Abstract:
:Repeated promotion of 7,12-dimethylbenz[alpha]anthracene-initiated cells in mouse skin with 12-O-tetradecanoylphorbol-13-acetate (TPA) induces them to grow as premalignant skin papillomas and some of these subsequently progress to carcinomas. In this study, we demonstrate that this TPA-induced progression of initiated cells to papillomas and carcinomas could be prevented by exposing them previously to weak promoting regimens or to agents that mimic TPA activity.
journal_name
Carcinogenesisjournal_title
Carcinogenesisauthors
Reddy AL,Fialkow PJdoi
10.1093/carcin/11.12.2123subject
Has Abstractpub_date
1990-12-01 00:00:00pages
2123-6issue
12eissn
0143-3334issn
1460-2180journal_volume
11pub_type
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