Abstract:
:A prohormone angiotensin antagonist, Sarcosyl1-Alanyl8-angiotensin I (Sar1-Ala8-A-I) was synthesized and its pharmacological properties were evaluated in three biological systems. It was found to be a good inhibitor in vivo in the rat blood pressure assay, somewhat less active in guinea pig ileum and a relatively weak antagonist in rat uterus. In vivo the inhibitory effect was greatly attenuated by the presence of the converting enzyme inhibitor BPP5alpha.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Chiu AT,Sutherland JC Jr,Day AR,Freer RJdoi
10.1016/0014-2999(79)90421-7subject
Has Abstractpub_date
1979-02-15 00:00:00pages
177-80issue
1-2eissn
0014-2999issn
1879-0712pii
0014-2999(79)90421-7journal_volume
54pub_type
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