Abstract：
:Older adults, even with clinically normal hearing sensitivity, have auditory perceptual deficits relative to their younger counterparts. This difficulty may in part, be related to a decline in the neural representation of frequency. The purpose of this study was to examine the effect of age on behavioral and physiological measures of frequency representation. Thirty two adults (ages 22-77), with hearing thresholds 25 dB HL at octave frequencies 0.25-8.0 kHz, participated in this experiment. Frequency discrimination difference limens (FDLs) were obtained at 500 and 1000 Hz using a two-interval, two-alternative forced choice procedure. Linear regression analyses showed significant declines in FDLs at both frequencies as age increased. Frequency-following responses (FFRs) were elicited by 500 and 1000 Hz tonebursts, as well as at frequencies within and outside those FDLs. Linear regression of FFR phase coherence and FFR amplitude at frequencies at and slightly below 1000 Hz showed significant decreases as age increased. Therefore, pitch discrimination, as measured by FDLs, and neural representation of frequency, as reflected by FFR, declined as age increased. Although perception and neural representation concurrently declined, one was not predictive of the other.
journal_name
Hear Resjournal_title
Hearing researchauthors
Clinard CG,Tremblay KL,Krishnan ARdoi
10.1016/j.heares.2009.11.010subject
Has Abstractpub_date
2010-06-01 00:00:00pages
48-55issue
1-2eissn
0378-5955issn
1878-5891pii
S0378-5955(09)00286-Xjournal_volume
264pub_type
杂志文章相关文献
HEARING RESEARCH文献大全abstract：:The dorsal cochlear nucleus (DCN) has been shown to project to a region of the nucleus reticularis pontis caudalis (PnC) critical for the evocation of startle in rats, suggesting a possible modulatory influence of the DCN on startle. This study examined the involvement of the DCN in the acoustic startle reflex and var...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(98)00040-9
更新日期：1998-05-01 00:00:00
abstract：:The glycoconjugates in the cochlea of the guinea pig were studied by staining samples by the silver methenamine method as well as after periodic acid-Schiff (PAS) staining. Results obtained by the two methods were similar but not identical. The silver methenamine method was much better in terms of resolution. However,...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(93)90234-r
更新日期：1993-05-01 00:00:00
abstract：:A hyperpolarization-activated current (termed I[h]) is believed to provide a pacemaker depolarization in sinoatrial node cells and in some central and peripheral neurons. In the present study, we examined if such an inward cation current exists in primary auditory neurons using the whole-cell patch-clamp technique. A ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(97)00078-6
更新日期：1997-08-01 00:00:00
abstract：:The scalp distributions of middle latency auditory evoked potentials (MAEPs) elicited by tone bursts of 250 and 4000 Hz were compared in two experiments. Na (19.9 ms), Pa (29.8 ms), and Pb (51.4 ms) components elicited by tones of either frequency had fronto-central distributions, whereas the Nb component (38.4 ms) wa...
journal_title：Hearing research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0378-5955(95)00035-3
更新日期：1995-05-01 00:00:00
abstract：:Biomarkers in easy-to-access body fluid compartments, such as blood, are commonly used to assess health of various organ systems in clinical medicine. At present, no such biomarkers are available to inform on the health of the inner ear. Previously, we proposed the outer-hair-cell-specific protein prestin, as a possib...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2018.11.013
更新日期：2019-01-01 00:00:00
abstract：:The purpose of this study was to investigate horizontal plane localization and interaural time difference (ITD) thresholds for 14 adult cochlear implant recipients with hearing preservation in the implanted ear. Localization to broadband noise was assessed in an anechoic chamber with a 33-loudspeaker array extending f...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2014.02.007
更新日期：2014-06-01 00:00:00
abstract：:We studied the 2IFC detectability of a 500 Hz tone masked by computer-generated maskers under the N0SII interaural condition, and under two masker conditions. In the first masker condition the maskers in the two intervals of a trial were independent of each other, and in the second masker condition the maskers were id...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(83)90074-6
更新日期：1983-08-01 00:00:00
abstract：:Despite the common use of guinea pigs in investigations of the neural mechanisms of binaural and spatial hearing, their behavioral capabilities in spatial hearing tasks have surprisingly not been thoroughly investigated. To begin to fill this void, we tested the spatial hearing of adult male guinea pigs in several exp...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2018.04.011
更新日期：2018-08-01 00:00:00
abstract：:Although speech understanding is highly variable amongst cochlear implants (CIs) subjects, the remarkably high speech recognition performance of many CI users is unexpected and not well understood. Numerous factors, including neural health and degradation of the spectral information in the speech signal of CIs, likely...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2017.05.009
更新日期：2017-08-01 00:00:00
abstract：:For the elevation and front-versus-back hemifield of a sound source to be accurately determined, the sound must contain a broad range of frequencies. Experiment 1 of this study examined the spectral integration time of the auditory localisation system by measuring the accuracy with which frequency-modulated (FM) tones...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2007.08.006
更新日期：2008-04-01 00:00:00
abstract：:Difference limens for the fundamental frequency (F0) of complex tones (DLCs) were measured for four normally hearing subjects and three subjects with cochlear hearing loss. The nominal F0 was 100, 200 or 400 Hz. The two tones to be compared contained either low resolved harmonics (RES), harmonics with intermediate res...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(03)00191-6
更新日期：2003-08-01 00:00:00
abstract：:We have injected by iontophoresis 4-amino-pyridine, a K+ channel blocker and BAPTA, (a Ca++ chelator), into scala media of the first three turns of the guinea pig cochlea. We measured the reduction in outer hair cell (OHC) receptor current, as indicated by cochlear microphonic measured in scala media evoked by a 207 H...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2005.05.016
更新日期：2006-01-01 00:00:00
abstract：:The tympanic membrane is a key component of the human auditory apparatus. Good estimates of tympanic membrane mechanical properties are important to obtain realistic models of middle ear mechanics. Current literature values are almost all derived from direct mechanical tests on cut-out strips. For a biomedical specime...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2012.05.001
更新日期：2012-08-01 00:00:00
abstract：:In Menière's disease, the increase of extracellular potassium concentration in the perilymph is thought to play a key role in determining the progressive loss of cochlear hair cells. In this paper, we describe a serum-free culture preparation of hair cells from 5 day-old rat and report the release by the cochlea, in r...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(90)90168-o
更新日期：1990-08-01 00:00:00
abstract：:Psychophysical measures of the electrically stimulated human auditory system were obtained for different types of symmetric and asymmetric charge-balanced waveforms. Absolute detection thresholds of biphasic, pseudomonophasic, and 'alternating monophasic' current waveforms delivered by a bipolar intra-cochlear electro...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2004.08.006
更新日期：2005-02-01 00:00:00
abstract：:We have estimated the transfer curve relating instantaneous sound pressure in the ear canal to instantaneous receptor current through the outer hair cells (OHCs) in the basal turn of the guinea pig cochlea using the cochlear microphonic (CM) elicited by continuous 200 Hz tones. The transfer curve is well approximated ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(98)00125-7
更新日期：1998-11-01 00:00:00
abstract：OBJECTIVES:Existing evidence suggests a strong relationship between tinnitus and emotion. The objective of this study was to examine the effects of short-term emotional changes along valence and arousal dimensions on tinnitus outcomes. Emotional stimuli were presented in two different modalities: auditory and visual. T...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2016.12.013
更新日期：2017-03-01 00:00:00
abstract：:Sharp spatial selectivity is critical to auditory performance, particularly in pitch-related tasks. Most contemporary cochlear implants have employed monopolar stimulation that produces broad electric fields, which presumably contribute to poor pitch and pitch-related performance by implant users. Bipolar or tripolar ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2011.11.005
更新日期：2012-01-01 00:00:00
abstract：:Amplitude modulation (AM) is an important temporal cue for precise speech and complex sound recognition. However, functional decline of the auditory periphery as well as degradation of central auditory processing due to aging can reduce the salience and resolution of temporal cues. Age-related deficits in central temp...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2015.07.017
更新日期：2015-09-01 00:00:00
abstract：:Sensorineural hearing loss is the most common sensory deficit worldwide, yet our understanding of the underlying pathophysiology is limited by the challenges of access to the inner ear in a safe and reliable manner. We present a novel microneedle device for trans-round window membrane liquid biopsy, which utilizes con...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2019.06.004
更新日期：2019-09-15 00:00:00
abstract：:Endocochlear potentials (EPs) were investigated in healthy guinea pigs and in those exposed to white noise of 125 dB SPL for 20-80 min. EPs were measured during and after temporary anoxia (3.5 min, denoted as reversible anoxia) and then during continuous anoxia to evaluate noise-induced changes in EP properties. Succi...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(90)90076-2
更新日期：1990-03-01 00:00:00
abstract：:Hypoxia/ischemia is a major pathogenetic factor in the development of hearing loss. An important transcription factor involved in the signaling and adaptation to hypoxia/ischemia is the hypoxia-inducible factor-1 (HIF-1). To study HIF-1 expression we used an in vitro hypoxia model of explant and dissociated cultures o...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(03)00222-3
更新日期：2003-09-01 00:00:00
abstract：:A field potential could be recorded in the deep layers of the superior colliculus (SCd) in the guinea pig following presentation of pure tone bursts at frequencies between 1 and 22 kHz, bursts of white noise, and clicks presented in the free field. The potentials evoked by these stimuli at different intensities had tw...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(87)90118-3
更新日期：1987-12-01 00:00:00
abstract：:Voice emotion is a fundamental component of human social interaction and social development. Unfortunately, cochlear implant users are often forced to interface with highly degraded prosodic cues as a result of device constraints in extraction, processing, and transmission. As such, individuals with cochlear implants ...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/j.heares.2017.01.006
更新日期：2017-09-01 00:00:00
abstract：OBJECTIVE:This paper introduces a new method to calculate relative risks of elevated hearing thresholds, at various ages and frequencies, between a study population and ISO1999:2003: Annex A Screened, Annex B Unscreened and ISO1999 Section 5.3 adjustment for noise exposure using Annex A Screened data. We demonstrate th...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2012.01.007
更新日期：2012-03-01 00:00:00
abstract：:When using bone vibrator transducers for clinical measurements, the transfer of energy from the bone driver depends on the impedance match between the driver and the load (human mastoid or otherwise) to which the driver will be applied. Current clinical calibration methods are incapable of quantifying this impedance m...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2010.02.013
更新日期：2010-05-01 00:00:00
abstract：:The inferior colliculus (IC) is one nucleus of the central auditory system which displays age-related changes. Inputs to the IC use primarily the amino acid neurotransmitters glutamate and gamma-aminobutryic acid (GABA). Neurochemical and anatomical studies of the Fischer 344 (F344) rat IC have shown decreases in GABA...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(96)00113-x
更新日期：1996-10-01 00:00:00
abstract：:Hearing aid (HA) users can differ markedly in their benefit from directional processing (or beamforming) algorithms. The current study therefore investigated candidacy for different bilateral directional processing schemes. Groups of elderly listeners with symmetric (N = 20) or asymmetric (N = 19) hearing thresholds f...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2017.07.014
更新日期：2017-09-01 00:00:00
abstract：:The cytosolic pH (pHi) of transitional cells from the ampulla of the gerbil was measured micro-fluorometrically with the pH-sensitive dye 2',7'-bicarboxyethyl-5(6)-carboxyfluorescein (BCECF) to assess the possible contribution of a Na+/H+ exchanger to the regulation of pHi. All experiments were conducted in virtually ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(93)90098-l
更新日期：1993-09-01 00:00:00
abstract：:The influence of noise exposure on the endothelial transport system in the cochlea was investigated using cationic polyethyleneimine (PEI), since systemically administered PEI passes through the capillary endothelial cell and attaches to basal lamina (BL) anionic sites in the cochlea. Under general anesthesia, all gui...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(01)00397-5
更新日期：2002-02-01 00:00:00
