Childhood acute lymphoblastic leukemia: are routine end-of-therapy bone marrow and cerebrospinal fluid examinations necessary?

Abstract:

OBJECTIVE:To ascertain the usefulness of bone marrow and cerebrospinal fluid (CSF) examinations in identifying or predicting relapse in children with acute lymphoblastic leukemia (ALL) before discontinuation of chemotherapy. MATERIAL AND METHODS:We retrospectively reviewed the medical records of 113 children with ALL in first continuous complete remission who had undergone routine end-of-therapy bone marrow aspiration and CSF examinations. RESULTS:One patient had frank bone marrow relapse at the completion of therapy, which was evident by the presence of blasts in the peripheral blood. None of the other 112 patients had morphologic evidence of bone marrow relapse or positive CSF cytologic findings. The seven subsequent relapses could not have been predicted by the results of end-of-therapy bone marrow or CSF studies. CONCLUSION:Routine morphologic examination of the bone marrow and CSF at the completion of therapy for ALL has no diagnostic or prognostic value.

journal_name

Mayo Clin Proc

journal_title

Mayo Clinic proceedings

authors

Hutt PJ,Sabio H,Gilchrist GS,O'Brien C

doi

10.4065/71.9.854

subject

Has Abstract

pub_date

1996-09-01 00:00:00

pages

854-6

issue

9

eissn

0025-6196

issn

1942-5546

pii

S0025-6196(11)63748-8

journal_volume

71

pub_type

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