Cardionatrin causes vasodilation in vitro which is not dependent on the presence of endothelial cells.

abstract：:Desensitization of serotonin 5-HT2 receptor-mediated enhancement of the N-methyl-D-aspartate (NMDA) depolarization was studied in rat cortical neurons. Serotonin and (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) induced long term desensitization. Staurosporine, a nonspecific protein kinase C inhibitor, pot...

journal_title：European journal of pharmacology

authors： Rahman S,Neuman RS

更新日期：1993-07-20 00:00:00

abstract：:In many vascular smooth muscle cells, physiological and pharmacological agonists initiate oscillatory fluctuations in intracellular Ca(2+) to initiate and maintain vasoconstriction. These oscillations are supported by the underlying cellular ultrastructure, particularly the close apposition between the plasma membrane...

journal_title：European journal of pharmacology

authors： Dai JM,Syyong H,Navarro-Dorado J,Redondo S,Alonso M,van Breemen C,Tejerina T

更新日期：2010-03-10 00:00:00

abstract：:Cisplatin (CDDP)-induced nephrotoxicity (CIN) is one of the most serious toxicities caused by this potent antitumor agent. It has been reported that Mg premedication attenuates CIN in clinical trials; however, the mechanism underlying its nephroprotection is not fully understood. Therefore, the aim of this study was t...

journal_title：European journal of pharmacology

authors： Saito Y,Okamoto K,Kobayashi M,Narumi K,Yamada T,Iseki K

更新日期：2017-09-15 00:00:00

abstract：:Factor Xa inhibitors reduce stroke in patients with atrial fibrillation. Pulmonary veins (PVs) and the sinoatrial node (SAN) are crucial for genesis of atrial fibrillation. However, the electrophysiological effects of factor Xa inhibitors (edoxaban and rivaroxaban) on PVs and the SAN remain unclear. Conventional micro...

journal_title：European journal of pharmacology

authors： Chang CJ,Cheng CC,Chen YC,Higa S,Huang JH,Chen SA,Chen YJ

更新日期：2018-08-15 00:00:00

abstract：:Pain is a global health challenge. For decades, we have been primarily relying upon opioids and nonsteroidal anti-inflammatory drugs (NSAIDs) for pain management. However, adverse effects related to opioid and NSAID use are severe and often lead to forced drug discontinuation and inadequate pain relief. Despite decade...

journal_title：European journal of pharmacology

authors： Li JX,Zhang Y

更新日期：2012-04-15 00:00:00

abstract：:Endoplasmic reticulum (ER) stress and associated protein aggregation are closely associated with human diseases, including alterations in hepatic lipid metabolism. Inhibition of ER stress can have a significant effect on the prevention of hepatic dyslipidemia. Here, we studied the role of 4-phenylbutyric acid (4-PBA),...

journal_title：European journal of pharmacology

authors： Lee HY,Marahatta A,Bhandary B,Kim HR,Chae HJ

更新日期：2016-04-15 00:00:00

abstract：:KDR-5169, 4-amino-5-chloro-N-[1-(3-fluoro-4-methoxybenzyl)piperidin-4-yl]-2-(2-hydroxyethoxy)benzamide hydrochloride dihydrate, is a new prokinetic with a dual action, i.e., stimulation of the 5-HT4 receptor and antagonism of the dopamine D2 receptor. In this study, we determined in vitro activities of KDR-5169 toward...

journal_title：European journal of pharmacology

authors： Tazawa S,Masuda N,Koizumi T,Kitazawa M,Nakane T,Miyata H

更新日期：2002-01-11 00:00:00

abstract：:The influence of the membrane environment on the alpha 1-adrenoceptor has been investigated by examining the effect of phospholipase digestion on the binding of [3H]prazosin to aortic and hepatic membranes. Membrane digestion by phospholipase A2 and phospholipase C was found to markedly reduce prazosin binding to the ...

journal_title：European journal of pharmacology

authors： Shreeve SM,Valliere JE

更新日期：1992-05-12 00:00:00

abstract：:We have used cannabinoid CB knock-out mice in a two-trial object recognition test to assess the role of cannabinoid CB receptors in memory. Cannabinoid CB1 knock-out mice are able to retain memory for at least 48 h after the first trial whereas the wild-type controls lose their capacity to retain memory after 24 h. Th...

journal_title：European journal of pharmacology

authors： Reibaud M,Obinu MC,Ledent C,Parmentier M,Böhme GA,Imperato A

更新日期：1999-08-20 00:00:00

abstract：:The effect of a leukotriene D(4) receptor antagonist, (3-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl(3-dimethyl amino-3-oxo propyl)thio)methyl)thio) propanoic acid (L-660,711; MK-571), was investigated on nociceptive responses in mice using three different assays: acetic-acid-induced abdominal constrictions, formalin ...

journal_title：European journal of pharmacology

authors： Gök S,Onal A,Cinar MG,Evinç A

更新日期：1999-12-15 00:00:00

abstract：:Gastrins and cholecystokinins contract the isolated taenia coli of the guinea-pig. Porcine CCK-39 produced the greatest contractile response and human gastrin-17 I and -34 the weakest. Pentagastrin had the highest affinity to the receptors and non-sulphated CCK-8 the lowest. The contractions produced by the CCK peptid...

journal_title：European journal of pharmacology

authors： Nilsson S,Leander S,Vallgren S,Håkanson R

更新日期：1983-06-03 00:00:00

abstract：:Rats were trained to discriminate between the stimulus properties of intraperitoneal 0.16 mg/kg apomorphine and saline in a two-lever, food-motivated operant task. Once trained, the rats were tested with the ED50 of apomorphine (0.02 mg/kg) or saline before and 1-22 days after a ten-day regimen of daily 2.0 mg/kg admi...

journal_title：European journal of pharmacology

authors： Schechter MD

更新日期：1981-09-24 00:00:00

abstract：:Anthracycline derivatives including 4'-epidoxorubicin are known to cause cardiovascular side effects. In this study we examined the effects of 4'-epidoxorubicin on sympathetic nerves of rat tail artery in vitro. Treatment with 4'-epidoxorubicin at concentrations higher than 10 microM gradually increased the resting te...

journal_title：European journal of pharmacology

authors： Sakai T,Inagaki R,Taniguchi T,Shinozuka K,Kunitomo M,Hayashi N,Ishii Y,Muramatsu I

更新日期：1998-08-28 00:00:00

abstract：:The effects of substitutions in the xanthine nucleus on tracheal relaxant activity, atrium chronotropic activity, adenosine A1 affinity, and inhibitory activities on cyclic AMP-phosphodiesterase isoenzymes in guinea pigs were studied. Substitution with a long alkyl chain at the N1-position of xanthine nucleus increase...

journal_title：European journal of pharmacology

authors： Miyamoto K,Kurita M,Ohmae S,Sakai R,Sanae F,Takagi K

更新日期：1994-05-17 00:00:00

abstract：:Piceatannol (3,3',4,5'-tetrahydroxy-trans-stilbene) is a polyphenol present in grapes and wine. By means of alkaline phosphatase activity and osteocalcin enzyme-linked immunosorbent assay (ELISA), we have shown that piceatannol exhibits a significant induction of differentiation in immortalized fetal osteoblasts (hFOB...

journal_title：European journal of pharmacology

authors： Chang JK,Hsu YL,Teng IC,Kuo PL

更新日期：2006-12-03 00:00:00

abstract：:The responsiveness of the rat striatal dopamine (DA) receptor system to apomorphine (APO) was assessed after 10 days of antidepressant administration. Desipramine (DMI), dothiepin (DOTH), iprindole (IPR) and nomifensine (NOM) were administered intra-peritoneally, twice daily, to rats for 10 days and 42 h after the las...

journal_title：European journal of pharmacology

authors： Diggory GL,Buckett WR

更新日期：1984-10-15 00:00:00

abstract：:One of the best known bioactive triterpenoids is oleanolic acid, a widespread 3-hydroxy-17-carboxy oleanane-type compound. In order to determine whether further oxidation of carbon 3 affects anti-inflammatory activity in mice, different tests were carried out on oleanolic acid and its 3-oxo-analogue oleanonic acid, wh...

journal_title：European journal of pharmacology

authors： Giner-Larza EM,Máñez S,Recio MC,Giner RM,Prieto JM,Cerdá-Nicolás M,Ríos JL

更新日期：2001-09-28 00:00:00

abstract：:Inflammatory processes may play an important role in the degeneration of basal forebrain cholinergic cells Alzheimer's disease. We infused the proinflammagen lipopolysaccharide into the basal forebrain of young rats and determined whether the chronic administration of two novel non-steroidal anti-inflammatory drugs or...

journal_title：European journal of pharmacology

authors： Wenk GL,McGann K,Mencarelli A,Hauss-Wegrzyniak B,Del Soldato P,Fiorucci S

更新日期：2000-08-18 00:00:00

abstract：:Cyclosporin A is implicated in the pathogenesis of post-transplantation bone disease. Because of recent evidence that cyclosporin A may cause renal and cardiovascular toxicity by inhibiting nitric oxide (NO) activity, and that NO slows bone remodeling and bone loss in animal and human studies, we investigated a possib...

journal_title：European journal of pharmacology

authors： Fiore CE,Pennisi P,Cutuli VM,Prato A,Messina R,Clementi G

更新日期：2000-11-24 00:00:00

abstract：:Dopamine agents (saline in control groups) were coadministered with indomethacin by either single or repeated application. The ulcerogenic effect (erosions and/or ulcers) of repeated given indomethacin on gastric mucosa differed clearly from that on intestinal mucosa. The effect on intestinal mucosa was markedly great...

journal_title：European journal of pharmacology

authors： Sikirić P,Rotkvić I,Mise S,Krizanac S,Gjuris V,Jukić J,Suchanek E,Petek M,Udovicić I,Kalogjera L

更新日期：1988-12-06 00:00:00

abstract：:Administration of methyl-beta-carboline-3-carboxamide (FG 7142, 15 mg/kg i.p.) to rats has previously been shown to cause a selective increase in the levels of 3,4-dihydroxy-phenylacetic acid (DOPAC) in the prefrontal cortex and ventral tegmental area (VTA) via an interaction with benzodiazepine receptors. On withdraw...

journal_title：European journal of pharmacology

authors： Ida Y,Roth RH

更新日期：1987-06-04 00:00:00

abstract：:The pharmacological profile of a new CCKA receptor antagonist, T-0632 [sodium (S)-1-(2-fluorophenyl)-2,3-dihydro-3-[(3-isoquinolinylcarbonyl) amino]-6-methoxy-2-oxo-1H-indole-3-propanoate], was examined in in vivo studies and compared with those of L-364, 718 [3S(-)-N-(2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1, 4-benzo...

journal_title：European journal of pharmacology

authors： Taniguchi H,Yazaki N,Yomota E,Shikano T,Endo T,Nagasaki M

更新日期：1996-09-26 00:00:00

abstract：:Although convulsions due to local anesthetic systemic toxicity are thought to be due to inhibition of GABA(A) receptor-linked currents in the central nervous system, the mechanism of action remains unclear. We therefore examined the effects of local anesthetics on gamma-aminobutyric acid (GABA)-induced currents using ...

journal_title：European journal of pharmacology

authors： Sugimoto M,Uchida I,Fukami S,Takenoshita M,Mashimo T,Yoshiya I

更新日期：2000-08-11 00:00:00

abstract：:The study compared the efficacy of acute versus chronic metrifonate treatment to improve initial and reversal learning of the water maze spatial navigation task in medial septal-lesioned rats. Acute oral administration of 30 mg/kg metrifonate at 30 min, but not at 150 or 360 min, before training improved the initial a...

journal_title：European journal of pharmacology

authors： Riekkinen M,Schmidt BH,Riekkinen P Jr

更新日期：1997-11-05 00:00:00

abstract：:Free radicals may cause part of the irreversible injury which occurs during myocardial infarction and reperfusion. In the present study MDL 73404, an alpha-tocopherol analogue which is a free radical scavenger has been evaluated for its effects on infarct size in an anaesthetised rat model of coronary artery ligation ...

journal_title：European journal of pharmacology

authors： Petty MA,Grisar JM,De Jong W

更新日期：1992-01-07 00:00:00

abstract：:In this study, the anti-inflammatory effects of flavonoids isolated from the roots of Glycyrrhiza uralensis (Leguminosae), namely, isoliquiritin (the glycoside of isoliquirigenin) and isoliquiritigenin (the aglycone of isoliquiritin) were evaluated on lipopolysaccharide (LPS)-treated RAW 264.7 macrophages. Isoliquirit...

journal_title：European journal of pharmacology

authors： Kim JY,Park SJ,Yun KJ,Cho YW,Park HJ,Lee KT

更新日期：2008-04-14 00:00:00

abstract：:The effects of four fluoroquinolones (sparfloxacin, fleroxacin, ofloxacin and levofloxacin) on K(+) currents were investigated in pyramidal neurons acutely isolated from rat hippocampus, to evaluate their relative potencies for inhibiting these channels. Using patch-clamp electrophysiological techniques, we found that...

journal_title：European journal of pharmacology

authors： Zhang LR,Li MH,Cheng NN,Chen BY,Wang YM

更新日期：2003-02-21 00:00:00

abstract：:The effect of aclarubicin on vasocontractility was investigated using aortic strips isolated from rats. The aortic strips from rats injected i.p. with aclarubicin (4 mg/kg body weight per day for 5 consecutive days) showed diminished contractile responses to KCl and phenylephrine in comparison with the controls inject...

journal_title：European journal of pharmacology

authors： Wakabayashi I,Hatake K,Kakishita E

更新日期：1989-08-11 00:00:00

abstract：:This study investigated whether increased polyol pathway activity could contribute to alterations in nitrergic neurotransmission in anococcygeus muscles from 8-week diabetic rats. In the presence of guanethidine (10-30 microM) and clonidine (0.01-0.05 microM), relaxations obtained to nitrergic nerve stimulation (0.5-5...

journal_title：European journal of pharmacology

authors： Way KJ,Reid JJ

更新日期：1996-12-27 00:00:00

abstract：:The present paper describes a theoretical study on the mechanism underlying the reaction of cellular glutathione (GSH) with polyunsaturated fatty acid ozonides. The reaction can be catalyzed by glutathione S-transferases and leads to detoxication of the ozonides. Semi-empirical molecular orbital computer calculations ...

journal_title：European journal of pharmacology

authors： Hempenius RA,de Vries J,Rietjens IM

更新日期：1992-12-01 00:00:00