Abstract:
:Nine patients treated with primary signet ring cell carcinoma of the prostate were identified among 29,783 cases of prostate cancer evaluated at Mayo Clinic from January 15, 1970, until January 2, 2009. A PubMed search of the English-language literature published from January 1, 1980, to January 1, 2010, was then performed using the key words signet ring cell and prostate, identifying 42 cases. This study reviews those cases, along with the additional 9 reported herein, and evaluates clinical characteristics, histologic diagnoses, treatment modalities, and outcomes. Mean age at diagnosis was 68 years (range, 50-85 years), and mean prostate-specific antigen level was 95.3 ng/mL (range, 1.9-536.0 ng/mL; to convert to μg/L, multiply by 1). Most patients (66%) had non-stage IV carcinoma, the most common Gleason sum was 8 (33%), and mean survival was 29 months. The presence of a primary signet ring cell carcinoma of the prostate was best confirmed by negative findings on gastrointestinal work-up, a positive stain for prostate-specific acid phosphatase, and negative carcinoembryonic antigen test results.
journal_name
Mayo Clin Procjournal_title
Mayo Clinic proceedingsauthors
Warner JN,Nakamura LY,Pacelli A,Humphreys MR,Castle EPdoi
10.4065/mcp.2010.0463subject
Has Abstractpub_date
2010-12-01 00:00:00pages
1130-6issue
12eissn
0025-6196issn
1942-5546pii
S0025-6196(11)60367-4journal_volume
85pub_type
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journal_title:Mayo Clinic proceedings
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pub_type: 临床试验,杂志文章
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pub_type: 临床试验,杂志文章,随机对照试验
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