Abstract:
:The effect of retinoids on the induction of both epithelial and mesenchymal tumors of the rat kidney by a single dose of 40 mg/kg dimethylnitrosamine was tested using 13-cis-retinoic acid and the trimethylmethoxy phenyl analog of retinoic acid ethylamide. 13-cis-retinoic acid was administered for 3 weeks, 10 weeks, or 26 weeks, post-carcinogen treatment, in order to coincide with known morphological phases occurring within the kidney which culminated in the development of macroscopic tumors. The ethylamide analog and placebo beadlets were administered for the 26 week period only. None of the retinoid schedules significantly influenced the survival of the animals, nor the incidences of renal mesenchymal tumors or renal cell adenomas/adenocarcinomas. Tumor latency, histological grade or frequency of metastatic invasion were also unaltered by the treatments. Possible reasons for the observed lack of effect are discussed, including speculation regarding the potency of this single-dose model of chemical carcinogenesis.
journal_name
Carcinogenesisjournal_title
Carcinogenesisauthors
Hard GC,Ogiu Tdoi
10.1093/carcin/5.5.665subject
Has Abstractpub_date
1984-05-01 00:00:00pages
665-9issue
5eissn
0143-3334issn
1460-2180journal_volume
5pub_type
杂志文章相关文献
CARCINOGENESIS文献大全abstract::Despite decreases in the cancer death rates in high-resource countries, such as the USA, the number of cancer cases and deaths is projected to more than double worldwide over the next 20-40 years. Cancer is now the third leading cause of death, with >12 million new cases and 7.6 million cancer deaths estimated to have...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgp263
更新日期:2010-01-01 00:00:00
abstract::Current procedures for diagnosis and biomarker examination of colorectal cancer (CRC) are invasive and unpleasant. There is a great need to identify sensitive and specific biomarkers for early diagnosis of CRC. Circulating microRNAs (miRNAs) are promising molecular markers for CRC prediction. We performed a comprehens...
journal_title:Carcinogenesis
pub_type: 杂志文章,随机对照试验
doi:10.1093/carcin/bgu189
更新日期:2014-12-01 00:00:00
abstract::Fish or vegetable oils were fed during the promotion stage of a mouse skin carcinogenesis model in order to investigate the effects of dietary fat on tumor development. Two weeks after initiation with 10 nmol dimethylbenz[a]anthracene, SENCAR mice were divided into five groups and maintained on one of the following se...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/12.6.1023
更新日期:1991-06-01 00:00:00
abstract::Ovarian surface epithelium (OSE) is considered to give rise to epithelial ovarian carcinomas (EOCs). To elucidate early processes contributing to the development of EOCs from the OSE, two batches of primary human OSE cells were transduced with non-viral human genes (mutant Cdk4, cyclinD1 and hTERT) so as to efficientl...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgp007
更新日期:2009-03-01 00:00:00
abstract::Hypoxia-inducible factors (HIFs), in particular HIF-1alpha, have been implicated in tumor biology. However, HIF target genes in the esophageal tumor microenvironment remain elusive. Gene expression profiling was performed upon hypoxia-exposed non-transformed immortalized human esophageal epithelial cells, EPC2-hTERT, ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgp326
更新日期:2010-03-01 00:00:00
abstract::The relationship between striatal dopamine-stimulated adenylate cyclase (DAC) and 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary tumors was studied. An inverse correlation between activity of this enzyme and the number and growth of tumors was observed in several strains and substrains of rats. Chronic, but not...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/5.7.971
更新日期:1984-07-01 00:00:00
abstract::Comparative in vitro metabolic experiments with 7,8-benzoflavone using microsomes prepared from the livers of control Sprague-Dawley rats or from rats of the same strain treated with phenobarbitone, 3-methylcholanthrene, or Aroclor 1254 (known inducers of hepatic cytochrome P450 mixed function oxidases) disclose varia...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/3.2.229
更新日期:1982-01-01 00:00:00
abstract::Prepubertal exposure to soy or its biologically active component genistein reduces later breast cancer risk in both animal models and human populations. We investigated whether that might be due to reported estrogenic properties of genistein. Our study indicated that daily prepubertal exposures between postnatal days ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgh065
更新日期:2004-05-01 00:00:00
abstract::5,9-Dimethyldibenzo[c,g]carbazole (DMDBC), a potent mouse hepatocarcinogen, has been shown to induce a non-linear increase in mutant frequency in the liver of the transgenic MutaMouse. To gain insight into the mechanisms underlying the mutagenicity of DMDBC in vivo, DNA damage formation and removal were monitored in m...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/21.2.289
更新日期:2000-02-01 00:00:00
abstract::The anti-neoplastic agent procarbazine is genetically active in a variety of short term mutagenicity tests, and it also possesses carcinogenic and teratogenic potential. This compound has consistently yielded false negative results in in vitro microbial mutagenicity tests in the presence and absence of mammalian metab...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/4.3.347
更新日期:1983-01-01 00:00:00
abstract::The role of haplotypes and the interaction of haplotypes and smoking in lung cancer risk have not been well characterized. We analyzed data from an Italian population-based, case-control study with 1815 lung cancer patients and 1959 healthy controls in discovery, and performed a validation using a case-control study w...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgv118
更新日期:2015-11-01 00:00:00
abstract::Calpains are cysteine proteases comprising members ubiquitously expressed in human tissues and other tissue-specific isoforms. Alterations of calpain 3 (p94), the muscle-specific isoform that contains three peculiar sequences (NS, IS1 and IS2), are strictly associated to the limb-girdle muscular dystrophy type 2A, in ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgp098
更新日期:2009-06-01 00:00:00
abstract::Twist1 is an essential transcription factor required to initiate epithelial-mesenchymal transition (EMT) and promote tumor metastasis. PAQR3 is a newly found tumor suppressor that is frequently downregulated in many types of human cancers. Downregulation of PAQR3 is associated with accelerated metastasis and poor prog...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgw013
更新日期:2016-04-01 00:00:00
abstract::Diethylstilbestrol (DES) is a transplacental carcinogen in humans and in rodents. As part of an attempt to examine the mechanism of transplacental carcinogenesis, the transplacental genotoxity of this stilbene estrogen has been investigated. Pregnant hamsters received single injections of 200 mg/kg DES on the 10th day...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/12.5.773
更新日期:1991-05-01 00:00:00
abstract::Cancer-associated fibroblasts (CAFs) tend to have tumor-promoting capacity, and can provide therapeutic targets. Even without cancer cells, CAF phenotypes are stably maintained, and DNA methylation and H3K27me3 changes have been shown to be involved. Here, we searched for a potential therapeutic target in primary CAFs...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgaa131
更新日期:2020-12-07 00:00:00
abstract::Progression of hepatic neoplasia was assessed in medaka (Oryzias latipes) following aqueous exposure to diethylnitrosamine (DEN). Larvae (2 weeks old) were exposed to 350 or 500 p.p.m. DEN for 48 h, while adults (3-6 months old) were exposed to 50 p.p.m. DEN for 5 weeks. Fish were maintained as long as possible to det...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/20.6.933
更新日期:1999-06-01 00:00:00
abstract::Matrix metalloproteinases (MMP) are enzymes responsible for extracellular matrix degradation which play a role in cancer progression and metastatic spreading. We investigated the effects of the MMP inhibitor, batimastat, in vitro on the proliferation and invasiveness of the rat colon cancer cell line DHD/K12, and in v...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/20.8.1445
更新日期:1999-08-01 00:00:00
abstract::Ouabain resistance (ouar) and 6-thioguanine resistance (6-TGr) mutation frequencies were measured in Chinese hamster ovary cells after treatment with N-ethyl-N-nitrosourea (ENU) for varying periods of time. Maximal mutation frequency at the Na+/K+ ATPase gene locus (ouar mutations) was attained within 5 min of exposur...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/8.1.25
更新日期:1987-01-01 00:00:00
abstract::The effect of exposing mice to both a chemical carcinogen and leukemia virus with and without an inhibitor of DNA repair were compared. The data indicated that benzo[a]pyrene (BP) could exert a potentiating effect of Friend viral leukemogenesis in mice, which was dependent on the relative times of administration of th...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/2.1.1
更新日期:1981-01-01 00:00:00
abstract::We have compared the regulation of ornithine decarboxylase (ODC) gene expression in primary cultures of hamster embryo fibroblasts and in two independently transformed hamster embryo cell lines. Previous studies have demonstrated that 12-O-tetradecanoylphorbol-13-acetate (TPA) can greatly potentiate the serum growth f...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/10.1.157
更新日期:1989-01-01 00:00:00
abstract::Male and female strain A/J mice were exposed to a mixture of cigarette sidestream and mainstream smoke at a chamber concentration of total suspended particulates of 82.5 mg/m3. Exposure time was 6 h/day, 5 days/week for 5 months. The animals were allowed to recover for another 4 months in filtered air before sacrifice...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/19.10.1789
更新日期:1998-10-01 00:00:00
abstract::Aromatic DNA adducts in total white blood cells, cytochrome P450 (CYP) class 1A1 and glutathione transferase (GST1) class mu genotypes and micronuclei in T- and B-lymphocytes were studied in 69 full-time chimney sweeps and 35 controls, all male subjects. The sweeps had a higher (22%) but statistically non-significant ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/15.7.1347
更新日期:1994-07-01 00:00:00
abstract::We previously reported that quinacrine (QC) has anticancer activity against breast cancer cells. Here, we examine the mechanism of action of QC and its ability to inhibit Wnt-TCF signaling in two independent breast cancer cell lines. QC altered Wnt-TCF signaling components by increasing the levels of adenomatous polyp...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgs351
更新日期:2013-02-01 00:00:00
abstract::4-Oxo-4-(3-pyridyl)butanal (OPB) is an aldehyde formed during the activation of the tobacco-specific N-nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Using the DNA alkaline elution technique, the properties of DNA alkali-labile sites induced in the isolated rat hepatocytes by NNK and OPB were compar...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/12.11.2135
更新日期:1991-11-01 00:00:00
abstract::An in vivo method for assessment of DNA adduct formation and unscheduled DNA synthesis (UDS) in the esophagus of rats was devised. Small ventral incisions were made in the neck and upper abdomen regions of 6 week old F344 rats and ligation of the esophagus with thread at the two extreme ends performed to make an esoph...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/11.2.235
更新日期:1990-02-01 00:00:00
abstract::Hepatocyte growth factor (HGF)-stimulated Met signaling influences tumor survival, growth and progression, all processes involving the transcription factor NF-kappaB. NF-kappaB plays a complex role in the control of survival due to the influence of cellular factors acting downstream. We undertook a comparative investi...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgh227
更新日期:2004-11-01 00:00:00
abstract::The mutagen sensitivity assay is an in vitro measure of DNA repair capacity used to evaluate intrinsic susceptibility for cancer. The high heritability of mutagen sensitivity to different mutagens validates the use of this phenotype to predict cancer susceptibility. However, genetic determinants of mutagen sensitivity...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgn121
更新日期:2008-07-01 00:00:00
abstract::Tuberin (protein encodes by tuberous sclerosis complex 2, Tsc2) deficiency is associated with the decrease in the DNA repair enzyme 8-oxoG-DNA glycosylase (OGG1) in tumour kidney of tuberous sclerosis complex (TSC) patients. The purpose of this study was to elucidate the mechanisms by which tuberin regulates OGG1. The...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgq189
更新日期:2010-11-01 00:00:00
abstract::Repeated promotion of 7,12-dimethylbenz[alpha]anthracene-initiated cells in mouse skin with 12-O-tetradecanoylphorbol-13-acetate (TPA) induces them to grow as premalignant skin papillomas and some of these subsequently progress to carcinomas. In this study, we demonstrate that this TPA-induced progression of initiated...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/11.12.2123
更新日期:1990-12-01 00:00:00
abstract::Alterations in the Rb pathway have been described in many different tumors. In order to study this cell cycle regulatory mechanism in murine T cell lymphomas, we have analyzed the RNA and protein expression of the cyclin D1, cdk4 and retinoblastoma genes in primary tumor samples. We have detected overexpression of the...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/20.9.1675
更新日期:1999-09-01 00:00:00