Abstract:
OBJECTIVE:To investigate the relationship between hormone replacement therapy (HRT) and level of cognitive performance intra-individual variability, and interactions with statin use, progesterone therapy and type of menopause. METHODS:A representative sample of 60-64 year olds was recruited from the Canberra and Queanbeyan regions in Australia. They were administered tests of verbal memory, working memory, speed of information processing, simple and complex reaction time, verbal intelligence and the Mini-Mental State Exam. Intra-individual variation (consistency) on performance on simple and complex reaction time tasks was calculated. Women provided information on HRT use and demographic, health and lifestyle variables. RESULTS:Four hundred and four (35.0%) current postmenopausal HRT users, 316 (27.4%) previous HRT users and 434 (37.6%) women who had never used HRT, were included in this study. There were significant overall differences between HRT current and previous users on age, prevalence of diabetes, alcohol use, body mass index, level of anxiety and lung function. After controlling for potentially confounding health and demographic variables, there were no significant main effects detected between HRT groups on any cognitive measure. Significant interactions were detected between HRT group and statin use on intra-individual variability on simple reaction time, and between HRT group and menopause type on intra-individual variability on choice reaction time. All other interactions were non-significant. CONCLUSIONS:HRT use had no effect on level of cognitive performance. Two interactions were detected between HRT use and statin use, and type of menopause on intra-individual variability. Given the large number of comparisons, little weight can be placed on these significant results.
journal_name
Maturitasjournal_title
Maturitasauthors
Low LF,Anstey KJ,Jorm AF,Christensen H,Rodgers Bdoi
10.1016/j.maturitas.2005.09.001keywords:
subject
Has Abstractpub_date
2006-04-20 00:00:00pages
86-94issue
1eissn
0378-5122issn
1873-4111pii
S0378-5122(05)00229-Xjournal_volume
54pub_type
杂志文章相关文献
MATURITAS文献大全abstract::Tibolone (Livial) has advantages over other forms of hormone replacement therapy (HRT); it is easy to use and does not induce withdrawal bleeding in postmenopausal women. The evidence for the effect of tibolone on climacteric symptoms is reviewed and shows that tibolone is effective in reducing vasomotor symptoms and ...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/0378-5122(94)00888-e
更新日期:1995-02-01 00:00:00
abstract:BACKGROUND:Increased frequency and severity of menopausal symptoms have been associated to black race. However, this situation has not been described in any Latin American population. OBJECTIVE:Compare frequency and severity of menopausal symptoms among Afro and non-Afro Hispanic Colombian climacteric women. METHODS:...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2007.12.002
更新日期:2008-02-20 00:00:00
abstract::Urogenital symptoms associated with estrogen loss can occur episodically throughout a woman's life (e.g. during lactation, during treatment with GnRH agonists, etc.) but it is most common and chronic in duration in postmenopausal women. More than 50% of postmenopausal women experience lack of vaginal lubrication and f...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/0378-5122(95)00956-6
更新日期:1995-12-01 00:00:00
abstract:INTRODUCTION:Obesity, defined as an excess of total body fat, is a matter of concern all over the world, and its prevalence is still increasing among elderly people. OBJECTIVES:To examine whether sedentary behaviour (hours sitting per day) is associated with higher risk of central obesity, overweight-obesity and overf...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2012.09.001
更新日期:2012-12-01 00:00:00
abstract::The pentraxin serum amyloid P component (SAP) is a 9.5Sz1-glycoprotein and it has recently been found to be deposited in atherosclerotic lesions or neurofibrillary tangles, which are related to the aging process and Alzheimer's disease. The level of SAP was measured by micro single radial-immunodiffusion. Sample sera ...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/s0378-5122(96)01086-9
更新日期:1997-03-01 00:00:00
abstract::This study was a cross-sectional survey of mid-aged Thai women with the following aims: to describe their experience of symptoms and attitudes to menopause and to examine the relationships between symptoms, attitudes to menopause, sociodemographic variables and menopausal status. The sample was 268 women aged between ...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/s0378-5122(96)01058-4
更新日期:1997-01-01 00:00:00
abstract:OBJECTIVES:this paper aims to report the prevalence of symptoms in the Hong Kong Chinese perimenopausal women; to construct reported symptoms into symptom groupings; and to clarify whether the symptom groups are associated with menopausal status. METHODS:a random telephone survey of perimenopausal women aged 44-55 yea...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/s0378-5122(99)00056-0
更新日期:1999-12-15 00:00:00
abstract::An open prospective multicentric trial has been conducted over 6 months in 241 postmenopausal volunteers. One-hundred forty-one women had an intact uterus. All patients received a fixed peroral combination of conjugated estrogens CE (1.25 mg per day from day 1 to day 21) and medrogestone (5 mg per day from day 12 to d...
journal_title:Maturitas
pub_type: 杂志文章,多中心研究
doi:10.1016/0378-5122(93)90055-m
更新日期:1993-03-01 00:00:00
abstract:INTRODUCTION:Osteoporosis and its consequent fractures is a major public health problem. AIM:To formulate a position statement on the use of bone densitometry in screening postmenopausal women for osteoporosis and in their management. MATERIALS AND METHODS:Literature review and consensus of expert opinion. RESULTS A...
journal_title:Maturitas
pub_type: 杂志文章,实务指引
doi:10.1016/j.maturitas.2010.09.009
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVES:To develop and evaluate a 30-min online training for managers, in order to improve menopause-related knowledge, attitudes and confidence in having supportive discussions with women experiencing menopausal symptoms at work. The study also explored intentions and behaviour in terms of having conversations. ST...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2018.12.001
更新日期:2019-02-01 00:00:00
abstract:OBJECTIVE:To assess predictors of sexual function in mid-aged women. METHODS:We analyzed data of 262 healthy sexually active women (40-59 years) who filled out the Female Sexual Functioning Index (FSFI), the Menopause Rating Scale (MRS) and a general questionnaire containing female/partner data. Correlations between t...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2010.12.004
更新日期:2011-04-01 00:00:00
abstract::The Women's Health in the Lund Area (WHILA) project (n=6917) is a cohort study that started in 1995 and includes a postal questionnaire, physical examination, bone density measurement and blood laboratory analyses. Fracture data have been added, and in this report fracture risk and its association with sex hormones wa...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2013.04.010
更新日期:2013-07-01 00:00:00
abstract::Tibolone appears to be at least as efficacious as other forms of hormonal replacement therapy (HRT) on climacteric symptoms. It does not cause withdrawal bleeding when used in women with at least 1 year of amenorrhea. It is, therefore, not indicated in perimenopause because it may cause irregular bleeding. The androge...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/s0378-5122(98)00059-0
更新日期:1998-11-16 00:00:00
abstract:OBJECTIVE:To correlate circulating hormone levels with the clinical and biological features of the tumors in menopausal breast cancer patients. DESIGN:Circulating hormone levels were measured in 161 previously untreated menopausal breast cancer patients within 72 h of their planned surgery. The obtained hormone levels...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2009.07.001
更新日期:2009-09-20 00:00:00
abstract::Examining such terms as climacteric or menopause and utilizing supportive historical data, an attempt is made to trace the development of these concepts, their time of inception and their spread. It is suggested that the persistence of popular terminology of the climacteric, especially in England, until late in the la...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/0378-5122(81)90013-x
更新日期:1981-03-01 00:00:00
abstract:OBJECTIVES:A cost-effectiveness analysis on osteoporosis treatment has been carried out as the basis for an estimate of the cost per avoided hip fracture (CPAHF) in Italy. METHODS:We have assumed as correct, reported data on the efficacy of calcitonin in preventing hip fractures in European women over 50 (Mediterranea...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/s0378-5122(96)01099-7
更新日期:1997-04-01 00:00:00
abstract:OBJECTIVE:To assess the risk of onset of menopausal symptoms at different periods surrounding menopause, and variations in this risk according to age at menopause and type of menopause. METHODS:We analyzed the 27,897 women participating in the French E3N cohort study who reached menopause during a 10-year follow-up pe...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2007.09.012
更新日期:2007-12-20 00:00:00
abstract:OBJECTIVES:To link the Menopause Rating Scale (MRS-II) to the International Classification of Functioning, Disability and Health (ICF) and present a clinical application of an ICF-based tool. STUDY DESIGN:The MRS-II was linked to the corresponding ICF category. The linked items were used to generate an ICF Categorical...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2018.10.003
更新日期:2018-12-01 00:00:00
abstract::Within the last decade, breast cancer is increasingly understood as a heterogeneous disease comprising distinct entities that vary significantly with regard to molecular biology and clinical features. Despite impressive advances in the treatment of patients with breast cancer, not all patients derive equal benefits fr...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2012.08.006
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVES:To better define the longitudinal changes in renal function, to examine the associated risk factors, and to investigate whether there is an independent association of decline in renal function with presence of carotid plaque in a middle-aged and elderly healthy population. METHODS:245 healthy individuals (9...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2012.07.014
更新日期:2012-11-01 00:00:00
abstract::As increasing numbers of individuals reach very advanced age, it is important to understand the influence of modifiable lifestyle factors such as diet and nutrition on both the achievement of exceptional longevity as well as the maintenance of optimal functional capacity. This includes determining the most appropriate...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2011.12.002
更新日期:2012-03-01 00:00:00
abstract:BACKGROUND:Cardiovascular disease (CVD) is the leading cause of death in women after menopause. In essence major risk factors for CVD are similar in women as for men inclusive of serum lipid perturbations. The effects of estrogens and hormone replacement therapy on lipid metabolism is widely discussed and warrant furth...
journal_title:Maturitas
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0378-5122(01)00302-4
更新日期:2002-05-20 00:00:00
abstract::Stroke represents one of the most important menaces to public health. A number of modifiable and non-modifiable risk factors have been identified and studied in detail; among those, obesity, the new world epidemic, seems to be one of the most important in terms of prevention. The discovery of the secretory role of the...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2011.09.002
更新日期:2011-12-01 00:00:00
abstract:OBJECTIVES:To explore any feelings and symptoms surrounding menopause among Mayan women in three ethnolinguistic groups in highland Guatemala and compare these with previous reports from Mexico. METHODS:This was a qualitative exploratory study of the experiences around menopause of eight middle aged women and one loca...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/s0378-5122(03)00036-7
更新日期:2003-04-25 00:00:00
abstract::Dementia has often thought to be unavoidable and incurable. In recent years, risk factors, including lifestyle attributes, have been associated with the two commonest forms of dementia, Alzheimer's Disease and vascular dementia. There is also new evidence that the adult brain maintains plasticity and response to exter...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2009.06.008
更新日期:2009-08-20 00:00:00
abstract:OBJECTIVE:The role of endogenous testosterone in the pathogenesis of type 2 diabetes mellitus remains vague. We investigated whether associations between endogenous testosterone and diabetes prevalence in men could be partially explained by modifiable risk factors. STUDY DESIGN:A random population-based cross-sectiona...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2010.12.007
更新日期:2011-03-01 00:00:00
abstract:BACKGROUND:Several studies drawn from the Ecuadorian population have previously reported that more than half of mid-aged women present hot flushes, which can impair their quality of life. However up-to-date risk factors for their presence and severity have not been assessed. OBJECTIVE:To assess hot flush frequency and...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2009.11.024
更新日期:2010-04-01 00:00:00
abstract:OBJECTIVES:Our pilot study tested the efficacy, acceptability and tolerability of DHA supplementation in addition to calcium and vitamin D in individuals with osteopenia. STUDY DESIGN:40 participants were randomised to either algal oil containing 400mg docosahexanoic acid (DHA) daily or placebo. All participants recei...
journal_title:Maturitas
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.maturitas.2011.10.004
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:To compare clinical characteristics and management of adnexal torsion in postmenopausal patients as compared to premenopausal ones. METHODS:A retrospective 22 year cohort of all cases of surgically verified adnexal torsion in postmenopausal and premenopausal patients, comparing presentation, imaging, surgica...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2015.02.261
更新日期:2015-05-01 00:00:00
abstract:OBJECTIVE:To investigate the effects of hormone therapy (HT) administered to postmenopausal women on pulmonary function tests (PFT). METHODS:Eighty-two postmenopausal women who were having natural or surgically initiated menopause and had no risk factor that could affect the respiratory system were included into this ...
journal_title:Maturitas
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.maturitas.2004.01.009
更新日期:2004-11-15 00:00:00