Abstract:
:Parasitic diseases affect more than 2 billion people globally and cause substantial morbidity and mortality, particularly among the world's poorest people. This overview focuses on the treatment of the major protozoan and helminth infections in humans. Recent developments in antiparasitic therapy include the expansion of artemisinin-based therapies for malaria, new drugs for soil-transmitted helminths and intestinal protozoa, expansion of the indications for antiparasitic drug treatment in patients with Chagas disease, and the use of combination therapy for leishmaniasis and human African trypanosomiasis.
journal_name
Mayo Clin Procjournal_title
Mayo Clinic proceedingsauthors
Kappagoda S,Singh U,Blackburn BGdoi
10.4065/mcp.2011.0203subject
Has Abstractpub_date
2011-06-01 00:00:00pages
561-83issue
6eissn
0025-6196issn
1942-5546pii
S0025-6196(11)60055-4journal_volume
86pub_type
杂志文章,评审abstract:OBJECTIVE:To determine the association between cardiorespiratory fitness and sedentary behavior, independent of exercise activity. PATIENTS AND METHODS:We included 2223 participants (aged 12-49 years; 1053 females [47%]) without known heart disease who had both cardiovascular fitness testing and at least 1 day of acce...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:10.1016/j.mayocp.2014.04.019
更新日期:2014-08-01 00:00:00
abstract::The extent of universal screening for gestational diabetes and the incidence of gestational diabetes mellitus (GDM) by diagnosis were analyzed in four primary-care sites. The medical records of 798 women were reviewed to identify the presence of historical risk factors, familial determinants, and biophysical attribute...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:10.1016/s0025-6196(12)60932-x
更新日期:1992-10-01 00:00:00
abstract:OBJECTIVE:To assess long-term secular trends in the utilization of bilateral compared with unilateral orchiectomy in the community. PATIENTS AND METHODS:This population-based descriptive study reviewed medical records of all Olmsted County, Minnesota, men undergoing orchiectomy between 1956 and 2000. RESULTS:Over the...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:10.4065/76.12.1199
更新日期:2001-12-01 00:00:00
abstract::Transesophageal echocardiography (TEE) is used frequently in patients with cerebrovascular ischemia. On TEE, a typical appearance of a cardiac fibroelastoma is that of a pedunculated, mobile mass attached to a leaflet of a valve. Surgical excision of the lesion may lead to resolution of the symptoms and prevent furthe...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:10.1016/S0025-6196(11)63944-X
更新日期:1995-09-01 00:00:00
abstract::We reviewed the results of preoperative screening laboratory tests in asymptomatic healthy patients who underwent elective surgical procedures at our institution in 1988. Substantially abnormal results were found in 160 of 3,782 patients. All such abnormalities involved five tests: aspartate aminotransferase, glucose,...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:10.1016/s0025-6196(12)60487-x
更新日期:1991-02-01 00:00:00
abstract:OBJECTIVE:To compare coronary artery bypass grafting (CABG) with percutaneous transluminal coronary angioplasty (PTCA) in patients with proximal, isolated de novo left anterior descending coronary artery disease and left ventricular ejection fraction of 45%. PATIENTS AND METHODS:In the multicenter Stenting vs Internal...
journal_title:Mayo Clinic proceedings
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.4065/75.11.1116
更新日期:2000-11-01 00:00:00
abstract::Aortic thrombus formation is rare in the patients with essential thrombocytosis (ET); therefore, no guidelines for its management have been established. Embolism from ET-associated large vessel thrombi is potentially lethal and has been managed surgically in a few reported cases. We describe herein a 45-year-old black...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:10.4065/76.4.427
更新日期:2001-04-01 00:00:00
abstract:OBJECTIVE:To explore the influence of referral bias on complication rates after vaginal hysterectomy. PATIENTS AND METHODS:Community-based (local) and referral patients had benign indications and underwent vaginal hysterectomy from January 1, 2004, through December 31, 2005. We retrospectively evaluated patient charac...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:10.4065/mcp.2009.0299
更新日期:2010-02-01 00:00:00
abstract:OBJECTIVE:To assess the effects of glutathione on pain-free walking distance (PFWD) and hemodynamic parameters in patients with peripheral artery disease. PATIENTS AND METHODS:Forty patients with Fontaine stage II peripheral artery disease who were seen between September 2000 and March 2001 at the vascular laboratory ...
journal_title:Mayo Clinic proceedings
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.4065/77.8.754
更新日期:2002-08-01 00:00:00
abstract::To many clinicians, the assessment of health-related quality of life (HRQL) seems more art than science. This belief is due in part to the lack of formal training available to clinicians regarding HRQL measurement and interpretation. When HRQL is used systematically, it has been shown to improve patient-physician comm...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:10.4065/82.10.1244
更新日期:2007-10-01 00:00:00
abstract::Two patients had both scleroderma and a columnar epithelium-lined lower esophagus (Barrett esophagus). Features of Barrett's esophagus included high esophageal strictures in both patients and ulcer craters in the columnar area of one. Biopsy confirmed columnar epithelium in the lower esophagus of each patient. In thes...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:
更新日期:1978-09-01 00:00:00
abstract::Cephalosporins are broad-spectrum antimicrobial agents that are often used empirically to treat suspected bacterial infections and also to treat culture-proven infections due to selected gram-positive and gram-negative microorganisms. Cephalosporins differ widely in their spectrum of activity, susceptibility to beta-l...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章,评审
doi:10.1016/s0025-6196(12)61731-5
更新日期:1991-10-01 00:00:00
abstract::Hypoxic liver injury is defined as a massive, but transient, increase in serum transaminase levels due to an imbalance between hepatic oxygen supply and demand in the absence of other acute causes of liver damage. It typically occurs in elderly individuals with right-sided congestive heart failure and low cardiac outp...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章,评审
doi:10.4065/81.9.1232
更新日期:2006-09-01 00:00:00
abstract:OBJECTIVE:To investigate presenting signs and symptoms of ovarian cancer and stage of tumor in a community cohort of women with the diagnosis of ovarian cancer. PATIENTS AND METHODS:We reviewed retrospectively the medical records of all women who sought primary and specialty care in Olmsted County, Minnesota, between ...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:10.4065/79.10.1277
更新日期:2004-10-01 00:00:00
abstract::Osteoporosis is a skeletal disorder characterized by compromised bone strength and increased risk of fracture. Properties related to bone strength include rate of bone turnover, bone mineral density, geometry, microarchitecture, and mean degree of mineralization. These properties (with or without bone density) are som...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章,评审
doi:10.4065/80.3.379
更新日期:2005-03-01 00:00:00
abstract::Nasal telangiectasias, a common condition, can be caused by chronic exposure to ultraviolet light, rosacea, topically applied corticosteroids, or rhinoplasty. Use of the argon laser for 15 to 45 minutes in a continuous mode over the entire involved area can produce considerable lightening of the nasal redness and impr...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:10.1016/s0025-6196(12)62611-1
更新日期:1986-11-01 00:00:00
abstract::During the 1960s, the Mustard or Senning operation was the conventional palliative therapy for patients with transposition of the great arteries. Many of these patients are now adults, and the durability of the morphologic right ventricle to function as the systemic ventricle is being questioned. Surgical options for ...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:10.4065/72.3.245
更新日期:1997-03-01 00:00:00
abstract:OBJECTIVE:To prospectively assess the safety and effectiveness of the investigational phosphodiesterase 5 inhibitor avanafil to treat erectile dysfunction in men with diabetes mellitus. PATIENTS AND METHODS:This 12-week, multicenter, double-blind, placebo-controlled study conducted between December 15, 2008, and Febru...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.mayocp.2012.06.016
更新日期:2012-09-01 00:00:00
abstract::Given the burden of cardiovascular disease (CVD), increasing the prevalence of healthy lifestyle choices is a global imperative. Currently, cardiac rehabilitation programs are a primary way that modifiable risk factors are addressed in the secondary prevention setting after a cardiovascular (CV) event/diagnosis. Even ...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章,评审
doi:10.1016/j.mayocp.2013.03.002
更新日期:2013-06-01 00:00:00
abstract::An 87-year-old woman was referred for evaluation of nervousness, tremor, insomnia, and fatigue of 2 months' duration. Initial laboratory evaluation revealed a suppressed thyrotropin level and an elevated triiodothyronine level. A review of her medications revealed that she had started taking several dietary supplement...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:10.4065/77.6.587
更新日期:2002-06-01 00:00:00
abstract:OBJECTIVE:To obtain pilot prospective data regarding the efficacy and tolerability of gabapentin for alleviating hot flashes. PATIENTS AND METHODS:This prospective single-arm clinical trial was conducted between July 26, 2001, and November 30, 2001. Patients underwent a baseline week and then 4 weeks of gabapentin tre...
journal_title:Mayo Clinic proceedings
pub_type: 临床试验,杂志文章
doi:10.4065/77.11.1159
更新日期:2002-11-01 00:00:00
abstract::Seven vertex-positive potentials--the brainstem auditory response--can be recorded from the human scalp within 10 milliseconds of an appropriate acoustic stimulus. The first of these potentials is generated in the acoustic nerve, the third in the pons, and the fifth in the midbrain. Measurement of the relative latenci...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:
更新日期:1977-12-01 00:00:00
abstract::Drugs that target G protein-coupled receptors (GPCRs) represent the primary treatment strategy for patients with acute and chronic pain; however, there is substantial individual variability in both the efficacy and adverse effects associated with these drugs. Variability in drug responses is due, in part, to individua...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章,评审
doi:10.1016/j.mayocp.2015.06.010
更新日期:2015-08-01 00:00:00
abstract::Diverticular disease is a common condition that is associated with variable presentations. For this review article, we performed a review of articles in PubMed through February 1, 2016, by using the following MeSH terms: colon diverticula, colonic diverticulitis, colonic diverticulosis, colonic diverticulum, colonic d...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章,评审
doi:10.1016/j.mayocp.2016.03.012
更新日期:2016-08-01 00:00:00
abstract:OBJECTIVE:To analyze the relationship of ideal cardiovascular health to disease-specific death. PATIENTS AND METHODS:We used data from the Aerobics Center Longitudinal Study from October 9, 1987, to March 3, 1999, to estimate the prevalence of ideal cardiovascular health in 11,993 individuals (24.3% women) and to exam...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:10.1016/j.mayocp.2012.07.015
更新日期:2012-10-01 00:00:00
abstract:OBJECTIVE:To assess whether dietary supplements that are herbal and/or animal-derived products, marketed for enhancing metabolism or promoting energy, "adrenal fatigue," or "adrenal support," contain thyroid or steroid hormones. METHODS:Twelve dietary adrenal support supplements were purchased. Pregnenolone, androsten...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:10.1016/j.mayocp.2017.10.019
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVE:To examine whether the outcome of patients with primary systemic amyloidosis (AL) has improved over time and to identify predictors of early mortality in patients with AL. PATIENTS AND METHODS:We studied 2 separate cohorts of patients. The first cohort, consisting of 1998 patients with AL seen at Mayo Clinic...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:10.4065/mcp.2010.0480
更新日期:2011-01-01 00:00:00
abstract::In the three major morphologic groups of lupus nephritis--diffuse, focal proliferative, and membranous--glomerular deposition of immunoglobulins is usually a combination of IgG, IgM, and IgA and is not a good indicator of initial renal severity or outcome. In this study of 60 patients with systemic lupus erythematosus...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:
更新日期:1978-06-01 00:00:00
abstract::Vancomycin is a glycopeptide antibiotic that is active against staphylococci, streptococci, and other gram-positive bacteria. It is the drug of choice for the treatment of infections due to methicillin-resistant staphylococci, Corynebacterium jeikeium, and multiply resistant strains of Streptococcus pneumoniae. Vancom...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章,评审
doi:10.1016/s0025-6196(12)65799-1
更新日期:1991-11-01 00:00:00
abstract::Hyperkalemia is a potentially life-threatening complication of chronic kidney disease (CKD). The management of CKD requires balancing the benefits of specific treatments, which may exacerbate the potential for hyperkalemia, with the risks of hyperkalemia itself. Renin-angiotensin-aldosterone system (RAAS) inhibitors, ...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章,评审
doi:10.1016/j.mayocp.2019.05.019
更新日期:2020-02-01 00:00:00