Autologous and allogeneic typing of human leukemia cells: definition of surface antigens restricted to lymphocytic leukemia cells.

abstract：:The Ah receptor (AHR) is a basic helix-loop-helix protein that mediates the effects of 2,3,7,8-tetrachloro-dibenzo-p-dioxin. In this report, we describe a rabbit reticulocyte system that allows functional expression of both the AHR and its dimeric partner, the AHR nuclear translocator protein (ARNT). By using this in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dolwick KM,Swanson HI,Bradfield CA

更新日期：1993-09-15 00:00:00

abstract：:A human liver cDNA library was screened by colony hybridization with a bovine factor X cDNA probe. Three of the positive plasmids contained overlapping DNA that coded for most of human factor X mRNA. DNA sequence analysis of these three clones allowed the prediction of the complete amino acid sequence of plasma factor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fung MR,Hay CW,MacGillivray RT

更新日期：1985-06-01 00:00:00

abstract：:Collective intelligence refers to the ability of groups to outperform individual decision makers when solving complex cognitive problems. Despite its potential to revolutionize decision making in a wide range of domains, including medical, economic, and political decision making, at present, little is known about the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kurvers RH,Herzog SM,Hertwig R,Krause J,Carney PA,Bogart A,Argenziano G,Zalaudek I,Wolf M

更新日期：2016-08-02 00:00:00

abstract：:The F9 teratocarcinoma cell line differentiates in vitro after treatment with retinoic acid and cAMP and has been a widely used model system for the study of the molecular events that are responsible for cellular commitment and differentiation during early development. Previous experiments have suggested intriguing pa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weigel RJ,Devoto SH,Nevins JR

更新日期：1990-12-01 00:00:00

abstract：:The 2-deoxy-D-glucose method was used to study asymmetries in cerebral metabolic activity in neonatal rats. Left-right asymmetries in 2-deoxy-D-glucose uptake were observed in hippocampus, diencephalon, cortex, and medulla-pons: 2-deoxy-D-glucose incorporation was greater in right hippocampus, right diencephalon, left...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ross DA,Glick SD,Meibach RC

更新日期：1981-03-01 00:00:00

abstract：:Studies of perception usually emphasize processes that are largely universal across observers and--except for short-term fluctuations--stationary over time. Here we test the universality and stationarity assumptions with two families of ambiguous visual stimuli. Each stimulus can be perceived in two different ways, pa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wexler M,Duyck M,Mamassian P

更新日期：2015-12-01 00:00:00

abstract：:The chimaeric protein repressor-galactosidase, in which fully active lac repressor is covalently linked to the active enzyme beta-galactosidase, was used as a system for probing the quaternary structure of lac repressor. Electron micrographs revealed repressor-galactosidase to be a tetrameric aggregate. When lac repre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kania J,Brown DT

更新日期：1976-10-01 00:00:00

abstract：:The molecular chaperone Hsp90 is a protein folding machine that is conserved from bacteria to man. Human, cytosolic Hsp90 is dedicated to folding of chiefly signal transduction components. The chaperoning mechanism of Hsp90 is controlled by ATP and various cochaperones, but is poorly understood and controversial. Here...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Karagöz GE,Duarte AM,Ippel H,Uetrecht C,Sinnige T,van Rosmalen M,Hausmann J,Heck AJ,Boelens R,Rüdiger SG

更新日期：2011-01-11 00:00:00

abstract：:SsrA/SsrB is a primary two-component system that mediates the survival and replication of Salmonella within host cells. When activated, the SsrB response regulator directly promotes the transcription of multiple genes within Salmonella pathogenicity island 2 (SPI-2). As expression of the SsrB protein is promoted by se...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Choi J,Shin D,Yoon H,Kim J,Lee CR,Kim M,Seok YJ,Ryu S

更新日期：2010-11-23 00:00:00

abstract：:In an autoshaping experiment, food-deprived pigeons pecked rapidly at a moving dot that preceded the delivery of food. When the moving dot and food were no longer correlated, the rate of pecking dropped nearly to zero. When, subsequently, no food was given, pecking reappeared at a high rate (nearly 200 pecks per min f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Epstein R,Skinner BF

更新日期：1980-10-01 00:00:00

abstract：:The 33-amino-acid ankyrin motif comprises a beta-turn followed by two anti-parallel alpha-helices and a loop and tandem arrays of the motif pack in a linear fashion to produce elongated structures characterized by short-range interactions. In this article we use site-directed mutagenesis to investigate the kinetic unf...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Werbeck ND,Rowling PJ,Chellamuthu VR,Itzhaki LS

更新日期：2008-07-22 00:00:00

abstract：:The discovery of arbuscules in Aglaophyton major, an Early Devonian land plant, provides unequivocal evidence that mycorrhizae were established >400 million years ago. Nonseptate hyphac and arbuscules occur in a specialized meristematic region of the cortex that continually provided new cells for fungal infection. Arb...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Remy W,Taylor TN,Hass H,Kerp H

更新日期：1994-12-06 00:00:00

abstract：:Recent evidence indicates there is a role for small membrane vesicles, including exosomes, as vehicles for intercellular communication. Exosomes secreted by most cell types can mediate transfer of proteins, mRNAs, and microRNAs, but their role in the transmission of infectious agents is less established. Recent studie...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ramakrishnaiah V,Thumann C,Fofana I,Habersetzer F,Pan Q,de Ruiter PE,Willemsen R,Demmers JA,Stalin Raj V,Jenster G,Kwekkeboom J,Tilanus HW,Haagmans BL,Baumert TF,van der Laan LJ

更新日期：2013-08-06 00:00:00

abstract：:For many intraoperative decisions surgeons depend on frozen section pathology, a technique developed over 150 y ago. Technical innovations that permit rapid molecular characterization of tissue samples at the time of surgery are needed. Here, using desorption electrospray ionization (DESI) MS, we rapidly detect the tu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Santagata S,Eberlin LS,Norton I,Calligaris D,Feldman DR,Ide JL,Liu X,Wiley JS,Vestal ML,Ramkissoon SH,Orringer DA,Gill KK,Dunn IF,Dias-Santagata D,Ligon KL,Jolesz FA,Golby AJ,Cooks RG,Agar NY

更新日期：2014-07-29 00:00:00

abstract：:Two affinity species of the interleukin 2 (IL-2) receptor are different states of a single receptor molecule. We assumed that a binary complex between the IL-2 receptor and another lymphocyte-specific protein would constitute the high-affinity receptor. To test this assumption, we counted the numbers of IL-2 receptors...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kondo S,Shimizu A,Saito Y,Kinoshita M,Honjo T

更新日期：1986-12-01 00:00:00

abstract：:Primates can store sensory stimulus parameters in working memory for subsequent manipulation, but until now, there has been no demonstration of this capacity in rodents. Here we report tactile working memory in rats. Each stimulus is a vibration, generated as a series of velocity values sampled from a normal distribut...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fassihi A,Akrami A,Esmaeili V,Diamond ME

更新日期：2014-02-11 00:00:00

abstract：:Mutations of MECP2 (Methyl-CpG Binding Protein 2) cause Rett syndrome. As a chromatin-associated multifunctional protein, how MeCP2 integrates external signals and regulates neuronal function remain unclear. Although neuronal activity-induced phosphorylation of MeCP2 at serine 421 (S421) has been reported, the full sp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tao J,Hu K,Chang Q,Wu H,Sherman NE,Martinowich K,Klose RJ,Schanen C,Jaenisch R,Wang W,Sun YE

更新日期：2009-03-24 00:00:00

abstract：:Proopiomelanocortin (POMC), a major pituitary product, is also present in the adult mouse testis. We have shown previously that POMC mRNAs are most abundant in a subpopulation of Leydig cells associated with tubules in specific stages of the cycle of the seminiferous epithelium. In the present study, we examined the e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gizang-Ginsberg E,Wolgemuth DJ

更新日期：1987-03-01 00:00:00

abstract：:Myelin basic proteins (MBP) are major constituents of the myelin sheath of oligodendrocytes and Schwann cells in the central nervous system and the peripheral nervous system, respectively. We previously showed that MBP-related transcripts are present in the bone marrow and the immune system. These mRNAs are transcribe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marty MC,Alliot F,Rutin J,Fritz R,Trisler D,Pessac B

更新日期：2002-06-25 00:00:00

abstract：:A perversion in an otherwise uniform helical structure, such as a climbing plant tendril, refers to a kink that connects two helices with opposite chiralities. Such singularity structures are widely seen in natural and artificial mechanical systems, and they provide the fundamental mechanism of helical symmetry breaki...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu S,Yao Z,Chiou K,Stupp SI,Olvera de la Cruz M

更新日期：2016-06-28 00:00:00

abstract：:Working memory (WM) is the ability to retain and associate information over brief time intervals. Functional imaging studies demonstrate that WM is mediated by a distributed network including frontal and posterior cortices, hippocampus, and cerebellum. In rodents, the presentation of stimuli in a WM task is followed b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tesche CD,Karhu J

更新日期：2000-01-18 00:00:00

abstract：:Although potassium channels play a variety of roles in shaping the electrical properties of neurons, little is known about how these channels are constituted in neurons. To examine the assembly and physiological function of A-type K+ channels in mature differentiated neurons, we have developed a highly efficient gene ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kaang BK,Pfaffinger PJ,Grant SG,Kandel ER,Furukawa Y

更新日期：1992-02-01 00:00:00

abstract：:O-GlcNAc glycosylation (or O-GlcNAcylation) is a dynamic, inducible posttranslational modification found on proteins associated with neurodegenerative diseases such as α-synuclein, amyloid precursor protein, and tau. Deletion of the O-GlcNAc transferase (ogt) gene responsible for the modification causes early postnata...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang AC,Jensen EH,Rexach JE,Vinters HV,Hsieh-Wilson LC

更新日期：2016-12-27 00:00:00

abstract：:Recent work using culture-independent methods suggests that the lungs of cystic fibrosis (CF) patients harbor a vast array of bacteria not conventionally implicated in CF lung disease. However, sampling lung secretions in living subjects requires that expectorated specimens or collection devices pass through the oroph...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goddard AF,Staudinger BJ,Dowd SE,Joshi-Datar A,Wolcott RD,Aitken ML,Fligner CL,Singh PK

更新日期：2012-08-21 00:00:00

abstract：:The present study examines the binding and postbinding cellular processing and recycling of the V1 arginine vasopressin (AVP) receptor in cultured vascular smooth muscle cells (VSMCs). The surface binding of AVP to VSMCs was temperature dependent and reached equilibrium within 60 min at 4 degrees C. Displacement studi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Briner VA,Williams B,Tsai P,Schrier RW

更新日期：1992-04-01 00:00:00

abstract：:The HER2 gene encodes a cell-surface glycoprotein with extensive homology to the epidermal growth factor receptor. Recently it was found to be amplified in about 30% of primary human breast malignancies. In experiments designed to assess the role of the HER2 gene in oncogenesis, we found that overexpression of unalter...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hudziak RM,Schlessinger J,Ullrich A

更新日期：1987-10-01 00:00:00

abstract：:A yeast genetic system was developed to study how the basic regions of basic-helix-loop-helix (bHLH) proteins distinguish between related consensus bHLH binding sites, with nucleotide sequence CANNTG. The yeast bHLH protein CBF1 binds to the sequence CAC(A/G)TG found in the yeast centromere element CDE1 and in promote...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dang CV,Dolde C,Gillison ML,Kato GJ

更新日期：1992-01-15 00:00:00

abstract：:Outer membrane protein (OMP) biogenesis is critical to bacterial physiology because the cellular envelope is vital to bacterial pathogenesis and antibiotic resistance. The process of OMP biogenesis has been studied in vivo, and each of its components has been studied in isolation in vitro. This work integrates paramet...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Costello SM,Plummer AM,Fleming PJ,Fleming KG

更新日期：2016-08-16 00:00:00

abstract：:We have previously proven that human macrophages can phagocytose porcine cells even in the absence of Ab or complement opsonization, indicating that macrophages present a pivotal immunological obstacle to xenotransplantation. A recent report indicates that the signal regulatory protein (SIRP)alpha is a critical immune...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ide K,Wang H,Tahara H,Liu J,Wang X,Asahara T,Sykes M,Yang YG,Ohdan H

更新日期：2007-03-20 00:00:00

abstract：:Myosins, a large family of actin-based motors, have one or two heavy chains with one or more light chains associated with each heavy chain. The heavy chains have a (generally) N-terminal head domain with an ATPase and actin-binding site, followed by a neck domain to which the light chains bind, and a C-terminal tail d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Korn ED

更新日期：2000-11-07 00:00:00