Abstract:
:Rat X rat hybridomas secreting monoclonal anti-idiotypic antibodies have been prepared from Hooded rats immunized with two tumour-reactive, syngeneic monoclonal antibodies 11/160 and M10/76 (specific, respectively, for the Hooded rat sarcomata HSN and MC24). The hybridomas were selected on the basis that the secreted antibodies competed with antigen for binding to the immunizing idiotype. One monoclonal anti-idiotype (HIM/1/230, gamma 2a isotype) that recognizes an antigen-binding site idiotope of antibody 11/160 has been found to substitute for antigen. Hooded rats vaccinated by three challenges with HIM/1/230 produce serum Ab3 that is indistinguishable in antigen specificity from the 11/160 Ab1, and show reduced tumour take following an i.v. challenge with 10(6) HSN cells. The response to vaccination with anti-idiotype was both qualitatively and quantitatively dependent on the mode of immunization. High titre 11/160-like Ab3 was generated only when the vaccine contained Freund's adjuvant, whereas resistance to tumour challenge was found only in animals vaccinated with anti-idiotype in the absence of adjuvant.
journal_name
Immunologyjournal_title
Immunologyauthors
Dunn PL,Johnson CA,Styles JM,Pease SS,Dean CJsubject
Has Abstractpub_date
1987-02-01 00:00:00pages
181-6issue
2eissn
0019-2805issn
1365-2567journal_volume
60pub_type
杂志文章相关文献
IMMUNOLOGY文献大全abstract::A sudden upsurge of fever cases with joint pain was observed in the outpatient department, Community Health Centre, Rangat during July-August 2010 in Rangat Middle Andaman, India. The aetiological agent responsible for the outbreak was identified as chikungunya virus (CHIKV), by using RT-PCR and IgM ELISA. The study i...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/imm.12128
更新日期:2013-10-01 00:00:00
abstract::Veiled cells (VC), isolated from the thoracic duct of irradiated lymphadenectomized mice (MLNX) or peritoneal macrophages (PM phi were incubated with isotope-labelled hen egg lysozyme (HEL), purified protein derivative (PPD) or keyhole limpet haemocyanin (KLH) in vitro. About 2-10 times less antigen was associated wit...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1989-11-01 00:00:00
abstract::Phagocytes such as dendritic cells (DC) and macrophages employ phagocytosis to take up pathogenic bacteria into phagosomes, digest the bacteria and present the bacteria-derived peptide antigens to the adaptive immunity. Hence, efficient antigen presentation depends greatly on a well-regulated phagocytosis process. Lip...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/imm.12051
更新日期:2013-05-01 00:00:00
abstract::Adrenaline is a catecholamine hormone secreted by the adrenal medulla in response to acute stress. Previous studies have shown that adrenaline suppresses the nitric oxide (NO) response of murine macrophages (M phi s) stimulated in vitro with lipopolysaccharide (LPS). We have now extended these studies to examine the e...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1046/j.1365-2567.2001.01332.x
更新日期:2001-12-01 00:00:00
abstract::The in vitro treatment with Fusarenon-X, a mycotoxin produced by Fusarium nivale Fn 2B, depressed the mitogenic responses of mouse lymphocytes to the T-cell mitogens, phytohaemagglutinin (PHA) and concanavalin A (Con A), but to a lesser extent to B-cell mitogen, a bacterial lypopolysaccharide (LPS). The in vitro treat...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1982-04-01 00:00:00
abstract::It is becoming increasingly clear that the T-cell-mediated immune response is important in many diseases. In this study, we used concanavalin A (Con A) -induced hepatitis to investigate the role of CD49a in the molecular and cellular mechanism of the T-cell-mediated immune response. We found that CD49a(-/-) mice had s...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/imm.12201
更新日期:2014-03-01 00:00:00
abstract::The induction of proliferation of murine splenocytes by lipopolysaccharide (LPS) of Shigella dysenteriae type 1 and its polysaccharide (PS) and lipid A fractions was investigated. The LPS-induced proliferation reached a maximum at a concentration of 30 ng/ml. The PS and lipid A induced proliferation of murine splenocy...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1995-02-01 00:00:00
abstract::Haemolytic assays were used to compare alternative and classical complement (C) pathway activities in sera obtained from neonatal pigs reared on porcine colostrum, bovine colostrum or an immunoglobulin-free synthetic diet. Dramatic increases in immunoglobulin concentrations were noted in the colostrum-fed animals duri...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1980-09-01 00:00:00
abstract::Thymocytes incubated with either ATP or GTP exhibit a brief period of enhanced DNA synthesis in contrast to the prolonged period of enhanced synthesis observed when thymocytes were incubated with concanavalin A. The cells responding to nucleotides represent a sub-population of theta antigen-bearing T cells comprising ...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1981-03-01 00:00:00
abstract::The sensitivity of host (circulating) forms of T. cruzi to cell-mediated immunological destruction and requirements for the reaction were examined. Both human and mouse leucocytes were found to kill significant numbers of parasites in the presence of specific antibodies against the flagellates. Antibody involvement wa...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1980-05-01 00:00:00
abstract::The intestinal epithelium is rich in γδ T cells and the gut is a site of residence for a wide variety of pathogens, including nematodes. Although CD4+ T-cell receptor (TCR) -αβ+ T helper type 2 T cells are essential for the expulsion of intestinal nematodes, little information is available on the function of γδ T cell...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2011.03503.x
更新日期:2011-12-01 00:00:00
abstract::It has been reported previously that environmental antigens such as intestinal microflora play an important role in an age-associated increase in number of T-cell receptor gamma/delta-bearing T cells. To extend the scope of this finding, this study examined the influences of local inflammation on the accumulation and/...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1990-05-01 00:00:00
abstract::It is now well accepted that sex hormones have immunoregulatory activity and may prevent exacerbations in multiple sclerosis during pregnancy. Our previous studies demonstrated that oestrogen (17β-oestradiol; E(2) ) protection against experimental autoimmune encephalomyelitis (EAE) is mediated mainly through oestrogen...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/imm.12013
更新日期:2012-12-01 00:00:00
abstract::Previous studies have shown that depletion of Langerhans' cells (LC) from murine epidermis by the superantigen, staphylococcal enterotoxin A (SEA) involves interleukin-1alpha (IL-1alpha) and is inhibitable by agents that block G-protein-associated kinases. The purpose of this study was to determine whether specific ki...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1046/j.1365-2567.1999.00680.x
更新日期:1999-02-01 00:00:00
abstract::Fc-gamma receptor III (Fc gamma RIII, CD16) type A is expressed on natural killer cells, on a small subset of peripheral blood monocytes and on mature macrophages. Along with differentiation into macrophages, monocytes will express Fc gamma RIII when cultured with transforming growth factor-beta (TGF-beta). In view of...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1996-01-01 00:00:00
abstract::Marginal zone (MZ) B cells are positioned within the spleen to capture blood-borne antigen and immune complexes and deliver them to follicular dendritic cells in the B-cell follicles. We show that within the spleens of aged mice antigen capture by MZ B cells, and their ability to shuttle between the follicle and MZ, w...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/imm.12737
更新日期:2017-07-01 00:00:00
abstract::The uptake by human blood monocytes of sheep erythrocytes treated with rabbit anti-sheep antibody with or without mouse complement was assessed by a radioactive method to discover whether immune complexes would inhibit this reaction. It was found that sera from SLE patients inhibited uptake whereas normal sera enhance...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1977-07-01 00:00:00
abstract::We produced three murine monoclonal antibodies (mAb) directed against the human T-cell differentiation antigen CD2 (formerly T11) and analysed their epitope specificity by E-rosette inhibition, cross-blocking and proliferation-induction experiments. When added together, two mAb (both IgG1 kappa) were able to induce pr...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1989-07-01 00:00:00
abstract::Cutaneous delayed hypersensitivity reactions to collagen in guinea-pigs were partially but specifically suppressed if the animals had been pretreated with collagen and Freund's incomplete adjuvant. Such animals responded normally to skin-reactive factor prepared with ovalbumin. Lymphoid cells from animals with normal ...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1976-07-01 00:00:00
abstract::Immunoglobulin G4 (IgG4) antibodies have been known for some time to be functionally monovalent. Recently, the structural basis for this monovalency has been elucidated: the in vivo exchange of IgG half-molecules (one H-plus one L-chain) among IgG4. This process results in bispecific antibodies that in most situations...
journal_title:Immunology
pub_type: 杂志文章,评审
doi:10.1046/j.0019-2805.2001.01341.x
更新日期:2002-01-01 00:00:00
abstract::The concentration of CXCL12/SDF-1 in the bloodstream is tightly regulated, given its central role in leucocyte and stem/progenitor cell egress from bone marrow and recruitment to sites of inflammation or injury. The mechanism responsible for this regulation is unknown. Here we show that both genetic deletion and pharm...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/imm.12176
更新日期:2014-01-01 00:00:00
abstract::The concept of immunological tolerance--the state of specific unresponsiveness to allogeneic transplants and all manner of other antigens--began in 1945 with R.D. Owen's finding that cattle dizygotic twins are red blood cell chimeras. Peter Medawar's group in Birmingham likewise discovered, quite independently, that c...
journal_title:Immunology
pub_type: 历史文章,杂志文章,评审
doi:10.1111/imm.12567
更新日期:2016-03-01 00:00:00
abstract::Mice were primed with TNP-derivatized insulin, or TNP-Mycobacteria, and lymph node cells were challenged in vitro with haptenated and unhaptenated antigens. Using either priming antigen, T-cell proliferative responses could be obtained to TNP-insulin. In B10 (H-2b), mice, which are responders to beef insulin (BI), but...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
abstract::The immunophenotypes of the HLA-DR-positive leucocyte populations in normal human skin were studied using an extensive panel of monoclonal antibodies, which included antibodies from the Third International Leucocyte Differentiation Antigen Workshop (3rd LDAW). Langerhans' cells (LC) in the epidermis stained with antib...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1988-12-01 00:00:00
abstract::Guinea-pig mitogenic factor(s) were found capable of stimulating both normal T and B cells. Preliminary physicochemical characterization could not dissociate the mitogenic factors for respective cell populations. Furthermore, both immune T and B cells could produce mitogenic factors upon stimulation with antigen in co...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1981-02-01 00:00:00
abstract::Purified pertussis toxin (PPT) is a potent mitogen for human T lymphocytes and is shown to cause rapid calcium mobilization in resting T cells, a T-cell line and CD3- lymphocytes with natural killer (NK) activity. In resting T cells the PPT activation is associated with cytoplasmic alkalinization. A similar rise in in...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1988-07-01 00:00:00
abstract::Although it is known that dendritic cells (DC) migrate in response to inflammatory stimuli. There is little information about the expression of receptors for chemotactic factors on DC. The present study has demonstrated by double immunostaining and flow cytometry of Langerhan's cell (LC)-enriched epidermal cell suspen...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1046/j.1365-2567.1996.d01-701.x
更新日期:1996-09-01 00:00:00
abstract::A 185,000 MW glycoprotein antigen derived from Streptococcus mutans was digested with subtilisin. Purification by reversed phase high-powered liquid chromatography (HPLC) resulted in a homogeneous 20,000 MW protein which possesses the streptococcal antigen (SA) I and II determinants. This protein was immunogenic in mi...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1989-02-01 00:00:00
abstract::Immune synapse formation is critical for T lymphocyte activation, and mitochondria have a role in this process, by localizing close to the immune synapse, regulating intracellular calcium concentration, and providing locally required ATP. The interaction between antigen presenting cells (APCs) and T lymphocytes is a t...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/imm.12392
更新日期:2014-09-23 00:00:00
abstract::The expression of Fc mu receptors was investigated using spleen cells from (LOU/M/Wsl X CFY) F1 rats bearing the IR202 tumour, an IgM-producing immunocytoma. It was found that the progressively growing solid tumour was accompanied by an extraordinary expansion of host splenocytes with Fc mu receptors. These cells were...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1987-07-01 00:00:00