Abstract:
:Spontaneous retinal degeneration of Celestial goldfish was studied histologically and electrophysiologically. Retinal degeneration was divided into three stages. Until the age of 75 days (Stage 0) the retina showed normal histological development and the electroretinograms (ERGs) exhibited dominant b-waves similar to those of adult common goldfish. By the age of 105 days (Stage 1), when the eyeballs began to protrude laterally, histological changes were first observed in the retinal pigment epithelium and photoreceptor layer. The b-wave amplitude decreased to 52% of that of Stage 0 with a prolongation of the peak latency. By the age of 135 days (Stage 2), when eyeballs protruded further anterodorsally, the retinal degeneration extended to the entire retinal layers and no b-waves were detected. The deterioration of the b-wave amplitude was closely correlated to the histological findings of retinal degeneration. The Celestial goldfish is considered to be a new model of hereditary retinal degeneration.
journal_name
Jpn J Ophthalmoljournal_title
Japanese journal of ophthalmologyauthors
Sakaue H,Negi A,Matsumura M,Ohkuma M,Honda Ysubject
Has Abstractpub_date
1987-01-01 00:00:00pages
109-13issue
1eissn
0021-5155issn
1613-2246journal_volume
31pub_type
杂志文章abstract::We studied family members of 9 patients with falciform retinal fold, and found a number of cases showing features of familial exudative vitreoretinopathy (FEVR) in the fundi. Retinal fold was also seen in the eye of a cousin of the propositus. Three cases with falciform retinal fold were bilateral and 7 cases were uni...
journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章
doi:
更新日期:1983-01-01 00:00:00
abstract:PURPOSE:To evaluate the relationship between visual disability and visual scores in patients with retinitis pigmentosa. METHODS:The relationship between visual disability and visual scores (visual acuity and visual field) was investigated in 93 patients with retinitis pigmentosa. The visual disability of each patient ...
journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0021-5155(99)00171-9
更新日期:2000-01-01 00:00:00
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journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章
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journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1007/s10384-019-00692-5
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abstract::The effects of three sulfhydryl agents on the cytoskeletal systems of cultured human trabecular cells were examined by the immunofluorescence method. Incubation with iodoacetamide or N-ethyl maleimide (10(-6) M, 10(-5) M, and 10(-4) M) caused a marked alteration on the actin and microtubule organization, but had littl...
journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
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journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0021-5155(01)00393-8
更新日期:2001-09-01 00:00:00
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journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章
doi:
更新日期:1982-01-01 00:00:00
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journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1007/s10384-016-0462-0
更新日期:2016-09-01 00:00:00
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journal_title:Japanese journal of ophthalmology
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journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章
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journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
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journal_title:Japanese journal of ophthalmology
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doi:
更新日期:1989-01-01 00:00:00
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journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章
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journal_title:Japanese journal of ophthalmology
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doi:
更新日期:1995-01-01 00:00:00
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journal_title:Japanese journal of ophthalmology
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doi:10.1016/s0021-5155(99)00017-9
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journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章
doi:10.1007/s10384-007-0455-0
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journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章
doi:
更新日期:1983-01-01 00:00:00
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journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章
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journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章
doi:
更新日期:1996-01-01 00:00:00
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journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章
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更新日期:1998-09-01 00:00:00
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pub_type: 杂志文章
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journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章
doi:
更新日期:1988-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-07-01 00:00:00
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journal_title:Japanese journal of ophthalmology
pub_type: 杂志文章
doi:
更新日期:1987-01-01 00:00:00