Abstract：
:BK virus (BKV)-transformed cells and BKV-induced tumors as well as in vitro derived tumor cell lines were all found to contain BKV DNA sequences when analysed by DNA-DNA reassociation kinetics. In transformed cells the number of viral genome equivalents per diploid cell genome (CG divided by VG) decreased with increasing generations. Likewise, single cell clones had a lower CG divided by VG than parental transformed cells. BKV-induced tumors had a high CG divided by VG. Tumor cells cultivated in vitro and their clones had a lower CG divided by VG than BKV-induced tumors from which they were derived, suggesting a multiclonal origin of tumors. Hamster tumors induced by subcutaneous inoculation of BKV-transformed cells or tumor cell lines had a higher CG divided by VG than cells producing them. Variation in CG divided by VG is discussed in terms of cell selection depending on different in vitro or in vivo conditions of cell growth. In some cases, however, the decrease in CG divided by VG most likely depends on loss on free viral sequences from transformed cells or tumors.
journal_name
Arch Viroljournal_title
Archives of virologyauthors
Grossi MP,Corallini A,Poli F,Valieri A,Milanesi G,Barbanti-Brodano Gdoi
10.1007/BF01314838subject
Has Abstractpub_date
1981-01-01 00:00:00pages
345-54issue
4eissn
0304-8608issn
1432-8798journal_volume
67pub_type
杂志文章abstract：:A novel potyvirus was discovered in Angelica lucida L. (wild celery) and A. genuflexa Nutt. (kneeling Angelica) (family Apiaceae) in the Matanuska- Susitna Valley, Alaska. The experimental plant host range of the virus included species in three families: Chenopodiaceae (Chenopodium amaranticolor Coste et Reyn and Chen...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-007-1003-4
更新日期：2007-01-01 00:00:00
abstract：:Banna virus, whose genome is composed of 12 segments of double-stranded RNA, is a member of the genus Seadornavirus in the family Reoviridae and is thought to be an emerging mosquito-transmitted human pathogen in Southeast Asia. A novel phylogenetic relative of Banna virus (Balaton virus, BALV, JX947843-JX947850 and K...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-013-1712-9
更新日期：2013-10-01 00:00:00
abstract：:Noroviruses, a major cause of acute gastroenteritis outbreaks worldwide, are constantly evolving. This ability is reflected in the speed and efficiency with which these viruses spread and remain in the human population. The present study reports the detection of a novel recombination event among norovirus genotypes in...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-012-1428-2
更新日期：2012-12-01 00:00:00
abstract：:R 61,837, a new antirhinovirus compound, was able to protect several susceptible rhinoviruses against inactivation by mild acidification or heat. This observation strengthens the hypothesis that the drug exerts antiviral activity by a direct interaction with the viral protein capsid to stabilize the particle. However,...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01311037
更新日期：1989-01-01 00:00:00
abstract：:In this study, a novel filamentous phage, φSHP1, of the environmental Stenotrophomonas maltophilia strain P2 was isolated and characterized. Electron microscopy showed that φSHP1 resembled members of the family Inoviridae and was about 2.1 μm long. The 6,867-nucleotide genome of φSHP1 was a circular single-stranded DN...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-012-1305-z
更新日期：2012-09-01 00:00:00
abstract：:The effects of human alpha-, beta-, or gamma-interferon (IFN) on the replication and production of human T-lymphotrophic virus type-I (HTLV-I) were investigated in a human T-cell line, MT-2. Virus transmission and production estimated by syncytium formation and HTLV-I-associated reverse transcriptase (RT) activity wer...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01310623
更新日期：1990-01-01 00:00:00
abstract：:The complete genome sequence of a Chinese very virulent infectious bursal disease virus (vvIBDV) strain, Harbin-1, was determined. Based on the sequence analysis, the molecular characteristics and potential virulence determinants and origin of vvIBDV strains were identified. Phylogenetic analysis indicated that a reas...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-008-0140-8
更新日期：2008-01-01 00:00:00
abstract：:A total of 34 highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) strains isolated from Vietnam during 2013-2014 were sequenced and analyzed. A partial sequence of ORF1a corresponding to the nonstructural protein 2 (Nsp2) coding region and the full sequence of open reading frame 5 (ORF5) g...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-015-2699-1
更新日期：2016-03-01 00:00:00
abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV) causes a variety of cancers, including Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman disease (MCD). Host cellular microRNAs (miRNAs) play important post-transcriptional regulatory roles in gene expression and can greatly influence viru...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-017-3478-y
更新日期：2017-11-01 00:00:00
abstract：:Chimeric plant viruses are emerging as promising vectors for use in innovative vaccination strategies. In this context, cucumber mosaic virus (CMV) has proven to be a suitable carrier of the hepatitis C virus (HCV)-derived R9 mimotope. In the present work, a new chimeric CMV, expressing on its surface the HCV-derived ...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-006-0916-7
更新日期：2007-01-01 00:00:00
abstract：:Four distinct double-stranded (ds) RNA bands were extracted from leaves of Raphanus sativus-root cv. Yidianhong [corrected] with yellowing at the leaf edge in China. Purified viral particles of 28-30 nm in diameter contained dsRNA segments with the same number and mobility as these extracted directly from radish leave...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-005-0685-8
更新日期：2006-05-01 00:00:00
abstract：:Changes in the NP gene of H5N1 highly pathogenic avian influenza (HPAI) viruses have previously been shown to affect viral replication, alter host gene expression levels and affect mean death times in infected chickens. Five amino acids at positions 22, 184, 400, 406, and 423 were different between the two recombinant...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-009-0399-4
更新日期：2009-01-01 00:00:00
abstract：:A well characterized strain of guinea pig cytomegalovirus (GPCMV) was used to infect pregnant guinea pigs during various periods of pregnancy. Transplacental transmission of virus with invasion of the fetus was observed, even in some mothers with preinoculation evidence of GPCMV antibody. Fetal infection occurred duri...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01317422
更新日期：1979-01-01 00:00:00
abstract：:To date, most members of the Siphoviridae family of bacteriophages remain unclassified, including the 46 staphylococcal phages for which the complete genome sequences have been deposited in public databases. Comparative nucleotide and protein sequence analysis, in addition to available data on phage morphology, allowe...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-013-1833-1
更新日期：2014-02-01 00:00:00
abstract：:Occult HCV infection (OCI) has been described as the presence of hepatitis C virus (HCV) genomic RNA in hepatocytes and/or peripheral blood mononuclear cell (PBMC) specimens and the lack of HCV genomic RNA and anti-HCV antibodies (Abs) in plasma samples. Injection drug users (IDUs) are the most important high-risk gro...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-018-4066-5
更新日期：2019-02-01 00:00:00
abstract：:Transgenic plants represent an inexpensive alternative to classical fermentation systems for production of recombinant subunit vaccines. Transgenic potato plants were created that express the N-terminal domain of the glycoprotein S (N-gS) from Transmissible gastroenteritis coronavirus (TGEV), containing the major anti...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s007050070087
更新日期：2000-01-01 00:00:00
abstract：:The PI3K/Akt signalling pathway is a crucial signalling cascade that regulates transcription, protein translation, cell growth, proliferation, cell survival, and metabolism. During viral infection, viruses exploit a variety of cellular pathways, including the well-known PI3K/Akt signalling pathway. Conversely, cells r...
journal_title：Archives of virology
pub_type： 杂志文章,评审
doi：10.1007/s00705-020-04740-1
更新日期：2020-10-01 00:00:00
abstract：:In this study, we isolated a mycobacteriophage infecting Mycobacterium smegmatis mc2155 from a soil sample collected in Shandong Province in China. This phage was named Shandong1. It is a member of the family Siphoviridae with an isometric head and a long tail. Its genome was found to be 60,618 bp long with 67.46% G +...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-017-3534-7
更新日期：2017-12-01 00:00:00
abstract：:Zika virus (ZIKV) is an emerging mosquito-borne flavivirus circulating in Asia and Africa. In 2013, a large outbreak was reported on the archipelago of French Polynesia. In this study, we report the detection and molecular characterization of Zika virus for the first time in Chile from an outbreak among the inhabitant...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-015-2695-5
更新日期：2016-03-01 00:00:00
abstract：:A bovine monoclonal antibody specific for bovine viral diarrhoea virus (BVDV) recognized all the reference strains of BVDV and over 90% of the field isolates tested. It neutralized the virus and precipitated a 56 k-58 k viral protein. ...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01316756
更新日期：1991-01-01 00:00:00
abstract：:A new aquareovirus was isolated from cultured Atlantic halibut (Hippoglossus hippoglossus) fry at a facility where massive mortalities had occurred during the start-feeding phase. The same virus was also detected in juveniles (about 10 grams) of the 2013 generation at two other production sites, but not in larger fish...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-014-2235-8
更新日期：2015-01-01 00:00:00
abstract：:Virus isolate Y3V, obtained from tobacco showing leaf curl symptoms in Yunnan, China, had particles with the size and morphology typical of geminiviruses. In reactions with a set of monoclonal antibodies raised against begomoviruses, Y3V was readily differentiated from two previously studied Chinese Begomovirus isolat...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s007050170081
更新日期：2001-08-01 00:00:00
abstract：:Use of Urografin and Conray for the equilibrium centrifugation of viruses is described. These pharmaceuticals, which consist of iodinated arylic compounds, reach densities of 1.6 g/cm3 and have low intrinsic viscosities. Poliovirus, Newcastle disease virus, and lymphocytic choriomeningitis virus were centrifuged to eq...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01318245
更新日期：1975-01-01 00:00:00
abstract：:Foot-and-mouth disease virus (FMDV) causes a highly contagious viral disease of cloven-hoofed animals, which has a considerable socio-economic impact on the countries affected. In addition, persistent infection can occur following clinical or sub-clinical disease in either vaccinated or non-vaccinated cattle. The mech...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-002-0867-6
更新日期：2002-11-01 00:00:00
abstract：:The objectives of this study were to determine the antigenic relationship among ruminant adenoviruses and determine their phylogenetic relationship based on the deduced hexon gene amino acid sequence. Results of reciprocal cross-neutralization tests demonstrated antigenic relationships in either one or both directions...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-008-0063-4
更新日期：2008-01-01 00:00:00
abstract：:Foot-and-mouth disease (FMD) is a highly contagious viral disease of transboundary importance. In India, since the launch of the FMD control programme, there has been a substantial increase in the vaccinated bovine population. In this scenario, there is a need for additional locally developed non-structural protein (N...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-013-1973-3
更新日期：2014-07-01 00:00:00
abstract：:The bovine papillomavirus (BPV) transforming gene E5 is thought to modulate growth factor receptor function leading to a stimulation of growth factor signal transduction pathways. However, the influence of E5 on the range of receptor mediated changes in protein phosphorylation has not been addressed. We looked for the...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s007050050131
更新日期：1997-01-01 00:00:00
abstract：:This is the first report on the morphology and fine structure of chlorella virus Göttingen-1 (CVG-1), an European member of the newly approved family Phycodnaviridae, which infects certain unicellular, eukaryotic, exsymbiotic, green algae. CVG-1 are polyhedral particles 145-160 nm in diameter. The capsid consists of t...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01319003
更新日期：1993-01-01 00:00:00
abstract：:Classical serotype 1 infectious bursal disease viruses (IBDV), but not very virulent (vv) isolates, react with neutralizing monoclonal antibody (NMab) 3 in virus neutralization tests or antigen-capture ELISA. Two other NMabs, 6 and 8, bind to both classical and most vv strains, but not to the atypical 94,432 and 91,16...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s007050050404
更新日期：1998-01-01 00:00:00
abstract：:Coronavirus disease 2019, also known as COVID-19, is caused by a novel coronavirus named severe acute respiratory syndrome coronavirus 2, or SARS-CoV-2. The infection has now catapulted into a full-blown pandemic across the world, which has affected more than 2 million people and has led to approximately 150,000 fatal...
journal_title：Archives of virology
pub_type： 杂志文章,评审
doi：10.1007/s00705-020-04768-3
更新日期：2020-11-01 00:00:00
