Primary signet ring cell carcinoma of the prostate.

Abstract:

:Nine patients treated with primary signet ring cell carcinoma of the prostate were identified among 29,783 cases of prostate cancer evaluated at Mayo Clinic from January 15, 1970, until January 2, 2009. A PubMed search of the English-language literature published from January 1, 1980, to January 1, 2010, was then performed using the key words signet ring cell and prostate, identifying 42 cases. This study reviews those cases, along with the additional 9 reported herein, and evaluates clinical characteristics, histologic diagnoses, treatment modalities, and outcomes. Mean age at diagnosis was 68 years (range, 50-85 years), and mean prostate-specific antigen level was 95.3 ng/mL (range, 1.9-536.0 ng/mL; to convert to μg/L, multiply by 1). Most patients (66%) had non-stage IV carcinoma, the most common Gleason sum was 8 (33%), and mean survival was 29 months. The presence of a primary signet ring cell carcinoma of the prostate was best confirmed by negative findings on gastrointestinal work-up, a positive stain for prostate-specific acid phosphatase, and negative carcinoembryonic antigen test results.

journal_name

Mayo Clin Proc

journal_title

Mayo Clinic proceedings

authors

Warner JN,Nakamura LY,Pacelli A,Humphreys MR,Castle EP

doi

10.4065/mcp.2010.0463

subject

Has Abstract

pub_date

2010-12-01 00:00:00

pages

1130-6

issue

12

eissn

0025-6196

issn

1942-5546

pii

S0025-6196(11)60367-4

journal_volume

85

pub_type

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