Abstract：
:Age, drugs, and noise are major causes of acquired hearing loss. The involvement of reactive oxygen species (ROS) in hair cell death has long been discussed, but there is considerably less information available as to the mechanisms underlying ROS formation. Most cellular ROS arise in mitochondria and this review will evaluate evidence for mitochondrial pathology in general and dysfunction of the mitochondrial respiratory chain in particular in acquired hearing loss. We will discuss evidence that different pathways can lead to the generation of ROS and that oxidative stress might not necessarily be causal to all three pathologies. Finally, we will detail recent advances in exploiting knowledge of aminoglycoside-mitochondria interactions for the development of non-ototoxic antibacterials. This article is part of a Special Issue entitled "Annual Reviews 2013".
journal_name
Hear Resjournal_title
Hearing researchauthors
Böttger EC,Schacht Jdoi
10.1016/j.heares.2013.01.006subject
Has Abstractpub_date
2013-09-01 00:00:00pages
12-9eissn
0378-5955issn
1878-5891pii
S0378-5955(13)00007-5journal_volume
303pub_type
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