Phosphate metabolism in intact human erythrocytes: determination by phosphorus-31 nuclear magnetic resonance spectroscopy.

abstract：:Legionella pneumophila is an intracellular parasite of freshwater protozoa and human macrophages. Recent studies determined that the macrophage infectivity potentiator (Mip) surface protein, a prokaryotic homolog of the FK506-binding proteins, is required for optimal infection of macrophages. To determine whether Mip ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cianciotto NP,Fields BS

更新日期：1992-06-01 00:00:00

abstract：:A mutation that confers resistance to the drug paromomycin is shown to be in the structural gene that codes for the ribosomal RNA in Tetrahymena. This observation was made by exploiting a variant of the ribosomal DNA that distorts amplification of this locus when a new somatic nucleus develops during conjugation. Beca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bruns PJ,Katzen AL,Martin L,Blackburn EH

更新日期：1985-05-01 00:00:00

abstract：:Male mice were injected intraperitoneally with 125 microCi (1 Ci = 3.7 X 10(10) becquerels) of [3H]thymidine at 1-hr intervals and killed 1 hr after the second injection. Testes were prepared for bright-field and electron microscopic autoradiography. Primary spermatocytes, identified by light microscopy to be at the p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grell RF,Oakberg EF,Generoso EE

更新日期：1980-11-01 00:00:00

abstract：:Thyroid hormone is a major regulator of thermogenesis, acting both in peripheral organs and on central autonomic pathways. Mice heterozygous for a point mutation in thyroid hormone receptor α1 display increased thermogenesis as a consequence of high sympathetic brown fat stimulation. Surprisingly, despite the hypermet...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Warner A,Rahman A,Solsjö P,Gottschling K,Davis B,Vennström B,Arner A,Mittag J

更新日期：2013-10-01 00:00:00

abstract：:Despite the widespread use of silicon in modern technology, its peculiar thermal expansion is not well understood. Adapting harmonic phonons to the specific volume at temperature, the quasiharmonic approximation, has become accepted for simulating the thermal expansion, but has given ambiguous interpretations for micr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim DS,Hellman O,Herriman J,Smith HL,Lin JYY,Shulumba N,Niedziela JL,Li CW,Abernathy DL,Fultz B

更新日期：2018-02-27 00:00:00

abstract：:The LSD1-CoREST histone demethylase complex is required to repress neuronal genes in nonneuronal tissues. Here we show that sumoylation of Braf35, one of the subunits of the complex, is required to maintain full repression of neuron-specific genes and for occupancy of the LSD1-CoREST complex at its gene targets. Inter...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ceballos-Chávez M,Rivero S,García-Gutiérrez P,Rodríguez-Paredes M,García-Domínguez M,Bhattacharya S,Reyes JC

更新日期：2012-05-22 00:00:00

abstract：:We present a unique proxy for the reconstruction of variation in precipitation over the Amazon: oxygen isotope ratios in annual rings in tropical cedar (Cedrela odorata). A century-long record from northern Bolivia shows that tree rings preserve the signal of oxygen isotopes in precipitation during the wet season, wit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brienen RJ,Helle G,Pons TL,Guyot JL,Gloor M

更新日期：2012-10-16 00:00:00

abstract：:Therapeutic cancer vaccines can be effective for treating patients, but clinical responses vary considerably from patient to patient. Early indicators of a favorable response are crucial for making individualized treatment decisions and advancing vaccine design, but no validated biomarkers are currently available. In ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Campbell CT,Gulley JL,Oyelaran O,Hodge JW,Schlom J,Gildersleeve JC

更新日期：2014-04-29 00:00:00

abstract：:For beta-D-glucosylisophosphoramide mustard (beta-D-Glc-IPM), a new alkylating drug in which isophosphoramide mustard is stabilized, a higher selectivity and lower myelotoxicity was observed than for the currently used cytostatic ifosfamide. Because beta-D-Glc-IPM is hydrophilic and does not diffuse passively through ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Veyhl M,Wagner K,Volk C,Gorboulev V,Baumgarten K,Weber WM,Schaper M,Bertram B,Wiessler M,Koepsell H

更新日期：1998-03-17 00:00:00

abstract：:Leaf-cutting ants combine large-scale herbivory with fungus farming to sustain advanced societies. Their stratified colonies are major evolutionary achievements and serious agricultural pests, but the crucial adaptations that allowed this mutualism to become the prime herbivorous component of neotropical ecosystems ha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： De Fine Licht HH,Schiøtt M,Rogowska-Wrzesinska A,Nygaard S,Roepstorff P,Boomsma JJ

更新日期：2013-01-08 00:00:00

abstract：:Progressive amyloid deposition in senile plaques and cortical blood vessels may play a central role in the pathogenesis of Alzheimer disease. We have used x-ray diffraction and electron microscopy to study the molecular organization and morphology of macromolecular assemblies formed by three synthetic peptides homolog...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kirschner DA,Inouye H,Duffy LK,Sinclair A,Lind M,Selkoe DJ

更新日期：1987-10-01 00:00:00

abstract：:Visual awareness has been proposed to depend on recurrent processing in early visual cortex areas including the primary visual cortex (V1). Here, we address this hypothesis with high spatiotemporal resolution magnetoencephalographic recordings in subjects performing a substitution masking paradigm. Neural activity ref...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Boehler CN,Schoenfeld MA,Heinze HJ,Hopf JM

更新日期：2008-06-24 00:00:00

abstract：:Differentiation of naive CD4(+) T cells into IFN-gamma-producing T helper 1 (T(H)1) cells is pivotal for protective immune responses against intracellular pathogens. T-bet, a recently discovered member of the T-box transcription factor family, has been reported to play a critical role in this process, promoting IFN-ga...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lighvani AA,Frucht DM,Jankovic D,Yamane H,Aliberti J,Hissong BD,Nguyen BV,Gadina M,Sher A,Paul WE,O'Shea JJ

更新日期：2001-12-18 00:00:00

abstract：:The adult repertoire of antibody specificities is acquired in a developmentally programmed fashion that, in mouse and man, parallels the ordered rearrangement of a limited number of germ-line heavy chain variable region (VH) gene segments during development. It has been hypothesized that this developmental bias is a c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Willems van Dijk K,Milner LA,Sasso EH,Milner EC

更新日期：1992-11-01 00:00:00

abstract：:Monoaminergic neurons use dopa decarboxylase (DDC; aromatic-L-amino-acid carboxy-lyase, EC 4.1.1.28) to form dopamine from L-3,4-dihydroxyphenylalanine (L-dopa). We measured regional dopa decarboxylase activity in brains of six healthy volunteers with 6-[18F]fluoro-L-dopa and positron emission tomography. We calculate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gjedde A,Reith J,Dyve S,Léger G,Guttman M,Diksic M,Evans A,Kuwabara H

更新日期：1991-04-01 00:00:00

abstract：:Two features make the tooth an excellent model in the study of evolutionary innovations: the relative simplicity of its structure and the fact that the major tooth-forming genes have been identified in eutherian mammals. To understand the nature of the innovation at the molecular level, it is necessary to identify the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Toyosawa S,O'hUigin C,Figueroa F,Tichy H,Klein J

更新日期：1998-10-27 00:00:00

abstract：:In the retina, dopamine plays a central role in neural adaptation to light. Progress in the study of dopaminergic amacrine (DA) cells has been limited because they are very few (450 in each mouse retina, 0.005% of retinal neurons). Here, we applied transgenic technology, single-cell global mRNA amplification, and cDNA...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gustincich S,Contini M,Gariboldi M,Puopolo M,Kadota K,Bono H,LeMieux J,Walsh P,Carninci P,Hayashizaki Y,Okazaki Y,Raviola E

更新日期：2004-04-06 00:00:00

abstract：:In Caenorhabditis elegans, pre-mRNA for the essential splicing factor U2AF65 sometimes is spliced to produce an RNA that includes an extra 216-bp internal exon, exon 3. Inclusion of exon 3 inserts an in-frame stop codon, yet this RNA is not subject to SMG-mediated RNA surveillance. To test whether exon 3 causes RNA to...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： MacMorris MA,Zorio DA,Blumenthal T

更新日期：1999-03-30 00:00:00

abstract：:We determined that a pigeon cytochrome c-derived peptide, p43-58, possesses two anchor residues, 46 and 54, for binding with the I-Ab molecule that are compatible to the position 1 (P1) and position 9 (P9) of the core region in the major histocompatibility complex (MHC) class II binding peptides, respectively. In the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Itoh Y,Kajino K,Ogasawara K,Takahashi A,Namba K,Negishi I,Matsuki N,Iwabuchi K,Kakinuma M,Good RA,Onoé K

更新日期：1997-10-28 00:00:00

abstract：:Understanding protein-protein interactions is central to our understanding of almost all complex biological processes. Computational tools exploiting rapidly growing genomic databases to characterize protein-protein interactions are urgently needed. Such methods should connect multiple scales from evolutionary conserv...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gueudré T,Baldassi C,Zamparo M,Weigt M,Pagnani A

更新日期：2016-10-25 00:00:00

abstract：:Vibrio cholerae serogroup O139 emerged on the Indian subcontinent in October 1992 to become the first non-O1 V. cholerae serogroup documented to cause epidemic cholera. Although related to V. cholerae El Tor O1 strains, O139 strains have unique surface structures that include a capsular surface layer and lipopolysacch...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Waldor MK,Colwell R,Mekalanos JJ

更新日期：1994-11-22 00:00:00

abstract：:Palmitoylation is a common lipid modification known to regulate the functional properties of various proteins and is a vital step in the biosynthesis of voltage-activated sodium (Nav) channels. We discovered a mutation in an intracellular loop of rNav1.2a (G1079C), which results in a higher apparent affinity for exter...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bosmans F,Milescu M,Swartz KJ

更新日期：2011-12-13 00:00:00

abstract：:Cytochrome c oxidase (CcO) uses the energy released by reduction of O2 to H2O to drive eight charges from the high pH to low pH side of the membrane, increasing the electrochemical gradient. Four electrons and protons are used for chemistry, while four more protons are pumped. Proton pumping requires that residues on ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lu J,Gunner MR

更新日期：2014-08-26 00:00:00

abstract：:Protein tyrosine phosphatase (PTP)σ (PTPRS) was shown previously to be associated with susceptibility to inflammatory bowel disease (IBD). PTPσ(-/-) mice exhibit an IBD-like phenotype in the intestine and show increased susceptibility to acute models of murine colitis. However, the function of PTPσ in the intestine is...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murchie R,Guo CH,Persaud A,Muise A,Rotin D

更新日期：2014-01-14 00:00:00

abstract：:Herpes simplex virus 1 (HSV-1) specifies in the infected cell a set of polypeptides (alpha) whose mRNAs are made in the absence of protein synthesis. The individual mRNAs specifying alpha polypeptides 0, 4, 22, and 27 were purified by hybridization to strand-separated or total HSV-1 DNA fragments cloned in pBR322 plas...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mackem S,Roizman B

更新日期：1980-12-01 00:00:00

abstract：:Levels and subcellular distribution of connexin 43 (Cx43), a gap junction protein, were studied in hamster leukocytes before and after activation with endotoxin (lipopolysaccharide, LPS) both in vitro and in vivo. Untreated leukocytes did not express Cx43. However, Cx43 was clearly detectable by indirect immunofluores...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jara PI,Boric MP,Sáez JC

更新日期：1995-07-18 00:00:00

abstract：:Primary--i.e., nonsyndromal-postlingual deafness is inherited as an autosomal dominant phenotype in a large kindred in Costa Rica. Genetically susceptible individuals begin to lose hearing at low frequencies at about age 10 years, after language and speaking are learned. Deafness inevitably progresses by age 30 years ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leon PE,Raventos H,Lynch E,Morrow J,King MC

更新日期：1992-06-01 00:00:00

abstract：:Walker-256 carcinosarcoma cells grown in tissue culture medium containing inhibitory DNA prepared from the tumor are shown to have an unaltered growth in vitro, but a diminished capacity to produce malignant tumors on injection into the rat. Coincident with this change in virulence is the induction of tRNA methylase i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Halpern BC,Halpern RM,Chaney SQ,Smith RA

更新日期：1970-12-01 00:00:00

abstract：:Inbred Lewis (LEW/N) female rats develop an arthritis in response to group A streptococcal cell wall peptidoglycan polysaccharide (SCW), which mimics human rheumatoid arthritis. Histocompatible Fischer (F344/N) rats do not develop arthritis in response to the same SCW stimulus. To evaluate this difference in inflammat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sternberg EM,Hill JM,Chrousos GP,Kamilaris T,Listwak SJ,Gold PW,Wilder RL

更新日期：1989-04-01 00:00:00

abstract：:This presentation reviews Chandra's major contribution to the understanding of nearby galaxies. After a brief summary on significant advances in characterizing various types of discrete x-ray sources, the presentation focuses on the global hot gas in and around galaxies, especially normal ones like our own. The hot ga...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang QD

更新日期：2010-04-20 00:00:00