Oral immunogenicity of the plant derived spike protein from swine-transmissible gastroenteritis coronavirus.

Abstract:

:Transgenic plants represent an inexpensive alternative to classical fermentation systems for production of recombinant subunit vaccines. Transgenic potato plants were created that express the N-terminal domain of the glycoprotein S (N-gS) from Transmissible gastroenteritis coronavirus (TGEV), containing the major antigenic sites of the protein. Extracts from potato tubers expressing N-gS were inoculated intraperitoneally to mice, and the vaccinated mice developed serum IgG specific for TGEV. Furthermore, when potato tubers expressing N-gS were fed directly to mice, they developed serum antibodies specific for gS protein, demonstrating the oral immunogenicity of the plant derived spike protein from TGEV.

journal_name

Arch Virol

journal_title

Archives of virology

authors

Gómez N,Wigdorovitz A,Castañón S,Gil F,Ordás R,Borca MV,Escribano JM

doi

10.1007/s007050070087

keywords:

subject

Has Abstract

pub_date

2000-01-01 00:00:00

pages

1725-32

issue

8

eissn

0304-8608

issn

1432-8798

journal_volume

145

pub_type

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