Abstract：
:A retrospective review of Mayo Clinic records through 1983 revealed 84 patients (24 male and 10 female; mean age, 41 years) with the diagnosis of pulmonary alveolar phospholipoproteinosis. The major clinical features were dyspnea, cough, fever, and chest pain. Chest roentgenograms usually showed bilateral symmetric alveolar infiltrates, but asymmetric, unilateral, and chronic patchy patterns were also noted. Diagnosis was established by thoracotomy-lung biopsy in 26 patients. Histologic analysis revealed uniform filling of the alveoli by periodic acid-Schiff-positive material and maintenance of normal alveolar architecture. Electron microscopy showed enlarged alveolar macrophages with lamellar osmiophilic inclusions, dense granules, and myeloid bodies. Of the 21 patients who underwent therapeutic bronchoalveolar lavage, 13 had no recurrence of the disease during a mean follow-up of 8.8 years. In patients who underwent pulmonary function testing both before and after lavage, significant restrictive dysfunctions present before the procedure were alleviated afterward. Three deaths occurred among the 34 patients. Pulmonary alveolar phospholipoproteinosis may result from defective clearance of phospholipids by the alveolar macrophages, excessive production of phospholipids by type II pneumocytes, or both. It is likely a nonspecific response to a variety of injuries to the alveolar macrophage or type II pneumocyte or both, including exposure to certain dusts and chemicals and occurrence of hematologic diseases or infections. The uncommon occurrence of this disorder suggests individual susceptibility.
journal_name
Mayo Clin Procjournal_title
Mayo Clinic proceedingsauthors
Prakash UB,Barham SS,Carpenter HA,Dines DE,Marsh HMdoi
10.1016/s0025-6196(12)65477-9subject
Has Abstractpub_date
1987-06-01 00:00:00pages
499-518issue
6eissn
0025-6196issn
1942-5546pii
S0025-6196(12)65477-9journal_volume
62pub_type
杂志文章,评审abstract：:Unintentional intra-arterial injection of medication, either iatrogenic or self-administered, is a source of considerable morbidity. Normal vascular anatomical proximity, aberrant vasculature, procedurally difficult situations, and medical personnel error all contribute to unintentional cannulation of arteries in an a...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章,评审
doi：10.1016/S0025-6196(11)61533-4
更新日期：2005-06-01 00:00:00
abstract：OBJECTIVE:To derive risk models for percutaneous coronary intervention (PCI) outcomes from clinical and laboratory variables available before the procedure so they can be used for preprocedure risk stratification. PATIENTS AND METHODS:Using the Mayo Clinic registry, we analyzed 9035 PCIs on 7640 unique patients from J...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.4065/82.6.701
更新日期：2007-06-01 00:00:00
abstract：:Many types of psychotherapeutic drugs (especially antidepressants) directly and indirectly interact with neurotransmitter receptors, the recognition sites for the chemical messengers released by neurons. These interactions can result in increased or decreased sensitivity of certain receptors. Hypotheses exist to expla...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：
更新日期：1982-09-01 00:00:00
abstract：:Crohn's disease can involve any portion of the digestive tract, but isolated gastric Crohn's disease is a rare entity. In the few previously reported cases, the inflammatory disorder has involved only a portion of the stomach. Herein we describe a patient with diffuse involvement of the entire stomach and an associate...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.1016/s0025-6196(12)61750-9
更新日期：1989-07-01 00:00:00
abstract：:Traditional treatments for men with localized prostate cancer have included both surgical removal and radiation therapy, with their potential adverse effects on patient quality of life. Thus, there has been increasing interest in the development of minimally invasive procedures that use various technologies to deliver...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章,评审
doi：10.4065/79.12.1547
更新日期：2004-12-01 00:00:00
abstract：OBJECTIVE:To determine whether a simple clinical score, which was shown previously to predict the likelihood of severe coronary artery disease (CAD) in patients referred for coronary angiography, could predict prognosis in a separate cohort of patients with normal or mildly abnormal findings on their resting electrocar...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.4065/77.6.515
更新日期：2002-06-01 00:00:00
abstract：OBJECTIVE:To investigate an association between tumor necrosis factors-alpha (TNFα) inhibitors or other immunosuppressants and the development of uveal and cutaneous melanoma. PATIENTS AND METHODS:We performed a retrospective incidence and case-control analysis of patients in Olmsted County, MN, who were diagnosed wit...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.1016/j.mayocp.2018.11.033
更新日期：2019-07-01 00:00:00
abstract：OBJECTIVE:To compare health care usage between suicide decedents and living controls in the year before suicide in a large representative US population. PATIENTS AND METHODS:Cases (n=1221) and controls (n=3663) belonged to an integrated health care system from January 1, 2009, through December 31, 2014. Cases and cont...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.1016/j.mayocp.2019.04.037
更新日期：2019-10-01 00:00:00
abstract：OBJECTIVE:To evaluate the association of coronary artery calcium (CAC) and coronary heart disease (CHD) events among young and elderly individuals. PARTICIPANTS AND METHODS:This is a secondary analysis of data from a prospective, multiethnic, population-based cohort study designed to study subclinical atherosclerosis....
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章,多中心研究
doi：10.1016/j.mayocp.2014.05.017
更新日期：2014-10-01 00:00:00
abstract：:Breast reconstruction immediately after mastectomy is being used with increasing frequency. In a study of the first 100 consecutive patients at our institution who underwent this procedure, with (21 patients) or without (79 patients) later nipple reconstruction, 85% responded affirmatively on a follow-up questionnaire...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.1016/s0025-6196(12)62440-9
更新日期：1987-03-01 00:00:00
abstract：OBJECTIVE:To examine patterns of the incidence of diabetes, hypertension, and mortality by single units of body mass index (BMI) and 5-year age groups using longitudinal data from middle-aged and older women. PATIENTS AND METHODS:Middle-aged (born between 1946 and 1951; N = 13,715) and older (born between 1921 and 192...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章,多中心研究
doi：10.1016/j.mayocp.2015.04.006
更新日期：2015-07-01 00:00:00
abstract：:Giant cell arteritis and polymyalgia rheumatica were described separately more than 100 years ago. However, the original reports of both conditions were neglected for many years. After the article by Horton et al on giant cell arteritis in the 1930s and studies published by others in the 1940s, giant cell arteritis be...
journal_title：Mayo Clinic proceedings
pub_type： 历史文章,杂志文章
doi：10.4065/81.8.1071
更新日期：2006-08-01 00:00:00
abstract：OBJECTIVE:To describe the history, objectives, statistics, and initiatives used to address challenges associated with the Mayo Clinic Visiting Medical Student (VMS) Clerkship Program. MATERIALS AND METHODS:Mayo Clinic administrative records were reviewed for calendar years 1995 through 2008 to determine the effect of ...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.4065/mcp.2009.0511
更新日期：2010-08-01 00:00:00
abstract：:Pulmonary hypertension (PH) in patients with interstitial lung diseases (ILDs) is not well recognized and can occur in the absence of advanced pulmonary dysfunction or hypoxemia. To address this topic, we identified relevant studies in the English language by searching the MEDLINE database (1966 to November 2006) and ...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章,评审
doi：10.4065/82.3.342
更新日期：2007-03-01 00:00:00
abstract：:Atherosclerosis is a diffuse, systemic disease that affects the coronary, cerebral, and peripheral arterial trees. Disruption of atherosclerotic plaques leads to thrombus formation and arterial occlusion. This unpredictable and potentially life-threatening atherothrombotic sequence underlies clinical events such as an...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章,评审
doi：10.4065/81.1.59
更新日期：2006-01-01 00:00:00
abstract：:This discussion concerns an overview of our considerations of the adrenergic nervous system with respect to those areas of the nervous system that provide direct sensory input to the brain in control of arterial pressure; those brain centers that also participate in regulating arterial pressure; certain neurohumoral c...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章,评审
doi：
更新日期：1977-06-01 00:00:00
abstract：:Restless legs syndrome (RLS) is a common disorder with a prevalence of 5% to 15%. Primary care physicians must become familiar with management of this disorder. This algorithm for the management of RLS was written by members of the Medical Advisory Board of the Restless Legs Syndrome Foundation and is based on scienti...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.4065/79.7.916
更新日期：2004-07-01 00:00:00
abstract：:Nine patients treated with primary signet ring cell carcinoma of the prostate were identified among 29,783 cases of prostate cancer evaluated at Mayo Clinic from January 15, 1970, until January 2, 2009. A PubMed search of the English-language literature published from January 1, 1980, to January 1, 2010, was then perf...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章,评审
doi：10.4065/mcp.2010.0463
更新日期：2010-12-01 00:00:00
abstract：:We reviewed the epidemiologic characteristics, diagnosis, clinical features, and management of cytomegalovirus (CMV) infection after renal transplantation. CMV, the major viral pathogen after renal transplantation, increases patient morbidity and mortality. The spectrum of CMV infection ranges from latent infection to...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章,评审
doi：10.1016/s0025-6196(12)60828-3
更新日期：1992-09-01 00:00:00
abstract：OBJECTIVE:To assess the association between exercise capacity and the risk of developing atrial fibrillation (AF). PATIENTS AND METHODS:A symptom-limited exercise tolerance test was conducted to assess exercise capacity in 5962 veterans (mean age, 56.8±11.0 years) from the Veterans Affairs Medical Center, Washington, ...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.1016/j.mayocp.2016.03.002
更新日期：2016-05-01 00:00:00
abstract：DESIGN:A quality-control retrospective review of medical records was conducted for cases of anaphylaxis encountered at Mayo Clinic Rochester during a 3 1/2-year period. PATIENTS:For inclusion in the study, all patients had to manifest general symptoms of mediator release such as generalized pruritus, urticaria, angioe...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.1016/s0025-6196(12)61606-1
更新日期：1994-01-01 00:00:00
abstract：:A rapidly growing literature strongly suggests that exercise, specifically aerobic exercise, may attenuate cognitive impairment and reduce dementia risk. We used PubMed (keywords exercise and cognition) and manuscript bibliographies to examine the published evidence of a cognitive neuroprotective effect of exercise. M...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章,评审
doi：10.4065/mcp.2011.0252
更新日期：2011-09-01 00:00:00
abstract：OBJECTIVE:To evaluate the effects of treatment with fluticasone propionate vs placebo on bone, hypothalamic-pituitary-adrenal (HPA) axis function, and the eyes in patients with asthma. PATIENTS AND METHODS:This randomized, double-blind, placebo-controlled study of 160 patients with asthma who had minimal previous expo...
journal_title：Mayo Clinic proceedings
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.4065/79.4.458
更新日期：2004-04-01 00:00:00
abstract：:Dyspnea is a common symptom that is difficult to define and can result from a wide variety of causes. This complex sensation that arises from multiple stimuli involves both subjective perceptions and objective reactions. In the assessment of patients with dyspnea, use of a systematic approach to determine the precipit...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章,评审
doi：10.1016/s0025-6196(12)61344-5
更新日期：1994-07-01 00:00:00
abstract：:Myocarditis, an inflammatory disease of heart muscle, is an important cause of dilated cardiomyopathy worldwide. Viral infection is also an important cause of myocarditis, and the spectrum of viruses known to cause myocarditis has changed in the past 2 decades. Several new diagnostic methods, such as cardiac magnetic ...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章,评审
doi：10.1016/S0025-6196(11)60670-8
更新日期：2009-11-01 00:00:00
abstract：:A careful clinical history and physical examination are the most important components of the preoperative assessment of the cardiac patient who is to undergo a noncardiac surgical procedure. From these factors and the nature of the surgical procedure planned, a reasonable estimate of potential cardiac risk can be form...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章,评审
doi：10.1016/s0025-6196(12)64980-5
更新日期：1989-09-01 00:00:00
abstract：OBJECTIVE:To ascertain the usefulness of bone marrow and cerebrospinal fluid (CSF) examinations in identifying or predicting relapse in children with acute lymphoblastic leukemia (ALL) before discontinuation of chemotherapy. MATERIAL AND METHODS:We retrospectively reviewed the medical records of 113 children with ALL ...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.4065/71.9.854
更新日期：1996-09-01 00:00:00
abstract：OBJECTIVE:To evaluate the effect of prior duration of diabetes, glycated hemoglobin level at study entry, and microalbuminuria or macroalbuminuria on the extent and severity of coronary artery disease (CAD) and peripheral arterial disease. PATIENTS AND METHODS:We studied baseline characteristics of the 2368 participan...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.4065/mcp.2009.0265
更新日期：2010-01-01 00:00:00
abstract：:Vitamin K antagonists were the only class of oral anticoagulants available to clinicians for decades. However, with the US Food and Drug Administration approval of new oral anticoagulants, such as dabigatran, rivaroxaban, and apixaban, clinicians now have a broader choice. Given the recent approval and availability of...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章,评审
doi：10.1016/j.mayocp.2013.03.006
更新日期：2013-05-01 00:00:00
abstract：:The Mayo Clinic experience with more than 200 bile acid breath tests was analyzed retrospectively to assess its clinical value. In patients with suspected bacterial overgrowth, the result of the bile acid breath test was compared with that of culture of aspirates of small bowel, and the test was found to have a sensit...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：
更新日期：1978-04-01 00:00:00
