Rapid recurrent processing gates awareness in primary visual cortex.

abstract：:Niemann-Pick type C (NPC) disease is predominantly caused by mutations in the NPC1 protein that affect intracellular cholesterol trafficking and cause accumulation of unesterified cholesterol and other lipids in lysosomal storage organelles. We report the use of a series of small molecule histone deacetylase (HDAC) in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pipalia NH,Cosner CC,Huang A,Chatterjee A,Bourbon P,Farley N,Helquist P,Wiest O,Maxfield FR

更新日期：2011-04-05 00:00:00

abstract：:Differentiation-inducing factor 1 [DIF-1; 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)-hexan-1-one] induces stalk cell differentiation during Dictyostelium development. It is present as a gradient in the multicellular slug, its lowest concentration being in the anterior. Here we demonstrate the existence of a locali...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kay RR,Large S,Traynor D,Nayler O

更新日期：1993-01-15 00:00:00

abstract：:The tails of newborn rats, consisting of slender continuous cones of avascular cartilage, were transplanted in subcutaneous spaces of allogeneic adolescents; colloidal carbon was injected in a vein before the transplants were harvested on days 7-28. Between 97 and 100% of the transplants were accepted, underwent diffe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huggins CB,Anderson KP

更新日期：1976-09-01 00:00:00

abstract：:The error frequency of in vitro DNA synthesis using a natural DNA template has been measured with a biological assay for nucleotide substitutions. phiX174 DNA containing an amber mutation was copied in vitro by Escherichia coli DNA polymerase I, and the reversion frequency of the progeny DNA was determined by transfec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weymouth LA,Loeb LA

更新日期：1978-04-01 00:00:00

abstract：:Nuclear import of classical nuclear localization sequence-bearing proteins is mediated by karyopherin alpha/beta1 heterodimers. A second nuclear import pathway, mediated by karyopherin beta2 (transportin), recently was described for mRNA-binding proteins. Here we report the cloning and characterization of human karyop...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yaseen NR,Blobel G

更新日期：1997-04-29 00:00:00

abstract：:There are numerous studies on the immune response against malignant human tumors. This study was aimed to address the complexity and specificity of humoral immune response against a benign human tumor. We assembled a panel of 62 meningioma-expressed antigens that show reactivity with serum antibodies of meningioma pat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Comtesse N,Zippel A,Walle S,Monz D,Backes C,Fischer U,Mayer J,Ludwig N,Hildebrandt A,Keller A,Steudel WI,Lenhof HP,Meese E

更新日期：2005-07-05 00:00:00

abstract：:Juvenile hormone III (JH) plays a key role in regulating the reproduction of female mosquitoes. Microarray time-course analysis revealed dynamic changes in gene expression during posteclosion (PE) development in the fat body of female Aedes aegypti. Hierarchical clustering identified three major gene clusters: 1,843 e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zou Z,Saha TT,Roy S,Shin SW,Backman TW,Girke T,White KP,Raikhel AS

更新日期：2013-06-11 00:00:00

abstract：:The discrepancy between the structural longitudinal organization of the parallel-fiber system in the cerebellar cortex and the functional mosaic-like organization of the cortex has provoked controversial theories about the flow of information in the cerebellum. We address this issue by characterizing the spatiotempora...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cohen D,Yarom Y

更新日期：1998-12-08 00:00:00

abstract：:The balance between mitochondrial fusion and fission influences the reticular shape of mitochondria in yeasts. Little is known about whether mitochondria fusion occurs in plants. Plant mitochondria are usually more numerous and more grain-shaped than animal mitochondria. BLAST searches of the nuclear and mitochondrial...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arimura S,Yamamoto J,Aida GP,Nakazono M,Tsutsumi N

更新日期：2004-05-18 00:00:00

abstract：:The neurofibromatosis type 1 (NF1) gene responsible for von Recklinghausen neurofibromatosis is related to regulators of ras proteins, and a portion of NF1 that is homologous to the ras GTPase-activating protein (GAP) encodes a similar GTPase-stimulating activity. We have raised rabbit antisera to a bacterially synthe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： DeClue JE,Cohen BD,Lowy DR

更新日期：1991-11-15 00:00:00

abstract：:Reversible ligands were attached covalently to membrane-bound acetylcholine receptor from Torpedo marmorata by a method which is generally applicable and does not require the synthesis of specially designed molecules. UV irradiation of the receptor in the presence of [3H]trimethisoquin, [3H]phencyclidine, or [3H]perhy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oswald R,Changeux JP

更新日期：1981-06-01 00:00:00

abstract：:A cDNA for parafusin, an evolutionarily conserved phosphoglycoprotein involved in exocytosis, has been cloned and sequenced from a unicellular eukaryote, Paramecium tetraurelia. A Paramecium cDNA library was screened with an oligonucleotide probe synthesized to an internal amino acid sequence of isolated parafusin. Th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Subramanian SV,Wyroba E,Andersen AP,Satir BH

更新日期：1994-10-11 00:00:00

abstract：:The ability of bacteria to regulate gene expression in response to changes in cell density is termed quorum sensing. This behavior involves the synthesis and recognition of extracellular, hormone-like compounds known as autoinducers. Here we report the structure of an autoinducer synthase, LuxS from Bacillus subtilis,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hilgers MT,Ludwig ML

更新日期：2001-09-25 00:00:00

abstract：:Human embryonic zeta-globin chains are alpha-globin-like chains that are normally present during the first three months of gestation. In this investigation, zeta-globin chains measured by a specific and sensitive radioimmunoassay and by an electrophoretic technique were found to be present in all 7 patients studied wi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chung SW,Wong SC,Clarke BJ,Patterson M,Walker WH,Chui DH

更新日期：1984-10-01 00:00:00

abstract：:Aire induces ectopic expression of peripheral tissue antigens (PTAs) in thymic medullary epithelial cells, which promotes immunological tolerance. Beginning with a broad screen of histone peptides, we demonstrate that the mechanism by which this single factor controls the transcription of thousands of genes involves r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koh AS,Kuo AJ,Park SY,Cheung P,Abramson J,Bua D,Carney D,Shoelson SE,Gozani O,Kingston RE,Benoist C,Mathis D

更新日期：2008-10-14 00:00:00

abstract：:Seed germination is regulated by endogenous hormonal cues and external environmental stimuli such as water, low temperature, and light. After germination, the young seedling must rapidly establish its root system and the photoautotrophic capability appropriate to its surrounding environment. Light and the phytohormone...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen H,Zhang J,Neff MM,Hong SW,Zhang H,Deng XW,Xiong L

更新日期：2008-03-18 00:00:00

abstract：:The deduced amino acid sequence of two members of the signal transducers and activators of transcription (STAT) family from the mouse are described. Comparison with the deduced protein sequence of the two previously described genes (Stat91 and Stat113), discovered because of their activation as transcription factors a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhong Z,Wen Z,Darnell JE Jr

更新日期：1994-05-24 00:00:00

abstract：:Transport of sodium, chloride, and taurocholate was studied in primary cultures of adult rat hepatocytes incubated in a balanced electrolyte solution containing 150 mM NaCl, various concentrations of taurocholate, and (22)Na, (36)Cl, [(3)H]taurocholate, and 3-O-[(3)H]methyl-D-glucose. Lithium chloride, choline chlorid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scharschmidt BF,Stephens JE

更新日期：1981-02-01 00:00:00

abstract：:The visual system of the macaque monkey has provided a useful model for understanding the neural basis of human vision, yet, there are few detailed comparisons of neural populations other than photoreceptors for the two species. Using intracellular staining in an in vitro preparation of the isolated and intact human r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dacey DM,Petersen MR

更新日期：1992-10-15 00:00:00

abstract：:In contrast to mechanisms mediating uptake of intracellular bacterial pathogens, bacterial egress and cell-to-cell transmission are poorly understood. Previously, we showed that the transmission of pathogenic mycobacteria between phagocytic cells also depends on nonlytic ejection through an F-actin based structure, ca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gerstenmaier L,Pilla R,Herrmann L,Herrmann H,Prado M,Villafano GJ,Kolonko M,Reimer R,Soldati T,King JS,Hagedorn M

更新日期：2015-02-17 00:00:00

abstract：:It is possible, by using Fourier-transform infrared (FTIR) difference spectroscopy, to detect the conformational changes occurring in both the protein and the chromophore of bacteriorhodopsin during the photocycle. In contrast to Raman spectroscopy, a laser is unnecessary and hence the problem of a perturbing probe be...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rothschild KJ,Marrero H

更新日期：1982-07-01 00:00:00

abstract：:Recent advances indicate that, in various chronic inflammatory disorders, the activation of the immune system is triggered locally rather than in lymphoid organs. In this study, we have evaluated whether the humoral alloimmune response involved in chronic rejection is elicited within the graft. We used the rat aortic ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thaunat O,Field AC,Dai J,Louedec L,Patey N,Bloch MF,Mandet C,Belair MF,Bruneval P,Meilhac O,Bellon B,Joly E,Michel JB,Nicoletti A

更新日期：2005-10-11 00:00:00

abstract：:The paucity of knowledge about cardiomyocyte maturation is a major bottleneck in cardiac regenerative medicine. In development, cardiomyocyte maturation is characterized by orchestrated structural, transcriptional, and functional specializations that occur mainly at the perinatal stage. Sarcomeres are the key cytoskel...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guo Y,Cao Y,Jardin BD,Sethi I,Ma Q,Moghadaszadeh B,Troiano EC,Mazumdar N,Trembley MA,Small EM,Yuan GC,Beggs AH,Pu WT

更新日期：2021-01-12 00:00:00

abstract：:To generate transgenic planarians we used a set of versatile vectors for animal transgenesis based on the promiscuous transposons, mariner, Hermes and piggyBac, and a universal enhanced GFP (EGFP) marker system with three Pax6 dimeric binding sites, the 3xP3-EGFP developed by Berghammer et al. [Berghammer, A. J., Klin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： González-Estévez C,Momose T,Gehring WJ,Saló E

更新日期：2003-11-25 00:00:00

abstract：:The amphibian tetradecapeptide, bombesin (BBS) has been shown to stimulate insulin secretion both in vivo and by pancreatic islet cells in vitro. To determine whether BBS can act directly on pancreatic beta cells, we examined its effects on insulin secretion by HIT-T15 cells (HIT cells), a clonal islet cell line. Addi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Swope SL,Schonbrunn A

更新日期：1984-03-01 00:00:00

abstract：:Monoclonal antibodies (mAbs) against purified human placental insulin-like growth factor I (IGF-I) receptors were prepared and characterized. Three IgG mAbs were specific for the human IGF-I receptor and displayed negligible crossreactivity with the human insulin receptor. They stimulated 125I-labeled IGF-I (125I-IGF-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xiong L,Kasuya J,Li SL,Kato J,Fujita-Yamaguchi Y

更新日期：1992-06-15 00:00:00

abstract：:Cl- channels in the apical membranes of salt-secreting epithelia are activated by both cAMP and Ca2+ second-messenger systems, and dysfunctions in their hormonal regulation have been demonstrated in patients with cystic fibrosis. We have transfected the epithelial cell line T84 with an expression vector containing a m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rogers KV,Goldman PS,Frizzell RA,McKnight GS

更新日期：1990-11-01 00:00:00

abstract：:The prediction of interresidue contacts and distances from coevolutionary data using deep learning has considerably advanced protein structure prediction. Here, we build on these advances by developing a deep residual network for predicting interresidue orientations, in addition to distances, and a Rosetta-constrained...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang J,Anishchenko I,Park H,Peng Z,Ovchinnikov S,Baker D

更新日期：2020-01-21 00:00:00

abstract：:In the mitochondrial genome of the hemichordate Balanoglossus carnosus, the codon AAA, which is assigned to lysine in most metazoans but to asparagine in echinoderms, is absent. Furthermore, the lysine tRNA gene carries an anticodon substitution that renders its gene product unable to decode AAA codons, whereas the as...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Castresana J,Feldmaier-Fuchs G,Pääbo S

更新日期：1998-03-31 00:00:00

abstract：:FtsEX is a bacterial ABC transporter that regulates the activity of periplasmic peptidoglycan amidases via its interaction with the murein hydrolase activator, EnvC. In Escherichia coli, FtsEX is required to separate daughter cells after cell division and for viability in low-osmolarity media. Both the ATPase activity...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cook J,Baverstock TC,McAndrew MBL,Stansfeld PJ,Roper DI,Crow A

更新日期：2020-11-10 00:00:00