Abstract:
:Most, but not all, aged rats exhibit a profound deficit in spatial memory when tested in a radial maze--a task known to depend on the integrity of the hippocampal formation. In this study, animals were divided into three groups based on their spatial memory capacity: young adult rats with good memory, aged rats with impaired memory, and aged rats with good memory. Memory-impaired aged animals showed a loss of perforated axospinous synapses in the dentate gyrus of the hippocampal formation in comparison with either young adults or aged rats with good memory. This finding suggests that the loss of perforated axospinous synapses in the hippocampal formation underlies the age-related deficit in spatial memory.
journal_name
Proc Natl Acad Sci U S Aauthors
Geinisman Y,de Toledo-Morrell L,Morrell Fdoi
10.1073/pnas.83.9.3027subject
Has Abstractpub_date
1986-05-01 00:00:00pages
3027-31issue
9eissn
0027-8424issn
1091-6490journal_volume
83pub_type
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