[The pharmacokinetics of doxorubicin].

abstract：:Meconium ileus equivalent (MIE) complicating cystic fibrosis of the pancreas (CF) increases in frequently with increasing age of patients. In the present paper the course of 11 children and adolescents with MIE diagnosed and treated at the University Dept. of Paediatrics in Zürich during the last 15 years, i.e. 9% of ...

journal_title：Klinische Padiatrie

authors： Rosenberg E,Shmerling DH

更新日期：1983-09-01 00:00:00

abstract：BACKGROUND:Acute viral bronchiolitis is a frequent disease in infancy. There is little knowledge on medical care of severely affected infants in different European countries. PATIENTS:Infants (n=146) with bronchiolitis requiring respiratory support in winter season 2015/2016 treated in either one of two regions in Cen...

journal_title：Klinische Padiatrie

authors： Dohna-Schwake C,Mücher K,Stehling F,Rothoeft T,Roll C,Brevis Nuńez F,Seiffert P,Heister P,Hofmann M,Stein A,Jacobs A,Zuzak T,Durand P,Felderhoff-Müser U,Tissières P

更新日期：2018-09-01 00:00:00

abstract：:Since reliable diagnosis of cystic fibrosis (CF) is still difficult, the occurrence of serum markers CA 19-9, CA 50 and elastase 1 was analysed. Serum levels of CA 19-9, CA 50, CA 125 and elastase 1 were estimated in 54 CF patients as well as in a control group of 66 children of similar age suffering from various othe...

journal_title：Klinische Padiatrie

authors： Uhlenbruck G,Scheuring U,Dienst C,Kaiser D,Roth B,Skopnik H

更新日期：1988-03-01 00:00:00

abstract：:Mycobacterial infections are rarely reported in Cystic Fibrosis patients although they quite often develop predisposing risk factors such as underweight, secondary diabetes mellitus and chronic inflammatory pulmonary disease. Furthermore glucocorticoid therapy is mandatory in some patients. CF heterozygotes are said t...

journal_title：Klinische Padiatrie

authors： Friedrichs F,Kusenbach G,Skopnik H

更新日期：1991-09-01 00:00:00

abstract：:From 1975-1986 6 boys with congenital nephrogenic diabetes insipidus were diagnosed at the age of 3 months to 10 years. Symptoms appeared within the first few weeks of life. The diagnosis was confirmed by polyuria, low urinary osmolality (97-225 mosm/kg H20), hypernatraemia (max. 171 mmol/l) and the missing response t...

journal_title：Klinische Padiatrie

authors： Kaulitz R,Brodehl J

更新日期：1989-11-01 00:00:00

abstract：BACKGROUND:Vaccination with 2 doses of > 95% of the population is necessary to eliminate measles. In Switzerland and especially in the central part, vaccine coverage is low (2006: 65%). This led 2006-2009 to a measles epidemic with thousands of cases and high costs. One death was noted in a formerly healthy 12 year old...

journal_title：Klinische Padiatrie

authors： Donas A,Marty-Nussbaumer A,Roost HP,Neuhaus TJ

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Most recent studies analyzing candidate biological prognostic factors in childhood medulloblastoma (MB) are limited by small patient numbers due to dependence on fresh-frozen tumor material. By contrast, large archives of formalin-fixed, paraffin-embedded MB samples exist from homogeneously treated patients....

journal_title：Klinische Padiatrie

authors： Grotzer MA,von Hoff K,von Bueren AO,Shalaby T,Hartmann W,Warmuth-Metz M,Emser A,Kortmann RD,Kuehl J,Pietsch T,Rutkowski S

更新日期：2007-11-01 00:00:00

abstract：:Since 1962, desferrioxamine (deferoxamine, DFO) has been utilized for the treatment of secondary hemosiderosis. For about 30 years, DFO therapy has been performed as nightly continuous subcutaneous infusion. About 20 years ago, the first oral iron chelator (deferiprone, DFP) was presented. Concerns about potential sid...

journal_title：Klinische Padiatrie

authors： Cario H,Janka-Schaub G,Janssen G,Jarisch A,Strauss G,Kohne E

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:The prevalence of asthma and overweight/obesity in children and adolescents is continuously increasing over the last decades. It remains unclear if overweight/obesity raises the risk of developing asthma or if an uncontrolled asthma increases the risk of developing overweight/obesity by restricting physical ...

journal_title：Klinische Padiatrie

authors： Schmauck-Gómez JS,Menrath I,Kaiser MM,Herz A,Kopp MV

更新日期：2016-07-01 00:00:00

abstract：:The selective uptake and accumulation of 131J-Metaiodobenzylguanidine in neuroblastoma cells in vivo may be utilized for targeted irradiation. The experience with 32 neuroblastoma patients refractory to conventional high dose chemotherapy is reported. At diagnosis 8 patients had Evans stage III and 22 stage IV. 11/32 ...

journal_title：Klinische Padiatrie

authors： Berthold F,Feine U,Fischer M,Gerein V,Klingebiel T,Maul FD,Waters W,Wehinger H,Treuner J

更新日期：1988-05-01 00:00:00

abstract：:Scoring systems for evaluation of the degree of severity in patients with cystic fibrosis are critically evaluated. Cross-sectional comparison of Shwachman's score, Cooperman's score, Taussig-NIH score, Bernese score and Huang score reveals that advantages and disadvantages of each score exist. In early days used as a...

journal_title：Klinische Padiatrie

authors： Schöni MH

更新日期：1993-01-01 00:00:00

abstract：:Since 1987, the authors have examined 186 patients (76 girls, 110 boys) with a variety of congenital and acquired heart diseases by means of magnetic resonance imaging (MRI). The patients' ages ranged from 2 days to 20 years (mean age 3.97 years). During the study new techniques were developed, which extend the applic...

journal_title：Klinische Padiatrie

authors： Sieverding L,Jung WI,Fleiter TH,Klose U,Steil E,Hassberg D,Rosendahl W

更新日期：1992-09-01 00:00:00

abstract：:Easier access to prenatal diagnostic procedures led to its widespread use as a screening measure. Hence, today it is more common for life-limiting illnesses to be diagnosed during fetal life. The concept of Advance Care Planning (ACP) provides a framework for caregivers, families and their multidisciplinary teams to a...

journal_title：Klinische Padiatrie

authors： Garten L,von der Hude K,Strahleck T,Krones T

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Transumbilical laparoscopic-assisted appendectomy (TULAA) is fast and cost-effective since no endoloops, staplers or wound protection devices are used. We analyzed the effects of TULAA as first approach for perforated (PA) and non-perforated (NPA) appendicitis in children. PATIENTS:We performed a retrospect...

journal_title：Klinische Padiatrie

authors： Dübbers M,Nikolaou E,Fuchs H,Fischer J,Alakus H,Leers J,Bruns C,Cernaianu G

更新日期：2018-07-01 00:00:00

abstract：:Initially a right sided pulmonary hypoplasia was diagnosed in our patient at the age of 9 years. The previous years were characterized by recurrent pneumonia, bronchitis and daily coughing fits. Findings of the chest radiograph suggested the diagnosis of right sided hypoplasia. The right hemithorax was small with medi...

journal_title：Klinische Padiatrie

authors： Riedler J,Rettenbacher L,Weiss P

更新日期：1990-03-01 00:00:00

abstract：:We have performed in situ hybridization (ISH) studies predominantly on paraffin sections and on isolated nuclei of 22 pediatric germ cell tumors (GCTs) from 18 patients including 4 recurrences from three patients. In addition, we performed conventional cytogenetic analyses in three tumor samples. Because reports on cy...

journal_title：Klinische Padiatrie

authors： Stock C,Ambros IM,Strehl S,Zoubek A,Fink FM,Gadner H,Ambros PF

更新日期：1995-07-01 00:00:00

abstract：:A case of true hermaphroditism was described. The patient had an uterus, a fallopian tube, a testide on the left in the position of the ovary and an ovary on the right side. The chromosome picture corresponded to a 47, XXY/46, XX/46 XXY mosaic. The phenotype of the patient was male so the decision for male sex seemed ...

journal_title：Klinische Padiatrie

authors： Barta L,Konyar E,Regöly-Merei A,Toth J

更新日期：1976-09-01 00:00:00

abstract：:Immunocompromised patients in pediatric hematology-oncology are faced with an increased risk of nosocomial infections (NI). The incidence of NI and the contribution of certain risk factors have not sufficiently been investigated in this population. It is therefore unknown how many NI are preventable through infection ...

journal_title：Klinische Padiatrie

authors： Simon A,Fleischhack G

更新日期：2001-09-01 00:00:00

abstract：:15 parameters of coagulation and fibrinolysis were investigated in 38 children with type I diabetes mellitus without clinical signs of diabetic angiopathy. Compared to an age matched non diabetic control group spontaneous platelet aggregation was enhanced, plasma levels for factor VIII C, von Willebrand factor, antith...

journal_title：Klinische Padiatrie

authors： Koert M,Nowak-Göttl U,Kreuz W,Grüttner HP,Kornhuber B,Breddin HK

更新日期：1991-11-01 00:00:00

abstract：:In children with primary immunodeficiencies, the onset of symptoms precedes the diagnosis and the initiation of appropriate treatment by months or years. This delay in diagnosis is due to the fact that while these disorders are rare, some of the infections seen in immunodeficient patients are common. Defective antibod...

journal_title：Klinische Padiatrie

authors： Vancikova Z,Freiberger T,Vach W,Trojanek M,Rizzi M,Janda A

更新日期：2013-11-01 00:00:00

abstract：:In 37 children with extrahepatic biliary atresia between 12 days in 9 years of age we performed 72 duplexsonographic examinations of the portal system and the hepatic artery. In the control group we investigated 61 healthy children. All investigations were performed with computer sonography (Acuson 128) with a 3.5 MHz...

journal_title：Klinische Padiatrie

authors： Grunert D,Stier B,Schöning M

更新日期：1990-01-01 00:00:00

abstract：:Corticosteroids for treatment or prevention of pulmonary disease are milestones in the management of preterm infants nowadays. Prenatal maternal administration as well as postnatal treatment of the mechanically ventilated preterm infant with bronchopulmonary dysplasia (BPD) are considered to be established concepts. H...

journal_title：Klinische Padiatrie

authors： Krause M

更新日期：1997-09-01 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is a rare malignant tumor arising from epithelial cells of the nasopharynx. Its incidence is highest in Southeast Asia. Age distribution of NPC is bimodal, with one peak in young adolescents and another in patients 55-59 years of age. EBV appears to be the primary etiologic agent in the ...

journal_title：Klinische Padiatrie

authors： Kontny U,Franzen S,Behrends U,Bührlen M,Christiansen H,Delecluse H,Eble M,Feuchtinger T,Gademann G,Granzen B,Kratz CP,Lassay L,Leuschner I,Mottaghy FM,Schmitt C,Staatz G,Timmermann B,Vorwerk P,Wilop S,Wolff HA,Mer

更新日期：2016-04-01 00:00:00

abstract：:In Germany, about 1,800 new cases of childhood cancer are diagnosed every year. The chances of survival have increased significantly over the last 40 years due to the continuous improvement of treatment strategies. The number of childhood cancer survivors in Germany thus ranges around 30,000 nowadays. But their treatm...

journal_title：Klinische Padiatrie

authors： Kock AK,Kaya RS,Müller C,Andersen B,Langer T,Ingenerf J

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:The aim of most of the trials of the Competence Network Malignant Lymphoma is to optimize the standard treatment of lymphoma using only registered drugs in the case of medicinal therapies (quality assurance protocols). In contrast to regulatory trials, special regulations for quality assurance protocols are ...

journal_title：Klinische Padiatrie

authors： Pfistner B,Mehl C,Klöss M,Löffler M,Herrmann-Frank A,Diehl V

更新日期：2003-11-01 00:00:00

abstract：BACKGROUND:Owing to twenty years of multicentric interdisciplinary cooperation, the COSS group has been able to collect data on a large group of osteosarcoma patients treated by neoadjuvant therapy. This paper reviews results achieved in patients with localized extremity tumors. PATIENTS AND METHODS: INCLUSION CRITER...

journal_title：Klinische Padiatrie

authors： Bielack S,Kempf-Bielack B,Schwenzer D,Birkfellner T,Delling G,Ewerbeck V,Exner GU,Fuchs N,Göbel U,Graf N,Heise U,Helmke K,von Hochstetter AR,Jürgens H,Maas R,Münchow N,Salzer-Kuntschik M,Treuner J,Veltmann U,Werner

更新日期：1999-07-01 00:00:00

abstract：:Human growth hormone was given to 6 boys with constitutional delay of growth and development. Three patients had normal growth hormone responses following exercise or insulin-induced hypoglycemia. Subnormal growth rate (less than 2 SD below normal for bone age) was found in 4 patients. The mean growth rate of the pati...

journal_title：Klinische Padiatrie

authors： Butenandt O

更新日期：1984-03-01 00:00:00

abstract：:Inherited disorders of platelets constitute a group of rare diseases that give rise to bleeding syndromes of variety severity, with more severe cases being first diagnosed during infancy and childhood. To appropriate diagnose a platelet function disorder during early childhood the knowledge of the physiological charac...

journal_title：Klinische Padiatrie

authors： Schlegel N,Bardet V,Kenet G,Muntean W,Zieger B,Nowak-Göttl U,Working Group on Standardisation in Perinatal and Pediatric Hemostasis.

更新日期：2010-05-01 00:00:00

abstract：:More than 40 years ago, Toxocara ssp. was identified as the cause of larva migrans visceralis and ocular larva migrans, which mainly affect infants and children. Although widespread in most parts of the world, the parasitic disease is rarely diagnosed in Germany. Focusing on clinical and pathophysiological similaritie...

journal_title：Klinische Padiatrie

authors： Hohenschild S

更新日期：1998-05-01 00:00:00

abstract：:The therapy of complicated Kaposiform hemangioendothelioma (KHE) is still difficult. We present the first case of laryngomalacia with simultaneous mammalian target of Rapamycin (mTOR)-positive KHE of the neck and thoracic inlet and concurrent Kasabach-Meritt Phenomenon (KMP) in an 11-month-old boy suffering life-threa...

journal_title：Klinische Padiatrie

authors： Schroeder U,Lauten M,Stichtenoth G,Gebhard MP,Buchholz M,Kaiser MM

更新日期：2014-11-01 00:00:00