Chemotherapy selection pressure alters sphingolipid composition and mitochondrial bioenergetics in resistant HL-60 cells.

abstract：:In order to study the metabolic responses of humans consuming a diet moderately high in cholesterol content, we carried out a long-term sterol balance study, up to 25 weeks in duration. Two subjects, one normocholesterolemic and one hypercholesterolemic, were given, in sequence, a very low cholesterol diet and then a ...

journal_title：Journal of lipid research

authors： Lin DS,Connor WE

更新日期：1980-11-01 00:00:00

abstract：:We studied the biogenesis of apolipoprotein B (apoB) in primary hepatocytes isolated from hamster liver, an animal model with striking resemblance to humans in lipoprotein metabolism. Hamster hepatocytes were found to assemble and secrete apoB-containing lipoproteins at a density of VLDL. Intracellular mechanisms of a...

journal_title：Journal of lipid research

authors： Taghibiglou C,Rudy D,Van Iderstine SC,Aiton A,Cavallo D,Cheung R,Adeli K

更新日期：2000-04-01 00:00:00

abstract：:Cell death-inducing DFF45-like effector b (Cideb), an endoplasmic reticulum (ER)- and lipid droplet (LD)-associated protein, has been shown to play a critical role in maintaining hepatic lipid homeostasis by promoting the lipidation and maturation of VLDL particles. Here, we observed that Cideb is expressed in the jej...

journal_title：Journal of lipid research

authors： Zhang LJ,Wang C,Yuan Y,Wang H,Wu J,Liu F,Li L,Gao X,Zhao YL,Hu PZ,Li P,Ye J

更新日期：2014-07-01 00:00:00

abstract：:Thus far, liver, intestine, heart, and placenta have been shown to secrete apolipoprotein (apo)B-containing lipoproteins. In the present study, we first investigated lipoproteins in human follicular fluid (FF), surrounding developing oocytes within the ovary, as well as in corresponding plasma samples (n = 12). HDL ch...

journal_title：Journal of lipid research

authors： Gautier T,Becker S,Drouineaud V,Ménétrier F,Sagot P,Nofer JR,von Otte S,Lagrost L,Masson D,Tietge UJ

更新日期：2010-08-01 00:00:00

abstract：:The reversibility and regression of histological and biochemical findings in a mouse model of Gaucher disease (4L/PS-NA) was evaluated using a liver-enriched activator protein promoter control of a tetracycline-controlled transcriptional activation-responsive human acid beta-glucosidase (hGCase) transgenic system. 4L/...

journal_title：Journal of lipid research

authors： Sun Y,Quinn B,Xu YH,Leonova T,Witte DP,Grabowski GA

更新日期：2006-10-01 00:00:00

abstract：:HMG-CoA reductase inhibitors (statins) are effective lipid-altering drugs for the treatment of dyslipidemia in patients with type 2 diabetes mellitus. We conducted a randomized, double-blind, placebo-controlled, crossover design trial to determine the effects of simvastatin, 80 mg/day, on plasma lipid and lipoprotein ...

journal_title：Journal of lipid research

authors： Myerson M,Ngai C,Jones J,Holleran S,Ramakrishnan R,Berglund L,Ginsberg HN

更新日期：2005-12-01 00:00:00

abstract：:Lipid metabolism plays an important role in the regulation of cellular homeostasis. However, because it is difficult to measure the actual rates of synthesis and degradation of individual lipid species, lipid compositions are often used as a surrogate to evaluate lipid metabolism even though they provide only static s...

journal_title：Journal of lipid research

authors： Schlame M,Xu Y,Erdjument-Bromage H,Neubert TA,Ren M

更新日期：2020-01-01 00:00:00

abstract：:Bile acids are a group of molecular species of acidic steroids with peculiar physical-chemical and biological characteristics. At high concentrations they become toxic to mammalian cells, and their presence is pertinent in the pathogenesis of several liver diseases and colon cancer. Bile acid cytoxicity has been relat...

journal_title：Journal of lipid research

authors： Amaral JD,Viana RJ,Ramalho RM,Steer CJ,Rodrigues CM

更新日期：2009-09-01 00:00:00

abstract：:Several studies have documented the presence of Lp[a] in nonhuman primates. However, data are lacking in great apes such as the chimpanzee. We have studied the quantitative distribution of Lp[a], as well as the frequency of apo[a] phenotypes, in a population of chimpanzees living in Gabon. Monoclonal antibody 14A12, d...

journal_title：Journal of lipid research

authors： Doucet C,Huby T,Chapman J,Thillet J

更新日期：1994-02-01 00:00:00

abstract：:The selective and reversible adsorption of bovine low density lipoproteins (LDL) by heparin-Sepharose has been exploited as the critical step in a procedure for the preparative isolation of very low density lipoproteins (VLDL)/chylomicrons, LDL, and high density lipoproteins (HDL) from bovine plasma. Molecular size ex...

journal_title：Journal of lipid research

authors： Cordle SR,Clegg RA,Yeaman SJ

更新日期：1985-06-01 00:00:00

abstract：:A new sample preparation method coupled to GC-MS analysis was developed and validated for quantification of sulfate esters of pregnenolone (PREG-S) and dehydroepiandrosterone (DHEA-S) in rat brain. Using a solid-phase extraction recycling protocol, the results show that little or no PREG-S and DHEA-S (<1 pmol/g) is pr...

journal_title：Journal of lipid research

authors： Liere P,Pianos A,Eychenne B,Cambourg A,Liu S,Griffiths W,Schumacher M,Sjövall J,Baulieu EE

更新日期：2004-12-01 00:00:00

abstract：:Human endothelial lipase (EL), a member of the triglyceride lipase gene family, has five potential N-linked glycosylation sites, two of which are conserved in both lipoprotein lipase and hepatic lipase. Reduction in molecular mass of EL after treatment with glycosidases and after treatment of EL-expressing cells with ...

journal_title：Journal of lipid research

authors： Miller GC,Long CJ,Bojilova ED,Marchadier D,Badellino KO,Blanchard N,Fuki IV,Glick JM,Rader DJ

更新日期：2004-11-01 00:00:00

abstract：:Apolipoprotein E plays a critical role in plasma lipoprotein clearance. Peptide models of a highly conserved, N-terminal domain of this protein have been shown to increase the binding of low density lipoprotein (LDL) to fibroblast cell surfaces independently of the low density lipoprotein receptor. Here we provide dat...

journal_title：Journal of lipid research

authors： Dominguez SR,Miller-Auer H,Reardon CA,Meredith SC

更新日期：1999-04-01 00:00:00

abstract：:The class B scavenger receptors SR-BI and CD36 exhibit a broad ligand binding specificity. SR-BI is well characterized as a HDL receptor that mediates selective cholesteryl ester uptake from HDL. CD36, a receptor for oxidized LDL, also binds HDL and mediates selective cholesteryl ester uptake, although much less effic...

journal_title：Journal of lipid research

authors： de Beer MC,Castellani LW,Cai L,Stromberg AJ,de Beer FC,van der Westhuyzen DR

更新日期：2004-04-01 00:00:00

abstract：:The 3-methyl-branched fatty acid phytanic acid is degraded by the peroxisomal alpha-oxidation route because the 3-methyl group blocks beta-oxidation. In adult Refsum disease (ARD), peroxisomal alpha-oxidation is defective, which is caused by mutations in the gene coding for phytanoyl-CoA hydroxylase in the majority of...

journal_title：Journal of lipid research

authors： Komen JC,Duran M,Wanders RJ

更新日期：2004-07-01 00:00:00

abstract：:We measured the amount of apoA-I in serum by isotope dilution, finding 1.33 mg/ml (standard deviation 0.177) in six normolipidemic, healthy subjects. We developed this method by adapting published techniques to purify apoA-I from 3 ml of serum in two steps: density gradient ultracentrifugation and high performance liq...

journal_title：Journal of lipid research

authors： Weech PK,Jewer D,Marcel YL

更新日期：1988-01-01 00:00:00

abstract：:This paper describes the purification and some of the properties of an enzyme from human spleen that catalyzes the hydrolysis of sphingomyelin with the formation of ceramide and phosphoryl choline. The enzyme, which is located in the subcellular particulate fraction that sediments between 700 and 8500 g, is readily ma...

journal_title：Journal of lipid research

authors： Schneider PB,Kennedy EP

更新日期：1967-05-01 00:00:00

abstract：:The central region of apolipoprotein A-I (apoA-I), spanning residues 143--165, has been implicated in lecithin:cholesterol acyltransferase (LCAT) activation and also in high density lipoprotein (HDL) structural rearrangements. To examine the role of individual amino acids in these functions, we constructed, overexpres...

journal_title：Journal of lipid research

authors： Cho KH,Durbin DM,Jonas A

更新日期：2001-03-01 00:00:00

abstract：:Diet-induced changes in high density lipoprotein (HDL) density and size were studied in patas monkeys. When the animals were switched from a moderate fat-low cholesterol diet to a high fat-high cholesterol (HFHC) diet, the plasma apoA-I levels increased initially in all of the animals. The apoA-I levels remained eleva...

journal_title：Journal of lipid research

authors： Melchior GW,Baker HN,Abee CR,Roheim PS

更新日期：1984-09-01 00:00:00

abstract：:A facile procedure is described for the preparation of [14C]epicholesterol from [14C]cholesterol. Cholesterol is first converted to cholesteryl mesylate, which is treated with cesium acetate and 18-crown-6 in refluxing toluene to give epicholesteryl acetate. The latter is hydrolyzed, without isolation, with potassium ...

journal_title：Journal of lipid research

authors： Yan JS,Bittman R

更新日期：1990-01-01 00:00:00

abstract：:The bile acid (BA) composition in mice is substantially different from that in humans. Chenodeoxycholic acid (CDCA) is an end product in the human liver; however, mouse Cyp2c70 metabolizes CDCA to hydrophilic muricholic acids (MCAs). Moreover, in humans, the gut microbiota converts the primary BAs, cholic acid and CDC...

journal_title：Journal of lipid research

authors： Honda A,Miyazaki T,Iwamoto J,Hirayama T,Morishita Y,Monma T,Ueda H,Mizuno S,Sugiyama F,Takahashi S,Ikegami T

更新日期：2020-01-01 00:00:00

abstract：:The enzyme 1-acylglycerol-3-phosphate-O-acyltransferase (AGPAT) converts lysophosphatidic acid (LPA) to phosphatidic acid (PA). In this study, we show enzymatic properties, tissue distribution, and subcellular localization of human AGPAT3 and AGPAT5. In cells overexpressing these isoforms, the proteins were detected i...

journal_title：Journal of lipid research

authors： Prasad SS,Garg A,Agarwal AK

更新日期：2011-03-01 00:00:00

abstract：:The palmitate (PA) binding and transport capacity of human and bovine red cell membranes enables us to establish, in a biological system, the existence of a well-defined monomer concentration in equilibrium with PA bound to bovine serum albumin (BSA, 30 microM) inside the resealed red cell ghosts. Supernatants of susp...

journal_title：Journal of lipid research

authors： Bojesen IN,Bojesen E

更新日期：1992-09-01 00:00:00

abstract：:It was the aim of this study to i) compare the effects of glucose and other hexoses with that of oleate on secretion of apolipoproteins (apos) A-I and B by HepG2 cells, and ii) document the effect of various metabolic inhibitors on the secretion of these apos in the absence or presence of extra glucose/oleate. i) The ...

journal_title：Journal of lipid research

authors： Kempen HJ,Imbach AP,Giller T,Neumann WJ,Hennes U,Nakada N

更新日期：1995-08-01 00:00:00

abstract：:Glycosylphosphatidylinositols (GPIs) act as membrane anchors of many eukaryotic cell surface proteins. GPIs in various organisms have a common backbone consisting of ethanolamine phosphate (EtNP), three mannoses (Mans), one non-N-acetylated glucosamine, and inositol phospholipid, whose structure is EtNP-6Manα-2Manα-6M...

journal_title：Journal of lipid research

authors： Kinoshita T,Fujita M

更新日期：2016-01-01 00:00:00

abstract：:Plasma levels of HDL cholesterol (HDL-C) have a strong inherited basis with heritability estimates of 40-60%. The well-established inverse relationship between plasma HDL-C levels and the risk of coronary artery disease (CAD) has led to an extensive search for genetic factors influencing HDL-C concentrations. Over the...

journal_title：Journal of lipid research

authors： Weissglas-Volkov D,Pajukanta P

更新日期：2010-08-01 00:00:00

abstract：:Apolipoprotein A-I (apoA-I) induces the translocation of newly synthesized cholesterol as well as caveolin-1 to the cytosolic lipid-protein particle (CLPP) fraction in astrocytes before its appearance in high density lipoprotein generated in the medium (Ito, J., Y. Nagayasu, K. Kato, R. Sato, and S. Yokoyama. 2002. Ap...

journal_title：Journal of lipid research

authors： Ito J,Li H,Nagayasu Y,Kheirollah A,Yokoyama S

更新日期：2004-12-01 00:00:00

abstract：:Characterization of the chemical form and stereo-specificity of the fatty acid derivatives of arachidonic and linoleic acid in psoriatic epidermis is needed to define the enzymatic origin of these compounds and their possible role in pathogenesis. In an analysis of psoriatic skin scales, both free and esterified 13-hy...

journal_title：Journal of lipid research

authors： Baer AN,Costello PB,Green FA

更新日期：1990-01-01 00:00:00

abstract：:We used [2-13C1]glycerol to characterize very low density lipoprotein (VLDL)-triglyceride kinetics and intrahepatic glycerol metabolism in normal men (n = 4) after alcohol (EtOH) ingestion. [2-13C1]glycerol was infused before and after the consumption of 48 g EtOH or a placebo. Three additional subjects also received ...

journal_title：Journal of lipid research

authors： Siler SQ,Neese RA,Parks EJ,Hellerstein MK

更新日期：1998-12-01 00:00:00

abstract：:Within the cholesterol biosynthesis cascade, the enzyme 2,3-oxidosqualene cyclase [EC 5.4.99.7] is of special interest due to its dual function: cyclization of 2,3-monoepoxysqualene to lanosterol and 2,3;22,23-diepoxysqualene to oxylanosterol. Further determination of the significance of this enzyme for the intracellu...

journal_title：Journal of lipid research

authors： Mark M,Muller P,Maier R,Eisele B

更新日期：1996-01-01 00:00:00