Abstract:
:Apart from the known hypothalamic controls, which have been well documented, a myriad of compounds both endogenous and exogenous have proved effective in influencing secretion of prolactin (PRL). Recent studies have shown that somatostatin (SRIF), when injected intra-atrially as a bolus, is able to inhibit PRL secretion in vivo. However, the inhibitory effect of SRIF occurs only in adenohypophyses previously primed with estradiol. This research was undertaken to examine the ultrastructural effects of that inhibition using male Sprague-Dawley rats primed for three weeks with subcutaneous implants of estradiol. Within 2 min of injection of SRIF (1 mg/kg), the adenohypophyses were removed and processed for electron microscopy. We found dramatic changes in the estradiol-primed mammotrophs, including 1) an apparent rearrangement of rough endoplasmic reticulum (RER) into concentric cisternae, and 2) the appearance of intracellular bodies closely associated with granules. These changes were not observed in non-estradiol-primed male rats injected with SRIF which is consistent with the fact that in the normal male rats, SRIF failed to inhibit PRL secretion. These findings suggest that SRIF causes reorganization of cellular organelles so that PRL granules are sequestered thereby inhibiting secretion of PRL.
journal_name
Cell Tissue Resjournal_title
Cell and tissue researchauthors
Saunders SL,Reifel CW,Shin SHdoi
10.1007/BF00222371subject
Has Abstractpub_date
1983-01-01 00:00:00pages
21-34issue
1eissn
0302-766Xissn
1432-0878journal_volume
232pub_type
杂志文章abstract::Tissue lectins appear to be involved in a broad range of physiological processes, as reflected for the members of the family of galectins by referring to them as adhesion/growth-regulatory effectors. In order to clarify the significance of galectin presence, key challenges are to define their binding partners and the ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-018-2931-x
更新日期:2019-03-01 00:00:00
abstract::Adenohypophysial primordia of rat embryos at 13 to 15 days gestation were cultured in Parker 199 synthetic medium for 2 to 11 days. At the end of the culture period their fine structure and the presence of immunoreactive trophic hormones using the peroxidase-labeled antibody technique were investigated. The degree of ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00224303
更新日期:1976-07-26 00:00:00
abstract::The fine structure of hair mechanoreceptors in crayfish during moulting was investigated with special attention to the interface apparatus between cuticular hairs and sensory cells: the chorda. The chordae are lost with old exuviae at every moulting. They are drawn out from a moulting canal at the tip of the new hair....
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00214236
更新日期:1984-01-01 00:00:00
abstract::Immunocytochemical application of the antimuscarinic acetylcholine receptor antibody M35 to pancreas tissue revealed the target areas for the parasympathetic nervous system. Immunoreactivity in the endocrine pancreas was much higher than that in the exocrine part. Moreover, the endocrine cells at the periphery of the ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00384730
更新日期:1992-07-01 00:00:00
abstract::Intercellular bridges have been detected in ovarian follicle cells of Drosophila melanogaster. These bridges occur widely between follicle cells of previtellogenic chambers, while, in vitellogenic chambers, they become restricted to the columnar follicle cells. Usually, only one bridge is detectable between adjacent f...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00224931
更新日期:1978-01-31 00:00:00
abstract::Human fibroblasts and HeLa cells were treated with bunaftine (N-butyl-N-/2-(diethylamino)ethyl/-1-naphthalenecarboxamide ) in vitro. At concentrations of 0.5-2.0 mM, the drug caused contraction and rounding of the cells with loss of microvilli-like processes. Aggregates of dense, partly granular, partly fibrillar mate...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00216519
更新日期:1984-01-01 00:00:00
abstract::The subcommissural organ secretes N-linked complex-type glycoproteins into the cerebrospinal fluid. These glycoproteins condense to form Reissner's fiber (RF), which extends along the fourth ventricle and central canal of the spinal cord. A set of three monoclonal antibodies (Mabs 3E6, 3B1, and 2A5) has been obtained ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s004410050672
更新日期:1996-10-01 00:00:00
abstract::The antigen detected by the rat anti-mouse monoclonal antibody (m Ab), anti-BSP-3, has been initially described as a brain cell-surface protein. Evidence is presented that this m Ab recognizes mouse (Na+ + K+)-ATPase (ATP phosphohydrolase, E.C.3.6.1.3). The antigen, purified from mouse brain by means of affinity chrom...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00218655
更新日期:1983-01-01 00:00:00
abstract::The antennal lobe is the primary processing center for olfactory information in insects. To understand further the neural circuitry of this brain area, we have investigated the distribution of gamma-aminobutyric acid (GABA) and its colocalization with neuropeptides in the antennal lobe of the noctuid moth Heliothis vi...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-008-0744-z
更新日期:2009-03-01 00:00:00
abstract::Semaphorin 3A (Sema3A) axon repellant serves multiple developmental functions. Sema3A mRNAs are expressed in epithelial and mesenchymal components of the developing incisor in a dynamic manner. Here, we investigate the functions of Sema3A during development of incisors using Sema3A-deficient mice. We analyze histomorp...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-014-1839-3
更新日期:2014-07-01 00:00:00
abstract::Spinal cord injury (SCI) is a major cause of paralysis, disability and even death in severe cases. Lithium has neuroprotective effects on SCI, while the underlying mechanisms remain obscure. In the present study, we established a SCI rat model, which subsequently received lithium treatment. Results displayed that lith...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-020-03298-3
更新日期:2021-01-19 00:00:00
abstract::To gain a better understanding of the neuroplasticity of sympathetic neurons during postnatal ontogenesis, the distribution of neuronal nitric oxide synthase (nNOS) immunoreactivity was studied in sympathetic preganglionic neurons (SPN) in the spinal cord (Th2 segment) of female Wistar rats at different ages (newborn,...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-018-2925-8
更新日期:2019-02-01 00:00:00
abstract::The spatial localisation of insulin-like growth-factor-binding protein-2 (IGFBP-2) and its mRNA was investigated during larval and post-larval developmental stages of the gilthead seabream ( Sparus aurata) by immunohistochemistry and in situ hybridisation with specific antisera and riboprobes. During larval developmen...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-004-0952-0
更新日期:2005-01-01 00:00:00
abstract::The distribution and interconnections of brainstem catecholamine cell groups thought to be important in cardiovascular control were studied using histochemical and ultrastructural techniques in the rabbit. Lesions and microinjections of horseradish peroxidase (HRP) were made in the nucleus tractus solitarii in the dor...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00209963
更新日期:1981-01-01 00:00:00
abstract::The freshwater polyp Hydra magnipapillata has a primitive nervous system that produces at least three distinct classes of neuropeptides: various peptides having the C-terminal sequence Arg-Phe-NH2 (the Hydra-RFamide family), Leu-Trp-NH2 (the Hydra-LWamide family), and a single peptide having the C-terminal sequence Ly...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s004410000240
更新日期:2000-08-01 00:00:00
abstract::The ontogeny of gut innervation in the anuran amphibian Xenopus laevis was studied using immunohistochemistry on sections of whole larvae from NF stages 38-52. Immunoreactivity to acetylated tubulin confirmed the presence of nerve fibres as early as stages 38-39. Actin immunoreactivity was found at stage 41, indicatin...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s004410100423
更新日期:2001-10-01 00:00:00
abstract::During the formation of dental enamel, maturation-stage ameloblasts express ion-transporting transmembrane proteins. The SLC4 family of ion-transporters regulates intra- and extracellular pH in eukaryotic cells by cotransporting HCO3 (-) with Na(+). Mutation in SLC4A4 (coding for the sodium-bicarbonate cotransporter N...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-014-1935-4
更新日期:2014-11-01 00:00:00
abstract::The ultrastructure of the isolated glycerinated penis retractor muscle (PRM) of Helix pomatia was investigated. The diameter distributions of thick myofilaments from birbre cross sections in the relaxed, phasic contracted, tonic contracted, and in the catch state.s show that a characteristic filament spectrum is forme...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00221808
更新日期:1975-01-01 00:00:00
abstract::The development of the heterophil granulocyte in the bone marrow of the rat is described, and an electron-microscopical analysis of the changes in the cytoplasm as well as in the granule population in several stages of maturation is reported. Three types of granule originate in consecutive stages of heterophil maturat...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00211466
更新日期:1983-01-01 00:00:00
abstract::Endothelins (ET) are a family of vasoactive peptides that act via two subtypes of receptors, named ETA and ETB. ET-1 binds to both ETA and ETB, whereas the isopeptide ET-3 preferentially binds to ETB. The localization of ETA and ETB receptors in the rat adrenal gland and their involvement in the adrenal secretagogue e...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s004410050820
更新日期:1997-05-01 00:00:00
abstract::The presence of 28 kDa calbindin in human odontoblasts was studied by use of specific antibodies raised against chick duodenal 28 kDa calbindin, in immunofluorescence, immuno-peroxidase, and electron-microscopic labelling experiments. The calbindin-like protein was detected mainly in the cytoplasm of odontoblast cell ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00225806
更新日期:1988-11-01 00:00:00
abstract::Previous studies have indicated that 19-day-old fetal long bones of the rat contain an adenylyl cyclase-stimulating activity antigenically related to parathyroid hormone-related peptide. To ascertain its origin, Northern blotting and in situ hybridization histochemistry were performed. Results demonstrate that mRNA of...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00645063
更新日期:1992-12-01 00:00:00
abstract::Four forms of short neuropeptide F (sNPF1-4), derived from the gene snpf, have been identified in Drosophila and are known to act on a single G-protein-coupled receptor (sNPFR). Several functions have been suggested for sNPFs in Drosophila, including the regulation of feeding and growth in larvae, the control of insul...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-013-1660-4
更新日期:2013-09-01 00:00:00
abstract::CYCLE (CYC) and CLOCK (CLK) are transcriptional activators of the circadian clock genes, period (per) and timeless (tim), binding at E-boxes of their upstream regulatory region in Drosophila. CYC-like and CLK-like immunohistochemical reactivities (CYC-ir and CLK-ir) were investigated in the ground cricket, Allonemobiu...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-007-0534-z
更新日期:2008-02-01 00:00:00
abstract::Recently, an antibody against the choline transporter (CHT), an essential molecule involved in ACh uptake, was used to label cholinergic nerves in the central nervous system; however, the enteric nervous system (ENS) was not examined. The present study localised CHT immunoreactivity (CHT-IR) within the rat ileum ENS a...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-006-0332-z
更新日期:2007-03-01 00:00:00
abstract::The adenohypophysial primordium of Xenopus laevis tadpoles at stages 33/34 to 46 (Nieuwkoop and Faber, 1956) were examined immunohistologically for alpha-MSH, beta-MSH and ACTH. beta-MSH was demonstrated from stage 37/38 onwards, and alpha-MSH from stage 39. No signs of ACTH production were detected. alpha-MSH and bet...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00231955
更新日期:1977-05-16 00:00:00
abstract::The reduced-folate carrier (Rfc-1), previously also called methotrexate carrier-1 (MTX-1), was recently identified as accounting for approximately 30% of the methotrexate (Mtx) uptake into rat kidney slices. The localization of the carrier and its contribution to secretory or reabsorptive flux of the drug was therefor...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-005-1092-x
更新日期:2005-06-01 00:00:00
abstract::During the first postnatal weeks of the developing rodent retina, rhodopsin can be detected in a number of neuron-like cells in the inner retina. In the present study, we aim to characterize the morphology, number and staining characteristics of this peculiar population. Misplaced rhodopsin-positive cells (MRCs) were ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-013-1788-2
更新日期:2014-04-01 00:00:00
abstract::The ultrastructural organization of the axons of retinula cells of the eye of the wax moth Galleria mellonella are described. The axons traverse an appreciable distance between the basement membrane of the retina and the lamina ganglionaris of the optic lobe of the brain. The optic tract was reconstructed from serial ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00232837
更新日期:1976-11-18 00:00:00
abstract::The relationship between nitric oxide synthase (NOS)- and galanin-immunoreactive nerve terminals and the origin of NOS-immunoreactive nerve terminals on the motor endplates in the striated muscles of the rat esophagus was investigated. Double immunohistochemical staining revealed a dual innervation of motor endplates ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s004410051230
更新日期:1999-02-01 00:00:00