IMP1/imp1: a gene involved in the nucleo-mitochondrial control of galactose fermentation in Saccharomyces cerevisiae.

abstract：:A procedure permitting deletion scanning of potential cis-regulatory sequences within a transgene whose genomic position remains fixed was applied to the study of the upstream sequences of the ecdysteroid-inducible Fat-body-protein-1 (Fbp1) gene. Deficiencies were induced in a Fbp1:Adh fusion transgene by means of a s...

journal_title：Genetics

authors： Lapie P,Nasr F,Lepesant JA,Deutsch J

更新日期：1993-11-01 00:00:00

abstract：:The regulation of chemoreceptor (CR) gene expression by environmental signals and internal cues may contribute to the modulation of multiple physiological processes and behavior in Caenorhabditis elegans. We previously showed that KIN-29, a homolog of salt-inducible kinase, acts in sensory neurons to regulate the expr...

journal_title：Genetics

authors： van der Linden AM,Wiener S,You YJ,Kim K,Avery L,Sengupta P

更新日期：2008-11-01 00:00:00

abstract：:Caenorhabditis elegans' behavioral states, like those of other animals, are shaped by its immediate environment, its past experiences, and by internal factors. We here review the literature on C. elegans behavioral states and their regulation. We discuss dwelling and roaming, local and global search, mate finding, sle...

journal_title：Genetics

authors： Flavell SW,Raizen DM,You YJ

更新日期：2020-10-01 00:00:00

abstract：:The identification of a second structural gene mutation at the feline arylsulfatase B locus (MPS VIb) provided the opportunity to investigate the expression of allelism by characterization of the residual enzymatic activity in feline mucopolysaccharidosis VI, an animal analogue of human Maroteaux-Lamy syndrome. Mating...

journal_title：Genetics

authors： McGovern MM,Mandell N,Haskins M,Desnick RJ

更新日期：1985-08-01 00:00:00

abstract：:According to theory, F(2) hybrid breakdown (lethality or sterility) is due to incompatibilities between interacting genes of the different species (i.e., the breaking up of coadapted gene complexes). Detection of such incompatibilities is particularly straightforward in haplodiploid species, because virgin F(1) hybrid...

journal_title：Genetics

authors： Gadau J,Page RE Jr,Werren JH

更新日期：1999-12-01 00:00:00

abstract：:Insulin-like growth factors (IGFs) control cell and organism growth through evolutionarily conserved signaling pathways. The mammalian acid-labile subunit (ALS) is a secreted protein that complexes with IGFs to modulate their activity. Recent work has shown that a Drosophila homolog of ALS, dALS, can also complex with...

journal_title：Genetics

authors： Swanson LE,Yu M,Nelson KS,Laprise P,Tepass U,Beitel GJ

更新日期：2009-04-01 00:00:00

abstract：:Mitotic cell divisions increase cell number while faithfully distributing the replicated genome at each division. The Caenorhabditis elegans embryo is a powerful model for eukaryotic cell division. Nearly all of the genes that regulate cell division in C. elegans are conserved across metazoan species, including humans...

journal_title：Genetics

authors： Pintard L,Bowerman B

更新日期：2019-01-01 00:00:00

abstract：:Crossovers (COs) generated through meiotic recombination are important for the correct segregation of homologous chromosomes during meiosis. Several models describing the molecular mechanism of meiotic recombination have been proposed. These models differ in the arrangement of heteroduplex DNA (hDNA) in recombination ...

journal_title：Genetics

authors： Radford SJ,Sabourin MM,McMahan S,Sekelsky J

更新日期：2007-05-01 00:00:00

abstract：:The Dissociation (Ds) mutant, Bz-wm, of the maize bronze-1 (bz) locus conditions a leaky phenotype. Plants carrying this mutant allele synthesize a low amount of an altered Bz gene product, which leads to reduced anthocyanin pigmentation in the seed. The molecular analysis reported here shows that the Bz-wm mutant has...

journal_title：Genetics

authors： Schiefelbein JW,Furtek DB,Dooner HK,Nelson OE Jr

更新日期：1988-11-01 00:00:00

abstract：:Orientation disruptor (ord), a meiotic mutant that is recombination defective in females and disjunction defective in males and females, has been analyzed using serial section electron and light microscopy. From analysis of primary spermatocytes we have confirmed that ord males are defective in some aspect of the mech...

journal_title：Genetics

authors： Lin HP,Church K

更新日期：1982-12-01 00:00:00

abstract：:Genetic analyses of nine traits associated with stem water-soluble carbohydrate (SWSC) accumulation and remobilization at grain-filling period under drought stress (DS) and well-watered (WW) conditions were undertaken using doubled haploid lines (DHLs) derived from two Chinese common wheat cultivars. Some significantl...

journal_title：Genetics

authors： Yang DL,Jing RL,Chang XP,Li W

更新日期：2007-05-01 00:00:00

abstract：:To avoid a loss in statistical power as a result of homozygous individuals being selected as parents of a mapping population, one can use multiple families of line crosses for quantitative trait genetic linkage analysis. Two strategies of combining data are investigated: the fixed-model and the random-model strategies...

journal_title：Genetics

authors： Xu S

更新日期：1998-01-01 00:00:00

abstract：:Chromosomal double-strand breaks (DSBs) that have only one end with homology to a donor duplex undergo repair by strand invasion followed by replication to the chromosome terminus (break-induced replication, BIR). Using a transformation-based assay system, it was previously shown that BIR could occur by several rounds...

journal_title：Genetics

authors： Stafa A,Donnianni RA,Timashev LA,Lam AF,Symington LS

更新日期：2014-04-01 00:00:00

abstract：:The vertebrate limb serves as an experimental paradigm to study mechanisms that regulate development of the stereotypical skeletal elements. In this study, we simultaneously inactivated Sall4 using Hoxb6Cre and Plzf in mouse embryos, and found that their combined function regulates development of the proximal-anterior...

journal_title：Genetics

authors： Chen KQ,Tahara N,Anderson A,Kawakami H,Kawakami S,Nishinakamura R,Pandolfi PP,Kawakami Y

更新日期：2020-05-01 00:00:00

abstract：:In the yeast Saccharomyces cerevisiae ectopic recombination has been shown to occur at high frequencies for artificially created repeats, but at relatively low frequencies for a natural family of repeated sequences, the Ty family. Little is known about the mechanism(s) that prevent recombination between repeated seque...

journal_title：Genetics

authors： Nevo-Caspi Y,Kupiec M

更新日期：1996-11-01 00:00:00

abstract：:In experiments with directional selection on a quantitative character a "reversed response" to selection is occasionally observed, when selection of individuals for a higher (lower) value of the character results in a lower (higher) value of the character among their offspring. A sudden change in environments or rando...

journal_title：Genetics

authors： Gimelfarb A

更新日期：1986-09-01 00:00:00

abstract：:The mutation rates of specific loci and chromosome regions were estimated for two types of dysgenic hybrid males. These came from crosses between P or Q males and M females in the P-M system of hybrid dysgenesis. The M X P hybrids were the more mutable for each of the loci and chromosome regions tested. The Beadex loc...

journal_title：Genetics

authors： Simmons MJ,Raymond JD,Johnson NA,Fahey TM

更新日期：1984-01-01 00:00:00

abstract：:The Neurospora crassa super-suppressor mutation, ssu-1, suppresses the auxotrophic phenotype of the mutant am(17) by inserting tyrosine at residue 313 of NADP-specific glutamate dehydrogenase, a position occupied in the wild type by glutamate. Two classes of am(17) revertants due to further mutation within the am gene...

journal_title：Genetics

authors： Seale TW,Brett M,Baron AJ,Fincham JR

更新日期：1977-06-01 00:00:00

abstract：:The RPS5 disease resistance gene of Arabidopsis mediates recognition of Pseudomonas syringae strains that possess the avirulence gene avrPphB. By screening for loss of RPS5-specified resistance, we identified five pbs (avrPphB susceptible) mutants that represent three different genes. Mutations in PBS1 completely bloc...

journal_title：Genetics

authors： Warren RF,Merritt PM,Holub E,Innes RW

更新日期：1999-05-01 00:00:00

abstract：:The developmental gene optomotor-blind (omb) encodes a T-box-containing transcription factor that has multiple roles in Drosophila development. Previous genetic analyses established that omb plays a key role in establishing the abdominal pigmentation pattern of Drosophila melanogaster. In this report we examine patter...

journal_title：Genetics

authors： Brisson JA,Templeton AR,Duncan I

更新日期：2004-12-01 00:00:00

abstract：:Maintenance of proper neuronal excitability is vital to nervous system function and normal behavior. A subset of Drosophila mutants that exhibit altered behavior also exhibit defective motor neuron excitability, which can be monitored with electrophysiological methods. One such mutant is the P-element insertion mutant...

journal_title：Genetics

authors： Schweers BA,Walters KJ,Stern M

更新日期：2002-07-01 00:00:00

abstract：:Centromere H3 proteins (CenH3's) are variants of histone H3 specialized for packaging centromere DNA. Unlike canonical H3, which is among the most conserved of eukaryotic proteins, CenH3's are rapidly evolving, raising questions about orthology and conservation of function across species. To gain insight on CenH3 evol...

journal_title：Genetics

authors： Baker RE,Rogers K

更新日期：2006-11-01 00:00:00

abstract：:Some populations of maize's closest relatives, the annual teosintes of Mexico, are unreceptive to maize pollen. When present in the pistil (silk and ovary) a number of maize genes discriminate against or exclude pollen not carrying the same allele. An analogous gene Tcb1-s was found in some teosinte populations but no...

journal_title：Genetics

authors： Kermicle JL

更新日期：2006-01-01 00:00:00

abstract：:In this article, we utilize stochastic search variable selection methodology to develop a Bayesian method for identifying multiple quantitative trait loci (QTL) for complex traits in experimental designs. The proposed procedure entails embedding multiple regression in a hierarchical normal mixture model, where latent ...

journal_title：Genetics

authors： Yi N,George V,Allison DB

更新日期：2003-07-01 00:00:00

abstract：:Genome-wide association studies have identified thousands of variants implicated in dozens of complex diseases. Most studies collect individuals with and without disease and search for variants with different frequencies between the groups. For many of these studies, additional disease traits are also collected. Joint...

journal_title：Genetics

authors： Bilow M,Crespo F,Pan Z,Eskin E,Eyheramendy S

更新日期：2017-03-01 00:00:00

abstract：:The parentals of the interspecific cross Cucurbita maxima xC. ecuadorensis had different isozyme phenotypes for 12 enzyme systems. Characterization of the systems demonstrated that the expression and intracellular distribution of the isozymes were similar to those in other plant taxa; however, a considerable number of...

journal_title：Genetics

authors： Weeden NF,Robinson RW

更新日期：1986-10-01 00:00:00

abstract：:Identifying loci under natural selection from genomic surveys is of great interest in different research areas. Commonly used methods to separate neutral effects from adaptive effects are based on locus-specific population differentiation coefficients to identify outliers. Here we extend such an approach to estimate d...

journal_title：Genetics

authors： Foll M,Gaggiotti O

更新日期：2008-10-01 00:00:00

abstract：:High baselines of transcription factor activities represent fundamental obstacles to regulated signaling. Here we show that in Drosophila, quenching of basal activator protein 1 (AP-1) transcription factor activity serves as a prerequisite to its tight spatial and temporal control by the JNK (Jun N-terminal kinase) si...

journal_title：Genetics

authors： Bates KL,Higley M,Letsou A

更新日期：2008-04-01 00:00:00

abstract：:An article by Singh and colleagues in this issue of GENETICS quantifies variation in recombination rate across a small region of the Drosophila melanogaster genome, providing an opportunity for instructors of genetics to introduce or reinforce important concepts such as recombination and recombination rate variation, ...

journal_title：Genetics

authors： Heil CS,Noor MA

更新日期：2013-06-01 00:00:00

abstract：:Wright's method of estimating the number of genes contributing to the difference in a quantitative character between two populations involves observing the means and variances of the two parental populations and their hybrid populations. Although simple, Wright's method provides seriously biased estimates, largely due...

journal_title：Genetics

authors： Zeng ZB

更新日期：1992-08-01 00:00:00