Abstract：
OBJECTIVE:To examine patterns of the incidence of diabetes, hypertension, and mortality by single units of body mass index (BMI) and 5-year age groups using longitudinal data from middle-aged and older women. PATIENTS AND METHODS:Middle-aged (born between 1946 and 1951; N = 13,715) and older (born between 1921 and 1926; N = 12,432) participants in the Australian Longitudinal Study on Women's Health completed surveys in 1996 and at approximately 3-year intervals thereafter until 2011. Proportions of women with diabetes, hypertension, and mortality over 3-year intervals were estimated for each unit of BMI and 5-year age group (45 to < 50, 50 to < 55, 55 to < 60, 70 to < 75, 75 to < 80, and 80 to < 85 years) using generalized additive modeling with adjustment for time-varying covariates. RESULTS:Three-year incidence of diabetes (1.2%-3.6%), hypertension (5.2%-17.8%), and death (0.4%-9.5%) increased with age. For both diabetes and hypertension, the associations with BMI were curvilinear in middle-aged women and became almost linear in older women. With increasing age, the slope became steeper, and the increase started at lower BMI values. For hypertension, there was a marked increase in intercept from 75 years onward. In contrast, mortality risks were highest for low BMI (≤ 20) in all age groups. A clear U-shaped curve was observed only in the oldest age group. CONCLUSION:The shapes of the relationships between BMI and incidence of diabetes, hypertension, and mortality change with age, suggesting that weight management interventions should be tailored for different age groups.
journal_name
Mayo Clin Procjournal_title
Mayo Clinic proceedingsauthors
Peeters GM,Herber-Gast GC,Dobson AJ,Brown WJdoi
10.1016/j.mayocp.2015.04.006subject
Has Abstractpub_date
2015-07-01 00:00:00pages
903-10issue
7eissn
0025-6196issn
1942-5546pii
S0025-6196(15)00315-8journal_volume
90pub_type
杂志文章,多中心研究abstract：OBJECTIVE:To examine the effect of objectively measured exercise capacity (EC) on early mortality (EM) after a first myocardial infarction (MI). PATIENTS AND METHODS:This retrospective cohort study included 2061 patients without a history of MI (mean age, 62±12 years; 38% [n=790] women; 56% [n=1153] white) who underwe...
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journal_title：Mayo Clinic proceedings
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pub_type： 杂志文章
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journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,多中心研究,随机对照试验
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pub_type： 杂志文章
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