Influence of food on the absorption of metoprolol administered as an Oros drug delivery system to man.

abstract：AIMS:High plasma cholesterol concentration and increased platelet activity are two major risk factors for atherosclerosis. Lovastatin, the lipophilic drug was shown to inhibit platelet aggregation whereas pravastatin, the hydrophilic drug had no such effect. Analysis of the effect of fluvastatin which is both a lipophi...

journal_title：British journal of clinical pharmacology

authors： Osamah H,Mira R,Sorina S,Shlomo K,Michael A

更新日期：1997-07-01 00:00:00

abstract：AIMS:The aim of this study was to investigate the effect of policosanol on the susceptibility of LDL-C to in vitro lipid peroxidation in human healthy volunteers. METHODS:The effect of policosanol (5 and 10 mg day(-1) on LDL-C oxidation was studied in a double-blind, randomized, placebo-controlled trial conducted in 6...

journal_title：British journal of clinical pharmacology

authors： Menéndez R,Más R,Amor AM,González RM,Fernández JC,Rodeiro I,Zayas M,Jiménez S

更新日期：2000-09-01 00:00:00

abstract：:Responses of human bronchial strip preparations to contractile and relaxant agonists were measured in preparations from non-diseased and from asthmatic lung obtained 3-15 h post-mortem. The potencies of carbachol and histamine were approximately two times less in asthmatic than in non-diseased bronchi. This was statis...

journal_title：British journal of clinical pharmacology

authors： Goldie RG,Spina D,Henry PJ,Lulich KM,Paterson JW

更新日期：1986-12-01 00:00:00

abstract：AIMS:To evaluate the comparative efficacy (50% reduction in seizure frequency) and tolerability (premature withdrawal due to adverse events) of anti-epileptic drugs (AEDs) for refractory epilepsy. METHODS:We searched Cochrane Central Register of Controlled Trials (Cochrane Library 2009, issue 2) including Epilepsy Gro...

journal_title：British journal of clinical pharmacology

authors： Bodalia PN,Grosso AM,Sofat R,Macallister RJ,Smeeth L,Dhillon S,Casas JP,Wonderling D,Hingorani AD

更新日期：2013-11-01 00:00:00

abstract：:1. The pharmacokinetics of streptokinase (SK) and anistreplase in conventional dosage regimens of 1.5 x 10(6) i.u. of SK infused over 60 min and 30 units of anistreplase over 5 min were studied in 24 consecutive patients presenting with acute myocardial infarction, using a functional bioassay to assess concentrations....

journal_title：British journal of clinical pharmacology

authors： Gemmill JD,Hogg KJ,Burns JM,Rae AP,Dunn FG,Fears R,Ferres H,Standring R,Greenwood H,Pierce D

更新日期：1991-02-01 00:00:00

abstract：:Monohydroxy acids (HETEs) and leukotriene B4 (LTB4) metabolites of arachidonic acid were measured in skin of healthy volunteers after ultraviolet B irradiation, and in the uninvolved skin of psoriatics after topical dithranol application. Exudate was collected from suction bullae on control and inflamed abdominal skin...

journal_title：British journal of clinical pharmacology

authors： Black AK,Barr RM,Wong E,Brain S,Greaves MW,Dickinson R,Shroot B,Hensby CN

更新日期：1985-09-01 00:00:00

abstract：AIM:To develop a semi-mechanistic model, based on glutathione depletion and predict a previously identified intra-individual reduction in busulfan clearance to aid in more precise dosing. METHODS:Busulfan concentration data, measured as part of regular care for allogeneic hematopoietic cell transplantation (HCT) patie...

journal_title：British journal of clinical pharmacology

authors： Langenhorst JB,Boss J,van Kesteren C,Lalmohamed A,Kuball J,Egberts ACG,Boelens JJ,Huitema ADR,van Maarseveen EM

更新日期：2020-08-01 00:00:00

abstract：:1 Self-poisoning with a selective weedkiller containing 2,4-D and mecoprop in a 39 year old man resulted in prolonged deep coma, pyrexia, hyperventilation, hypoxaemia, myotonia, skeletal muscle damage and electrocardiographic changes consistent with cardiomyopathy. 2 The admission plasma concentrations of 2,4-D and me...

journal_title：British journal of clinical pharmacology

authors： Prescott LF,Park J,Darrien I

更新日期：1979-01-01 00:00:00

abstract：AIMS:Voriconazole is a novel triazole with broad-spectrum antifungal activity. It is likely that some patients receiving voriconazole may also require treatment with the anticoagulant warfarin. Cytochrome P450 isoenzymes are important in the metabolism of both these drugs. This study investigated the effect of voricona...

journal_title：British journal of clinical pharmacology

authors： Purkins L,Wood N,Kleinermans D,Nichols D

更新日期：2003-12-01 00:00:00

abstract：:1 We have given fifteen healthy volunteers single doses of racemic (+/-)-propranolol orally (40 mg) and intravenously (5-10 mg) to find out how large the variation was of the ratio between (-)- and (+)-propranolol plasma levels in relation to that of total levels of propranolol and 4-hydroxypropranolol. 2 Total propra...

journal_title：British journal of clinical pharmacology

authors： Von Bahr C,Hermansson J,Tawara K

更新日期：1982-07-01 00:00:00

abstract：:The binding of disopyramide (DP) and mono-N-dealkyldisopyramide (MND) was measured by equilibrium dialysis in spiked whole blood (10 mumol l-1 DP or MND) from 50 patients having a serum concentration of alpha 1-acid glycoprotein (AAG) ranging from 0.40 to 3.14 g l-1, as well as in whole blood from five healthy subject...

journal_title：British journal of clinical pharmacology

authors： Bredesen JE,Kierulf P

更新日期：1986-09-01 00:00:00

abstract：AIMS:BG00010 is a protein in the glial cell line-derived neurotrophic factor (GDNF) family. It is a selective ligand for the GDNF family receptor alpha-3 (GFRα3) co-receptor that normalizes cellular changes resulting from damage or disease, and potentially alleviates neuropathic pain. The main objectives of this study ...

journal_title：British journal of clinical pharmacology

authors： Okkerse P,Hay JL,Versage E,Tang Y,Galluppi G,Ravina B,Verma A,Williams L,Aycardi E,Groeneveld GJ

更新日期：2016-07-01 00:00:00

abstract：AIMS:SNF472 is a calcification inhibitor being developed for the treatment of cardiovascular calcification in haemodialysis (HD) and in calciphylaxis patients. This study investigated the safety, tolerability and pharmacokinetics (PK) of intravenous (IV) SNF472 in healthy volunteers (HV) and HD patients. METHODS:This ...

journal_title：British journal of clinical pharmacology

authors： Perelló J,Joubert PH,Ferrer MD,Canals AZ,Sinha S,Salcedo C

更新日期：2018-12-01 00:00:00

abstract：AIMS:Ibandronate, a highly potent nitrogen-containing bisphosphonate, is the subject of an ongoing clinical development programme that aims to maximize the potential of simplified, less frequent oral and intravenous (i.v.) administration in osteoporosis. A modelling and simulation project was undertaken to characterize...

journal_title：British journal of clinical pharmacology

authors： Pillai G,Gieschke R,Goggin T,Jacqmin P,Schimmer RC,Steimer JL

更新日期：2004-12-01 00:00:00

abstract：AIMS:To assess the prevalence of potentially inappropriate medications (PIMs) use in a population of community-based multicompartment compliance aid (MCA) users in north-east Scotland. METHODS:Data for MCAs dispensed by 48 of the 50 community pharmacies in Aberdeen City between 1st June to 31st October 2014, together ...

journal_title：British journal of clinical pharmacology

authors： Counter D,Stewart D,MacLeod J,McLay JS

更新日期：2017-07-01 00:00:00

abstract：AIMS:The aim was to describe the utilization of antidiabetic agents, in terms of persistence and regimen change, in the management of a cohort of newly treated type 2 diabetes patients and to investigate associated socio-demographic and treatment factors. METHODS:A population-based retrospective cohort study was condu...

journal_title：British journal of clinical pharmacology

authors： Grimes RT,Bennett K,Tilson L,Usher C,Smith SM,Henman MC

更新日期：2015-06-01 00:00:00

abstract：AIMS:The objective of this study is to develop a generic model for tacrolimus pharmacokinetics modelling using a meta-analysis approach, that could serve as a first step towards a prediction tool to inform pharmacokinetics-based optimal dosing of tacrolimus in different populations and indications. METHODS:A systemati...

journal_title：British journal of clinical pharmacology

authors： Nanga TM,Doan TTP,Marquet P,Musuamba FT

更新日期：2019-12-01 00:00:00

abstract：:1 Six healthy male volunteers received a total of 2500 mg of a new cephalosporin antibiotic Ro13-9904 by intramuscular injection in five divided doses at intervals of 12 h. 2 No significant systemic side-effects were observed and this was confirmed haematologically and biochemically. 3 The drug was distributed followi...

journal_title：British journal of clinical pharmacology

authors： Pickup ME,Bird HA,Lowe JR,Lees L,Wright V

更新日期：1981-08-01 00:00:00

abstract：BACKGROUND:Benzodiazepines and "Z drugs" are often prescribed in residents of nursing homes (NH) despite their well-known deleterious effects. We aimed to investigate if a general intervention on quality of care led to discontinuation of benzodiazepine, and to examine which NH-related factors were associated in change ...

journal_title：British journal of clinical pharmacology

authors： de Souto Barreto P,Lapeyre-Mestre M,Cestac P,Vellas B,Rolland Y

更新日期：2016-04-01 00:00:00

abstract：:1. Double-blind controlled comparisons of nomifensine with placebo, imipramine, desipramine, viloxazine, nortriptyline, a combination of amitriptyline and chlordiazepoxide, and diazepam have been carried out in various parts of the world. 2. Dosage ranged from 50-225 mg daily, and treatment lasted from 2-26 weeks. 3. ...

journal_title：British journal of clinical pharmacology

authors： Habermann W

更新日期：1977-01-01 00:00:00

abstract：AIMS:The aims of the present study were to evaluate the pharmacokinetic properties of dihydroartemisinin (DHA) and piperaquine, potential drug-drug interactions with concomitant primaquine treatment, and piperaquine effects on the electrocardiogram in healthy volunteers. METHODS:The population pharmacokinetic properti...

journal_title：British journal of clinical pharmacology

authors： Chotsiri P,Wattanakul T,Hoglund RM,Hanboonkunupakarn B,Pukrittayakamee S,Blessborn D,Jittamala P,White NJ,Day NPJ,Tarning J

更新日期：2017-12-01 00:00:00

abstract：:1 The inotropic effect of penbutolol, a new beta-adrenergic receptor blocking drug, has been compared with that of propranolol in two similar groups of six subjects each. 2 Inotropic changes were assessed from changes in myocardial contractility index [LV dp-dt/11 T] as well as the slope of the regression line relatin...

journal_title：British journal of clinical pharmacology

authors： Sapru RP,Sharma PL

更新日期：1978-12-01 00:00:00

abstract：AIMS:To demonstrate the bioequivalence of macitentan/tadalafil fixed-dose combination (FDC) tablets with single-component tablets of macitentan and tadalafil in healthy subjects. METHODS:Studies AC-077-101 and AC-077-103 were single-centre, open-label, single-dose, 2-period, randomized, crossover Phase 1 studies condu...

journal_title：British journal of clinical pharmacology

authors： Grill S,Bruderer S,Sidharta PN,Antonova M,Globig S,Carlson J,Schultz A,Csonka D

更新日期：2020-12-01 00:00:00

abstract：:1. The oral kinetics of oxazepam after a single 15 mg oral dose was investigated in six healthy volunteers before and during concomitant administration of the beta-adrenoceptor antagonists propranolol (80 mg) and labetalol (200 mg) (racemates). 2. A possible pharmacodynamic interaction between oxazepam and the beta-ad...

journal_title：British journal of clinical pharmacology

authors： Sonne J,Døssing M,Loft S,Olesen KL,Vollmer-Larsen A,Victor MA,Hamberg O,Thyssen H

更新日期：1990-01-01 00:00:00

abstract：:Medroxalol, a new drug which has been reported to possess both alpha- and beta-adrenoceptor antagonist properties, was compared with labetalol in single dose studies in normotensive males. Oral doses of 400 mg of each drug significantly reduced blood pressure, both supine and erect, without significant changes in hear...

journal_title：British journal of clinical pharmacology

authors： Elliott HL,McLean K,Meredith PA,Sumner DJ,Reid JL

更新日期：1984-05-01 00:00:00

abstract：AIMS:It is estimated that two-thirds of cancer patients will at some point during their illness experience breakthrough pain. In this study, the pharmacokinetics of a novel sublingual dosage form of fentanyl developed for breakthrough pain was evaluated. METHODS:Eleven Caucasian patients (seven male and 4 female, aged...

journal_title：British journal of clinical pharmacology

authors： Lennernäs B,Hedner T,Holmberg M,Bredenberg S,Nyström C,Lennernäs H

更新日期：2005-02-01 00:00:00

abstract：AIMS:Vancomycin is an important antibiotic for critically ill patients with Gram-positive bacterial infections. Critically ill patients typically have severely altered pathophysiology, which leads to inefficacy or toxicity. Model-informed precision dosing may aid in optimizing the dose, but prospectively validated tool...

journal_title：British journal of clinical pharmacology

authors： Ter Heine R,Keizer RJ,van Steeg K,Smolders EJ,van Luin M,Derijks HJ,de Jager CPC,Frenzel T,Brüggemann R

更新日期：2020-12-01 00:00:00

abstract：:1. A questionnaire examining the use of, and knowledge about over-the-counter (OTC) drugs was administered verbally to representatives from 200 urban and 200 rural households. Self-medication was common in both groups but there were more drugs present in rural (336 items) than urban homes (231 items) with the differen...

journal_title：British journal of clinical pharmacology

authors： Stein CM,Gora NP,Macheka BM

更新日期：1989-06-01 00:00:00

abstract：:1. The pharmacokinetics of MTX and its 7-hydroxy metabolite (7-OHMTX) were investigated in nine patients with rheumatoid arthritis (RA). Each patient received 15 mg MTX i.v., i.m. and p.o. after an overnight fast in a randomized cross-over design. The plasma concentrations of MTX and 7-OHMTX were measured over 7 days ...

journal_title：British journal of clinical pharmacology

authors： Seideman P,Beck O,Eksborg S,Wennberg M

更新日期：1993-04-01 00:00:00

abstract：AIMS:To determine whether enzyme-inducing antiseizure drugs (ASDs) affect the risk of developing chronic obstructive pulmonary disease (COPD) or lung cancer in smokers. METHODS:Cases of COPD and lung cancer and matched controls without these conditions were identified from a population of smokers with ≥1 prescription ...

journal_title：British journal of clinical pharmacology

authors： Leuppi-Taegtmeyer AB,Reinau D,Yilmaz S,Rüegg S,Krähenbühl S,Jick SS,Leuppi JD,Meier CR

更新日期：2020-08-01 00:00:00