Abstract:
:Cephalosporins are broad-spectrum antimicrobial agents that are often used empirically to treat suspected bacterial infections and also to treat culture-proven infections due to selected gram-positive and gram-negative microorganisms. Cephalosporins differ widely in their spectrum of activity, susceptibility to beta-lactamases, serum half-life, and penetration of the central nervous system. In general, the first-generation and second-generation agents are most active against staphylococci and streptococci, and the third-generation agents are most active against the Enterobacteriaceae and Pseudomonas. As a group, cephalosporins have a favorable profile of toxicity in comparison with other antimicrobial agents. The development of bacterial resistance has affected all steps of the cephalosporin mechanism of action, including production of beta-lactamases, alterations in penicillin-binding proteins, and modification of the cell wall. New cephalosporins are among the most expensive pharmaceutical agents in use today. Maintaining expertise in the choice and use of these agents will remain a challenge to physicians as additional investigational cephalosporins continue to be developed and introduced into clinical practice.
journal_name
Mayo Clin Procjournal_title
Mayo Clinic proceedingsauthors
Gustaferro CA,Steckelberg JMdoi
10.1016/s0025-6196(12)61731-5subject
Has Abstractpub_date
1991-10-01 00:00:00pages
1064-73issue
10eissn
0025-6196issn
1942-5546pii
S0025-6196(12)61731-5journal_volume
66pub_type
杂志文章,评审abstract::Despite the successful growth of the hospice movement during the past 30 years in the United States, almost 85% of Americans continue to die in hospitals or nursing homes. While the benefits of palliative care principles are well established, palliative care interventions remain underused in clinical practice in the s...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章,评审
doi:10.4065/75.12.1305
更新日期:2000-12-01 00:00:00
abstract::Cirrhosis and its disease-related complications are the 12th leading cause of mortality among U.S. adults and are the 5th leading cause of death for individuals aged 45 to 54 years. Hospitalization costs for disease-related complications are estimated at 18,000 dollars per episode of care, and 10% of admitted patients...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章,评审
doi:10.4065/80.11.1501
更新日期:2005-11-01 00:00:00
abstract:OBJECTIVE:To determine whether N-acetylcysteine rinse was safe and could improve thickened secretions and dry mouth during and after radiotherapy. PATIENTS AND METHODS:We designed a prospective pilot double-blind, placebo-controlled randomized clinical trial (Alliance MC13C2). Adult patients (age ≥18 years) were enrol...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.mayocp.2019.03.031
更新日期:2019-09-01 00:00:00
abstract:OBJECTIVE:To assess the frequency and clinical implications of positive autoimmune serologies in patients with biopsy-confirmed idiopathic pulmonary fibrosis (IPF). PATIENTS AND METHODS:We reviewed the records of patients at our institution with biopsy-confirmed usual interstitial pneumonia (UIP) from January 1, 1995,...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:10.1016/j.mayocp.2013.11.018
更新日期:2014-03-01 00:00:00
abstract:OBJECTIVE:To describe the Mayo Clinic experience with emergency video telemedicine consultations for high-risk newborn deliveries. PATIENTS AND METHODS:From March 26, 2013, through December 31, 2015, the Division of Neonatal Medicine offered newborn telemedicine consultations to 6 health system sites. A wireless table...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:10.1016/j.mayocp.2016.08.006
更新日期:2016-12-01 00:00:00
abstract::A 54-year-old man with no known cardiac disease collapsed outdoors in a small rural community. The cardiac arrest was witnessed, and immediate cardiopulmonary resuscitation was begun by a bystander and a trained first responder who was nearby. The patient was moved into a building across the street for continued resus...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:10.4065/mcp.2011.0229
更新日期:2011-06-01 00:00:00
abstract::Two cases of rare, catastrophic calcium emboli to the coronary arteries immediately after percutaneous mitral balloon valvuloplasty are presented. Preoperative echocardiographic findings may identify patients at risk for this complication. These cases should increase the awareness of calcium emboli and lead to conside...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:10.4065/76.7.753
更新日期:2001-07-01 00:00:00
abstract::Two entities of special interest in sleep disorders medicine are restless legs syndrome and periodic movements of sleep. Most patients with restless legs syndrome have periodic movements of sleep, but most patients with the nocturnal disorder do not have restless legs when awake. In both conditions, the underlying cau...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章,评审
doi:10.1016/s0025-6196(12)65163-5
更新日期:1990-07-01 00:00:00
abstract:OBJECTIVE:To estimate the 3-month cumulative incidence of thromboembolism (TE), bleeding, and death among consecutive patients with nonvalvular atrial fibrillation (AF) who were receiving long-term anticoagulation therapy and were referred to the Thrombophilia Center at Mayo Clinic for periprocedural anticoagulation ma...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:10.4065/83.6.639
更新日期:2008-06-01 00:00:00
abstract::Six insulin-requiring chronically hyperglycemic diabetic patients underwent glucose control for 72 hours with an artificial endocrine pancreas, the Biostator Glucose Controller. Euglycemia was within 4 hours and was maintained (110 leads to 2 mg/dl) thereafter. The concentration of hemoglobin A (HbA) was elevated, at ...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:
更新日期:1981-06-01 00:00:00
abstract::Plasma concentration of brain natriuretic peptide (BNP), as measured by the Triage BNP Test, is approved by the Food and Drug Administration to aid in the diagnosis of heart failure. This diagnostic test is available in many institutions. The purpose of this article is to help the physician know the appropriate time t...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章,评审
doi:10.4065/78.4.481
更新日期:2003-04-01 00:00:00
abstract:OBJECTIVE:To determine whether dehydroepiandrosterone (DHEA) replacement therapy in hypoadrenal women improves performance, muscle protein accretion, and mitochondrial functions. PARTICIPANTS AND METHODS:Thirty-three hypoadrenal women were enrolled in the study from May 1, 2002, through May 31, 2003. Twenty-eight comp...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章,随机对照试验
doi:10.4065/83.11.1218
更新日期:2008-11-01 00:00:00
abstract:OBJECTIVE:To assess the potential electromagnetic interference (EMI) effects that new or current-generation cellular telephones have on medical devices. MATERIAL AND METHODS:For this study, performed at the Mayo Clinic in Rochester, Minn, between March 9, 2004, and April 24, 2004, we tested 16 different medical device...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:10.4065/80.10.1286
更新日期:2005-10-01 00:00:00
abstract::The penicillin family of antibiotics remains an important part of our antimicrobial armamentarium. In general, these agents have bactericidal activity, excellent distribution throughout the body, low toxicity, and efficacy against infections caused by susceptible bacteria. The initial introduction of aqueous penicilli...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章,评审
doi:10.4065/74.3.290
更新日期:1999-03-01 00:00:00
abstract:OBJECTIVE:To investigate the pharmacodynamic properties of inclisiran, a small interfering RNA targeting proprotein convertase subtilisin-kexin type 9 (PCSK9), in individuals with normal renal function and renal impairment (RI). PATIENTS AND METHODS:The analysis included participants with normal renal function and mil...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.mayocp.2019.08.021
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:To provide a practical formula for fresh frozen plasma (FFP) dosing for warfarin reversal. PATIENTS AND METHODS:We reviewed data on all adult patients who received a total of 7778 units of FFP for warfarin reversal at Sentara Norfolk General Hospital (Norfolk, VA) between April 1, 2009, and March 31, 2010. P...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:10.1016/j.mayocp.2012.12.011
更新日期:2013-03-01 00:00:00
abstract:OBJECTIVE:To determine the effect of adding a trained intensivist on patient care and educational outcomes in a community teaching hospital. MATERIAL AND METHODS:We retrospectively reviewed outcomes for patients admitted to the medical intensive-care unit (MICU) of a 270-bed community teaching hospital between July 19...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:10.4065/72.5.391
更新日期:1997-05-01 00:00:00
abstract:OBJECTIVE:To evaluate the overall risk of breast cancer and breast cancer characteristics in women given supradiaphragmatic radiation therapy for Hodgkin lymphoma. PATIENTS AND METHODS:Medical records of 653 female patients who received supradiaphragmatic radiation therapy for Hodgkin lymphoma at the Mayo Clinic in Ro...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:10.4065/78.6.708
更新日期:2003-06-01 00:00:00
abstract::Allergen immunotherapy involves exposing a patient to a gradually escalating dose of a specific allergen with the intention of decreasing allergic and inflammatory responses, ultimately leading to a sustained decrease in allergic symptoms. A build-up phase (once weekly injections) is followed by a maintenance phase (o...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:10.4065/82.9.1119
更新日期:2007-09-01 00:00:00
abstract::As alternatives to transurethral resection of the prostate for treatment of benign prostatic hyperplasia, various types of laser prostatectomy-most notably, neodymium:yttrium-aluminum-garnet (YAG) and potassium titanyl phosphate laser procedures-have proved to be associated with considerably less morbidity (for exampl...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章,评审
doi:10.4065/73.8.792
更新日期:1998-08-01 00:00:00
abstract::Drugs that target G protein-coupled receptors (GPCRs) represent the primary treatment strategy for patients with acute and chronic pain; however, there is substantial individual variability in both the efficacy and adverse effects associated with these drugs. Variability in drug responses is due, in part, to individua...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章,评审
doi:10.1016/j.mayocp.2015.06.010
更新日期:2015-08-01 00:00:00
abstract:OBJECTIVE:To investigate the impact on cardiovascular events (CVEs) in a real-world population of patients with atrial fibrillation (AF) by implementing the Atrial fibrillation Better Care (ABC: A, Avoid stroke with anticoagulation; B, better symptom management; C, Cardiovascular and comorbidity risk management) pathwa...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:10.1016/j.mayocp.2018.10.022
更新日期:2019-07-01 00:00:00
abstract::Although measurements of trunk flexibility are an important part of a clinical examination, subjective methods are usually used to assess spinal mobility. We studied three easily performed objective techniques for determining trunk flexibility (the common "fingertip-to-floor" test, the modified Schober and Moll tests,...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:10.1016/s0025-6196(12)61848-5
更新日期:1986-03-01 00:00:00
abstract:OBJECTIVE:To assess presentation, imaging, treatment, and outcome of patients with myelopathy due to a dural arteriovenous fistula (DAVF). PATIENTS AND METHODS:This retrospective review identified 94 patients with DAVF surgically treated at our institution between June 1985 and December 1999. The mean ages of the 75 m...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:10.4065/76.11.1120
更新日期:2001-11-01 00:00:00
abstract::Risedronate sodium is a pyridinyl bisphosphonate effective for treatment and prevention of postmenopausal and glucocorticoid-induced osteoporosis. Some bisphosphonates have been associated with upper gastrointestinal (GI) tract adverse effects. The objective of this study was to determine the frequency of upper GI tra...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章,meta分析
doi:10.4065/77.3.262
更新日期:2002-03-01 00:00:00
abstract::Primary sclerosing cholangitis (PSC) predisposes to the development of cholangiocarcinoma, a usually fatal complication that is difficult to diagnose. Serum concentrations of CA 19-9, a tumor-associated antigen, are frequently increased in patients with only cholangiocarcinoma. The aim of this study was to assess the ...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:10.1016/s0025-6196(12)60696-x
更新日期:1993-09-01 00:00:00
abstract::Hypothyroidism and hyperthyroidism are common medical disorders that are often accompanied by diverse types of neurologic and neuromuscular dysfunction. Although some of these associated disorders are well known to physicians, others are not. All of these neurologic manifestations are important because they can severe...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:
更新日期:1981-08-01 00:00:00
abstract:OBJECTIVE:To evaluate the effects of treatment with fluticasone propionate vs placebo on bone, hypothalamic-pituitary-adrenal (HPA) axis function, and the eyes in patients with asthma. PATIENTS AND METHODS:This randomized, double-blind, placebo-controlled study of 160 patients with asthma who had minimal previous expo...
journal_title:Mayo Clinic proceedings
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.4065/79.4.458
更新日期:2004-04-01 00:00:00
abstract::Two-dimensional echocardiography is useful for the immediate diagnosis of acute myocardial infarction when diagnostic electrocardiographic changes are absent. The technique is also helpful in distinguishing myocardial infarction from other conditions that may clinically or electrocardiographically mimic infarction. Th...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:10.1016/s0025-6196(12)61526-2
更新日期:1987-01-01 00:00:00
abstract::Usual causes of intolerance to thyroxine sodium include coronary artery disease, advanced age, untreated adrenal insufficiency, and severe hypothyroidism. We describe 4 patients with iron deficiency anemia and primary hypothyroidism. After treatment with thyroxine sodium, these patients developed palpitations and feel...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:
更新日期:2000-02-01 00:00:00