Cephalosporin antimicrobial agents and related compounds.

Abstract:

:Cephalosporins are broad-spectrum antimicrobial agents that are often used empirically to treat suspected bacterial infections and also to treat culture-proven infections due to selected gram-positive and gram-negative microorganisms. Cephalosporins differ widely in their spectrum of activity, susceptibility to beta-lactamases, serum half-life, and penetration of the central nervous system. In general, the first-generation and second-generation agents are most active against staphylococci and streptococci, and the third-generation agents are most active against the Enterobacteriaceae and Pseudomonas. As a group, cephalosporins have a favorable profile of toxicity in comparison with other antimicrobial agents. The development of bacterial resistance has affected all steps of the cephalosporin mechanism of action, including production of beta-lactamases, alterations in penicillin-binding proteins, and modification of the cell wall. New cephalosporins are among the most expensive pharmaceutical agents in use today. Maintaining expertise in the choice and use of these agents will remain a challenge to physicians as additional investigational cephalosporins continue to be developed and introduced into clinical practice.

journal_name

Mayo Clin Proc

journal_title

Mayo Clinic proceedings

authors

Gustaferro CA,Steckelberg JM

doi

10.1016/s0025-6196(12)61731-5

subject

Has Abstract

pub_date

1991-10-01 00:00:00

pages

1064-73

issue

10

eissn

0025-6196

issn

1942-5546

pii

S0025-6196(12)61731-5

journal_volume

66

pub_type

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