Abstract:
OBJECTIVE:To assess the frequency and clinical implications of positive autoimmune serologies in patients with biopsy-confirmed idiopathic pulmonary fibrosis (IPF). PATIENTS AND METHODS:We reviewed the records of patients at our institution with biopsy-confirmed usual interstitial pneumonia (UIP) from January 1, 1995, through December 31, 2010, for frequency and distribution of autoimmune serologies. Patients with IPF with and without positive serologies were compared. RESULTS:Three hundred eighty-nine consecutive patients with biopsy-confirmed IPF underwent serologic testing, with positive serologic test results being found in 112 (29%). Of 2051 individual screening serologic tests performed, results of 163 tests were positive (8%), with antinuclear antibody being the most frequent (47%). There was no difference in age at biopsy (P=.21), gender (P=.21), or presenting radiologic features between those with or without positive serology. More frequent use of immunosuppressive treatment (P=.02) was noted in those with positive serology. No survival difference was observed (log-rank; P=.43). Median follow-up for the whole cohort was 43.5 months. CONCLUSION:Positive autoimmune serology may occur in as much as one-third of the patients with biopsy-confirmed IPF with no associated clinical implication or survival advantage. Systematic use of autoimmune laboratory panels in patients without clinical features of connective tissue disease should be reconsidered in patients with suspected UIP on chest computed tomography scan or confirmed UIP on biopsy.
journal_name
Mayo Clin Procjournal_title
Mayo Clinic proceedingsauthors
Moua T,Maldonado F,Decker PA,Daniels CE,Ryu JHdoi
10.1016/j.mayocp.2013.11.018subject
Has Abstractpub_date
2014-03-01 00:00:00pages
319-26issue
3eissn
0025-6196issn
1942-5546pii
S0025-6196(13)01114-2journal_volume
89pub_type
杂志文章abstract:OBJECTIVE:To describe the causes, evaluation, and management of urinary incontinence in the elderly population. DESIGN:We reviewed pertinent articles in the medical literature and summarized the types of incontinence and contributing factors. RESULTS:Urinary incontinence is common in elderly patients and often has a ...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章,评审
doi:10.4065/71.1.93
更新日期:1996-01-01 00:00:00
abstract:OBJECTIVE:To assess the value of adding remote pointer and dynamic display capabilities to a telemedicine system designed to provide consultative services for patients with congenital heart disease. MATERIAL AND METHODS:Independent observations by the referring physician and the consulting physician provided the data ...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:10.4065/74.8.758
更新日期:1999-08-01 00:00:00
abstract:OBJECTIVE:To record long-term follow-up data on patients with chronic idiopathic meningitis. DESIGN:We retrospectively reviewed the outcome of 49 patients who were examined at the Mayo Clinic between 1978 and 1990. MATERIAL AND METHODS:For all patients, symptoms, signs, laboratory values, results of imaging studies, ...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:10.1016/s0025-6196(12)62246-0
更新日期:1994-06-01 00:00:00
abstract:OBJECTIVE:To investigate the impact of obesity and underweight on adverse in-hospital outcomes in pulmonary embolism (PE). PATIENTS AND METHODS:Patients diagnosed as having PE based on International Statistical Classification of Diseases and Related Health Problems, 10th Revision, German Modification code I26 in the G...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:10.1016/j.mayocp.2019.04.035
更新日期:2019-10-01 00:00:00
abstract:OBJECTIVE:To determine the separate effects of exercise intensity and amount on interindividual cardiorespiratory fitness (CRF) response. PARTICIPANTS AND METHODS:Participants were 121 (75 females, 62%) sedentary, middle-aged (mean [SD] age, 53.2 [7.5] years), abdominally obese adults who completed at least 90% of 5 w...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.mayocp.2015.07.024
更新日期:2015-11-01 00:00:00
abstract::The patient with a hypersensitive carotid sinus reflex and syncope may pose special challenges in evaluation and treatment. Specifically, although the finding of carotid sinus hypersensitivity may indeed indicate an exaggerated vagal tone that causes syncope, it may also be a chance association in a patient with synco...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:10.1016/s0025-6196(12)62417-3
更新日期:1984-09-01 00:00:00
abstract:OBJECTIVE:To ascertain the incidence and timing of fever in patients at risk for temperature modulation of brain injury resulting from ischemia or trauma. DESIGN:We retrospectively reviewed the medical records of patients admitted between January 1991 and December 1994. MATERIAL AND METHODS:We investigated three grou...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:10.1016/S0025-6196(11)64885-4
更新日期:1998-07-01 00:00:00
abstract:OBJECTIVE:To analyze a large cohort of patients who underwent exercise testing and also report sex differences in other exercise heart rate (HR) parameters to determine whether separate sex-based equations to predict peak HR are indicated. PATIENTS AND METHODS:Patients aged 40 to 89 years who performed treadmill exerc...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:10.1016/j.mayocp.2014.08.018
更新日期:2014-12-01 00:00:00
abstract::An unusual case of a capillary hemangioma of the filum terminale is presented. The successful removal returned the patient to an asymptomatic state. ...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:
更新日期:1975-03-01 00:00:00
abstract::Transesophageal echocardiography (TEE) is used frequently in patients with cerebrovascular ischemia. On TEE, a typical appearance of a cardiac fibroelastoma is that of a pedunculated, mobile mass attached to a leaflet of a valve. Surgical excision of the lesion may lead to resolution of the symptoms and prevent furthe...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:10.1016/S0025-6196(11)63944-X
更新日期:1995-09-01 00:00:00
abstract::Prospective data and follow-up information were collected on the initial 200 patients who underwent laparoscopic cholecystectomy at the Mayo Clinic. The operation was completed laparoscopically in all but five patients, who required conversion to laparotomy because of dense scarring or stones in the common bile duct. ...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:10.1016/s0025-6196(12)60390-5
更新日期:1992-05-01 00:00:00
abstract::Because fasting nerve myo-inositol (myo-Ins) is not decreased in patients with diabetes treated conventionally, in whom neuropathy may develop or may have already developed, it seems unlikely that myo-Ins is the metabolic abnormality that initiates diabetic neuropathy, if nerve myo-Ins is not spuriously high during fa...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:10.1016/s0025-6196(12)61217-8
更新日期:1989-08-01 00:00:00
abstract::Susac syndrome (retinocochleocerebral vasculopathy) is a syndrome of unknown pathogenesis. The triad of multifocal encephalopathy, visual loss, and hearing loss is caused by microangiopathy of the brain, retina, and cochlea. The illness tends to be monophasic, and to our knowledge, recurrence after years of remission ...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:10.4065/76.9.958
更新日期:2001-09-01 00:00:00
abstract::Gastric and gastroesophageal adenocarcinomas continue to be a major health burden globally and collectively represent the third leading cause of cancer death. Among patients with metastatic disease, most die of their cancer because of the limited number of modestly effective treatment regimens available today. The pro...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章,评审
doi:10.1016/j.mayocp.2016.07.018
更新日期:2016-09-01 00:00:00
abstract:OBJECTIVE:To evaluate the efficacy and tolerability of sumatriptan, 50-mg and 100-mg tablets, compared with placebo for treatment of migraine at the first sign of pain. PATIENTS AND METHODS:Two identical multicenter randomized, double-blind, placebo-controlled, single-attack studies were conducted from May through Nov...
journal_title:Mayo Clinic proceedings
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.4065/78.10.1214
更新日期:2003-10-01 00:00:00
abstract::Thalamic deep brain stimulation is becoming increasingly popular for the control of drug-refractory tremor. Implantable cardiac pacemakers and defibrillators are commonly used therapeutic modalities. Concerns exist about the potential interactions between these 2 devices in the same patient, but no experience has been...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:10.4065/76.1.87
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVE:To provide external validation of the diagnostic accuracy of the Sleep Apnea Clinical Score (SACS) tool in a new setting and patient population. PATIENTS AND METHODS:We conducted a prospective cohort study. Potential participants were adult family medicine patients. We excluded patients with a SACS of 0, kno...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:10.1016/j.mayocp.2016.01.022
更新日期:2016-04-01 00:00:00
abstract::Crohn's disease can involve any portion of the digestive tract, but isolated gastric Crohn's disease is a rare entity. In the few previously reported cases, the inflammatory disorder has involved only a portion of the stomach. Herein we describe a patient with diffuse involvement of the entire stomach and an associate...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:10.1016/s0025-6196(12)61750-9
更新日期:1989-07-01 00:00:00
abstract::Nasal telangiectasias, a common condition, can be caused by chronic exposure to ultraviolet light, rosacea, topically applied corticosteroids, or rhinoplasty. Use of the argon laser for 15 to 45 minutes in a continuous mode over the entire involved area can produce considerable lightening of the nasal redness and impr...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:10.1016/s0025-6196(12)62611-1
更新日期:1986-11-01 00:00:00
abstract:OBJECTIVE:To assess the efficacy of brief couples support groups offered concurrently with in vitro fertilization (IVF) treatment. PATIENTS AND METHODS:Couples in IVF treatment were given the option of participating in a biweekly support group at the IVF clinic at Wilford Hall Medical Center, San Antonio, Tex. At leas...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:10.4065/77.10.1060
更新日期:2002-10-01 00:00:00
abstract::Patient-centered care requires that treatments respond to the problematic situation of each patient in a manner that makes intellectual, emotional, and practical sense, an achievement that requires shared decision making (SDM). To implement SDM in practice, tools-sometimes called conversation aids or decision aids-are...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章,评审
doi:10.1016/j.mayocp.2018.08.030
更新日期:2019-04-01 00:00:00
abstract::With the ever-expanding elderly population in the United States, benign prostatic hyperplasia (BPH) has become a widespread condition. Although surgical intervention (open prostatectomy and transurethral resection of the prostate) was the typical management approach for BPH in the past, other options currently include...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章,评审
doi:10.4065/73.6.597
更新日期:1998-06-01 00:00:00
abstract:OBJECTIVE:To assess the efficacy and safety of hyperbaric oxygenation (HBO) therapy as adjunctive treatment for diabetic foot ulcers with a systematic review and meta-analysis of the literature. METHODS:MEDLINE, EMBASE, and the Cochrane Library were searched to find relevant articles published up to April 20, 2012, wi...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章,评审
doi:10.1016/j.mayocp.2012.10.021
更新日期:2013-02-01 00:00:00
abstract::Physical inactivity increases the risk of many chronic disorders. Numerous studies have convincingly demonstrated that undertaking and maintaining moderate levels of physical activity (eg, brisk walking 3 hours a week) greatly reduces the incidence of developing many chronic health conditions, most notably type 2 diab...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章,评审
doi:10.4065/77.2.165
更新日期:2002-02-01 00:00:00
abstract::In August 2015, an expert colloquium commissioned by the Sexual Medicine Society of North America (SMSNA) convened in Washington, DC, to discuss the common clinical scenario of men who present with low testosterone (T) and associated signs and symptoms accompanied by low or normal gonadotropin levels. This syndrome is...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章,评审
doi:10.1016/j.mayocp.2016.04.022
更新日期:2016-07-01 00:00:00
abstract::The platelets of a patient with the Bernard-Soulier syndrome were studied by electron microscopy. The main abnormalities were the presence of giant and often round platelets, hypertrophic and frequently widely dilated open canalicular system, disorganized microtubules, and platelets with sparse or absent granulation....
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:
更新日期:1975-07-01 00:00:00
abstract::Treatment of seniors with Parkinson disease is within the domain of primary care physicians and internists. A good working knowledge of carbidopa/levodopa principles should allow excellent care of most patients, at least during the early years of the disease. Even later, when levodopa responses become more complicated...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章,评审
doi:10.4065/mcp.2011.0443
更新日期:2011-12-01 00:00:00
abstract:OBJECTIVE:To determine the frequency of fetal urinary tract anomalies and to characterize the types of such abnormalities detected on ultrasonography and the outcome of affected patients during a 15-year period at our institution. DESIGN:We retrospectively reviewed the findings on maternal prenatal ultrasound examinat...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:10.4065/70.6.526
更新日期:1995-06-01 00:00:00
abstract::A follow-up study of 224 male patients from Rochester, Minnesota, diagnosed with cryptorchidism during the period from 1935 through 1974 was conducted to assess the frequency of subsequent testicular neoplasms. Age-specific rates for testicular neoplasm in this community were used to estimate an expected number for co...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:10.1016/s0025-6196(12)60660-0
更新日期:1991-04-01 00:00:00
abstract::Restless legs syndrome (RLS)/Willis-Ekbom disease (WED) is a common disorder, occurring at least twice a week and causing at least moderate distress in 1.5% to 2.7% of the population. It is important for primary care physicians to be familiar with this disorder and its management. Much has changed in its management si...
journal_title:Mayo Clinic proceedings
pub_type: 共识发展会议,杂志文章
doi:10.1016/j.mayocp.2013.06.016
更新日期:2013-09-01 00:00:00