exposure to external influences (extrinsic ageing) such as ultraviolet radiation (UVR) which promote wrinkle formation and loss of tissue elasticity. Whilst both ageing processes are associated with phenotypic changes ...
journal_title：Maturitas
pub_type： 杂志文章,评审
doi：10.1016/j.maturitas.2011.04.011
更新日期：2011-07-01 00:00:00
abstract：OBJECTIVE:To determine whether individually tailored acupuncture is an effective treatment option for reducing postmenopausal hot flashes and improving quality of life. METHODS:In a randomized, placebo-controlled pilot study, 29 postmenopausal participants averaging at least seven moderate to severe hot flashes per 24...
journal_title：Maturitas
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.maturitas.2006.11.001
更新日期：2007-04-20 00:00:00
abstract：:During the past 50 years, the prevalence of a cluster of chronic, inactivity-related diseases including obesity, insulin resistance and type 2 diabetes mellitus (T2DM), collectively referred to as 'metabolic syndrome' (MetS) has reached global epidemic proportions. Appropriate exercise training is a clinically proven,...
journal_title：Maturitas
pub_type： 杂志文章,评审
doi：10.1016/j.maturitas.2012.05.015
更新日期：2012-08-01 00:00:00
abstract：OBJECTIVES:Levonorgestrel (LNG), delivered locally into the uterine cavity has a profound effect on the endometrium. The aim of the study was to use a LNG intrauterine system to treat non-atypical and atypical endometrial hyperplasia in women and to evaluate the long-term cure (remission) rate. METHODS:Each of the 20 ...
journal_title：Maturitas
pub_type： 临床试验,杂志文章
doi：10.1016/j.maturitas.2006.12.004
更新日期：2007-06-20 00:00:00
abstract：OBJECTIVES:The purpose of this study was to evaluate endothelium-dependent flow-mediated dilation (FMD) in the brachial artery and the plasma levels of endothelin-1 in postmenopausal women at risk for coronary artery disease before and after treatment with both estradiol and estradiol plus dydrogesterone. METHODS:Sixt...
journal_title：Maturitas
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0378-5122(02)00184-6
更新日期：2002-10-25 00:00:00
abstract：OBJECTIVES:To investigate the influence and specificity of sociodemographic and psychological factors on the perception of symptoms associated with menopause. STUDY DESIGN:Data are based on a nationwide cross-sectional survey study in Germany. A representative sample of 1350 females aged 14-95 years was examined. Soci...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2020.03.004
更新日期：2020-06-01 00:00:00
