Abstract：
:Pseudozyma sp. are yeasts that are commercially important due to their production of glycolipid biosurfactants, squalene, itaconic acid, and exopolysaccharide. The search for other analgesia inducing drugs, such as opiates and non-steroidal anti-inflammatory drugs (NSAIDs), as alternatives is beneficial. In this study, the antinociceptive and anti-inflammatory actions of α-d-mannan were studied using acetic acid-induced writhing, open field test, formalin test, and carrageenan-induced paw oedema tests in mice. The α-d-mannan obtained from Pseudozyma sp. was confirmed by methylation analysis, 1D and 2D NMR spectroscopic analysis, and GC-MS. The results show that α-d-mannan from Pseudozyma sp. has analgesic and anti-inflammatory activities. Supplementary Information:The online version contains supplementary material available at 10.1007/s13205-020-02635-1.
journal_name
3 Biotechjournal_title
3 Biotechauthors
Valasques Junior GL,Dos Santos JDG,Chaves PFP,Cordeiro LMC,de Jesus CL,de Lima FO,Boffo EF,de Assis SAdoi
10.1007/s13205-020-02635-1subject
Has Abstractpub_date
2021-02-01 00:00:00pages
73issue
2eissn
2190-572Xissn
2190-5738pii
2635journal_volume
11pub_type
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