Metabolism of cholesterol-enriched chylomicrons. Catabolism of triglyceride by lipoprotein lipase of perfused heart and adipose tissues.

abstract：:A novel metabolite of d-delta-tocopherol was isolated from the urine of rats given d-3,4-[3H2]-delta-tocopherol intravenously. The metabolite was collected from the urine of rats given d-delta-tocopherol in the same manner as that of the labeled compound. It was found that the metabolites consisted of sulfate conjugat...

journal_title：Journal of lipid research

authors： Chiku S,Hamamura K,Nakamura T

更新日期：1984-01-01 00:00:00

abstract：:HDL plays crucial roles at multiple stages of the pathogenesis of atherosclerosis. AMP-activated protein kinase (AMPK) is a therapeutic candidate for the treatment of cardiovascular disease. However, the effect of AMPK activation on HDL functionality has not been established in vivo. We assessed the effects of pharmac...

journal_title：Journal of lipid research

authors： Ma A,Wang J,Yang L,An Y,Zhu H

更新日期：2017-08-01 00:00:00

abstract：:The isolated perfused mouse liver was utilized to evaluate the relative contribution of various molecules believed to participate in the removal of chylomicron remnants by the liver. Sixty percent of asialofetuin was removed from the perfusate per pass; bovine serum albumin was not removed. Normal mouse livers removed...

journal_title：Journal of lipid research

authors： Yu KC,Jiang Y,Chen W,Cooper AD

更新日期：1999-10-01 00:00:00

abstract：:The content of serum gangliosides was examined in VM and C57BL/6J (B6) mice that contained subcutaneous metastatic (VM) and non-metastatic (CT-2A) brain tumors, respectively. Gas-liquid chromatography (GLC) and high performance thin-layer chromatography (HPTLC) were used to analyze the serum gangliosides. N-glycolylne...

journal_title：Journal of lipid research

authors： Cotterchio M,Seyfried TN

更新日期：1994-01-01 00:00:00

abstract：:Ceramides (Cers) with ultralong (∼32-carbon) chains and ω-esterified linoleic acid, composing a subclass called omega-O-acylceramides (acylCers), are indispensable components of the skin barrier. Normal barriers typically contain acylCer concentrations of ∼10 mol%; diminished concentrations, along with altered or miss...

journal_title：Journal of lipid research

authors： Opálka L,Kováčik A,Pullmannová P,Maixner J,Vávrová K

更新日期：2020-02-01 00:00:00

abstract：:Measurements of enzymatic activity have demonstrated that lipoprotein lipase (LPL), the principal enzyme responsible for hydrolysis of circulating triglyceride, is present in a number of tissues including brain, kidney, and adrenal gland. To determine the sites of synthesis of LPL in these tissues, in situ hybridizati...

journal_title：Journal of lipid research

authors： Goldberg IJ,Soprano DR,Wyatt ML,Vanni TM,Kirchgessner TG,Schotz MC

更新日期：1989-10-01 00:00:00

abstract：:The concentration of cholesterol carried in low density lipoproteins (LDL-C) is primarily determined by the rate at which LDL-C is produced (Jt) and the rate at which the liver takes up this particle through receptor-dependent transport (Jm). The accumulation of specific dietary fatty acids in the liver profoundly alt...

journal_title：Journal of lipid research

authors： Woollett LA,Daumerie CM,Dietschy JM

更新日期：1994-09-01 00:00:00

abstract：:The regulation of hepatic and intestinal 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase and acyl-CoA; cholesterol acyltransferase (ACAT) activities by dietary fish oil was examined in the rabbit. Rabbits were fed 10% menhaden oil or menhaden oil plus 1% cholesterol for 14 days. They were compared with animals fed ...

journal_title：Journal of lipid research

authors： Field FJ,Albright EJ,Mathur SN

更新日期：1987-01-01 00:00:00

abstract：:The human retina is well-known to have unique lipid profiles enriched in long-chain polyunsaturated fatty acids (LC-PUFAs) and very long-chain polyunsaturated fatty acids (VLC-PUFAs) that appear to promote normal retinal structure and function, but the influence of diet on retinal lipid profiles in health and disease ...

journal_title：Journal of lipid research

authors： Gorusupudi A,Liu A,Hageman GS,Bernstein PS

更新日期：2016-03-01 00:00:00

abstract：:Interactions of apolipoprotein A-I (apoA-I) with cell membranes appear to be important in the initial steps of reverse cholesterol transport. The objective of this work was to examine the effect of three distinct conformations of apoA-I (lipid-free and in 78 A or 96 A reconstituted high density lipoproteins, rHDL) on ...

journal_title：Journal of lipid research

authors： Tricerri MA,Sanchez SA,Arnulphi C,Durbin DM,Gratton E,Jonas A

更新日期：2002-02-01 00:00:00

abstract：:Recent findings described the role of CD36-mediated signaling in regulating cellular calcium and the release of various bioactive molecules, including the prostaglandins, neurotransmitters, cholecystokinin, and secretin. Here we document the role of CD36 in the secretion of hepatic VLDL. CD36 deletion resulted in 60% ...

journal_title：Journal of lipid research

authors： Nassir F,Adewole OL,Brunt EM,Abumrad NA

更新日期：2013-11-01 00:00:00

abstract：:Elaborate control mechanisms of intracellular triacylglycerol (TAG) breakdown are critically involved in the maintenance of energy homeostasis. Hypoxia-inducible lipid droplet-associated protein (HILPDA)/hypoxia-inducible gene-2 (Hig-2) has been shown to affect intracellular TAG levels, yet, the underlying molecular m...

journal_title：Journal of lipid research

authors： Padmanabha Das KM,Wechselberger L,Liziczai M,De la Rosa Rodriguez M,Grabner GF,Heier C,Viertlmayr R,Radler C,Lichtenegger J,Zimmermann R,Borst JW,Zechner R,Kersten S,Oberer M

更新日期：2018-03-01 00:00:00

abstract：:Previous studies have indicated that a G to A substitution at position -76 in the gene encoding apolipoprotein A-I (apoA-I) confers increased plasma high density lipoprotein cholesterol (HDL-C). Increased HDL-C may be a direct consequence of the A allele, or may reflect the action of a locus in linkage disequilibrium ...

journal_title：Journal of lipid research

authors： Barre DE,Guerra R,Verstraete R,Wang Z,Grundy SM,Cohen JC

更新日期：1994-07-01 00:00:00

abstract：:Apolipoprotein (apo)A-IV is synthesized in the small intestine during fat absorption and is incorporated onto the surface of nascent chylomicrons. In circulation, apoA-IV is displaced from the chylomicron surface by high density lipoprotein-associated C and E apolipoproteins; this exchange is critical for activation o...

journal_title：Journal of lipid research

authors： Hockey KJ,Anderson RA,Cook VR,Hantgan RR,Weinberg RB

更新日期：2001-02-01 00:00:00

abstract：:Based on our previous observation that monoclonal antibody anti-apoD-4E11 reacted with several HDL proteins we studied them further with three questions in mind: i) is there common protein polymorphism in healthy individuals? ii) how many proteins are present and what are their characteristics? iii) are they all apoli...

journal_title：Journal of lipid research

authors： Camato R,Marcel YL,Milne RW,Lussier-Cacan S,Weech PK

更新日期：1989-06-01 00:00:00

abstract：:A gas-liquid chromatographic-mass spectrometric method of determining the position of oxygen atoms on polyfunctional fatty acids has been explored. The method consists of reduction of keto, hydroperoxy, epoxy, and carboxylic acid groups with LiAlH(4) to the corresponding alcohols; trimethylsilylation with bis(trimethy...

journal_title：Journal of lipid research

authors： Esselman WJ,Clagett CO

更新日期：1969-03-01 00:00:00

abstract：:We have shown that expression of apolipoprotein (apo) C-III promotes VLDL secretion from transfected McA-RH7777 cells under lipid-rich conditions. To determine structural elements within apoC-III that confer to this function, we contrasted wild-type apoC-III with a mutant Ala23Thr originally identified in hypotriglyce...

journal_title：Journal of lipid research

authors： Sundaram M,Zhong S,Bou Khalil M,Zhou H,Jiang ZG,Zhao Y,Iqbal J,Hussain MM,Figeys D,Wang Y,Yao Z

更新日期：2010-06-01 00:00:00

abstract：:There is unequivocal evidence of an inverse association between plasma high-density lipoprotein (HDL) cholesterol concentrations and the risk of cardiovascular disease, a finding that has led to the hypothesis that HDL protects from atherosclerosis. This review details the experimental evidence for this "HDL hypothesi...

journal_title：Journal of lipid research

authors： Vergeer M,Holleboom AG,Kastelein JJ,Kuivenhoven JA

更新日期：2010-08-01 00:00:00

abstract：:Biliary lipids (bile salts, phospholipids, cholesterol, plant sterols) were determined in 89 vertebrate species (cartilaginous and bony fish, reptiles, birds, and mammals), and individual phospholipid classes were measured in 35 species. All samples contained conjugated bile salts (C(27) bile alcohol sulfates and/or N...

journal_title：Journal of lipid research

authors： Moschetta A,Xu F,Hagey LR,van Berge-Henegouwen GP,van Erpecum KJ,Brouwers JF,Cohen JC,Bierman M,Hobbs HH,Steinbach JH,Hofmann AF

更新日期：2005-10-01 00:00:00

abstract：:The combination of daunorubicin (dnr) and cytarabine (Ara-C) is a cornerstone of treatment for acute myelogenous leukemia (AML); resistance to these drugs is a major cause of treatment failure. Ceramide, a sphingolipid (SL), plays a critical role in cancer cell apoptosis in response to chemotherapy. Here, we investiga...

journal_title：Journal of lipid research

authors： Kao LP,Morad SAF,Davis TS,MacDougall MR,Kassai M,Abdelmageed N,Fox TE,Kester M,Loughran TP Jr,Abad JL,Fabrias G,Tan SF,Feith DJ,Claxton DF,Spiegel S,Fisher-Wellman KH,Cabot MC

更新日期：2019-09-01 00:00:00

abstract：:A woman with primary lipoprotein lipase (LPL) deficiency developed marked hypertriglyceridemia, pancreatitis, eruptive xanthomas, and unusual palmar xanthomas during pregnancy. Hypotheses to account for the palmar xanthomas were that oxidative modification of triglyceride (TG)-rich lipoproteins occurred due to increas...

journal_title：Journal of lipid research

authors： Steinberg FM,Tsai EC,Brunzell JD,Chait A

更新日期：1996-05-01 00:00:00

abstract：:Expression of bile salt export pump (BSEP) is regulated by the bile acid/farnesoid X receptor (FXR) signaling pathway. Two FXR isoforms, FXRα1 and FXRα2, are predominantly expressed in human liver. We previously showed that human BSEP was isoform-dependently regulated by FXR and diminished with altered expression of F...

journal_title：Journal of lipid research

authors： Song X,Chen Y,Valanejad L,Kaimal R,Yan B,Stoner M,Deng R

更新日期：2013-11-01 00:00:00

abstract：:The acute-phase response (APR) leads to alterations in lipid metabolism and type II nuclear hormone receptors, which regulate lipid metabolism, are suppressed, in liver, heart, and kidney. Here, we examine the effect of the APR in adipose tissue. In mice, lipopolysaccharide produces a rapid, marked decrease in mRNA le...

journal_title：Journal of lipid research

authors： Lu B,Moser AH,Shigenaga JK,Feingold KR,Grunfeld C

更新日期：2006-10-01 00:00:00

abstract：:Investigations of the topography of glycerolipid synthetic enzymes within the transverse plane of microsomal vesicles indicated an exclusive cytoplasmic surface location of active sites. Evidence was derived from studies employing proteases and other impermeant inhibitors, from investigations of latency and substrate ...

journal_title：Journal of lipid research

authors： Bell RM,Ballas LM,Coleman RA

更新日期：1981-03-01 00:00:00

abstract：:We studied the effects of the lecithin:cholesterol acyltransferase reaction on the size and composition of the small spherical high density lipoproteins of patients afflicted with familial lecithin:cholesterol acyltransferase deficiency. We isolated these lipoproteins by preparative ultracentrifugation and rate zonal ...

journal_title：Journal of lipid research

authors： Chen C,Applegate K,King WC,Glomset JA,Norum KR,Gjone E

更新日期：1984-03-01 00:00:00

abstract：:We used [2-13C1]glycerol to characterize very low density lipoprotein (VLDL)-triglyceride kinetics and intrahepatic glycerol metabolism in normal men (n = 4) after alcohol (EtOH) ingestion. [2-13C1]glycerol was infused before and after the consumption of 48 g EtOH or a placebo. Three additional subjects also received ...

journal_title：Journal of lipid research

authors： Siler SQ,Neese RA,Parks EJ,Hellerstein MK

更新日期：1998-12-01 00:00:00

abstract：:Absorption rates for many biologically important compounds are determined by the relative hydrophobicity of the jejunal microvillus membrane. An estimate of this parameter may be obtained by measuring the incremental change in free energy that occurs when a methylene group partitions into the bilayer form an external ...

journal_title：Journal of lipid research

authors： Meddings JB,Dietschy JM

更新日期：1989-08-01 00:00:00

abstract：:Subcutaneous fat cells were isolated from genetically obese rats and from rats with obesity produced by hypothalamic lesions. Insulin did not augment the oxidation of fatty acids or their synthesis from glucose-1-(14)C or glucose-1-(3)H by fat cells from either group. Radioactivity from pyruvate-3-(14)C was incorporat...

journal_title：Journal of lipid research

authors： Bray GA

更新日期：1968-11-01 00:00:00

abstract：:The genus Acinetobacter is composed of ubiquitous, generally nonpathogen environmental bacteria. Interest concerning these microorganisms has increased during the last 30 years, because some strains, belonging to the so-called A. baumannii-A. calcoaceticus complex, have been implicated in some severe pathological stat...

journal_title：Journal of lipid research

authors： Leone S,Sturiale L,Pessione E,Mazzoli R,Giunta C,Lanzetta R,Garozzo D,Molinaro A,Parrilli M

更新日期：2007-05-01 00:00:00

abstract：:The relationship between overnight postabsorptive (fasting) respiratory exchange ratio (RER) and plasma FFA concentrations was addressed using data from three separate protocols, each of which involved careful control of the antecedent diet. Protocol 1 examined the relationship between fasting RER and the previous day...

journal_title：Journal of lipid research

authors： Jensen MD,Bajnárek J,Lee SY,Nielsen S,Koutsari C

更新日期：2009-09-01 00:00:00