Frequency and implication of autoimmune serologies in idiopathic pulmonary fibrosis.

Abstract:

OBJECTIVE:To assess the frequency and clinical implications of positive autoimmune serologies in patients with biopsy-confirmed idiopathic pulmonary fibrosis (IPF). PATIENTS AND METHODS:We reviewed the records of patients at our institution with biopsy-confirmed usual interstitial pneumonia (UIP) from January 1, 1995, through December 31, 2010, for frequency and distribution of autoimmune serologies. Patients with IPF with and without positive serologies were compared. RESULTS:Three hundred eighty-nine consecutive patients with biopsy-confirmed IPF underwent serologic testing, with positive serologic test results being found in 112 (29%). Of 2051 individual screening serologic tests performed, results of 163 tests were positive (8%), with antinuclear antibody being the most frequent (47%). There was no difference in age at biopsy (P=.21), gender (P=.21), or presenting radiologic features between those with or without positive serology. More frequent use of immunosuppressive treatment (P=.02) was noted in those with positive serology. No survival difference was observed (log-rank; P=.43). Median follow-up for the whole cohort was 43.5 months. CONCLUSION:Positive autoimmune serology may occur in as much as one-third of the patients with biopsy-confirmed IPF with no associated clinical implication or survival advantage. Systematic use of autoimmune laboratory panels in patients without clinical features of connective tissue disease should be reconsidered in patients with suspected UIP on chest computed tomography scan or confirmed UIP on biopsy.

journal_name

Mayo Clin Proc

journal_title

Mayo Clinic proceedings

authors

Moua T,Maldonado F,Decker PA,Daniels CE,Ryu JH

doi

10.1016/j.mayocp.2013.11.018

subject

Has Abstract

pub_date

2014-03-01 00:00:00

pages

319-26

issue

3

eissn

0025-6196

issn

1942-5546

pii

S0025-6196(13)01114-2

journal_volume

89

pub_type

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