Abstract：
:HMG-CoA reductase inhibitors (statins) are effective lipid-altering drugs for the treatment of dyslipidemia in patients with type 2 diabetes mellitus. We conducted a randomized, double-blind, placebo-controlled, crossover design trial to determine the effects of simvastatin, 80 mg/day, on plasma lipid and lipoprotein levels and on the metabolism of apolipoprotein B (apoB) in VLDL, intermediate density lipoprotein (IDL), and LDL and of triglycerides (TGs) in VLDL. Simvastatin therapy decreased TG, cholesterol, and apoB significantly in VLDL, IDL, and LDL. These effects were associated with reduced production of LDL-apoB, mainly as a result of reduced secretion of apoB-lipoproteins directly into the LDL density range. Statin therapy also reduced hepatic production of VLDL-TG. There were no effects of simvastatin on the fractional catabolic rates of VLDL-apoB or -TG or LDL-apoB. The basis for decreased VLDL-TG secretion during simvastatin treatment is not clear, but recent studies suggest that statins may activate peroxisomal proliferator-activated receptor alpha (PPARalpha). Activation of PPARalpha could lead to increased hepatic oxidation of fatty acids and less synthesis of TG for VLDL assembly.
journal_name
J Lipid Resjournal_title
Journal of lipid researchauthors
Myerson M,Ngai C,Jones J,Holleran S,Ramakrishnan R,Berglund L,Ginsberg HNdoi
10.1194/jlr.M500335-JLR200keywords:
subject
Has Abstractpub_date
2005-12-01 00:00:00pages
2735-44issue
12eissn
0022-2275issn
1539-7262pii
M500335-JLR200journal_volume
46pub_type
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doi：
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journal_title：Journal of lipid research
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更新日期：1972-07-01 00:00:00
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journal_title：Journal of lipid research
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