Short bed-continuous development thin-layer chromatography of glycosphingolipids.

abstract：:A synthetic analog of glucocerebroside, N-hexyl-O-glucosyl sphingosine, was found to inhibit the glucosidase in rat spleen that hydrolyzes glucocerebroside. At a concentration of 1 micro m, the analog inhibited the enzyme by 48%. The mode of action appeared to be competitive, probably aided by tight binding of the ami...

journal_title：Journal of lipid research

authors： Erickson JS,Radin NS

更新日期：1973-03-01 00:00:00

abstract：:Elevated serum levels of triglyceride-rich remnant lipoproteins (TRL) are a major risk factor predisposing a subject to atherosclerosis. Apolipoprotein C-III (apoC-III) is a major constituent of TRL that impedes triglyceride hydrolysis and remnant clearance and, as such, may exert pro-atherogenic activities. In the pr...

journal_title：Journal of lipid research

authors： Raspé E,Duez H,Mansén A,Fontaine C,Fiévet C,Fruchart JC,Vennström B,Staels B

更新日期：2002-12-01 00:00:00

abstract：:Atherogenic mixed dyslipidemia associates with oxidative stress and defective HDL antioxidative function in metabolic syndrome (MetS). The impact of statin treatment on the capacity of HDL to inactivate LDL-derived, redox-active phospholipid hydroperoxides (PCOOHs) in MetS is indeterminate. Insulin-resistant, hypertri...

journal_title：Journal of lipid research

authors： Orsoni A,Thérond P,Tan R,Giral P,Robillard P,Kontush A,Meikle PJ,Chapman MJ

更新日期：2016-11-01 00:00:00

abstract：:Lipidomics, the mass spectrometry-based comprehensive analysis of lipids, has attracted attention as an analytical approach to provide novel insight into lipid metabolism and to search for biomarkers. However, an ideal method for both comprehensive and quantitative analysis of lipids has not been fully developed. Here...

journal_title：Journal of lipid research

authors： Takeda H,Izumi Y,Takahashi M,Paxton T,Tamura S,Koike T,Yu Y,Kato N,Nagase K,Shiomi M,Bamba T

更新日期：2018-07-01 00:00:00

abstract：:Acyl-CoA:monoglyceride acyltransferase in microsomal preparations from the small intestine of the rat has been measured by means of continuous recording spectrophotometry. The reaction of 5,5'-dithiobis(2-nitrobenzoic acid) with CoA has been employed for this assay and optimal conditions for the reaction have been def...

journal_title：Journal of lipid research

authors： Rodgers JB Jr

更新日期：1969-07-01 00:00:00

abstract：:Lipid peroxidation is a common event in health and is greatly accelerated in pro-inflammatory settings such as hypercholesterolemia. Consequently, oxidation-specific epitopes are generated, which are pro-inflammatory and immunogenic, leading to both adaptive and innate responses. Because innate immune mechanisms use c...

journal_title：Journal of lipid research

authors： Hartvigsen K,Chou MY,Hansen LF,Shaw PX,Tsimikas S,Binder CJ,Witztum JL

更新日期：2009-04-01 00:00:00

abstract：:ABCG1 and ABCG4 are highly homologous members of the ATP binding cassette (ABC) transporter family that regulate cellular cholesterol homeostasis. In adult mice, ABCG1 is known to be expressed in numerous cell types and tissues, whereas ABCG4 expression is limited to the central nervous system (CNS). Here, we show sig...

journal_title：Journal of lipid research

authors： Bojanic DD,Tarr PT,Gale GD,Smith DJ,Bok D,Chen B,Nusinowitz S,Lövgren-Sandblom A,Björkhem I,Edwards PA

更新日期：2010-01-01 00:00:00

abstract：:A novel water-soluble polysaccharide fraction, CME-1, with a molecular mass of 27.6 kDa and containing mannose and galactose in a respective ratio of 4:6, was prepared from Cordyceps sinensis mycelia and identified by NMR and GC-MS. In the current study, we examined whether CME-1 has anti-inflammatory effects in RAW26...

journal_title：Journal of lipid research

authors： Wang SH,Yang WB,Liu YC,Chiu YH,Chen CT,Kao PF,Lin CM

更新日期：2011-03-01 00:00:00

abstract：:Despite a complete lack of microsomal triglyceride transfer protein (MTP), L35 rat hepatoma cells secrete triglyceride-containing lipoproteins, albeit at a rate 25% of that of parental FAO hepatoma cells, which express high levels of MTP. The inability to express MTP was associated with a complete block in the secreti...

journal_title：Journal of lipid research

authors： Hui TY,Olivier LM,Kang S,Davis RA

更新日期：2002-05-01 00:00:00

abstract：:High plasma cholesterol levels are found in several metabolic disorders and their reductions are advocated to reduce the risk of atherosclerosis. A way to lower plasma lipids is to curtail lipoprotein production; however, this is associated with steatosis. We previously showed that microRNA (miR)-30c lowers diet-induc...

journal_title：Journal of lipid research

authors： Irani S,Iqbal J,Antoni WJ,Ijaz L,Hussain MM

更新日期：2018-01-01 00:00:00

abstract：:In the chick, the large cholesteryl ester (CE) store present in the liver during the last period of embryonic life increases at hatching and is rapidly depleted after 2-7 days of postnatal life. In this study we asked whether these changes were associated with variations in the hepatic production of apoB-containing li...

journal_title：Journal of lipid research

authors： Tarugi P,Nicolini S,Marchi L,Ballarini G,Calandra S

更新日期：1994-11-01 00:00:00

abstract：:Using solid phase systems, the kinetics of binding of monoclonal antibody (LRB 45, IgG2b,kappa) to apoC-I and apoC-I on lipoproteins were investigated. At 25 degrees C, the association constant of LRB 45 antibody to apoC-I (3.56 X 10(6) M-1 X sec-1) was almost three times slower than the association constant LRB 45 an...

journal_title：Journal of lipid research

authors： Wong L

更新日期：1985-07-01 00:00:00

abstract：:An in vitro assay to study lipolysis of very low density lipoproteins (VLDL) by heparan sulfate proteoglycan (HSPG-bound lipoprotein lipase (LPL) was developed. Optimal conditions for VLDL lipolysis by HSPG-bound LPL were obtained by incubating plastic wells with 0.5 microg HSPG and 1.5 microg LPL, subsequently. Contr...

journal_title：Journal of lipid research

authors： de Man FH,de Beer F,van der Laarse A,Smelt AH,Havekes LM

更新日期：1997-12-01 00:00:00

abstract：:Human apolipoprotein (apo) E occurs as three common isoforms (apoE4, E3, and E2), all of which influence plasma cholesterol levels. Although both apoE4 and E3 bind with equal effectiveness to the low density lipoprotein receptor, they associate preferentially with different classes of plasma lipoproteins: apoE4 with v...

journal_title：Journal of lipid research

authors： Weisgraber KH

更新日期：1990-08-01 00:00:00

abstract：:Niacin, the first antidyslipidemic drug, has been at the center stage of lipid research for many decades before the discovery of statins. However, to date, despite its remarkable effects on lipid profiles, the clinical outcomes of niacin treatment on cardiac events is still debated. In addition to its historically wel...

journal_title：Journal of lipid research

authors： Romani M,Hofer DC,Katsyuba E,Auwerx J

更新日期：2019-04-01 00:00:00

abstract：:Five samples from three different types of 1500-year-old Mediterranean amphorae, as well as from a contemporary oil lamp found in the same deposit, were analyzed for the presence of lipid residues. Each sample of finely ground amphorae powder weighed 1-2 g. The abundance of interfering secondary products makes thin-la...

journal_title：Journal of lipid research

authors： Passi S,Rothschild-Boros MC,Fasella P,Nazzaro-Porro M,Whitehouse D

更新日期：1981-07-01 00:00:00

abstract：:Dysbetalipoproteinemia, an uncommon but highly atherogenic mixed hyperlipidemia due to the accumulation of remnants of triglyceride-rich lipoproteins, is characterized by cholesterol-enriched VLDL that migrates in the beta-position on agarose gels. The demonstration of a broad beta-band on agarose gel electrophoresis ...

journal_title：Journal of lipid research

authors： Blom DJ,Byrnes P,Jones S,Marais AD

更新日期：2003-01-01 00:00:00

abstract：:Vitamin A (VA) is stored in tissues predominantly as retinyl esters (REs), which provide substrate for the production of bioactive retinoids. Retinoic acid (RA), a principal metabolite, has been shown to induce postnatal lung development. To better understand lung RE storage, we compared VA (given as retinyl palmitate...

journal_title：Journal of lipid research

authors： Ross AC,Ambalavanan N,Zolfaghari R,Li NQ

更新日期：2006-08-01 00:00:00

abstract：:Boiled coffee contains an unidentified lipid that raises serum cholesterol. We studied the effects of the ingestion of coffee oil fractions of increasing purity in volunteers in order to identify the cholesterol-raising factor. In 15 volunteers who ingested 0.75 g/d of a non-triglyceride-fraction from coffee oil for 4...

journal_title：Journal of lipid research

authors： Weusten-Van der Wouw MP,Katan MB,Viani R,Huggett AC,Liardon R,Liardon R,Lund-Larsen PG,Thelle DS,Ahola I,Aro A

更新日期：1994-04-01 00:00:00

abstract：:3alpha-Hydroxy-5-cholanoic acid (lithocholic acid) and some unidentified acids (one of them perhaps 3-hydroxy-cholest-5-en-26-oic acid) have been detected in the brains of guinea pigs afflicted with experimental "allergic" encephalomyelitis. None of the acids could be identified in comparable amounts of brain tissue f...

journal_title：Journal of lipid research

authors： Naqvi SH,Herndon BL,Kelley MT,Bleisch V,Aexel RT,Nicholas HJ

更新日期：1969-01-01 00:00:00

abstract：:The hypothesis of lipid domains in cellular plasma membranes is well established. However, direct visualization of the domains has been difficult. Here we report direct visualization of plasma membrane cholesterol microdomains modulated by agents that affect cholesterol trafficking to and from the plasma membrane. The...

journal_title：Journal of lipid research

authors： Kruth HS,Ifrim I,Chang J,Addadi L,Perl-Treves D,Zhang WY

更新日期：2001-09-01 00:00:00

abstract：:Eubacterium sp. 144 dehydroxylated 16 alpha-hydroxy-progesterone; however, the expected intermediate, delta 16-progesterone, did not accumulate to significant concentrations in the culture medium. Moreover, the final end product of this biotransformation, 17 alpha-progesterone, was produced at a very slow rate. It was...

journal_title：Journal of lipid research

authors： Glass TL,Winter J,Bokkenheuser VD,Hylemon PB

更新日期：1982-02-01 00:00:00

abstract：:Human endothelial lipase (EL), a member of the triglyceride lipase gene family, has five potential N-linked glycosylation sites, two of which are conserved in both lipoprotein lipase and hepatic lipase. Reduction in molecular mass of EL after treatment with glycosidases and after treatment of EL-expressing cells with ...

journal_title：Journal of lipid research

authors： Miller GC,Long CJ,Bojilova ED,Marchadier D,Badellino KO,Blanchard N,Fuki IV,Glick JM,Rader DJ

更新日期：2004-11-01 00:00:00

abstract：:Trans-10,cis-12 conjugated linoleic acid (CLA) has previously been shown to be the CLA isomer responsible for CLA-induced reductions in body fat in animal models, and we have shown that this isomer, but not the cis-9,trans-11 CLA isomer, specifically decreased triglyceride (TG) accumulation in primary human adipocytes...

journal_title：Journal of lipid research

authors： Brown JM,Boysen MS,Jensen SS,Morrison RF,Storkson J,Lea-Currie R,Pariza M,Mandrup S,McIntosh MK

更新日期：2003-07-01 00:00:00

abstract：:Expression of constitutively activated Akt in the mammary glands of transgenic mice results in a delay in post-lactational involution. We now report precocious lipid accumulation in the alveolar epithelium of mouse mammary tumor virus-myr-Akt transgenic mice accompanied by a lactation defect that results in a 50% decr...

journal_title：Journal of lipid research

authors： Schwertfeger KL,McManaman JL,Palmer CA,Neville MC,Anderson SM

更新日期：2003-06-01 00:00:00

abstract：:Analyses have been made of glycosphingolipids from visceral organs and brain of a patient with an unusual lipid storage disorder diagnosed initially as classical Tay-Sachs disease. Levels of the lipids from fresh-frozen sections of gray and white matter, kidney, spleen, liver, and heart from this patient were compared...

journal_title：Journal of lipid research

authors： Snyder PD Jr,Krivit W,Sweeley CC

更新日期：1972-01-01 00:00:00

abstract：:Initiation of atherosclerosis is characterized by accumulation of aggregates of small lipid droplets and vesicles in the extracellular matrix of the arterial intima. The droplets and vesicles have features that suggest that they are formed from modified plasma-derived low density lipoprotein (LDL) particles. A variety...

journal_title：Journal of lipid research

authors： Oörni K,Pentikäinen MO,Ala-Korpela M,Kovanen PT

更新日期：2000-11-01 00:00:00

abstract：:To assess the possible role of altered hepatic processing of free fatty acids in dietary sucrose-induced accumulation of triglyceride in the liver and blood plasma, livers from rats fed commercial laboratory stock and high sucrose diets were perfused both with and without oleic acid substrate. Consumption of the sucro...

journal_title：Journal of lipid research

authors： Yamamoto M,Yamamoto I,Tanaka Y,Ontko JA

更新日期：1987-10-01 00:00:00

abstract：:The effect of fatty acids on secretion of triglyceride-rich lipoprotein (d less than 1.006 g/ml) by CaCo-2 cells was studied. Of the fatty acids studied, oleic acid (18:1) was the most potent stimulator of newly synthesized triglyceride secretion in triglyceride-rich lipoproteins followed in descending order by 18:2, ...

journal_title：Journal of lipid research

authors： Field FJ,Albright E,Mathur SN

更新日期：1988-11-01 00:00:00

abstract：:Cholesteryl ester storage disease (CESD) and Wolman disease (WD) are both autosomal recessive disorders associated with reduced activity and genetic defects of lysosomal acid lipase (LAL). The strikingly more severe course of WD is caused by genetic defects of LAL that leave no residual enzymatic activity. Mutations a...

journal_title：Journal of lipid research

authors： Ries S,Aslanidis C,Fehringer P,Carel JC,Gendrel D,Schmitz G

更新日期：1996-08-01 00:00:00