Hairpin-tail: a case of post-reductional gene action in the mouse egg.

Abstract:

:Hairpin-tail (T(hp)) is a new allele of brachyury on chromosome 17 (linkage group IX) of the mouse. The morphological effects in the heterozygote are on the notochord and the tail. The homozygous abnormal is unknown. T(hp) is unique in that the phenotype of the heterozygote seems to depend on the source of the T(hp) gene. If it is inherited via the egg the phenotype is extreme and death follows in utero. Embryos derived from a T(hp) sperm and a+egg are less abnormal and viable. This is not a simple maternal effect, as T(hp)xT(hp) matings produce two distinct types of heterozygous embryos.

journal_name

Genetics

journal_title

Genetics

authors

JOHNSON DR

subject

Has Abstract

pub_date

1974-04-01 00:00:00

pages

795-805

issue

4

eissn

0016-6731

issn

1943-2631

journal_volume

76

pub_type

杂志文章

相关文献

GENETICS文献大全
  • Models of evolution of reproductive isolation.

    abstract::Mathematical models are presented for the evolution of postmating and premating reproductive isolation. In the case of postmating isolation it is assumed that hybrid sterility or inviability is caused by incompatibility of alleles at one or two loci, and evolution of reproductive isolation occurs by random fixation of...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Nei M,Maruyama T,Wu CI

    更新日期:1983-03-01 00:00:00

  • Wolbachia infection and cytoplasmic incompatibility in Drosophila species.

    abstract::Forty-one stocks from 30 Drosophila species were surveyed for Wolbachia infection using PCR technology. D. sechellia and two strains of D. auraria were found to be infected and were tested for the expression of cytoplasmic incompatibility, along with D. ananassae and D. melanogaster strains, which are already known to...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Bourtzis K,Nirgianaki A,Markakis G,Savakis C

    更新日期:1996-11-01 00:00:00

  • Comparing evolvability and variability of quantitative traits.

    abstract::There are two distinct reasons for making comparisons of genetic variation for quantitative characters. The first is to compare evolvabilities, or ability to respond to selection, and the second is to make inferences about the forces that maintain genetic variability. Measures of variation that are standardized by the...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Houle D

    更新日期:1992-01-01 00:00:00

  • Challenges of detecting directional selection after a bottleneck: lessons from Sorghum bicolor.

    abstract::Multilocus surveys of sequence variation can be used to identify targets of directional selection, which are expected to have reduced levels of variation. Following a population bottleneck, the signal of directional selection may be hard to detect because many loci may have low variation by chance and the frequency sp...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.105.054312

    authors: Hamblin MT,Casa AM,Sun H,Murray SC,Paterson AH,Aquadro CF,Kresovich S

    更新日期:2006-06-01 00:00:00

  • Interaction between Ustilago maydis REC2 and RAD51 genes in DNA repair and mitotic recombination.

    abstract::A gene encoding a Ustilago maydis Rad51 orthologue has been isolated, rad51-1, a mutant constructed by disrupting the gene, was as sensitive to killing by ultraviolet light and gamma radiation as the rec2-1 mutant and slightly more sensitive to killing by methyl methanesulfonate. There was no suppression of killing by...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Ferguson DO,Rice MC,Rendi MH,Kotani H,Kmiec EB,Holloman WK

    更新日期:1997-02-01 00:00:00

  • Ancient allelism at the cytosolic chaperonin-alpha-encoding gene of the zebrafish.

    abstract::The T-complex protein 1, TCP1, gene codes for the CCT-alpha subunit of the group II chaperonins. The gene was first described in the house mouse, in which it is closely linked to the T locus at a distance of approximately 11 cM from the Mhc. In the zebrafish, Danio rerio, in which the T homolog is linked to the class ...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Takami K,Figueroa F,Mayer WE,Klein J

    更新日期:2000-01-01 00:00:00

  • A powerful and adaptive association test for rare variants.

    abstract::This article focuses on conducting global testing for association between a binary trait and a set of rare variants (RVs), although its application can be much broader to other types of traits, common variants (CVs), and gene set or pathway analysis. We show that many of the existing tests have deteriorating performan...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.114.165035

    authors: Pan W,Kim J,Zhang Y,Shen X,Wei P

    更新日期:2014-08-01 00:00:00

  • Recognition of homeology by the wheat Ph1 locus.

    abstract::Chromosome 1A(m) of Triticum monococcum is closely homeologous to T. aestivum chromosome 1A but recombines with it little in the presence of the wheat suppressor of homeologous chromosome pairing, Ph1. In the absence of Ph1, the two chromosomes recombine as if they were completely homologous. Chromosomes having either...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Luo MC,Dubcovsky J,Dvorák J

    更新日期:1996-11-01 00:00:00

  • Quantification of inbreeding due to distant ancestors and its detection using dense single nucleotide polymorphism data.

    abstract::Inbreeding depression, which refers to reduced fitness among offspring of related parents, has traditionally been studied using pedigrees. In practice, pedigree information is difficult to obtain, potentially unreliable, and rarely assessed for inbreeding arising from common ancestors who lived more than a few generat...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.111.130922

    authors: Keller MC,Visscher PM,Goddard ME

    更新日期:2011-09-01 00:00:00

  • Genetic and nongenetic bases for the L-shaped distribution of quantitative trait loci effects.

    abstract::The L-shaped distribution of estimated QTL effects (R(2)) has long been reported. We recently showed that a metabolic mechanism could account for this phenomenon. But other nonexclusive genetic or nongenetic causes may contribute to generate such a distribution. Using analysis and simulations of an additive genetic mo...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Bost B,de Vienne D,Hospital F,Moreau L,Dillmann C

    更新日期:2001-04-01 00:00:00

  • A key transcription cofactor on the nascent sex chromosomes of European tree frogs (Hyla arborea).

    abstract::We show that MED15, a key component of the transcription complex Mediator, lies within the nonrecombining segment of nascent sex chromosomes in the male-heterogametic Hyla arborea. Both X and Y alleles are expressed during embryonic development and differ by three frame-preserving indels (eight amino acids in total) w...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.108.090746

    authors: Niculita-Hirzel H,Stöck M,Perrin N

    更新日期:2008-07-01 00:00:00

  • Genetic transformation of Drosophila melanogaster with an autonomous P element: phenotypic and molecular analyses of long-established transformed lines.

    abstract::Following transformation of a Drosophila melanogaster true M strain with an autonomous P element, six lines were established and monitored for their molecular and phenotypic properties during a 4-yr period. The number of P elements increased with time in all the lines but the rate of increase differed among lines. Fur...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Daniels SB,Clark SH,Kidwell MG,Chovnick A

    更新日期:1987-04-01 00:00:00

  • Re-interpretation of genetic variation in simocephalus (cladocera, daphniidae).

    abstract::Populations of several co-existing species of Simocephalus were examined electrophoretically at 11 enzyme loci. The prevailing pattern was one of extensive allelic substitution between species and low levels of polymorphism (0-10%) within species. Genetic identity values between species were very low (10-50%). These r...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Hann BJ,Hebert PD

    更新日期:1982-09-01 00:00:00

  • Autosomal factors with correlated effects on the activities of the glucose 6-phosphate and 6-phosphogluconate dehydrogenases in Drosophila melanogaster.

    abstract::Isogenic lines, in which chromosomes sampled from natural populations of C. melanogaster are substituted into a common genetic background, were used to detect and partially characterize autosomal factors that affect the activities of the two pentose phosphate pathway enzymes, glucose 6-phosphate dehydrogenase (G6PD) a...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Laurie-Ahlberg CC,Williamson JH,Cochrane BJ,Wilton AN,Chasalow FI

    更新日期:1981-09-01 00:00:00

  • Drosophila Mitochondrial Genetics: Evolution of Heteroplasmy through Germ Line Cell Divisions.

    abstract::The mitochondrial genotype of all F(1) female offspring (426 individuals) of a single Drosophila mauritiana female, heteroplasmic for two types of mtDNA (a short and a long genome), was established. All descendants were heteroplasmic. The earliest eggs laid by this female show the cytoplasmic genetic structure of ovar...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Solignac M,Génermont J,Monnerot M,Mounolou JC

    更新日期:1987-12-01 00:00:00

  • Transmission genetics of allorecognition in Hydractinia symbiolongicarpus (Cnidaria:Hydrozoa).

    abstract::Allorecognition is ubiquitous, or nearly so, amongst colonial invertebrates. Despite the prominent role that such phenomena have played both in evolutionary theory and in on the origin of the vertebrate immune system, unambiguous data on the transmission genetics of fusibility (i.e., the ability of two individuals to ...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Mokady O,Buss LW

    更新日期:1996-06-01 00:00:00

  • Nucleoporin FG domains facilitate mRNP remodeling at the cytoplasmic face of the nuclear pore complex.

    abstract::Directional export of messenger RNA (mRNA) protein particles (mRNPs) through nuclear pore complexes (NPCs) requires multiple factors. In Saccharomyces cerevisiae, the NPC proteins Nup159 and Nup42 are asymmetrically localized to the cytoplasmic face and have distinct functional domains: a phenylalanine-glycine (FG) re...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.114.164012

    authors: Adams RL,Terry LJ,Wente SR

    更新日期:2014-08-01 00:00:00

  • Quantitative trait loci affecting components of wing shape in Drosophila melanogaster.

    abstract::Two composite multiple regression-interval mapping analyses were performed to identify candidate quantitative trait loci (QTL) affecting components of wing shape in Drosophila melanogaster defined by eight relative warp-based measures. A recombinant inbred line design was used to map QTL for the shape of two intervein...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Zimmerman E,Palsson A,Gibson G

    更新日期:2000-06-01 00:00:00

  • Lethal mutagenesis in viruses and bacteria.

    abstract::In this work we study how mutations that change physical properties of cell proteins (stability) affect population survival and growth. We present a model in which the genotype is presented as a set folding free energies of cell proteins. Mutations occur upon replication, so stabilities of some proteins in daughter ce...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.109.106492

    authors: Chen P,Shakhnovich EI

    更新日期:2009-10-01 00:00:00

  • Maximizing transcription efficiency causes codon usage bias.

    abstract::The rate of protein synthesis depends on both the rate of initiation of translation and the rate of elongation of the peptide chain. The rate of initiation depends on the encountering rate between ribosomes and mRNA; this rate in turn depends on the concentration of ribosomes and mRNA. Thus, patterns of codon usage th...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Xia X

    更新日期:1996-11-01 00:00:00

  • Haplotype probabilities for multiple-strain recombinant inbred lines.

    abstract::Recombinant inbred lines (RIL) derived from multiple inbred strains can serve as a powerful resource for the genetic dissection of complex traits. The use of such multiple-strain RIL requires a detailed knowledge of the haplotype structure in such lines. Broman (2005) derived the two- and three-point haplotype probabi...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.106.064063

    authors: Teuscher F,Broman KW

    更新日期:2007-03-01 00:00:00

  • Better estimates of genetic covariance matrices by "bending" using penalized maximum likelihood.

    abstract::Obtaining accurate estimates of the genetic covariance matrix Sigma(G) for multivariate data is a fundamental task in quantitative genetics and important for both evolutionary biologists and plant or animal breeders. Classical methods for estimating Sigma(G) are well known to suffer from substantial sampling errors; i...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.109.113381

    authors: Meyer K,Kirkpatrick M

    更新日期:2010-07-01 00:00:00

  • The cytoplasmic end of transmembrane domain 3 regulates the activity of the Saccharomyces cerevisiae G-protein-coupled alpha-factor receptor.

    abstract::The binding of alpha-factor to its receptor (Ste2p) activates a G-protein-signaling pathway leading to conjugation of MATa cells of the budding yeast S. cerevisiae. We conducted a genetic screen to identify constitutively activating mutations in the N-terminal region of the alpha-factor receptor that includes transmem...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Parrish W,Eilers M,Ying W,Konopka JB

    更新日期:2002-02-01 00:00:00

  • Mutations in the extra sex combs and Enhancer of Polycomb genes increase homologous recombination in somatic cells of Drosophila melanogaster.

    abstract::We found that heterozygous mutant alleles of E(Pc) and esc increased homologous recombination from an allelic template in somatic cells in a P-element-induced double-strand break repair assay. Flies heterozygous for mutant alleles of these genes showed increased genome stability and decreased levels of apoptosis in im...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.105.042473

    authors: Holmes AM,Weedmark KA,Gloor GB

    更新日期:2006-04-01 00:00:00

  • Expression patterns and mutant phenotype of teosinte branched1 correlate with growth suppression in maize and teosinte.

    abstract::The evolution of domesticated maize from its wild ancestor teosinte is a dramatic example of the effect of human selection on agricultural crops. Maize has one dominant axis of growth, whereas teosinte is highly branched. The axillary branches in maize are short and feminized whereas the axillary branches of teosinte ...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Hubbard L,McSteen P,Doebley J,Hake S

    更新日期:2002-12-01 00:00:00

  • Thermal rescue of UV-irradiated bacteriophage T4 and biphasic mode of action of the WXY system.

    abstract::When ultraviolet-irradiated bacteriophage T4 is assayed at plating temperatures ranging from 20 degrees to 40 degrees, its survival increases at the higher temperatures. This "thermal rescue" requires an intact WXY system but not the denV pyrimidine dimer excision system. Mutation rates decrease with increasing temper...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Conkling MA,Drake JW

    更新日期:1984-08-01 00:00:00

  • Recombination in relation to ultraviolet sensitivity in Chlamydomonas reinhardi.

    abstract::A mutant strain of Chlamydomonas reinhardi which is UV sensitive as a result of a single-gene chromosomal mutation has also been found to exhibit reduced recombination. In crosses homozygous for the mutant allele, a reduction in recombination frequency was demonstrated in two different linkage groups and in three diff...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Rosen H,Ebersold WT

    更新日期:1972-06-01 00:00:00

  • The rec8 gene of Schizosaccharomyces pombe is involved in linear element formation, chromosome pairing and sister-chromatid cohesion during meiosis.

    abstract::The fission yeast Schizosaccharomyces pombe does not form tripartite synaptonemal complexes during meiotic prophase, but axial core-like structures (linear elements). To probe the relationship between meiotic recombination and the structure, pairing, and segregation of meiotic chromosomes, we genetically and cytologic...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Molnar M,Bähler J,Sipiczki M,Kohli J

    更新日期:1995-09-01 00:00:00

  • Genomic prediction in animals and plants: simulation of data, validation, reporting, and benchmarking.

    abstract::The genomic prediction of phenotypes and breeding values in animals and plants has developed rapidly into its own research field. Results of genomic prediction studies are often difficult to compare because data simulation varies, real or simulated data are not fully described, and not all relevant results are reporte...

    journal_title:Genetics

    pub_type: 杂志文章,评审

    doi:10.1534/genetics.112.147983

    authors: Daetwyler HD,Calus MP,Pong-Wong R,de Los Campos G,Hickey JM

    更新日期:2013-02-01 00:00:00

  • Cytogenic analysis of chromosome 3 in Drosophila melanogaster: mapping of the proximal portion of the right arm.

    abstract::In order to define more precisely the most proximal portion of chromosome 3R in Drosophila melanogaster, several new chromosome aberrations involving this region have been recovered and analyzed. These new arrangements were recovered as induced reversions of two dominant mutations, ANTPNs and dsxD, located in the regi...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Duncan IW,Kaufman TC

    更新日期:1975-08-01 00:00:00