Abstract：
:Healthy guinea pigs were exposed to broad band noise at levels between 95 and 115 dBA for 7 days. A significant decrease of the sound-induced cochlear responses, together with a substantial increase of the endocochlear potential, was observed in guinea pigs exposed to noise at 105 or 115 dBA. Microsamples of the endolymph obtained from these guinea pigs showed a significant increase of K+ and Cl- concentrations and a decrease of Na+ concentration, when compared with those from control animals. The K+, Na+ and Cl- concentrations in the perilymph were not markedly affected by noise exposure. When the perilymphatic space was perfused with artificial perilymph containing 43K, 22Na or 36 Cl, the uptake of radiotracers into the endolymph showed a single exponential function of the perfusion time. When compared with rate constants in normal animals, the value of rate constant for K+ was significantly decreased in animals exposed to noise. These results indicate that ionic permeability changes of the endolymph-perilymph barrier are a significant factor in the physiological mechanisms underlying noise-induced hearing loss.
journal_name
Hear Resjournal_title
Hearing researchauthors
Konishi T,Salt AN,Hamrick PEdoi
10.1016/0378-5955(79)90004-2subject
Has Abstractpub_date
1979-12-01 00:00:00pages
325-42issue
4eissn
0378-5955issn
1878-5891pii
0378-5955(79)90004-2journal_volume
1pub_type
杂志文章相关文献
HEARING RESEARCH文献大全abstract：:Decrement detection is a commonly used psychophysical technique in which a subject is required to detect partially filled gaps in an ongoing sound. The paradigm provides information regarding both temporal resolution and intensity discrimination. The purpose of this project was to determine if an evoked-potential para...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2005.10.011
更新日期：2006-02-01 00:00:00
abstract：:Left-handed individuals show a 4 ms later Wave Pb in the 45-60 ms latency range of the auditory middle latency response (MLR) than right-handed individuals. Examination of auditory evoked potentials in fifteen right-handed and fifteen left-handed normal hearing adults showed that this difference was not evident in tim...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(90)90187-t
更新日期：1990-04-01 00:00:00
abstract：:Age, drugs, and noise are major causes of acquired hearing loss. The involvement of reactive oxygen species (ROS) in hair cell death has long been discussed, but there is considerably less information available as to the mechanisms underlying ROS formation. Most cellular ROS arise in mitochondria and this review will ...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/j.heares.2013.01.006
更新日期：2013-09-01 00:00:00
abstract：:Nitric oxide (NO) not only has normal physiological roles like vasodilation and neurotransmission in the living organism, it could also have possible neurodestructive effects under certain pathological conditions. The present study aimed to determine whether direct exposure of guinea pig cochlea to a NO donor like sod...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(97)00159-7
更新日期：1997-12-01 00:00:00
abstract：:Endocochlear potentials (EPs) were investigated in healthy guinea pigs and in those exposed to white noise of 125 dB SPL for 20-80 min. EPs were measured during and after temporary anoxia (3.5 min, denoted as reversible anoxia) and then during continuous anoxia to evaluate noise-induced changes in EP properties. Succi...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(90)90076-2
更新日期：1990-03-01 00:00:00
abstract：:Kanamycin ototoxicity, combined with behavioral audiometry to evaluate threshold shifts, was used to destroy outer hair cells (OHCs) in the basal cochlea of the chincilla while leaving the inner hair cell (IHC) population largely intact. After survival times of four weeks to one year, transmission electron microscopy ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(80)90027-1
更新日期：1980-12-01 00:00:00
abstract：:The auditory filter may be considered as a weighting function representing frequency selectivity at a particular centre frequency. Its shape can be derived using the power-spectrum model of masking which assumes: (1) in detecting a signal in a masker the observer uses the single auditory filter giving the highest sign...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(87)90050-5
更新日期：1987-01-01 00:00:00
abstract：:The influence of an external tone on transitory evoked otoacoustic emissions (TEOAE) is investigated. Three different averaging techniques were used with the same acoustic stimulus paradigm. These techniques permitted the separation of those parts of the otoacoustic emission (OAE) that contribute to the transitory evo...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(96)00160-8
更新日期：1997-01-01 00:00:00
abstract：:Prior research [Caine et al., 1981] suggested that scopolamine, a central cholinergic antagonist, may increase gap thresholds in young human listeners. If confirmed, an effect of scopolamine on gap detection might help to explain why both aged humans and aged laboratory animals have less sensitive temporal acuity on g...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(00)00088-5
更新日期：2000-07-01 00:00:00
abstract：:Proper functioning of the auditory nerve is of critical importance for auditory rehabilitation by cochlear implants. Here we used the Cldn14-/- mouse to study in detail the effects of Claudin 14 loss on auditory synapses and the auditory nerve. Mutations in the tight junction protein Claudin 14 cause autosomal recessi...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2020.107950
更新日期：2020-06-01 00:00:00
abstract：:Older adults, even with clinically normal hearing sensitivity, have auditory perceptual deficits relative to their younger counterparts. This difficulty may in part, be related to a decline in the neural representation of frequency. The purpose of this study was to examine the effect of age on behavioral and physiolog...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2009.11.010
更新日期：2010-06-01 00:00:00
abstract：:Crossmodal plasticity takes place following sensory loss, such that areas that normally process the missing modality are reorganized to provide compensatory function in the remaining sensory systems. For example, congenitally deaf cats outperform normal hearing animals on localization of visual stimuli presented in th...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2016.06.003
更新日期：2017-01-01 00:00:00
abstract：:Tone-burst-evoked compound action potentials (CAP) from the guinea pig round window (RW) are altered by DC current injection through the RW. The CAP waveform consists of a series of interleaved negative and positive peaks (N(1), P(1), N(2), P(2) etc.) of decreasing amplitude. During positive DC current injection (arou...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/S0378-5955(03)00404-0
更新日期：2004-04-01 00:00:00
abstract：:Differences between inner and outer hair cells in the cellular content of precipitable calcium were detected using a potassium pyroantimonate precipitation method and the electron spectroscopic imaging (ESI-) technique. The cytoplasm of the inner hair cells was scattered with a high number of calcium precipitates in a...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(94)90213-5
更新日期：1994-01-01 00:00:00
abstract：:Neural auditory thresholds in the guinea pig can be temporarily improved by up to 6 dB about 2 min after the cessation of an moderately intense low-frequency tone (Kirk and Patuzzi, 1997). We have measured changes in the f2-f1 distortion product otoacoustic emission (DPOAE) and low-frequency microphonic potential in s...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(97)00104-4
更新日期：1997-10-01 00:00:00
abstract：:Within auditory pathways, the intrinsic electrical properties of neurons, and in particular their complement of potassium channels, play a key role in shaping the timing and pattern of action potentials produced by sound stimuli. The Kv9.1 gene encodes a potassium channel alpha subunit that is expressed in a variety o...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(00)00117-9
更新日期：2000-09-01 00:00:00
abstract：:We review event-related slow firing changes in the auditory cortex and related brain structures. Two types of changes can be distinguished, namely increases and decreases of firing, lasting in the order of seconds. Triggering events can be auditory stimuli, reinforcers, and behavioral responses. Slow firing changes te...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/j.heares.2010.05.003
更新日期：2011-01-01 00:00:00
abstract：:Potassium channels play a critical role in defining the electrophysiological properties accounting for the unique response patterns of auditory neurons. Serial analysis of gene expression (SAGE), microarrays, RT-PCR, and real-time RT-PCR were used to generate a broad profile of potassium channel expression in the rat ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2007.01.024
更新日期：2007-06-01 00:00:00
abstract：:A common problem among the elderly is a difficulty in discriminating speech sounds. One factor that may contribute to this is a deterioration in the ability to process dynamic aspects of speech such as formant transitions. For the aging auditory system, this deterioration in temporal processing speed may be manifest a...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(01)00294-5
更新日期：2001-08-01 00:00:00
abstract：:Transient-evoked otoacoustic emissions (TEOAEs) at high frequencies are a non-invasive physiological test of basilar membrane mechanics at the basal end, and have clinical potential to detect risk of hearing loss related to outer-hair-cell dysfunction. Using stimuli with constant incident pressure across frequency, TE...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2018.09.010
更新日期：2019-01-01 00:00:00
abstract：:Glutamate plays a role in hair cell afferent transmission, but the receptors that mediate neurotransmission between outer hair cells (OHCs) and type II ganglion neurons are not well defined. A previous study using in situ hybridization showed that several kainate-type glutamate receptor (KAR) subunits are expressed in...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2014.05.001
更新日期：2014-08-01 00:00:00
abstract：:Otoconia are biomineral particles of microscopic size essential for perception of gravity and maintenance of balance. Millions of older Americans are affected in their mobility, quality of life and in their health by progressive demineralization of otoconia. Currently, no effective means to prevent or counteract this ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2010.05.019
更新日期：2010-09-01 00:00:00
abstract：:The effects of endogenous and exogenous Ca(2+) buffers on Ca(2+) current kinetics have been investigated by patch clamp in hair cells mechanically isolated from frog semicircular canals. This preparation displays at least three different Ca(2+) channel types: transient currents flow through a drug-resistant channel ("...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2004.05.009
更新日期：2004-09-01 00:00:00
abstract：:Systematic, slow variations of the amplitude and frequency of spontaneous otoacoustic emissions in human ears, occurring over the first 20-30 min of recording, are described. Experimental observations suggest that these variations may arise from a centrally mediated, bilateral influence on the mechanics of the ear. ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(91)90060-m
更新日期：1991-06-01 00:00:00
abstract：:Electrical stimulation of the cochlea is known to cause auditory sensations in humans and other animals. It also has been shown to produce emissions of sound from the inner ear. In the current study we investigate the relationship between electrically induced motion of the basilar membrane (BM) and the production of o...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(95)00216-2
更新日期：1995-12-01 00:00:00
abstract：:The relation between hearing loss and loss of hair cells after prolonged exposure to a simulated industrial noise environment was determined in normotensive albino rats. Hearing loss was assessed behaviorally by a conditioned suppression technique and electrophysiologically by auditory brainstem response to pulses of ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(87)90129-8
更新日期：1987-01-01 00:00:00
abstract：:It is generally believed that all bone surfaces are covered by a nearly continuous layer of cells known as bone lining cells (BLC) which separate the general extracellular fluid (GECF) from bone and its fluid compartment. Within the cochlea of some mammals regions of bone matrix are exposed to extracellular fluid. Wit...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(94)90074-4
更新日期：1994-05-01 00:00:00
abstract：:The directional dependence of sound pressure transformation of head and pinna has been measured in the phyllostomid bat Phyllostomus discolor for the frontal hemisphere using a maximum length sequence method. The azimuthal position of the axis of highest pinna gain came closer to the midsagital plane with increasing f...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(03)00164-3
更新日期：2003-07-01 00:00:00
abstract：:The otoprotective peptide AM-111, a cell-permeable inhibitor of JNK mediated apoptosis, was tested for its efficacy as a rescue agent following impulse noise trauma. Single dose administrations of AM-111 at 1h or 4h post-impulse noise exposure (155 dB peak SPL) via systemic or local routes were evaluated with a total ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2006.05.006
更新日期：2007-04-01 00:00:00
abstract：:Single neuron responses to sinusoidal 20 Hz amplitude modulated tone bursts (612.5 ms stimulus-on time at the rate of once per 2.2 s) were studied in the auditory midbrain (torus semicircularis) of the immobilized grass frog (Rana temporaria temporaria). The characteristic frequency stimuli at 30 dB above the minimum ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(96)00128-1
更新日期：1996-11-01 00:00:00
