Adhesive recognition and retinotectal specificity.

abstract：:The enzymes responsible for the oxidation of n-octane to octanoic acid or beyond in Pseudomonas oleovorans are octane inducible and are coded by genes borne on a transmissible extrachromosomal element. The octane to octanoate enzymes induced by octane are repressed by octanol. The chromosome also carries genes coding ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chakrabarty AM,Chou G,Gunsalus IC

更新日期：1973-04-01 00:00:00

abstract：:The structural requirements of E. coli formylmethionine tRNA for aminoacylation have been examined by chemical modification of the tRNA, followed by separation of the modified molecules into active and inactive components. Photooxidation of tRNA(fMet) at 50 degrees in the presence of methylene blue results in modifica...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schulman LH

更新日期：1972-12-01 00:00:00

abstract：:The alternative adaptive immune system of jawless vertebrates is based on different isotypes of variable lymphocyte receptors (VLRs) that are composed of leucine-rich repeats (LRRs) and expressed by distinct B- and T-like lymphocyte lineages. VLRB is expressed by B-like cells, whereas VLRA and VLRC are expressed by tw...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Holland SJ,Gao M,Hirano M,Iyer LM,Luo M,Schorpp M,Cooper MD,Aravind L,Mariuzza RA,Boehm T

更新日期：2014-10-14 00:00:00

abstract：:Myosin generates force by a rotation of its lever arm. Crystal structures of myosin II indicate an unloaded working stroke of 10-12 nm, a range confirmed by recent x-ray interference experiments. However, when an actin filament, held between two weakly, optically trapped beads is made to interact with a single head of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sleep J,Lewalle A,Smith D

更新日期：2006-01-31 00:00:00

abstract：:Classification within the genus Pistacia has been based on leaf morphology and geographical distribution. Molecular genetic tools (PCR amplification followed by restriction analysis of a 3.2-kb region of variable chloroplast DNA, and restriction fragment length polymorphism analysis of the Pistacia cpDNA with tobacco ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Parfitt DE,Badenes ML

更新日期：1997-07-22 00:00:00

abstract：:The long-lived ethylene, cyclohexene, and norbornenemercurinium ions prepared in superacidic, low-nucleophilic media have been studied by (13)C and (199)Hg NMR spectroscopy. The norbornenemercurinium ion shows temperature-dependent (13)C and (199)Hg NMR spectra, consistent with equilibration via rapid hydride and Wagn...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Olah GA,Garcia-Luna A

更新日期：1980-09-01 00:00:00

abstract：:Domestic animals can be cloned using techniques such as embryo splitting and nuclear transfer to produce genetically identical individuals. Although embryo splitting is limited to the production of only a few identical individuals, nuclear transfer of donor nuclei into recipient oocytes, whose own nuclear DNA has been...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Keefer CL

更新日期：2015-07-21 00:00:00

abstract：:Endocrine therapy resistance invariably develops in advanced estrogen receptor-positive (ER+) breast cancer, but the underlying mechanisms are largely unknown. We have identified C-terminal SRC kinase (CSK) as a critical node in a previously unappreciated negative feedback loop that limits the efficacy of current ER-t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xiao T,Li W,Wang X,Xu H,Yang J,Wu Q,Huang Y,Geradts J,Jiang P,Fei T,Chi D,Zang C,Liao Q,Rennhack J,Andrechek E,Li N,Detre S,Dowsett M,Jeselsohn RM,Liu XS,Brown M

更新日期：2018-07-31 00:00:00

abstract：:Antibodies to electrolectin, a lectin endogenous to embryonic skeletal muscle, have been used to study the distribution of electrolectin during myogenesis in L6 cells and rat primary muscle cultures. Antibody binding is highest to mononucleated cells and is low to myotubes in both systems. Binding is much lower to fib...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Podleski TR,Greenberg I

更新日期：1980-02-01 00:00:00

abstract：:Global warming is expected to lead to a large increase in atmospheric water vapor content and to changes in the hydrological cycle, which include an intensification of precipitation extremes. The intensity of precipitation extremes is widely held to increase proportionately to the increase in atmospheric water vapor c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： O'Gorman PA,Schneider T

更新日期：2009-09-01 00:00:00

abstract：:A metabolite of estradiol, 2-methoxyestradiol (2ME), inhibits angiogenesis in the chicken embryo chorioallantoic membrane assay. Since 2ME causes mitotic perturbations, we examined its interactions with tubulin. In our standard 1.0 M glutamate system (plus 1.0 mM MgCl2 at 37 degrees C), superstoichiometric concentrati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： D'Amato RJ,Lin CM,Flynn E,Folkman J,Hamel E

更新日期：1994-04-26 00:00:00

abstract：:Rat, but not human, erythrocytes undergo fusion promoted by the membrane-mobility agent 2-(2-methoxyethoxy)-ethyl cis-8-(2-octylcyclopropyl)octanoate (A2C). The difference in behavior is correlated with rat erythrocyte membrane protein degradation caused by Ca2+-activated proteases. The human erythrocyte is deficient ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kosower NS,Glaser T,Kosower EM

更新日期：1983-12-01 00:00:00

abstract：:The murine paired box-containing gene Pax1 is required for normal development of the vertebral column, the sternum, and the scapula. Previous studies have shown that three natural Pax1 mouse mutants, the undulated alleles, exhibit phenotypes of different severity in these skeletal elements. Nevertheless, these analyse...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wilm B,Dahl E,Peters H,Balling R,Imai K

更新日期：1998-07-21 00:00:00

abstract：:Argonaute and Piwi proteins are key players in the RNA silencing pathway, with the former interacting with micro-RNAs (miRNAs) and siRNAs, whereas the latter targets piwi-interacting RNAs (piRNAs) that are 2'-O-methylated (2(')-OCH(3)) at their 3' ends. Germline-specific piRNAs and Piwi proteins play a critical role i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tian Y,Simanshu DK,Ma JB,Patel DJ

更新日期：2011-01-18 00:00:00

abstract：:We describe a procedure for predicting the tertiary folds of alpha-helical proteins from their primary sequences. The central component of the procedure is a method for predicting interhelical contacts that is based on a helix-packing model. Instead of predicting the individual contacts, our method attempts to identif...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang C,Hou J,Kim SH

更新日期：2002-03-19 00:00:00

abstract：:Because RNAs fold as they are being synthesized, their transcription rate can affect their folding. Here, we report the results of single-molecule fluorescence studies that characterize the ligand-dependent cotranscriptional folding of the Escherichia coli thiM riboswitch that regulates translation. We found that the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Uhm H,Kang W,Ha KS,Kang C,Hohng S

更新日期：2018-01-09 00:00:00

abstract：:Identification of genomic regions that control tissue-specific gene expression is currently problematic. ChIP and high-throughput sequencing (ChIP-seq) of enhancer-associated proteins such as p300 identifies some but not all enhancers active in a tissue. Here we show that co-occupancy of a chromatin region by multiple...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： He A,Kong SW,Ma Q,Pu WT

更新日期：2011-04-05 00:00:00

abstract：:Recent research has emphasized the importance of the metabolic cluster, which includes glucose intolerance, dyslipidemia, and high blood pressure, as a strong predictor of the obesity-related morbidities and premature mortality. Fundamental to this association, commonly referred to as the metabolic syndrome, is the cl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kissebah AH,Sonnenberg GE,Myklebust J,Goldstein M,Broman K,James RG,Marks JA,Krakower GR,Jacob HJ,Weber J,Martin L,Blangero J,Comuzzie AG

更新日期：2000-12-19 00:00:00

abstract：:We have recently demonstrated that immunization with hepatitis C virus-like particles (HCV-LPs) generated in insect cells can elicit both humoral and cellular immune responses in BALB/c mice. Here, we evaluate the immunogenicity of HCV-LPs in HLA2.1 transgenic (AAD) mice in comparison to DNA immunization. HCV-LP immun...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murata K,Lechmann M,Qiao M,Gunji T,Alter HJ,Liang TJ

更新日期：2003-05-27 00:00:00

abstract：:Brefeldin A, a fungal metabolite that inhibits membrane transport, induces the mono(ADP-ribosyl)ation of two cytosolic proteins of 38 and 50 kDa as judged by SDS/PAGE. The 38-kDa substrate has been previously identified as glyceraldehyde-3-phosphate dehydrogenase (GAPDH). We report that the 50-kDa BFA-induced ADP-ribo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Di Girolamo M,Silletta MG,De Matteis MA,Braca A,Colanzi A,Pawlak D,Rasenick MM,Luini A,Corda D

更新日期：1995-07-18 00:00:00

abstract：:Although the occurrence of epistasis and pleiotropy is widely accepted at the molecular level, its effect on the adaptive value of fitness-related genes is rarely investigated in plants. Knowledge of these features of a gene is critical to understand the molecular basis of adaptive evolution. Here we investigate the i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scarcelli N,Cheverud JM,Schaal BA,Kover PX

更新日期：2007-10-23 00:00:00

abstract：:Visual information is conveyed from the eye to the brain by distinct types of retinal ganglion cells (RGCs). It is largely unknown how RGCs acquire their defining morphological and physiological features and connect to upstream and downstream synaptic partners. The three Brn3/Pou4f transcription factors (TFs) particip...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sajgo S,Ghinia MG,Brooks M,Kretschmer F,Chuang K,Hiriyanna S,Wu Z,Popescu O,Badea TC

更新日期：2017-05-16 00:00:00

abstract：:The amount of extra-pair paternity in socially monogamous bird species varies from 0% to 76% extra-pair offspring. The causes of this remarkable interspecific variation are largely unknown, although intraspecific analyses suggest that females seek extra-pair matings to improve the genetic quality of their offspring. I...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Petrie M,Doums C,Moller AP

更新日期：1998-08-04 00:00:00

abstract：:Fast axoplasmic transport was studied in dorsal root ganglion cells of the cat. Proteins carried in the fast axoplasmic flow were labeled after an intraganglionic injection of (L)-[4,5-(3)H]leucine. The rate of transport was 380 +/- 26 mm/day in both the central and peripheral branches of the bifurcating axons that ar...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Anderson LE,McClure WO

更新日期：1973-05-01 00:00:00

abstract：:Plasma growth hormone (GH) profiles are sexually differentiated in many species and regulate the sex-dependence of peripubescent growth rates and liver function, including steroid hydroxylase cytochrome P450 expression, by mechanisms that are poorly understood. By use of an external pump to deliver to hypophysectomize...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Waxman DJ,Pampori NA,Ram PA,Agrawal AK,Shapiro BH

更新日期：1991-08-01 00:00:00

abstract：:Biocompatible gold nanoparticles designed to absorb light at wavelengths of high tissue transparency have been of particular interest for biomedical applications. The ability of such nanoparticles to convert absorbed near-infrared light to heat and induce highly localized hyperthermia has been shown to be highly effec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rastinehad AR,Anastos H,Wajswol E,Winoker JS,Sfakianos JP,Doppalapudi SK,Carrick MR,Knauer CJ,Taouli B,Lewis SC,Tewari AK,Schwartz JA,Canfield SE,George AK,West JL,Halas NJ

更新日期：2019-09-10 00:00:00

abstract：:The neutrality theory predicts that the rate of neutral molecular evolution is constant over time, and thus that there is a molecular clock for timing evolutionary events. It has been observed that the variance of the rate of evolution is generally larger than expected according to the neutrality theory, which has rai...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rodríguez-Trelles F,Tarrío R,Ayala FJ

更新日期：2001-09-25 00:00:00

abstract：:To identify genes important for hair-cell function, we conducted a mutagenic screen in zebrafish. Larvae from one mutant line, ru848, were unresponsive to acoustic stimuli and unable to balance. The mutation results in a 90% reduction in hair-cell number and partial retinal degeneration by 5 days postfertilization. We...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Starr CJ,Kappler JA,Chan DK,Kollmar R,Hudspeth AJ

更新日期：2004-02-24 00:00:00

abstract：:In most organisms, light plays a key role in the synchronization of the circadian timing system with the environmental day-night cycle. Light pulses that phase-shift the circadian clock also induce the expression of period (per) genes in vertebrates. Here, we report the cloning of a zebrafish per gene, zfper4, which i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vallone D,Gondi SB,Whitmore D,Foulkes NS

更新日期：2004-03-23 00:00:00

abstract：:Recent evidence indicates there is a role for small membrane vesicles, including exosomes, as vehicles for intercellular communication. Exosomes secreted by most cell types can mediate transfer of proteins, mRNAs, and microRNAs, but their role in the transmission of infectious agents is less established. Recent studie...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ramakrishnaiah V,Thumann C,Fofana I,Habersetzer F,Pan Q,de Ruiter PE,Willemsen R,Demmers JA,Stalin Raj V,Jenster G,Kwekkeboom J,Tilanus HW,Haagmans BL,Baumert TF,van der Laan LJ

更新日期：2013-08-06 00:00:00