Seasonal aggression independent of seasonal testosterone in wood rats.

abstract：:The rhizobium-legume symbiosis has been widely studied as the model of mutualistic evolution and the essential component of sustainable agriculture. Extensive genetic and recent genomic studies have led to the hypothesis that many distinct strategies, regardless of rhizobial phylogeny, contributed to the varied rhizob...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tian CF,Zhou YJ,Zhang YM,Li QQ,Zhang YZ,Li DF,Wang S,Wang J,Gilbert LB,Li YR,Chen WX

更新日期：2012-05-29 00:00:00

abstract：:Embryonic pluripotency in the mouse is established and maintained by a gene-regulatory network under the control of a core set of transcription factors that include octamer-binding protein 4 (Oct4; official name POU domain, class 5, transcription factor 1, Pou5f1), sex-determining region Y (SRY)-box containing gene 2 ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fernandez-Tresguerres B,Cañon S,Rayon T,Pernaute B,Crespo M,Torroja C,Manzanares M

更新日期：2010-11-16 00:00:00

abstract：:We reported in previous studies that prostaglandin E2 (PGE2) has central effects of augmenting wakefulness and suppressing slow-wave sleep (SWS) and paradoxical sleep (PS) in rats. In the present study, we tested the effect of AH 6809, an antagonist of PGE2 receptors, on sleep-wake activities. AH 6809 in saline was in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Matsumura H,Honda K,Choi WS,Inoué S,Sakai T,Hayaishi O

更新日期：1989-07-01 00:00:00

abstract：:Let G be a reductive algebraic group and let B be an affine variety with an algebraic action of G. Everything is defined over the field C of complex numbers. Consider the trivial G-vector bundle B x S = S over B where S is a G-module. From the endomorphism ring R of the G-vector bundle S a construction of G-vector bun...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Masuda M,Petrie T

更新日期：1991-10-15 00:00:00

abstract：:Here, using further optimized 3D culture that allows highly selective induction and long-term growth of human ES cell (hESC)-derived cortical neuroepithelium, we demonstrate unique aspects of self-organization in human neocorticogenesis. Self-organized cortical tissue spontaneously forms a polarity along the dorsocaud...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kadoshima T,Sakaguchi H,Nakano T,Soen M,Ando S,Eiraku M,Sasai Y

更新日期：2013-12-10 00:00:00

abstract：:Understanding the genetics of susceptibility to infectious agents is of great importance to our ability to combat disease. Here, we show that voltage-gated calcium channels (VGCCs) are critical for cellular binding and entry of the New World arenaviruses Junín and Tacaribe virus, suggesting that zoonosis via these rec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sarute N,Ross SR

更新日期：2020-08-11 00:00:00

abstract：:In yeast meiosis, crossing-over between homologues is dependent upon double-strand breaks. We demonstrate that the occurrence of these breaks is independent of pairing between homologues by showing that they occur with normal frequency, timing, and position in the absence of a homologue. This observation supports mode...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gilbertson LA,Stahl FW

更新日期：1994-12-06 00:00:00

abstract：:Thrombospondin, a 450-kDa multinodular glycoprotein with lectin-type activity, is found in human platelets, endothelial cells, fibroblasts, smooth muscle cells, monocytes, and granular pneumocytes. Thrombospondin interacts with heparin, fibrinogen, fibronectin, collagen, histidine-rich glycoprotein, and plasminogen. R...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Asch AS,Leung LL,Shapiro J,Nachman RL

更新日期：1986-05-01 00:00:00

abstract：:The circadian clock is a global regulatory mechanism that controls the expression of 50 to 80% of transcripts in mammals. Some of the genes controlled by the circadian clock are oncogenes or tumor suppressors. Among these Myc has been the focus of several studies which have investigated the effect of clock genes and p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu Z,Selby CP,Yang Y,Lindsey-Boltz LA,Cao X,Eynullazada K,Sancar A

更新日期：2020-09-01 00:00:00

abstract：:Somatic cell hybrids have been prepared at high frequency between the rat muscle cell line L6 and human fetal muscle cells. The hybrid cells express several human gene products including an antigen, 12E7, controlled by the human X chromosome, Thy-1, and several human isoenzymes. In addition, one clone (37-11) expresse...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Quinn CA,Goodfellow PN,Povey S,Walsh FS

更新日期：1981-08-01 00:00:00

abstract：:Understanding the approach to faulting in continental rocks is critical for identifying processes leading to fracturing in geomaterials and the preparation process of large earthquakes. In situ dynamic X-ray imaging and digital volume correlation analysis of a crystalline rock core, under a constant confining pressure...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Renard F,McBeck J,Kandula N,Cordonnier B,Meakin P,Ben-Zion Y

更新日期：2019-08-13 00:00:00

abstract：:A short, highly stereoselective (over 97%) synthesis of all-trans squalene is described. Starting with succinaldehyde, a tetraenedichlorodione having the complete squalene skeleton with the four internal trans olefinic bonds has been developed in four steps involving a sequence of two double Claisen rearrangements. Th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Werthemann L,Johnson WS

更新日期：1970-11-01 00:00:00

abstract：:Recent studies by x-ray crystallography, NMR, and molecular simulations have suggested that monovalent counterions can penetrate deeply into the minor groove of B form DNA. Such groove-bound ions potentially could play an important role in AT-tract bending and groove narrowing, thereby modulating DNA function in vivo....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Denisov VP,Halle B

更新日期：2000-01-18 00:00:00

abstract：:Human T-lymphotropic virus type 1 (HTLV-1) is a retrovirus that causes malignant and inflammatory diseases in ∼10% of infected people. A typical host has between 10(4) and 10(5) clones of HTLV-1-infected T lymphocytes, each clone distinguished by the genomic integration site of the single-copy HTLV-1 provirus. The HTL...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Satou Y,Miyazato P,Ishihara K,Yaguchi H,Melamed A,Miura M,Fukuda A,Nosaka K,Watanabe T,Rowan AG,Nakao M,Bangham CR

更新日期：2016-03-15 00:00:00

abstract：:The total sequence of 365 amino acid residues in bovine prochymosin is presented. Alignment with the amino acid sequence of porcine pepsinogen shows that 204 amino acid residues are common to the two zymogens. Further comparison and alignment with the amino acid sequence of penicillopepsin shows that 66 residues are l...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Foltmann B,Pedersen VB,Jacobsen H,Kauffman D,Wybrandt G

更新日期：1977-06-01 00:00:00

abstract：:A quantum computer (QC) can operate in parallel on all its possible inputs at once, but the amount of information that can be extracted from the result is limited by the phenomenon of wave function collapse. We present a new computational model, which differs from a QC only in that the result of a measurement is the e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cory DG,Fahmy AF,Havel TF

更新日期：1997-03-04 00:00:00

abstract：:Legionella pneumophila causes a potentially fatal form of pneumonia by replicating within macrophages in the Legionella-containing vacuole (LCV). Bacterial survival and proliferation within the LCV rely on hundreds of secreted effector proteins comprising high functional redundancy. The vacuolar membrane-localized Mav...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Christenson ET,Isaac DT,Yoshida K,Lipo E,Kim JS,Ghirlando R,Isberg RR,Banerjee A

更新日期：2019-09-03 00:00:00

abstract：:Renal medullary cells contain high concentrations of myo-inositol, sorbitol, betaine, and glycerophosphocholine, whose levels vary with urinary osmolality. Accumulation of these "compatible" organic osmolytes is believed to help the cells osmoregulate in response to the high extracellular osmolality that occurs as par...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakanishi T,Turner RJ,Burg MB

更新日期：1989-08-01 00:00:00

abstract：:The neutrality theory predicts that the rate of neutral molecular evolution is constant over time, and thus that there is a molecular clock for timing evolutionary events. It has been observed that the variance of the rate of evolution is generally larger than expected according to the neutrality theory, which has rai...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rodríguez-Trelles F,Tarrío R,Ayala FJ

更新日期：2001-09-25 00:00:00

abstract：:Bacterial proteins often localize to distinct sites within the cell, but the primary cues that dictate localization are largely unknown. Recent evidence has shown that positive membrane curvature can serve as a cue for localization of a peripheral membrane protein. Here we report that localization of the peripheral me...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ramamurthi KS,Losick R

更新日期：2009-08-11 00:00:00

abstract：:Nonenzymatic manganese was first shown to provide protection against superoxide toxicity in vivo in 1981, but the chemical mechanism responsible for this protection subsequently became controversial due to conflicting reports concerning the ability of Mn to catalyze superoxide disproportionation in vitro. In a recent ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barnese K,Gralla EB,Valentine JS,Cabelli DE

更新日期：2012-05-01 00:00:00

abstract：:We have isolated a protein from Saccharomyces cerevisiae that binds specifically to a nucleotide sequence associated with the autonomously replicating sequence (ARS) ARS120, located in the telomeric region of a yeast chromosome. "Footprinting" analysis revealed that a 26-base-pair DNA sequence, 5'-CAAGTGCCGTGCATAATGAT...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eisenberg S,Civalier C,Tye BK

更新日期：1988-02-01 00:00:00

abstract：:A mouse cDNA clone has been isolated that contains the complete coding region of a protein highly homologous to the delta subunit of the Torpedo acetylcholine receptor (AcChoR). The cDNA library was constructed in the vector lambda 10 from membrane-associated poly(A)+ RNA from BC3H-1 mouse cells. Surprisingly, the del...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： LaPolla RJ,Mayne KM,Davidson N

更新日期：1984-12-01 00:00:00

abstract：:Adult rat arterial smooth muscle cells (SMC) in primary culture modulate from contractile to synthetic phenotype. This process includes partial loss of myofilaments and formation of an extensive rough endoplasmic reticulum and a large Golgi complex. It gives the cells the ability to initiate DNA synthesis and actively...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nilsson J,Sjölund M,Palmberg L,Thyberg J,Heldin CH

更新日期：1985-07-01 00:00:00

abstract：:Cachectin (tumor necrosis factor) is a powerful macrophage hormone released during infection, which circulates in blood to produce diverse effects in the organism. We examined the effect of cachectin on release of anterior pituitary hormones from either hemipituitaries or dispersed pituitary cells incubated in vitro. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Milenkovic L,Rettori V,Snyder GD,Beutler B,McCann SM

更新日期：1989-04-01 00:00:00

abstract：:A cloned segment of yeast DNA containing the structural gene for imidazoleglycerolphosphate dehydratase (D-erythro-imidazoleglycerolphosphate hydro-lase, EC 4.2.1.19) is transcribed and translated in Escherichia coli with sufficient fidelity to produce functional enzyme. This segment of yeast DNA was isolated as a via...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Struhl K,Davis RW

更新日期：1977-12-01 00:00:00

abstract：:COVID-19 has emerged as one of the deadliest and most disruptive events in recent human history. Drawing from political science and psychological theories, we examine the effects of daily confirmed cases in a country on citizens' support for the political leader through the first 120 d of 2020. Using three unique data...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yam KC,Jackson JC,Barnes CM,Lau J,Qin X,Lee HY

更新日期：2020-10-13 00:00:00

abstract：:We have developed a simple yet powerful technique for delineating the morphological events of tumor-induced angiogenesis and other tumor-induced host processes with dual-color fluorescence. The method clearly images implanted tumors and adjacent stroma, distinguishing unambiguously the host and tumor-specific componen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang M,Li L,Jiang P,Moossa AR,Penman S,Hoffman RM

更新日期：2003-11-25 00:00:00

abstract：:An acid extract of pedal ganglia of the mollusc Mytilus edulis was fractionated by high-pressure liquid chromatography with a reverse-phase column. Peak fractions with retention times of those of [Met]- and [Leu]enkephalin were subjected to binding assays in both invertebrate and vertebrate tissues. The results showed...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leung MK,Stefano GB

更新日期：1984-02-01 00:00:00

abstract：:Ca2+ influx through voltage-gated Ca2+ channels and the resulting elevation of intracellular Ca2+ concentration, [Ca2+]i, triggers transmitter release in nerve terminals. However, it is controversial whether in addition to the opening of Ca2+ channels, membrane potential directly affects transmitter release. Here, we ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Felmy F,Neher E,Schneggenburger R

更新日期：2003-12-09 00:00:00