Abstract:
:RNA polymerase III in an extract of HeLa cells transcribes RNA 5S in size from genomic bovine DNA template. This RNA represents a major fraction of the RNA synthesized. 5S RNA is not transcribed from bovine chromatin at equivalent concentrations and RNA the size of tRNA or tRNA precursor is not detected. At low UTP concentrations RNA slightly smaller in size than 5S is synthesized in addition to 5S RNA.
journal_name
Mol Biol Repjournal_title
Molecular biology reportsauthors
Furth JJ,Su CYdoi
10.1007/BF00775362subject
Has Abstractpub_date
1983-08-01 00:00:00pages
163-7issue
3eissn
0301-4851issn
1573-4978journal_volume
9pub_type
杂志文章abstract::High glycemic index diet can induce multiple diseases. Many research indicated that oxidative stress played important role in many pathological conditions. However, the impact of gene expression and dietary habit on oxidation process are still less clear. We used high-glucose diet to feed C57BL/6J mice for 4 weeks, me...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-010-0039-9
更新日期:2010-12-01 00:00:00
abstract::We reported that an aqueous extract of Portulaca oleracea L. inhibited high-fat-diet-induced oxidative injury in a dose-dependent manner. Male kunming mice (5-weeks-old, 24 g) were used in this experiment. After a 4-day adaptation period, animals were randomly divided into four groups (n = 10 in each group); Group 1: ...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-012-1644-6
更新日期:2012-08-01 00:00:00
abstract::RNase MRP is a ribonucleoprotein enzyme with a structure similar to RNase P. It is required for normal processing of precursor rRNA, cleaving it in the Internal Transcribed Spacer 1. ...
journal_title:Molecular biology reports
pub_type: 杂志文章,评审
doi:10.1007/BF00988708
更新日期:1995-01-01 00:00:00
abstract::Common bean is gaining acceptance as one of the most valuable major food consumed worldwide owing to innumerable nutritional and therapeutic benefits. Comparatively less productivity in underdeveloped countries encouraged us to proceed for QTL mining of yield traits in common bean. Heretofore, multiple yield associate...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-020-05735-6
更新日期:2020-09-01 00:00:00
abstract::Sheep are valuable resources for the wool industry. Wool growth of Aohan fine wool sheep has cycled during different seasons in 1 year. Therefore, identifying genes that control wool growth cycling might lead to ways for improving the quality and yield of fine wool. In this study, we employed Agilent sheep gene expres...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-014-3405-1
更新日期:2014-08-01 00:00:00
abstract::We reported earlier about the detection of a chromosomally located arsenic operon (arsRBC) in a gram-negative bacterium Pseudomonas fluorescens strain MSP3, which showed resistance to elevated levels of sodium arsenate and sodium arsenite. The genes for arsenic resistance were cloned into the HindIII site of pBluescri...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1023/a:1017950207981
更新日期:2001-01-01 00:00:00
abstract::ERBB2/HER2/NEU, a member of the epidermal growth factor receptor family, is overexpressed in more than 25 % of non-small cell lung cancer and is considered to be a significant and independent prognostic factor in lung cancer. Here we generated a lung specific HER2 overexpressing transgenic mouse model. In this model, ...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-012-1635-7
更新日期:2012-08-01 00:00:00
abstract::Folate is crucial for various cellular functions. Several transport mechanisms allow folate to enter the intracellular compartment with folate receptor-α being the major high-affinity receptor. Rare genetic variations in exons of the FR-α gene, FOLR1, were recently shown to cause severe folate deficiency accompanied b...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-011-1236-x
更新日期:2012-04-01 00:00:00
abstract::LNX (Ligand of Numb-protein X) was originally isolated as a binding partner to the cell-fate Determinant Numb during development, and then identified to act as a RING finger-type E3 ubiquitin ligase for the ubiquitylation and degradation of Numb. LNX contains 4 PDZ domains which are proved to play a central role in or...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-009-9754-5
更新日期:2010-06-01 00:00:00
abstract::Gibberellic acid (GA) is involved in the regulation of plant growth and development. We defined GA-stimulated transcript (GAST) gene family and characterized its four members (TaGAST1, 2, 3, and 4) in wheat spikes. Triticum aestivum whole spikes were collected at ten developmental stages and dehulled spikelets were ob...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-016-4077-9
更新日期:2016-12-01 00:00:00
abstract::J The [Ca2+] regulation of contractile ATPase flux, Jp, in skeletal muscle was analysed by computation of the Response R(Jp) Ca2+ for a 10 Hz range of electrical stimulation frequencies. Results of our analysis of the kinetic controls in ATP free energy metabolism in a network model of contracting muscle (J.A.L. Jenes...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1023/a:1020317610863
更新日期:2002-01-01 00:00:00
abstract::Tomato bacterial wilt (BW) incited by Ralstonia solanacearum is a constraint on tomato production in tropical, subtropical and humid regions of the world. In this paper, we present the results of a research aimed at the identification of PCR-based markers amplified fragment length polymorphism (AFLP) linked to the gen...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-007-9204-1
更新日期:2009-03-01 00:00:00
abstract::The swine fatty acid binding protein gene (FABP3) has been screened with 4 primer sets for 270 purebred Yorkshire pigs from National Institute of Animal Science. The selection of primers was based on the swine cDNA sequence (AJ416019), and primer sets (FABP3-2 and FABP3-3) amplified target segments in real time PCR to...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-010-0344-3
更新日期:2011-03-01 00:00:00
abstract::Proton beam therapy is widely used for treating brain tumor. Despite the efficacy of treatment, the use of this therapy has met some limitations associated with possible damage to normal brain tissues located beyond the tumor site. In this context, the exploration of the harmful effects of protons on the normal brain ...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-020-05491-7
更新日期:2020-06-01 00:00:00
abstract::Identifying patients at high risk of metastasis is a major challenge in lung adenocarcinoma (ADC) therapy, therefore discovery of noninvasive biomarkers and therapeutic targets is urgent. We found significant differences between the secretomes of differentially expressed proteins in lung ADC cell lines, clinical tissu...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-014-3641-4
更新日期:2014-11-01 00:00:00
abstract::Autoantibodies to SS-A/Ro are among the most common found in sera of patients with systemic rheumatic diseases. These autoimmune diseases can affect various organ systems of the body and are variable in their manifestations and presentation. One of the autoimmune targets is the 60 kDa SS-A/Ro protein known to be assoc...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/BF00351170
更新日期:1996-01-01 00:00:00
abstract::The present study demonstrates that protein biosynthesis can be studied in single isolated human scalp hair follicles. The matrix and the sheath are the main regions where amino acids are built in. Incorporation is linear for at least five hours. The newly synthesized proteins can be separated into a water-soluble, a ...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/BF00777556
更新日期:1979-02-15 00:00:00
abstract::The blue swimming crab (Portunus pelagicus) is a valuable marine fishery resource in Indo-West Pacific Ocean. So far, rare genetic resource of this species is available. In this report, the restriction-site associated DNA (RAD) approach was employed to mine the genomic information and identify molecular markers in P. ...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-018-4339-9
更新日期:2018-12-01 00:00:00
abstract::Complementary DNA to mouse globin mRNA was prepared using viral reverse transcriptase. Molecular hybridisation of this cDNA to Friend virus RNA demonstrates the absence of globin gene sequences. ...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/BF00357645
更新日期:1973-12-01 00:00:00
abstract::microRNAs (miRNAs) are a new class of small non-coding RNAs that function as tumor suppressors or oncogenes. Single nucleotide polymorphisms (SNPs) in miRNA may contribute to cancer development. We hypothesized that genetic variations of the miRNA could be associated with the risk of hepatitis B virus (HBV)-related he...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-012-1532-0
更新日期:2012-06-01 00:00:00
abstract::Many studies have examined the association between the GSTP1 Ile105Val (rs 1695) gene polymorphism and lung cancer risk in various populations, but their results have been inconsistent. To assess this relationship more precisely, a meta-analysis was performed. The PubMed and CNKI database was searched for case-control...
journal_title:Molecular biology reports
pub_type: 杂志文章,meta分析
doi:10.1007/s11033-014-3290-7
更新日期:2014-07-01 00:00:00
abstract::Macroautophagy is a regulated bulk degradation process of cellular components, mainly long-lived proteins or cytoplasmic organelles. Nutrient depletion is a classic inducer of macroautophagy. In this report, we have induced heat-mediated macroautophagy in several cell lines in the absence of nutrient depletion. Heat t...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-009-9451-4
更新日期:2009-11-01 00:00:00
abstract::STAT4 is a transcription factor that has been implicated in the pathogenesis of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Recently, several reports has documented that a STAT4 haplotype is associated with RA, SLE and Sjogren's syndrome. To summarize and review these findings, we conducted a met...
journal_title:Molecular biology reports
pub_type: 杂志文章,meta分析
doi:10.1007/s11033-009-9553-z
更新日期:2010-01-01 00:00:00
abstract::Most living organisms exhibit circadian rhythms in physiology and behavior. These oscillations are generated by an endogenous circadian clock and control many biological processes. Ceramide has attracted attention as a signal mediator in diverse cell processes including cell death and differentiation. The relationship...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-011-1207-2
更新日期:2012-04-01 00:00:00
abstract::Imprinted genes play important roles in mammalian growth, development and behavior. In this study, we obtained 1568 bp mRNA sequence of porcine DIO3 (deiodinase, iodothyronine, type III), and also identified its imprinting status during porcine fetal development. The complete open reading frame (ORF) encoding 278 amin...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-011-0983-z
更新日期:2012-03-01 00:00:00
abstract::Silky Fowl is a natural mutant with hyperpigmentation of various internal tissues. Although the mechanism of hyperpigmentation remains unclear, recent studies have shown that the abnormal migration of melanoblast and the absence of environmental barrier molecules are responsible for the hyperpigmentation in Silky Fowl...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-010-0248-2
更新日期:2011-02-01 00:00:00
abstract::Hepatitis C virus (HCV) can be classified into six major genotypes. The HCV genotypes variability accounts for its geographical distribution, its responses to treatments and the clinical outcomes. The aim of this study was to determine the distribution of HCV genotypes among volunteer blood donors in Thailand. Samples...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-010-0552-x
更新日期:2011-10-01 00:00:00
abstract::It has been demonstrated that ACSL3 and ACSL5 play important roles in fat metabolism. To investigate the primary functions of ACSL3 and ACSL5 and to evaluate their expression levels during goose fatty liver development, we cloned the ACSL3 and ACSL5 coding domain sequences (CDSs) of geese using RT-PCR and analyzed the...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-014-3053-5
更新日期:2014-01-01 00:00:00
abstract::The present study aimed to obtain analgesic-antitumor peptide (AGAP) gene expression in plants. The analgesic-antitumor peptide (AGAP) gene was from the venom of Buthus martensii Karsch. Previous studies showed that AGAP has both analgesic and antitumor activities, suggesting that AGAP would be useful in clinical situ...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-008-9277-5
更新日期:2009-05-01 00:00:00
abstract::CD40 signaling plays a critical role in the survival rate of gastric cancer patients. Tumour samples were collected from 73 patients with who were diagnosed as gastric cancer in general surgery department in the 1st affiliated hospital of Suzhou University between September 2002 and July 2003. All patients had not rec...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-012-1734-5
更新日期:2012-09-01 00:00:00