A gene function required for cell cycle progression during the G1 portion of the cell cycle and for maintenance of macronuclear DNA synthesis in Paramecium tetraurelia.

Abstract:

:The ccl mutation in Paramecium tetraurelia reversibly and rapidly blocks cell cycle progression and DNA synthesis at the restrictive temperature. Progression through the cell cycle is blocked during both the G1 and S portions of the cell cycle, while at the restrictive temperature there is neither residual cell cycle progression nor induction of excess delay of subsequent cell cycle events. DNA synthesis activity is reduced to 50% of the normal level in about 5 min and is completely blocked at 30 min after a shift to restrictive temperature. On return to permissive conditions, DNA synthesis is reactivated with similar kinetics.

journal_name

Exp Cell Res

authors

Rasmussen CD,Berger JD

doi

10.1016/0014-4827(84)90220-9

subject

Has Abstract

pub_date

1984-12-01 00:00:00

pages

593-7

issue

2

eissn

0014-4827

issn

1090-2422

journal_volume

155

pub_type

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